{
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},
{
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}
},
{
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}
},
{
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}
},
{
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}
},
{
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}
},
{
"id":"6pgg_c",
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}
},
{
"id":"co2_e",
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}
},
{
"id":"akg_e",
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}
},
{
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},
{
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}
},
{
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}
},
{
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}
},
{
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},
{
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}
},
{
"id":"din_p",
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}
},
{
"id":"2pg_c",
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],
"sbo":"SBO:0000247"
}
},
{
"id":"ptrc_p",
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}
},
{
"id":"malt_p",
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},
{
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},
{
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}
},
{
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},
{
"id":"__Ecoli_panGEMs__phphhlipa_c",
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},
{
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}
},
{
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{
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}
},
{
"id":"__Ecoli_panGEMs__1odec11eg3p_c",
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},
{
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{
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{
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},
{
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},
{
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},
{
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},
{
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}
},
{
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{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
"id":"fum_p",
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},
{
"id":"galctn__L_e",
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},
{
"id":"btn_e",
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},
{
"id":"pydxn_p",
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}
},
{
"id":"ocdcea_e",
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}
},
{
"id":"preq0_c",
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},
{
"id":"tyr__L_p",
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},
{
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},
{
"id":"__Ecoli_panGEMs__acmum_e",
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},
{
"id":"man_p",
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}
},
{
"id":"adocbl_e",
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}
},
{
"id":"__Ecoli_panGEMs__iscu_2fe2s_c",
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},
{
"id":"frulysp_c",
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},
{
"id":"dump_p",
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}
},
{
"id":"novbcn_e",
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}
},
{
"id":"__Ecoli_panGEMs__feenter_e",
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"charge":3.0,
"formula":"C30H27FeN3O15",
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},
{
"id":"__Ecoli_panGEMs__eca4und_p",
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"charge":-6.0,
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},
{
"id":"gg4abut_c",
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}
},
{
"id":"__Ecoli_panGEMs__flxr_c",
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"charge":-1.0,
"formula":"XH",
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},
{
"id":"pa160_c",
"name":"1,2-dihexadecanoyl-sn-glycerol-3-phosphate(2-)",
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"charge":-2.0,
"formula":"C35H67O8P",
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},
{
"id":"lcts_c",
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"charge":0.0,
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},
{
"id":"arbtn_e",
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"charge":-3.0,
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}
},
{
"id":"__Ecoli_panGEMs__cdpdhdec9eg_c",
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"charge":-2.0,
"formula":"C44H75N3O15P2",
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},
{
"id":"aso3_c",
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"chebi":[
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}
},
{
"id":"progly_c",
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{
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}
},
{
"id":"__Ecoli_panGEMs__clpn161_p",
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{
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},
{
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}
},
{
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{
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},
{
"id":"tre_e",
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}
},
{
"id":"__Ecoli_panGEMs__iscssh_c",
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},
{
"id":"glyald_c",
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},
{
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}
},
{
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}
},
{
"id":"__Ecoli_panGEMs__3ohexACP_c",
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}
},
{
"id":"rpntp_c",
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},
{
"id":"adocbl_c",
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}
},
{
"id":"__Ecoli_panGEMs__3ocddec5eACP_c",
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{
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},
{
"id":"r5p_c",
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}
},
{
"id":"__Ecoli_panGEMs__clpn120_p",
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},
{
"id":"idon__L_e",
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},
{
"id":"akg_c",
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}
},
{
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}
},
{
"id":"__Ecoli_panGEMs__apg141_c",
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{
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{
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},
{
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},
{
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},
{
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},
{
"id":"all__D_e",
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},
{
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{
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},
{
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},
{
"id":"chtbs_p",
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},
{
"id":"34hpp_c",
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},
{
"id":"__Ecoli_panGEMs__fusa_p",
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},
{
"id":"__Ecoli_panGEMs__metglcur_c",
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},
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"id":"g1p_e",
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},
{
"id":"duri_c",
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},
{
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},
{
"id":"ag_e",
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},
{
"id":"pep_c",
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},
{
"id":"ala_B_c",
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},
{
"id":"h_c",
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}
},
{
"id":"__Ecoli_panGEMs__pa141_c",
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"charge":-2.0,
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},
{
"id":"no2_e",
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}
},
{
"id":"__Ecoli_panGEMs__cdpdddecg_c",
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"charge":-2.0,
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},
{
"id":"rib__D_c",
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}
},
{
"id":"tag6p__D_c",
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}
},
{
"id":"2dr1p_c",
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"charge":-2.0,
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}
},
{
"id":"gthrd_c",
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}
},
{
"id":"__Ecoli_panGEMs__pe140_p",
"name":"Phosphatidylethanolamine (ditetradecanoyl, n-C14:0)",
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"charge":0.0,
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},
{
"id":"__Ecoli_panGEMs__2agpg120_c",
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"charge":-1.0,
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},
{
"id":"dhpppn_c",
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}
},
{
"id":"__Ecoli_panGEMs__2tdecg3p_p",
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"charge":-1.0,
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},
{
"id":"ala__L_e",
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"charge":0.0,
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}
},
{
"id":"g6p_e",
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}
},
{
"id":"__Ecoli_panGEMs__actACP_c",
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"charge":-1.0,
"formula":"C15H25N2O9PRS",
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},
{
"id":"__Ecoli_panGEMs__2odecg3p_c",
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"charge":-1.0,
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},
{
"id":"hdcea_c",
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"charge":-1.0,
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},
{
"id":"hdcoa_c",
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}
},
{
"id":"actp_c",
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"charge":-2.0,
"formula":"C2H3O5P",
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},
{
"id":"2pglyc_c",
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"charge":-3.0,
"formula":"C2H2O6P",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__o16a4colipa_e",
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"charge":-11.0,
"formula":"C312H523N6O200P4",
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},
{
"id":"acgam6p_c",
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"charge":-2.0,
"formula":"C8H14NO9P",
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}
},
{
"id":"g3pc_c",
"name":"choline alfoscerate",
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"charge":0.0,
"formula":"C8H20NO6P",
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"chebi":[
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}
},
{
"id":"thmpp_c",
"name":"thiamine(1+) diphosphate(3-)",
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"charge":-2.0,
"formula":"C12H16N4O7P2S",
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}
},
{
"id":"dmbzid_c",
"name":"5,6-dimethylbenzimidazole",
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"charge":0.0,
"formula":"C9H10N2",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"val__L_p",
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"charge":0.0,
"formula":"C5H11NO2",
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}
},
{
"id":"xtp_c",
"name":"XTP(4-)",
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"charge":-4.0,
"formula":"C10H11N4O15P3",
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"sbo":"SBO:0000247"
}
},
{
"id":"udcpgl_c",
"name":"alpha-D-glucosyl ditrans,polycis-undecaprenyl diphosphate(2-)",
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{
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"id":"__Ecoli_panGEMs__pa181_c",
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},
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},
{
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},
{
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},
{
"id":"__Ecoli_panGEMs__toct2eACP_c",
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{
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},
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{
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},
{
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},
{
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{
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},
{
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},
{
"id":"preq1_c",
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},
{
"id":"__Ecoli_panGEMs__bmoco_c",
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},
{
"id":"__Ecoli_panGEMs__hdceap_c",
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{
"id":"ade_e",
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},
{
"id":"mepn_e",
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},
{
"id":"__Ecoli_panGEMs__bmoco1gdp_c",
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},
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},
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},
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},
{
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},
{
"id":"acnam_p",
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{
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},
{
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"id":"phaccoa_c",
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},
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},
{
"id":"pnto__R_p",
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},
{
"id":"isetac_p",
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},
{
"id":"amp_p",
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}
},
{
"id":"__Ecoli_panGEMs__kdo2lipid4p_c",
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},
{
"id":"dhmptp_c",
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},
{
"id":"cobalt2_e",
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},
{
"id":"cbl1_c",
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},
{
"id":"gal_bD_p",
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},
{
"id":"alaala_p",
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},
{
"id":"fald_p",
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},
{
"id":"uri_p",
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}
},
{
"id":"__Ecoli_panGEMs__thex2eACP_c",
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},
{
"id":"ocdcea_p",
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}
},
{
"id":"__Ecoli_panGEMs__LalaDgluMdapDala_e",
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}
},
{
"id":"__Ecoli_panGEMs__t3c9palmeACP_c",
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"charge":-1.0,
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},
{
"id":"hlipa_c",
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},
{
"id":"dimp_c",
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},
{
"id":"octdececoa_c",
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}
},
{
"id":"__Ecoli_panGEMs__cpe160_c",
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},
{
"id":"cgly_c",
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}
},
{
"id":"__Ecoli_panGEMs__phhlipa_c",
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"charge":-8.0,
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},
{
"id":"__Ecoli_panGEMs__alpp_p",
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},
{
"id":"__Ecoli_panGEMs__lpp_p",
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"formula":"XC16H30O1",
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},
{
"id":"5mtr_p",
"name":"S-methyl-5-thio-D-ribofuranose",
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}
},
{
"id":"__Ecoli_panGEMs__1agpe181_p",
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"charge":0.0,
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},
{
"id":"sf_c",
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}
},
{
"id":"fuc__L_c",
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}
},
{
"id":"__Ecoli_panGEMs__ghb_c",
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},
{
"id":"4abutn_c",
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}
},
{
"id":"accoa_c",
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},
{
"id":"arg__L_c",
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}
},
{
"id":"LalaLglu_p",
"name":"L-alanyl-L-glutamate(1-)",
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}
},
{
"id":"26dap_LL_c",
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}
},
{
"id":"tmam_e",
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}
},
{
"id":"mdhdhf_c",
"name":"(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one",
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}
},
{
"id":"octcoa_c",
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}
},
{
"id":"__Ecoli_panGEMs__moadamp_c",
"name":"MoaD Protein with bound AMP",
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"charge":-1.0,
"formula":"C11H12N5O8P1X",
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}
},
{
"id":"lyx__L_e",
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}
},
{
"id":"mththf_p",
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}
},
{
"id":"gtp_e",
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"charge":-4.0,
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}
},
{
"id":"3hbz_c",
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"charge":0.0,
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}
},
{
"id":"man6p_p",
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}
},
{
"id":"cellb_e",
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"charge":0.0,
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}
},
{
"id":"prpmn_c",
"name":"alpha-D-ribose 1-methylphosphonate 5-phosphate(3-)",
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}
},
{
"id":"uamr_c",
"name":"UDP-N-acetyl-alpha-D-muramate(3-)",
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}
},
{
"id":"__Ecoli_panGEMs__fecrm_un_c",
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"charge":-3.0,
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},
{
"id":"asp__L_c",
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}
},
{
"id":"__Ecoli_panGEMs__lipa_cold_p",
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"charge":-6.0,
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},
{
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}
},
{
"id":"acg5sa_c",
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"charge":-1.0,
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},
{
"id":"arg__L_e",
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}
},
{
"id":"__Ecoli_panGEMs__murein3p3p_p",
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},
{
"id":"__Ecoli_panGEMs__hexACP_c",
"name":"Hexanoyl-ACP (n-C6:0ACP)",
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"charge":-1.0,
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},
{
"id":"dgsn_e",
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"charge":0.0,
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}
},
{
"id":"spmd_e",
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}
},
{
"id":"__Ecoli_panGEMs__pg161_c",
"name":"Phosphatidylglycerol (dihexadec-9-enoyl, n-C16:1)",
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"charge":-1.0,
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},
{
"id":"skm_c",
"name":"shikimate",
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"charge":-1.0,
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}
},
{
"id":"__Ecoli_panGEMs__pe120_p",
"name":"Phosphatidylethanolamine (didodecanoyl, n-C12:0)",
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"charge":0.0,
"formula":"C29H58N1O8P1",
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},
{
"id":"sucgsa_c",
"name":"N-succinyl-L-glutamic 5-semialdehyde(2-)",
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"charge":-2.0,
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},
{
"id":"imp_c",
"name":"IMP(2-)",
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"charge":-2.0,
"formula":"C10H11N4O8P",
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}
},
{
"id":"tartr__L_c",
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"charge":-2.0,
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},
{
"id":"ppal_p",
"name":"propanal",
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},
{
"id":"__Ecoli_panGEMs__colipap_p",
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"charge":-12.0,
"formula":"C176H303N2O103P5",
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},
{
"id":"o2_c",
"name":"dioxygen",
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"charge":0.0,
"formula":"O2",
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},
{
"id":"dhps_p",
"name":"3-sulfopropanediol(1-)",
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"charge":-1.0,
"formula":"C3H7O5S",
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},
{
"id":"ocdcea_c",
"name":"oleate",
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"charge":-1.0,
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},
{
"id":"h_p",
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}
},
{
"id":"3hbcoa_c",
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"charge":-4.0,
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},
{
"id":"succ_p",
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"formula":"C4H4O4",
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}
},
{
"id":"gal_p",
"name":"alpha-D-galactose",
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"formula":"C6H12O6",
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}
},
{
"id":"__Ecoli_panGEMs__2hptcl_c",
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"charge":-1.0,
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},
{
"id":"phpyr_c",
"name":"keto-phenylpyruvate",
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"charge":-1.0,
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}
},
{
"id":"s17bp_c",
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}
},
{
"id":"4ampm_c",
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"charge":-2.0,
"formula":"C6H8N3O4P",
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}
},
{
"id":"__Ecoli_panGEMs__maltttr_p",
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"charge":0.0,
"formula":"C24H42O21",
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},
{
"id":"pydxn_c",
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"charge":0.0,
"formula":"C8H11NO3",
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}
},
{
"id":"__Ecoli_panGEMs__met__D_c",
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"compartment":"c",
"charge":0.0,
"formula":"C5H10NO2S",
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},
{
"id":"fru_e",
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"charge":0.0,
"formula":"C6H12O6",
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}
},
{
"id":"sucorn_c",
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"charge":-1.0,
"formula":"C9H15N2O5",
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},
{
"id":"pyr_e",
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"charge":-1.0,
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},
{
"id":"dtmp_p",
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"charge":-2.0,
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},
{
"id":"34dhcinm_c",
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"charge":-1.0,
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},
{
"id":"arsna_c",
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"charge":-3.0,
"formula":"AsO4",
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}
},
{
"id":"acgal_p",
"name":"N-acetyl-alpha-D-galactosamine",
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"charge":0.0,
"formula":"C8H15NO6",
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}
},
{
"id":"__Ecoli_panGEMs__dtdp4addg_c",
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"charge":-1.0,
"formula":"C16H26N3O14P2",
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},
{
"id":"unagamuf_c",
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"charge":-3.0,
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}
},
{
"id":"idon__L_c",
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"charge":-1.0,
"formula":"C6H11O7",
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}
},
{
"id":"__Ecoli_panGEMs__malttr_e",
"name":"Maltotriose C18H32O16",
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"charge":0.0,
"formula":"C18H32O16",
"annotation":{
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},
{
"id":"cys__D_e",
"name":"D-cysteine zwitterion",
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"charge":0.0,
"formula":"C3H7NO2S",
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}
},
{
"id":"pac_c",
"name":"phenylacetate",
"compartment":"c",
"charge":-1.0,
"formula":"C8H7O2",
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__pgp160_p",
"name":"Phosphatidylglycerophosphate (dihexadecanoyl, n-C16:0)",
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"charge":-3.0,
"formula":"C38H73O13P2",
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},
{
"id":"cbm_c",
"name":"carbamate",
"compartment":"c",
"charge":-1.0,
"formula":"CH2NO2",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__5mthf_c",
"name":"5-Methyltetrahydrofolate",
"compartment":"c",
"charge":-1.0,
"formula":"C20H24N7O6",
"annotation":{
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"sbo":"SBO:0000247"
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},
{
"id":"3hpppn_e",
"name":"3-(3-hydroxyphenyl)propanoate",
"compartment":"e",
"charge":-1.0,
"formula":"C9H9O3",
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"sbo":"SBO:0000247"
}
},
{
"id":"ppt_e",
"name":"hydrogenphosphite",
"compartment":"e",
"charge":-2.0,
"formula":"HO3P",
"annotation":{
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"chebi":[
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"CHEBI:29259"
],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__pmeACP_c",
"name":"Pimeloyl-[acyl-carrier protein] methyl ester",
"compartment":"c",
"charge":-1.0,
"formula":"C19H33N2O10PRS",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"ctbt_c",
"name":"(E)-4-(trimethylammonio)but-2-enoate",
"compartment":"c",
"charge":0.0,
"formula":"C7H13NO2",
"annotation":{
"biggr":"ctbt_c:0",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"nad_c",
"name":"NAD(1-)",
"compartment":"c",
"charge":-1.0,
"formula":"C21H26N7O14P2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"na1_p",
"name":"sodium(1+)",
"compartment":"p",
"charge":1.0,
"formula":"Na",
"annotation":{
"biggr":"na1_p:1",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"glyald_p",
"name":"D-glyceraldehyde",
"compartment":"p",
"charge":0.0,
"formula":"C3H6O3",
"annotation":{
"biggr":"glyald_p:0",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"r1p_c",
"name":"alpha-D-ribose 1-phosphate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C5H9O8P",
"annotation":{
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"chebi":[
"CHEBI:57720"
],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__tdeACP_c",
"name":"Cis-tetradec-7-enoyl-[acyl-carrier protein] (n-C14:1)",
"compartment":"c",
"charge":-1.0,
"formula":"C25H45N2O8PRS",
"annotation":{
"biggr":"__Ecoli_panGEMs__tdeACP_c:-1",
"sbo":"SBO:0000247"
}
},
{
"id":"5mta_c",
"name":"5'-S-methyl-5'-thioadenosine",
"compartment":"c",
"charge":0.0,
"formula":"C11H15N5O3S",
"annotation":{
"biggr":"5mta_c:0",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"23dhba_c",
"name":"2,3-dihydroxybenzoyl 5'-adenylate(1-)",
"compartment":"c",
"charge":-1.0,
"formula":"C17H17N5O10P",
"annotation":{
"biggr":"23dhba_c:-1",
"chebi":[
"CHEBI:57417"
],
"sbo":"SBO:0000247"
}
},
{
"id":"val__L_e",
"name":"L-valine zwitterion",
"compartment":"e",
"charge":0.0,
"formula":"C5H11NO2",
"annotation":{
"biggr":"val__L_e:0",
"chebi":[
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"CHEBI:16414"
],
"sbo":"SBO:0000247"
}
},
{
"id":"ddcacoa_c",
"name":"lauroyl-CoA(4-)",
"compartment":"c",
"charge":-4.0,
"formula":"C33H54N7O17P3S",
"annotation":{
"biggr":"ddcacoa_c:-4",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"gdpofuc_c:-2",
"name":"GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C16H21N5O15P2",
"annotation":{
"biggr":"gdpofuc_c:-2",
"chebi":[
"CHEBI:57964"
],
"sbo":"SBO:0000247"
}
},
{
"id":"rbl__D_c",
"name":"D-ribulose",
"compartment":"c",
"charge":0.0,
"formula":"C5H10O5",
"annotation":{
"biggr":"rbl__D_c:0",
"chebi":[
"CHEBI:17173"
],
"sbo":"SBO:0000247"
}
},
{
"id":"chol_c",
"name":"choline",
"compartment":"c",
"charge":1.0,
"formula":"C5H14NO",
"annotation":{
"biggr":"chol_c:1",
"chebi":[
"CHEBI:15354"
],
"sbo":"SBO:0000247"
}
},
{
"id":"his__L_p",
"name":"L-histidine zwitterion",
"compartment":"p",
"charge":0.0,
"formula":"C6H9N3O2",
"annotation":{
"biggr":"his__L_p:0",
"chebi":[
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"CHEBI:15971"
],
"sbo":"SBO:0000247"
}
},
{
"id":"malt_c",
"name":"maltose",
"compartment":"c",
"charge":0.0,
"formula":"C12H22O11",
"annotation":{
"biggr":"malt_c:0",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"hom__L_e",
"name":"L-homoserine",
"compartment":"e",
"charge":0.0,
"formula":"C4H9NO3",
"annotation":{
"biggr":"hom__L_e:0",
"chebi":[
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"CHEBI:15699"
],
"sbo":"SBO:0000247"
}
},
{
"id":"no2_p",
"name":"nitrite",
"compartment":"p",
"charge":-1.0,
"formula":"NO2",
"annotation":{
"biggr":"no2_p:-1",
"chebi":[
"CHEBI:16301"
],
"sbo":"SBO:0000247"
}
},
{
"id":"dcmp_e",
"name":"2'-deoxycytosine 5'-monophosphate(2-)",
"compartment":"e",
"charge":-2.0,
"formula":"C9H12N3O7P",
"annotation":{
"biggr":"dcmp_e:-2",
"chebi":[
"CHEBI:57566"
],
"sbo":"SBO:0000247"
}
},
{
"id":"dgmp_e",
"name":"2'-deoxyguanosine 5'-monophosphate(2-)",
"compartment":"e",
"charge":-2.0,
"formula":"C10H12N5O7P",
"annotation":{
"biggr":"dgmp_e:-2",
"chebi":[
"CHEBI:57673"
],
"sbo":"SBO:0000247"
}
},
{
"id":"rhcys_c",
"name":"S-(5-deoxy-D-ribos-5-yl)-L-homocysteine",
"compartment":"c",
"charge":0.0,
"formula":"C9H17NO6S",
"annotation":{
"biggr":"rhcys_c:0",
"chebi":[
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"CHEBI:17575"
],
"sbo":"SBO:0000247"
}
},
{
"id":"cd2_e",
"name":"cadmium(2+)",
"compartment":"e",
"charge":2.0,
"formula":"Cd",
"annotation":{
"biggr":"cd2_e:2",
"chebi":[
"CHEBI:48775"
],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__met__D_e",
"name":"D-Methionine",
"compartment":"e",
"charge":0.0,
"formula":"C5H10NO2S",
"annotation":{
"biggr":"__Ecoli_panGEMs__met__D_e:0",
"sbo":"SBO:0000247"
}
},
{
"id":"gbbtn_c",
"name":"4-(trimethylammonio)butanoate",
"compartment":"c",
"charge":0.0,
"formula":"C7H15NO2",
"annotation":{
"biggr":"gbbtn_c:0",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"fald_c",
"name":"formaldehyde",
"compartment":"c",
"charge":0.0,
"formula":"CH2O",
"annotation":{
"biggr":"fald_c:0",
"chebi":[
"CHEBI:16842"
],
"sbo":"SBO:0000247"
}
},
{
"id":"Nmtrp_c",
"name":"3-(1H-indol-3-yl)-2-(methylamino)propanoic acid",
"compartment":"c",
"charge":0.0,
"formula":"C12H14N2O2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"23ccmp_e",
"name":"2',3'-cyclic CMP(1-)",
"compartment":"e",
"charge":-1.0,
"formula":"C9H11N3O7P",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"dmso_e",
"name":"dimethyl sulfoxide",
"compartment":"e",
"charge":0.0,
"formula":"C2H6OS",
"annotation":{
"biggr":"dmso_e:0",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"udpg_e",
"name":"UDP-alpha-D-glucose(2-)",
"compartment":"e",
"charge":-2.0,
"formula":"C15H22N2O17P2",
"annotation":{
"biggr":"udpg_e:-2",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__icolipa_c",
"name":"Inner core oligosaccharide lipid A (E coli)",
"compartment":"c",
"charge":-11.0,
"formula":"C145H251N2O74P4",
"annotation":{
"biggr":"__Ecoli_panGEMs__icolipa_c:-11",
"sbo":"SBO:0000247"
}
},
{
"id":"acgal_e",
"name":"N-acetyl-alpha-D-galactosamine",
"compartment":"e",
"charge":0.0,
"formula":"C8H15NO6",
"annotation":{
"biggr":"acgal_e:0",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"r15bp_c",
"name":"alpha-D-ribose 1,5-bisphosphate(4-)",
"compartment":"c",
"charge":-4.0,
"formula":"C5H8O11P2",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"g3pe_p",
"name":"glycerophosphatidylethanolamine",
"compartment":"p",
"charge":0.0,
"formula":"C5H14NO6P",
"annotation":{
"biggr":"g3pe_p:0",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"crn__D_p",
"name":"(S)-carnitine",
"compartment":"p",
"charge":0.0,
"formula":"C7H15NO3",
"annotation":{
"biggr":"crn__D_p:0",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__3ocvac11eACP_c",
"name":"3-oxo-cis-vacc-11-enoyl-[acyl-carrier protein]",
"compartment":"c",
"charge":-1.0,
"formula":"C29H51N2O9PRS",
"annotation":{
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}
},
{
"id":"cd2_p",
"name":"cadmium(2+)",
"compartment":"p",
"charge":2.0,
"formula":"Cd",
"annotation":{
"biggr":"cd2_p:2",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__3hoctaACP_c",
"name":"(R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]",
"compartment":"c",
"charge":-1.0,
"formula":"C29H55N2O9PRS",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__2agpe181_p",
"name":"2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:1)",
"compartment":"p",
"charge":0.0,
"formula":"C23H46NO7P1",
"annotation":{
"biggr":"__Ecoli_panGEMs__2agpe181_p:0",
"sbo":"SBO:0000247"
}
},
{
"id":"arab__D_c",
"name":"D-arabinopyranose",
"compartment":"c",
"charge":0.0,
"formula":"C5H10O5",
"annotation":{
"biggr":"arab__D_c:0",
"chebi":[
"CHEBI:46994"
],
"sbo":"SBO:0000247"
}
},
{
"id":"2doxg6p_c",
"name":"2-deoxy-D-glucopyranose 6-phosphate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C6H11O8P",
"annotation":{
"biggr":"2doxg6p_c:-2",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"ocdca_c",
"name":"octadecanoate",
"compartment":"c",
"charge":-1.0,
"formula":"C18H35O2",
"annotation":{
"biggr":"ocdca_c:-1",
"chebi":[
"CHEBI:25629"
],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__murein4px4p4p_p",
"name":"Three disacharide linked murein units (tetrapeptide crosslinked tetrapeptide (A2pm->D-ala), one uncrosslinked tetrapaptide) (middle of chain)",
"compartment":"p",
"charge":-6.0,
"formula":"C111H169N21O59",
"annotation":{
"biggr":"__Ecoli_panGEMs__murein4px4p4p_p:-6",
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__2agpg180_c",
"name":"2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)",
"compartment":"c",
"charge":-1.0,
"formula":"C24H48O9P1",
"annotation":{
"biggr":"__Ecoli_panGEMs__2agpg180_c:-1",
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__2tdec7eg3p_p",
"name":"2-tetradec-7-enoyl-sn-glycerol 3-phosphate",
"compartment":"p",
"charge":-1.0,
"formula":"C17H32O7P1",
"annotation":{
"biggr":"__Ecoli_panGEMs__2tdec7eg3p_p:-1",
"sbo":"SBO:0000247"
}
},
{
"id":"sulfac_c",
"name":"sulfonatoacetate",
"compartment":"c",
"charge":-2.0,
"formula":"C2H2O5S",
"annotation":{
"biggr":"sulfac_c:-2",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"mg2_c",
"name":"magnesium(2+)",
"compartment":"c",
"charge":2.0,
"formula":"Mg",
"annotation":{
"biggr":"mg2_c:2",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"dt5hsu_c",
"name":"5-dehydro-4-deoxy-D-glucuronate",
"compartment":"c",
"charge":-1.0,
"formula":"C6H7O6",
"annotation":{
"biggr":"dt5hsu_c:-1",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"acmalt_c",
"name":"1-O-acetylmaltose",
"compartment":"c",
"charge":0.0,
"formula":"C14H24O12",
"annotation":{
"biggr":"acmalt_c:0",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"malcoame_c",
"name":"malonyl-CoA methyl ester(4-)",
"compartment":"c",
"charge":-4.0,
"formula":"C25H36N7O19P3S",
"annotation":{
"biggr":"malcoame_c:-4",
"chebi":[
"CHEBI:71242"
],
"sbo":"SBO:0000247"
}
},
{
"id":"slnt_p",
"name":"selenite(2-)",
"compartment":"p",
"charge":-2.0,
"formula":"O3Se",
"annotation":{
"biggr":"slnt_p:-2",
"chebi":[
"CHEBI:18212"
],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__gmeACP_c",
"name":"Glutaryl-[acyl-carrier protein] methyl ester",
"compartment":"c",
"charge":-1.0,
"formula":"C17H29N2O10PRS",
"annotation":{
"biggr":"__Ecoli_panGEMs__gmeACP_c:-1",
"sbo":"SBO:0000247"
}
},
{
"id":"1hdecg3p_c",
"name":"1-palmitoyl-sn-glycerol 3-phosphate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C19H37O7P",
"annotation":{
"biggr":"1hdecg3p_c:-2",
"chebi":[
"CHEBI:57518"
],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__hgmeACP_c",
"name":"3-Hydroxyglutaryl-[acyl-carrier protein] methyl ester",
"compartment":"c",
"charge":-1.0,
"formula":"C17H29N2O11PRS",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__pg141_p",
"name":"Phosphatidylglycerol (ditetradec-7-enoyl, n-C14:1)",
"compartment":"p",
"charge":-1.0,
"formula":"C34H62O10P1",
"annotation":{
"biggr":"__Ecoli_panGEMs__pg141_p:-1",
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__mpt_c",
"name":"Molybdopterin",
"compartment":"c",
"charge":-2.0,
"formula":"C10H10N5O6PS2Cu",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"ttrcyc_p",
"name":"tetracycline zwitterion",
"compartment":"p",
"charge":0.0,
"formula":"C22H24N2O8",
"annotation":{
"biggr":"ttrcyc_p:0",
"chebi":[
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"CHEBI:27902"
],
"sbo":"SBO:0000247"
}
},
{
"id":"pcresol_c",
"name":"p-cresol",
"compartment":"c",
"charge":0.0,
"formula":"C7H8O",
"annotation":{
"biggr":"pcresol_c:0",
"chebi":[
"CHEBI:17847"
],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__apg181_c",
"name":"Acyl phosphatidylglycerol (n-C18:1)",
"compartment":"c",
"charge":-1.0,
"formula":"C60H110O11P",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"pydx_p",
"name":"pyridoxal",
"compartment":"p",
"charge":0.0,
"formula":"C8H9NO3",
"annotation":{
"biggr":"pydx_p:0",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"2sephchc_c",
"name":"(1R,2S,5S,6S)-2-(3-carboxylatopropanoyl)-5-[(1-carboxylatovinyl)oxy]-6-hydroxycyclohex-3-ene-1-carboxylate",
"compartment":"c",
"charge":-3.0,
"formula":"C14H13O9",
"annotation":{
"biggr":"2sephchc_c:-3",
"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"cellb_p",
"name":"cellobiose",
"compartment":"p",
"charge":0.0,
"formula":"C12H22O11",
"annotation":{
"biggr":"cellb_p:0",
"chebi":[
"CHEBI:17057"
],
"sbo":"SBO:0000247"
}
},
{
"id":"adp_c",
"name":"ADP(3-)",
"compartment":"c",
"charge":-3.0,
"formula":"C10H12N5O10P2",
"annotation":{
"biggr":"adp_c:-3",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"dhps_c",
"name":"3-sulfopropanediol(1-)",
"compartment":"c",
"charge":-1.0,
"formula":"C3H7O5S",
"annotation":{
"biggr":"dhps_c:-1",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"mal__L_c",
"name":"(S)-malate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C4H4O5",
"annotation":{
"biggr":"mal__L_c:-2",
"chebi":[
"CHEBI:15589"
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"sbo":"SBO:0000247"
}
},
{
"id":"urea_c",
"name":"carbamimidic acid",
"compartment":"c",
"charge":0.0,
"formula":"CH4N2O",
"annotation":{
"biggr":"urea_c:0",
"chebi":[
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"CHEBI:48376"
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"sbo":"SBO:0000247"
}
},
{
"id":"gam_c",
"name":"2-ammonio-2-deoxy-D-glucopyranose",
"compartment":"c",
"charge":1.0,
"formula":"C6H14NO5",
"annotation":{
"biggr":"gam_c:1",
"chebi":[
"CHEBI:58723"
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"sbo":"SBO:0000247"
}
},
{
"id":"mercpeth_c",
"name":"mercaptoethanol",
"compartment":"c",
"charge":0.0,
"formula":"C2H6OS",
"annotation":{
"biggr":"mercpeth_c:0",
"chebi":[
"CHEBI:41218"
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"sbo":"SBO:0000247"
}
},
{
"id":"psuri_p",
"name":"pseudouridine",
"compartment":"p",
"charge":0.0,
"formula":"C9H12N2O6",
"annotation":{
"biggr":"psuri_p:0",
"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"5apru_c",
"name":"5-amino-6-(5-phospho-D-ribosylamino)uracil(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C9H13N4O9P",
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{
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{
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{
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{
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{
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{
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{
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{
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{
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},
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{
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{
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{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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{
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},
{
"id":"thymd_p",
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},
{
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},
{
"id":"ditp_c",
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},
{
"id":"__Ecoli_panGEMs__u23ga_c",
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},
{
"id":"__Ecoli_panGEMs__23dappa_e",
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},
{
"id":"__Ecoli_panGEMs__um4p_c",
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{
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{
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{
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},
{
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{
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{
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"charge":-2.0,
"formula":"C4H4O5",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"pacald_p",
"name":"phenylacetaldehyde",
"compartment":"p",
"charge":0.0,
"formula":"C8H8O",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__eca4colipa_p",
"name":"(enterobacterial common antigen)x4 core oligosaccharide lipid A",
"compartment":"p",
"charge":-15.0,
"formula":"C272H447N14O160P4",
"annotation":{
"biggr":"__Ecoli_panGEMs__eca4colipa_p:-15",
"sbo":"SBO:0000247"
}
},
{
"id":"lcts_e",
"name":"lactose",
"compartment":"e",
"charge":0.0,
"formula":"C12H22O11",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"btcoa_c",
"name":"butyryl-CoA(4-)",
"compartment":"c",
"charge":-4.0,
"formula":"C25H38N7O17P3S",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"tmao_p",
"name":"trimethylamine N-oxide",
"compartment":"p",
"charge":0.0,
"formula":"C3H9NO",
"annotation":{
"biggr":"tmao_p:0",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"u3hga_c",
"name":"UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-)",
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"charge":-1.0,
"formula":"C29H50N3O18P2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"tdcoa_c",
"name":"myristoyl-CoA(4-)",
"compartment":"c",
"charge":-4.0,
"formula":"C35H58N7O17P3S",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"udpglcur_e",
"name":"UDP-alpha-D-glucuronate(3-)",
"compartment":"e",
"charge":-3.0,
"formula":"C15H19N2O18P2",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"hxa_p",
"name":"hexanoate",
"compartment":"p",
"charge":-1.0,
"formula":"C6H11O2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__murein3px3p_p",
"name":"Two disacharide linked murein units, tripeptide crosslinked tripeptide (A2pm->A2pm) (middle of chain)",
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"charge":-4.0,
"formula":"C68H102N12O37",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__3hcpalm9eACP_c",
"name":"(R)-3-hydroxy-cis-palm-9-eoyl-[acyl-carrier protein]",
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"charge":-1.0,
"formula":"C27H49N2O9PRS",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"dca_e",
"name":"decanoate",
"compartment":"e",
"charge":-1.0,
"formula":"C10H19O2",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"mobd_p",
"name":"molybdate",
"compartment":"p",
"charge":-2.0,
"formula":"MoO4",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"malt6p_c",
"name":"alpha-maltose 6'-phosphate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C12H21O14P",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"met__L_p",
"name":"L-methionine",
"compartment":"p",
"charge":0.0,
"formula":"C5H11NO2S",
"annotation":{
"biggr":"met__L_p:0",
"chebi":[
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"CHEBI:16643"
],
"sbo":"SBO:0000247"
}
},
{
"id":"g1p_p",
"name":"D-glucopyranose 1-phosphate(2-)",
"compartment":"p",
"charge":-2.0,
"formula":"C6H11O9P",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"ser__L_p",
"name":"L-serine",
"compartment":"p",
"charge":0.0,
"formula":"C3H7NO3",
"annotation":{
"biggr":"ser__L_p:0",
"chebi":[
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"CHEBI:17115"
],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__3ocpalm9eACP_c",
"name":"3-oxo-cis-palm-9-eoyl-[acyl-carrier protein]",
"compartment":"c",
"charge":-1.0,
"formula":"C27H47N2O9PRS",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__2ddecg3p_c",
"name":"2-dodecanoyl-sn-glycerol 3-phosphate",
"compartment":"c",
"charge":-1.0,
"formula":"C15H30O7P1",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__anhgm3p_c",
"name":"N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide",
"compartment":"c",
"charge":-2.0,
"formula":"C34H52N6O19",
"annotation":{
"biggr":"__Ecoli_panGEMs__anhgm3p_c:-2",
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__1agpe161_p",
"name":"1-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:1)",
"compartment":"p",
"charge":0.0,
"formula":"C21H42NO7P1",
"annotation":{
"biggr":"__Ecoli_panGEMs__1agpe161_p:0",
"sbo":"SBO:0000247"
}
},
{
"id":"octa_p",
"name":"octanoate",
"compartment":"p",
"charge":-1.0,
"formula":"C8H15O2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__ggagicolipa_c",
"name":"Glucosyl-galactosyl-glucosyl-inner core oligosaccharide lipid A",
"compartment":"c",
"charge":-11.0,
"formula":"C163H281N2O89P4",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"chtbs_e",
"name":"N,N'-diacetylchitobiose",
"compartment":"e",
"charge":0.0,
"formula":"C16H28N2O11",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"dopa_e",
"name":"dopaminium(1+)",
"compartment":"e",
"charge":1.0,
"formula":"C8H12NO2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"prpnte_p",
"name":"propionate",
"compartment":"p",
"charge":-1.0,
"formula":"C3H5O2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"msa_c",
"name":"3-oxopropanoate",
"compartment":"c",
"charge":-1.0,
"formula":"C3H3O3",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"pser_p",
"name":"O-phosphonato-L-serine(2-)",
"compartment":"p",
"charge":-2.0,
"formula":"C3H6NO6P",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"slnt_c",
"name":"selenite(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"O3Se",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"isetac_e",
"name":"isethionate",
"compartment":"e",
"charge":-1.0,
"formula":"C2H5O4S",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__fe3dhbzs_p",
"name":"Ferric 2,3-dihydroxybenzoylserine",
"compartment":"p",
"charge":2.0,
"formula":"C10H10NO6Fe",
"annotation":{
"biggr":"__Ecoli_panGEMs__fe3dhbzs_p:2",
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__cpgn_c",
"name":"Coprogen",
"compartment":"c",
"charge":-1.0,
"formula":"C35H52N6O13Fe",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__butACP_c",
"name":"Butyryl-ACP (n-C4:0ACP)",
"compartment":"c",
"charge":-1.0,
"formula":"C15H27N2O8PRS",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__metglcur_e",
"name":"1-O-methyl-Beta-D-glucuronate",
"compartment":"e",
"charge":-1.0,
"formula":"C7H11O7",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"cu_e",
"name":"copper(1+)",
"compartment":"e",
"charge":1.0,
"formula":"Cu",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"dgsn_c",
"name":"2'-deoxyguanosine",
"compartment":"c",
"charge":0.0,
"formula":"C10H13N5O4",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__1hdec9eg3p_c",
"name":"1-hexadec-9-enoyl-sn-glycerol 3-phosphate",
"compartment":"c",
"charge":-2.0,
"formula":"C19H35O7P1",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__cdpdtdecg_c",
"name":"CDP-1,2-ditetradecanoylglycerol",
"compartment":"c",
"charge":-2.0,
"formula":"C40H71N3O15P2",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__pe181_c",
"name":"Phosphatidylethanolamine (dioctadec-11-enoyl, n-C18:1)",
"compartment":"c",
"charge":0.0,
"formula":"C41H78N1O8P1",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"dttp_c",
"name":"dTTP(4-)",
"compartment":"c",
"charge":-4.0,
"formula":"C10H13N2O14P3",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__pe120_c",
"name":"Phosphatidylethanolamine (didodecanoyl, n-C12:0)",
"compartment":"c",
"charge":0.0,
"formula":"C29H58N1O8P1",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"but_c",
"name":"butyrate",
"compartment":"c",
"charge":-1.0,
"formula":"C4H7O2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"pe160_p",
"name":"1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine zwitterion",
"compartment":"p",
"charge":0.0,
"formula":"C37H74NO8P",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__pg160_p",
"name":"Phosphatidylglycerol (dihexadecanoyl, n-C16:0)",
"compartment":"p",
"charge":-1.0,
"formula":"C38H74O10P1",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__2agpg160_c",
"name":"2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)",
"compartment":"c",
"charge":-1.0,
"formula":"C22H44O9P1",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__glutrna_c",
"name":"L-Glutamyl-tRNA(Glu)",
"compartment":"c",
"charge":0.0,
"formula":"C5H7NO3R",
"annotation":{
"biggr":"__Ecoli_panGEMs__glutrna_c:0",
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__pa120_p",
"name":"1,2-didodecanoyl-sn-glycerol 3-phosphate",
"compartment":"p",
"charge":-2.0,
"formula":"C27H51O8P1",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"adn_e",
"name":"adenosine",
"compartment":"e",
"charge":0.0,
"formula":"C10H13N5O4",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"3otdcoa_c",
"name":"3-oxotetradecanoyl-CoA(4-)",
"compartment":"c",
"charge":-4.0,
"formula":"C35H56N7O18P3S",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__ddcap_c",
"name":"Dodecanoly-phosphate (n-C12:0)",
"compartment":"c",
"charge":-1.0,
"formula":"C12H24O5P1",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"3hhdcoa_c",
"name":"(S)-3-hydroxypalmitoyl-CoA(4-)",
"compartment":"c",
"charge":-4.0,
"formula":"C37H62N7O18P3S",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"octdp_c",
"name":"all-trans-octaprenyl diphosphate(3-)",
"compartment":"c",
"charge":-3.0,
"formula":"C40H65O7P2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__hdcap_c",
"name":"Hexadecanoyl-phosphate (n-C16:0)",
"compartment":"c",
"charge":-1.0,
"formula":"C16H32O5P",
"annotation":{
"biggr":"__Ecoli_panGEMs__hdcap_c:-1",
"sbo":"SBO:0000247"
}
},
{
"id":"cinnm_c",
"name":"trans-cinnamate",
"compartment":"c",
"charge":-1.0,
"formula":"C9H7O2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"hx2coa_c",
"name":"trans-hex-2-enoyl-CoA(4-)",
"compartment":"c",
"charge":-4.0,
"formula":"C27H40N7O17P3S",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__egmeACP_c",
"name":"Enoylglutaryl-[acyl-carrier protein] methyl ester",
"compartment":"c",
"charge":-1.0,
"formula":"C17H27N2O10PRS",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"uacmam_c",
"name":"UDP-N-acetyl-alpha-D-mannosamine(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C17H25N3O17P2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"arbt6p_c",
"name":"arbutin 6-phosphate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C12H15O10P",
"annotation":{
"biggr":"arbt6p_c:-2",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"cph4_c",
"name":"5,6,7,8-tetrahydropterin-6-carboxylate",
"compartment":"c",
"charge":-1.0,
"formula":"C7H8N5O3",
"annotation":{
"biggr":"cph4_c:-1",
"chebi":[
"CHEBI:61032"
],
"sbo":"SBO:0000247"
}
},
{
"id":"ttdca_c",
"name":"tetradecanoate",
"compartment":"c",
"charge":-1.0,
"formula":"C14H27O2",
"annotation":{
"biggr":"ttdca_c:-1",
"chebi":[
"CHEBI:30807"
],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__glycogen_c",
"name":"Glycogen C6H10O5",
"compartment":"c",
"charge":0.0,
"formula":"C6H10O5",
"annotation":{
"biggr":"__Ecoli_panGEMs__glycogen_c:0",
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__iscu_2fe2s2_c",
"name":"IscU with two bound [2Fe-2S] clusters",
"compartment":"c",
"charge":-4.0,
"formula":"O2S10Fe4R",
"annotation":{
"biggr":"__Ecoli_panGEMs__iscu_2fe2s2_c:-4",
"sbo":"SBO:0000247"
}
},
{
"id":"ahcys_c",
"name":"S-adenosyl-L-homocysteine zwitterion",
"compartment":"c",
"charge":0.0,
"formula":"C14H20N6O5S",
"annotation":{
"biggr":"ahcys_c:0",
"chebi":[
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"CHEBI:16680"
],
"sbo":"SBO:0000247"
}
},
{
"id":"pydx_c",
"name":"pyridoxal",
"compartment":"c",
"charge":0.0,
"formula":"C8H9NO3",
"annotation":{
"biggr":"pydx_c:0",
"chebi":[
"CHEBI:17310"
],
"sbo":"SBO:0000247"
}
},
{
"id":"tmam_p",
"name":"trimethylammonium",
"compartment":"p",
"charge":1.0,
"formula":"C3H10N",
"annotation":{
"biggr":"tmam_p:1",
"chebi":[
"CHEBI:58389"
],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__fe3dcit_e",
"name":"Fe(III)dicitrate",
"compartment":"e",
"charge":-3.0,
"formula":"C12H10FeO14",
"annotation":{
"biggr":"__Ecoli_panGEMs__fe3dcit_e:-3",
"sbo":"SBO:0000247"
}
},
{
"id":"thmnp_c",
"name":"tetrahydromonapterin",
"compartment":"c",
"charge":0.0,
"formula":"C9H15N5O4",
"annotation":{
"biggr":"thmnp_c:0",
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__fe3hox_un_c",
"name":"Fe(III)hydoxamate, unloaded",
"compartment":"c",
"charge":-3.0,
"formula":"C9H18O6N3",
"annotation":{
"biggr":"__Ecoli_panGEMs__fe3hox_un_c:-3",
"sbo":"SBO:0000247"
}
},
{
"id":"lac__D_e",
"name":"(R)-lactate",
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"charge":-1.0,
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"chebi":[
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],
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}
},
{
"id":"__Ecoli_panGEMs__trdox_c",
"name":"Oxidized thioredoxin",
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"charge":0.0,
"formula":"X",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"2mcacn_c",
"name":"(Z)-but-2-ene-1,2,3-tricarboxylate",
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"charge":-3.0,
"formula":"C7H5O6",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"damp_e",
"name":"2'-deoxyadenosine 5'-monophosphate(2-)",
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"charge":-2.0,
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"5mtr_c",
"name":"S-methyl-5-thio-D-ribofuranose",
"compartment":"c",
"charge":0.0,
"formula":"C6H12O4S",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__o16a4und_p",
"name":"(O16 antigen)x4 undecaprenyl diphosphate",
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"charge":-2.0,
"formula":"C191H310N4O107P2",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"aconm_c",
"name":"(2E)-3-(methoxycarbonyl)pent-2-enedioate(2-)",
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"charge":-2.0,
"formula":"C7H6O6",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"adn_p",
"name":"adenosine",
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"charge":0.0,
"formula":"C10H13N5O4",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"3ig3p_c",
"name":"(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate(2-)",
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"charge":-2.0,
"formula":"C11H12NO6P",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"asn__L_p",
"name":"L-asparagine",
"compartment":"p",
"charge":0.0,
"formula":"C4H8N2O3",
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"chebi":[
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"CHEBI:17196"
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"sbo":"SBO:0000247"
}
},
{
"id":"n2o_c",
"name":"dinitrogen oxide",
"compartment":"c",
"charge":0.0,
"formula":"N2O",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"sl26da_c",
"name":"N-(3-carboxylatopropionyl)-LL-2,6-diaminopimelate(2-)",
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"charge":-2.0,
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"hg2_e",
"name":"mercury(2+)",
"compartment":"e",
"charge":2.0,
"formula":"Hg",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"dgsn_p",
"name":"2'-deoxyguanosine",
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"charge":0.0,
"formula":"C10H13N5O4",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__3hoctACP_c",
"name":"(R)-3-Hydroxyoctanoyl-[acyl-carrier protein]",
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"charge":-1.0,
"formula":"C19H35N2O9PRS",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"dctp_c",
"name":"dCTP(4-)",
"compartment":"c",
"charge":-4.0,
"formula":"C9H12N3O13P3",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__toctd2eACP_c",
"name":"Trans-octadec-2-enoyl-[acyl-carrier protein]",
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"charge":-1.0,
"formula":"C29H53N2O8PRS",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"manglyc_p",
"name":"2-(alpha-D-mannosyl)-D-glycerate",
"compartment":"p",
"charge":-1.0,
"formula":"C9H15O9",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"dms_p",
"name":"dimethyl sulfide",
"compartment":"p",
"charge":0.0,
"formula":"C2H6S",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"din_c",
"name":"2'-deoxyinosine",
"compartment":"c",
"charge":0.0,
"formula":"C10H12N4O4",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"h2s_p",
"name":"hydrogen sulfide",
"compartment":"p",
"charge":0.0,
"formula":"H2S",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__dsbcox_p",
"name":"Protein disulfide isomerase II (oxidized)",
"compartment":"p",
"charge":0.0,
"formula":"X",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"ichor_c",
"name":"isochorismate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C10H8O6",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__clpn160_p",
"name":"Cardiolipin (tetrahexadecanoyl, n-C16:0)",
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"charge":-2.0,
"formula":"C73H140O17P2",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__clpn181_p",
"name":"Cardiolipin (tetraoctadec-11-enoyl, n-C18:1)",
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"charge":-2.0,
"formula":"C81H148O17P2",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__feoxam_e",
"name":"Generic ferrioxamine-Fe-III",
"compartment":"e",
"charge":1.0,
"formula":"C25H46FeN6O8",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"lipoate_e",
"name":"(R)-lipoic acid",
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"charge":0.0,
"formula":"C8H14O2S2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"pacald_c",
"name":"phenylacetaldehyde",
"compartment":"c",
"charge":0.0,
"formula":"C8H8O",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"arbt_p",
"name":"hydroquinone O-beta-D-glucopyranoside",
"compartment":"p",
"charge":0.0,
"formula":"C12H16O7",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"cpppg3_c",
"name":"coproporphyrinogen III(4-)",
"compartment":"c",
"charge":-4.0,
"formula":"C36H40N4O8",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__ttdceap_c",
"name":"Tetradecanoyl-phosphate (n-C14:1)",
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"charge":-1.0,
"formula":"C14H26O5P",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__cpmp_c",
"name":"Cyclic pyranopterin monophosphate",
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"charge":-1.0,
"formula":"C10H13N5O8P",
"annotation":{
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}
},
{
"id":"isetac_c",
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"charge":-1.0,
"formula":"C2H5O4S",
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__anhgm4p_c",
"name":"N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide",
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"charge":-2.0,
"formula":"C37H57N7O20",
"annotation":{
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}
},
{
"id":"3ohcoa_c",
"name":"3-oxohexanoyl-CoA(4-)",
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"charge":-4.0,
"formula":"C27H40N7O18P3S",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__gggagicolipa_c",
"name":"Glucosyl-glucosyl-galactosyl-glucosyl-inner core oligosaccharide lipid A",
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"charge":-11.0,
"formula":"C169H291N2O94P4",
"annotation":{
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}
},
{
"id":"doxrbcn_e",
"name":"doxorubicin",
"compartment":"e",
"charge":0.0,
"formula":"C27H29NO11",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"dxylnt_p",
"name":"D-xylonate",
"compartment":"p",
"charge":-1.0,
"formula":"C5H9O6",
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"chebi":[
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}
},
{
"id":"ser__D_e",
"name":"D-serine",
"compartment":"e",
"charge":0.0,
"formula":"C3H7NO3",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__2hptcoa_c",
"name":"2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA",
"compartment":"c",
"charge":-5.0,
"formula":"C29H37N7P3S1O18",
"annotation":{
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},
{
"id":"__Ecoli_panGEMs__grxrd_c",
"name":"Glutaredoxin (reduced)",
"compartment":"c",
"charge":0.0,
"formula":"XH2",
"annotation":{
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},
{
"id":"so2_e",
"name":"sulfur dioxide",
"compartment":"e",
"charge":0.0,
"formula":"O2S",
"annotation":{
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"chebi":[
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}
},
{
"id":"ohpb_c",
"name":"(R)-3-hydroxy-2-oxo-4-(phosphonatoooxy)butanoate",
"compartment":"c",
"charge":-3.0,
"formula":"C4H4O8P",
"annotation":{
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"chebi":[
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}
},
{
"id":"cys__D_c",
"name":"D-cysteine zwitterion",
"compartment":"c",
"charge":0.0,
"formula":"C3H7NO2S",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__pa161_c",
"name":"1,2-dihexadec-9-enoyl-sn-glycerol 3-phosphate",
"compartment":"c",
"charge":-2.0,
"formula":"C35H63O8P1",
"annotation":{
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},
{
"id":"ru5p__D_c",
"name":"D-ribulose 5-phosphate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C5H9O8P",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"23dhmb_c",
"name":"(R)-2,3-dihydroxy-3-methylbutanoate",
"compartment":"c",
"charge":-1.0,
"formula":"C5H9O4",
"annotation":{
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"chebi":[
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}
},
{
"id":"amp_e",
"name":"adenosine 5'-monophosphate(2-)",
"compartment":"e",
"charge":-2.0,
"formula":"C10H12N5O7P",
"annotation":{
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"chebi":[
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},
{
"id":"galur_c",
"name":"aldehydo-D-galacturonate",
"compartment":"c",
"charge":-1.0,
"formula":"C6H9O7",
"annotation":{
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"chebi":[
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},
{
"id":"arab__L_e",
"name":"aldehydo-L-arabinose",
"compartment":"e",
"charge":0.0,
"formula":"C5H10O5",
"annotation":{
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__pgp140_c",
"name":"Phosphatidylglycerophosphate (ditetradecanoyl, n-C14:0)",
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"charge":-3.0,
"formula":"C34H65O13P2",
"annotation":{
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},
{
"id":"o2s_c",
"name":"superoxide",
"compartment":"c",
"charge":-1.0,
"formula":"O2",
"annotation":{
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__pgp161_c",
"name":"Phosphatidylglycerophosphate (dihexadec-9-enoyl, n-C16:1)",
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"charge":-3.0,
"formula":"C38H69O13P2",
"annotation":{
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},
{
"id":"__Ecoli_panGEMs__ps180_c",
"name":"Phosphatidylserine (dioctadecanoyl, n-C18:0)",
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"charge":-1.0,
"formula":"C42H81N1O10P1",
"annotation":{
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},
{
"id":"lald__L_c",
"name":"(S)-lactaldehyde",
"compartment":"c",
"charge":0.0,
"formula":"C3H6O2",
"annotation":{
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"chebi":[
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}
},
{
"id":"ugmd_c",
"name":"UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate(4-)",
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"charge":-4.0,
"formula":"C35H51N7O26P2",
"annotation":{
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"chebi":[
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}
},
{
"id":"2ahhmp_c",
"name":"2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol",
"compartment":"c",
"charge":0.0,
"formula":"C7H9N5O2",
"annotation":{
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"chebi":[
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},
{
"id":"ppcoa_c",
"name":"propionyl-CoA(4-)",
"compartment":"c",
"charge":-4.0,
"formula":"C24H36N7O17P3S",
"annotation":{
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__pe141_c",
"name":"Phosphatidylethanolamine (ditetradec-7-enoyl, n-C14:1)",
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"charge":0.0,
"formula":"C33H62N1O8P1",
"annotation":{
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},
{
"id":"__Ecoli_panGEMs__cpg160_c",
"name":"Cyclopropane phosphatidylglycerol (dihexadec-9,10-cyclo-anoyl, n-C16:0 cyclo)",
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"charge":-1.0,
"formula":"C40H74O10P1",
"annotation":{
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},
{
"id":"__Ecoli_panGEMs__fecrm_c",
"name":"Ferrichrome",
"compartment":"c",
"charge":0.0,
"formula":"C27H42FeN9O12",
"annotation":{
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},
{
"id":"adocbi_c",
"name":"adenosylcobinamide",
"compartment":"c",
"charge":1.0,
"formula":"C58H84CoN16O11",
"annotation":{
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"chebi":[
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}
},
{
"id":"ile__L_p",
"name":"L-isoleucine zwitterion",
"compartment":"p",
"charge":0.0,
"formula":"C6H13NO2",
"annotation":{
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"chebi":[
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}
},
{
"id":"acac_c",
"name":"acetoacetate",
"compartment":"c",
"charge":-1.0,
"formula":"C4H5O3",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"crn__D_e",
"name":"(S)-carnitine",
"compartment":"e",
"charge":0.0,
"formula":"C7H15NO3",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"acmanap_c",
"name":"N-acetyl-D-mannopyranosamine 6-phosphate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C8H14NO9P",
"annotation":{
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"chebi":[
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}
},
{
"id":"nmn_p",
"name":"NMN(-)",
"compartment":"p",
"charge":-1.0,
"formula":"C11H14N2O8P",
"annotation":{
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"chebi":[
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}
},
{
"id":"pppn_e",
"name":"3-phenylpropionate",
"compartment":"e",
"charge":-1.0,
"formula":"C9H9O2",
"annotation":{
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"chebi":[
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}
},
{
"id":"13ppd_c",
"name":"propane-1,3-diol",
"compartment":"c",
"charge":0.0,
"formula":"C3H8O2",
"annotation":{
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"chebi":[
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},
{
"id":"hxan_p",
"name":"hypoxanthine",
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},
{
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},
{
"id":"3hcinnm_e",
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},
{
"id":"gsn_c",
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}
},
{
"id":"metsox_R__L_p",
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},
{
"id":"ins_c",
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},
{
"id":"tmao_c",
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},
{
"id":"__Ecoli_panGEMs__tsul_c",
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{
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},
{
"id":"man6pglyc_c",
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},
{
"id":"ura_c",
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},
{
"id":"__Ecoli_panGEMs__LalaDgluMdap_e",
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{
"id":"chol_e",
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},
{
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}
},
{
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}
},
{
"id":"dha_p",
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},
{
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}
},
{
"id":"__Ecoli_panGEMs__LalaDgluMdapDala_c",
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{
"id":"8aonn_c",
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}
},
{
"id":"__Ecoli_panGEMs__2hdecg3p_c",
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},
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"id":"pdx5p_c",
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},
{
"id":"__Ecoli_panGEMs__colipa_p",
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{
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"id":"tmao_e",
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},
{
"id":"4abzglu_p",
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},
{
"id":"__Ecoli_panGEMs__pe141_p",
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},
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"id":"34dhpha_c",
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{
"id":"__Ecoli_panGEMs__pe181_p",
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},
{
"id":"__Ecoli_panGEMs__2hdecg3p_p",
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},
{
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},
{
"id":"__Ecoli_panGEMs__enlipa_e",
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},
{
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},
{
"id":"__Ecoli_panGEMs__mptamp_c",
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{
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},
{
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},
{
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},
{
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},
{
"id":"dhor__S_c",
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},
{
"id":"mmet_p",
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},
{
"id":"aso3_e",
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},
{
"id":"glyc_e",
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},
{
"id":"adn_c",
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"charge":0.0,
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},
{
"id":"4mop_c",
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},
{
"id":"gal1p_c",
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},
{
"id":"__Ecoli_panGEMs__dsbgox_p",
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"charge":0.0,
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},
{
"id":"2me4p_c",
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},
{
"id":"__Ecoli_panGEMs__pg140_p",
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},
{
"id":"dann_c",
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},
{
"id":"tre_c",
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},
{
"id":"gdpmann_c",
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},
{
"id":"2h3opp_c",
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"formula":"C3H3O4",
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},
{
"id":"hpyr_c",
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},
{
"id":"__Ecoli_panGEMs__2agpg181_c",
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},
{
"id":"__Ecoli_panGEMs__apg120_c",
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"formula":"C42H80O11P",
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},
{
"id":"__Ecoli_panGEMs__apg160_c",
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"charge":-1.0,
"formula":"C54H104O11P",
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},
{
"id":"dad_2_e",
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"charge":0.0,
"formula":"C10H13N5O3",
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},
{
"id":"mchtbs6p_c",
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"formula":"C14H26N2O13P",
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},
{
"id":"fdp_c",
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},
{
"id":"mthgxl_c",
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},
{
"id":"tartr__L_e",
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"formula":"C4H4O6",
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},
{
"id":"cbi_c",
"name":"cobinamide",
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"charge":0.0,
"formula":"C48H72CoN11O8",
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{
"id":"__Ecoli_panGEMs__ocACP_c",
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{
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}
},
{
"id":"hemeO_c",
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}
},
{
"id":"orn__L_e",
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}
},
{
"id":"kdo2lipid4_p",
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}
},
{
"id":"4abut_e",
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"charge":0.0,
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}
},
{
"id":"athtp_c",
"name":"adenosine thiamine triphosphate(2-)",
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}
},
{
"id":"galt1p_c",
"name":"galactitol 1-phosphate(2-)",
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"charge":-2.0,
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}
},
{
"id":"glu__L_e",
"name":"L-glutamate(1-)",
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"charge":-1.0,
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}
},
{
"id":"prpnte_c",
"name":"propionate",
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"charge":-1.0,
"formula":"C3H5O2",
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}
},
{
"id":"3ohodcoa_c",
"name":"3-oxooctadecanoyl-CoA(4-)",
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"charge":-4.0,
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}
},
{
"id":"2oph_c",
"name":"2-octaprenylphenol",
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"charge":0.0,
"formula":"C46H70O",
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],
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}
},
{
"id":"taur_c",
"name":"taurine",
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"charge":0.0,
"formula":"C2H7NO3S",
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}
},
{
"id":"ckdo_c",
"name":"CMP-3-deoxy-beta-D-manno-octulosonate(2-)",
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"charge":-2.0,
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}
},
{
"id":"uamag_c",
"name":"UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate(4-)",
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"charge":-4.0,
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}
},
{
"id":"__Ecoli_panGEMs__23dhbzs3_c",
"name":"2-3-dihydroxybenzoylserine trimer",
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"charge":-1.0,
"formula":"C30H28N3O16",
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}
},
{
"id":"glcr_c",
"name":"D-glucarate(2-)",
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"charge":-2.0,
"formula":"C6H8O8",
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],
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}
},
{
"id":"dhpt_c",
"name":"7,8-dihydropteroate",
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"charge":-1.0,
"formula":"C14H13N6O3",
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}
},
{
"id":"sqg_c",
"name":"3-(alpha-D-6-sulfoquinovosyl)-sn-glycerol(1-)",
"compartment":"c",
"charge":-1.0,
"formula":"C9H17O10S",
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}
},
{
"id":"gmhep7p_c",
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"charge":-2.0,
"formula":"C7H13O10P",
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__fad_p",
"name":"Flavin adenine dinucleotide oxidized",
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"charge":-2.0,
"formula":"C27H31N9O15P2",
"annotation":{
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}
},
{
"id":"manglyc_e",
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"charge":-1.0,
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}
},
{
"id":"ascb__L_p",
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"chebi":[
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],
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}
},
{
"id":"od2coa_c",
"name":"trans-2-octadecenoyl-CoA(4-)",
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"charge":-4.0,
"formula":"C39H64N7O17P3S",
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}
},
{
"id":"idon__L_p",
"name":"L-idonate",
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"charge":-1.0,
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}
},
{
"id":"urea_p",
"name":"carbamimidic acid",
"compartment":"p",
"charge":0.0,
"formula":"CH4N2O",
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"sbo":"SBO:0000247"
}
},
{
"id":"rhmn_c",
"name":"L-rhamnonate",
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"charge":-1.0,
"formula":"C6H11O6",
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}
},
{
"id":"cbp_c",
"name":"carbamoyl phosphate(2-)",
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"charge":-2.0,
"formula":"CH2NO5P",
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}
},
{
"id":"agm_p",
"name":"agmatinium(2+)",
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"formula":"C5H16N4",
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}
},
{
"id":"3mob_c",
"name":"3-methyl-2-oxobutanoate",
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"charge":-1.0,
"formula":"C5H7O3",
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}
},
{
"id":"suchms_c",
"name":"O-succinyl-L-homoserinate(1-)",
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"charge":-1.0,
"formula":"C8H12NO6",
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}
},
{
"id":"__Ecoli_panGEMs__gicolipa_c",
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"charge":-11.0,
"formula":"C151H261N2O79P4",
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}
},
{
"id":"__Ecoli_panGEMs__halipa_e",
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"charge":-6.0,
"formula":"C126H226N2O40P2",
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},
{
"id":"chol_p",
"name":"choline",
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"charge":1.0,
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],
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}
},
{
"id":"butso3_c",
"name":"butane-1-sulfonate",
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"charge":-1.0,
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}
},
{
"id":"dcyt_c",
"name":"2'-deoxycytidine",
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"charge":0.0,
"formula":"C9H13N3O4",
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}
},
{
"id":"3hpppn_p",
"name":"3-(3-hydroxyphenyl)propanoate",
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"charge":-1.0,
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}
},
{
"id":"dc2coa_c",
"name":"trans-dec-2-enoyl-CoA(4-)",
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"charge":-4.0,
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}
},
{
"id":"lipoate_p",
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"charge":0.0,
"formula":"C8H14O2S2",
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}
},
{
"id":"minohp_p",
"name":"myo-inositol hexakisphosphate(12-)",
"compartment":"p",
"charge":-12.0,
"formula":"C6H6O24P6",
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}
},
{
"id":"__Ecoli_panGEMs__2agpg120_p",
"name":"2-Acyl-sn-glycero-3-phosphoglycerol (n-C12:0)",
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"charge":-1.0,
"formula":"C18H36O9P1",
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}
},
{
"id":"dcmp_p",
"name":"2'-deoxycytosine 5'-monophosphate(2-)",
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"charge":-2.0,
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}
},
{
"id":"__Ecoli_panGEMs__2agpg180_p",
"name":"2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)",
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"charge":-1.0,
"formula":"C24H48O9P1",
"annotation":{
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}
},
{
"id":"acglc__D_c",
"name":"6-O-acetyl-beta-D-glucose",
"compartment":"c",
"charge":0.0,
"formula":"C8H14O7",
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__eca3und_p",
"name":"(enterobacterial common antigen)x3 undecaprenyl-diphosphate",
"compartment":"p",
"charge":-5.0,
"formula":"C127H198N9O52P2",
"annotation":{
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}
},
{
"id":"r5p_p",
"name":"D-ribofuranose 5-phosphate(2-)",
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"charge":-2.0,
"formula":"C5H9O8P",
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}
},
{
"id":"1agpe120_p",
"name":"PE(12:0/0:0)",
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"charge":0.0,
"formula":"C17H36NO7P",
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__ragund_c",
"name":"Rhamanosyl-N-acetylglucosamyl-undecaprenyl diphosphate",
"compartment":"c",
"charge":-2.0,
"formula":"C69H113N1O16P2",
"annotation":{
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}
},
{
"id":"oxa_c",
"name":"oxalate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C2O4",
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"chebi":[
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}
},
{
"id":"r5p_e",
"name":"D-ribofuranose 5-phosphate(2-)",
"compartment":"e",
"charge":-2.0,
"formula":"C5H9O8P",
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}
},
{
"id":"no_p",
"name":"nitric oxide",
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"charge":0.0,
"formula":"NO",
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"chebi":[
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}
},
{
"id":"acser_e",
"name":"O-acetyl-L-serine",
"compartment":"e",
"charge":0.0,
"formula":"C5H9NO4",
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}
},
{
"id":"dxylnt_e",
"name":"D-xylonate",
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"charge":-1.0,
"formula":"C5H9O6",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__murein4p4p_p",
"name":"Two linked disacharide tetrapeptide murein units (uncrosslinked, middle of chain)",
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"charge":-4.0,
"formula":"C74H114N14O40",
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}
},
{
"id":"nalme_c",
"name":"N(alpha)-acetyl-L-lysine methyl ester(1+)",
"compartment":"c",
"charge":1.0,
"formula":"C9H19N2O3",
"annotation":{
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}
},
{
"id":"mn2_p",
"name":"manganese(2+)",
"compartment":"p",
"charge":2.0,
"formula":"Mn",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__tpalm2eACP_c",
"name":"Trans-Hexadec-2-enoyl-[acyl-carrier protein]",
"compartment":"c",
"charge":-1.0,
"formula":"C27H49N2O8PRS",
"annotation":{
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}
},
{
"id":"__Ecoli_panGEMs__3hpalmACP_c",
"name":"R-3-hydroxypalmitoyl-[acyl-carrier protein]",
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"charge":-1.0,
"formula":"C27H51N2O9PRS",
"annotation":{
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}
},
{
"id":"12dgr140_c",
"name":"1,2 ditetradecanoylglycerol",
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"charge":0.0,
"formula":"C31H60O5",
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"chebi":[
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}
},
{
"id":"udpg_c",
"name":"UDP-alpha-D-glucose(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C15H22N2O17P2",
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"sbo":"SBO:0000247"
}
},
{
"id":"gln__L_c",
"name":"L-glutamine",
"compartment":"c",
"charge":0.0,
"formula":"C5H10N2O3",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__pgp160_c",
"name":"Phosphatidylglycerophosphate (dihexadecanoyl, n-C16:0)",
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"charge":-3.0,
"formula":"C38H73O13P2",
"annotation":{
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}
},
{
"id":"3c3hmp_c",
"name":"(2S)-2-isopropylmalate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C7H10O5",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__apg161_c",
"name":"Acyl phosphatidylglycerol (n-C16:1)",
"compartment":"c",
"charge":-1.0,
"formula":"C54H98O11P",
"annotation":{
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}
},
{
"id":"pe160_c",
"name":"1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine zwitterion",
"compartment":"c",
"charge":0.0,
"formula":"C37H74NO8P",
"annotation":{
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}
},
{
"id":"tartr__D_e",
"name":"D-tartrate(2-)",
"compartment":"e",
"charge":-2.0,
"formula":"C4H4O6",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"anth_c",
"name":"anthranilate",
"compartment":"c",
"charge":-1.0,
"formula":"C7H6NO2",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__enlipa_p",
"name":"Phosphoethanolamine KDO(2)-lipid (A)",
"compartment":"p",
"charge":-6.0,
"formula":"C112H202N3O42P3",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"pap_c",
"name":"adenosine 3',5'-bismonophosphate(4-)",
"compartment":"c",
"charge":-4.0,
"formula":"C10H11N5O10P2",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__pg181_p",
"name":"Phosphatidylglycerol (dioctadec-11-enoyl, n-C18:1)",
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"charge":-1.0,
"formula":"C42H78O10P1",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"xmp_c",
"name":"5'-xanthylate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C10H11N4O9P",
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"chebi":[
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}
},
{
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},
{
"id":"thcur_c",
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"sbo":"SBO:0000247"
}
},
{
"id":"5phua_c",
"name":"N-carbamoyl-D-phenylglycine",
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}
},
{
"id":"ile__L_e",
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"charge":0.0,
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}
},
{
"id":"nadhx__R_c",
"name":"(R)-NADHX(2-)",
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"charge":-2.0,
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"sbo":"SBO:0000247"
}
},
{
"id":"2omhmbl_c",
"name":"3-demethylubiquinol-8",
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}
},
{
"id":"uppg3_c",
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}
},
{
"id":"3hocoa_c",
"name":"(S)-3-hydroxyoctanoyl-CoA(4-)",
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}
},
{
"id":"2cpr5p_c",
"name":"1-(2-carboxylatophenylamino)-1-deoxy-D-ribulose 5-phosphate(3-)",
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"charge":-3.0,
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"sbo":"SBO:0000247"
}
},
{
"id":"uagmda_c",
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}
},
{
"id":"5dh4dglc_c",
"name":"5-dehydro-4-deoxy-D-glucarate(2-)",
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"charge":-2.0,
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}
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{
"id":"dcmp_c",
"name":"2'-deoxycytosine 5'-monophosphate(2-)",
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}
},
{
"id":"cechddd_c",
"name":"3-(cis-5,6-dihydroxycyclohexa-1,3-dienyl)propanoate",
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"charge":-1.0,
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"25dkglcn_c",
"name":"2,5-didehydro-D-gluconate",
"compartment":"c",
"charge":-1.0,
"formula":"C6H7O7",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"his__L_e",
"name":"L-histidine zwitterion",
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"charge":0.0,
"formula":"C6H9N3O2",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"dgmp_c",
"name":"2'-deoxyguanosine 5'-monophosphate(2-)",
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"charge":-2.0,
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"hxan_e",
"name":"hypoxanthine",
"compartment":"e",
"charge":0.0,
"formula":"C5H4N4O",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"adphep_DD_c",
"name":"ADP-D-glycero-beta-D-manno-heptose(2-)",
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"charge":-2.0,
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"4mhetz_c",
"name":"5-(2-hydroxyethyl)-4-methylthiazole",
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"charge":0.0,
"formula":"C6H9NOS",
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"chebi":[
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}
},
{
"id":"h2s_e",
"name":"hydrogen sulfide",
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"charge":0.0,
"formula":"H2S",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"na1_e",
"name":"sodium(1+)",
"compartment":"e",
"charge":1.0,
"formula":"Na",
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"chebi":[
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}
},
{
"id":"tyr__L_e",
"name":"L-tyrosine",
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"charge":0.0,
"formula":"C9H11NO3",
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"chebi":[
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}
},
{
"id":"acac_e",
"name":"acetoacetate",
"compartment":"e",
"charge":-1.0,
"formula":"C4H5O3",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"2dmmq8_c",
"name":"2-demethylmenaquinone-8",
"compartment":"c",
"charge":0.0,
"formula":"C50H70O2",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"4adcho_c",
"name":"4-amino-4-deoxychorismate(1-)",
"compartment":"c",
"charge":-1.0,
"formula":"C10H10NO5",
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__fmn_e",
"name":"FMN C17H19N4O9P",
"compartment":"e",
"charge":-2.0,
"formula":"C17H19N4O9P",
"annotation":{
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}
},
{
"id":"cys__L_e",
"name":"L-cysteine zwitterion",
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"charge":0.0,
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"chebi":[
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}
},
{
"id":"glyc3p_e",
"name":"sn-glycerol 3-phosphate(2-)",
"compartment":"e",
"charge":-2.0,
"formula":"C3H7O6P",
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"chebi":[
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}
},
{
"id":"rib__D_p",
"name":"D-ribofuranose",
"compartment":"p",
"charge":0.0,
"formula":"C5H10O5",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"26dap__M_e",
"name":"meso-2,6-diaminopimelic acid dizwitterion",
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"charge":0.0,
"formula":"C7H14N2O4",
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"chebi":[
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}
},
{
"id":"xyl__D_p",
"name":"D-xylopyranose",
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"charge":0.0,
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}
},
{
"id":"3hcinnm_c",
"name":"trans-3-coumarate",
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"charge":-1.0,
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"chebi":[
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}
},
{
"id":"inost_p",
"name":"myo-inositol",
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"charge":0.0,
"formula":"C6H12O6",
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}
},
{
"id":"pppn_c",
"name":"3-phenylpropionate",
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"charge":-1.0,
"formula":"C9H9O2",
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}
},
{
"id":"ocdca_p",
"name":"octadecanoate",
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"charge":-1.0,
"formula":"C18H35O2",
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__dtdp4aaddg_c",
"name":"DTDP-4-acetamido-4,6-dideoxy-D-galactose",
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"charge":-2.0,
"formula":"C18H27N3O15P2",
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}
},
{
"id":"__Ecoli_panGEMs__malthx_c",
"name":"Maltohexaose",
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"charge":0.0,
"formula":"C36H62O31",
"annotation":{
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}
},
{
"id":"__Ecoli_panGEMs__maltpt_c",
"name":"Maltopentaose",
"compartment":"c",
"charge":0.0,
"formula":"C30H52O26",
"annotation":{
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}
},
{
"id":"g3ps_e",
"name":"sn-glycero-3-phosphoserine(1-)",
"compartment":"e",
"charge":-1.0,
"formula":"C6H13NO8P",
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"chebi":[
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}
},
{
"id":"acon_T_c",
"name":"trans-aconitate(3-)",
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"charge":-3.0,
"formula":"C6H3O6",
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"chebi":[
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}
},
{
"id":"3gmp_p",
"name":"guanosine 3'-monophosphate(2-)",
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"charge":-2.0,
"formula":"C10H12N5O8P",
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__maltttr_c",
"name":"Maltotetraose",
"compartment":"c",
"charge":0.0,
"formula":"C24H42O21",
"annotation":{
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}
},
{
"id":"bbtcoa_c",
"name":"gamma-butyrobetainyl-CoA(3-)",
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"charge":-3.0,
"formula":"C28H46N8O17P3S",
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"chebi":[
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}
},
{
"id":"duri_p",
"name":"2'-deoxyuridine",
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"charge":0.0,
"formula":"C9H12N2O5",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__anhgm4p_p",
"name":"N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide",
"compartment":"p",
"charge":-2.0,
"formula":"C37H57N7O20",
"annotation":{
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}
},
{
"id":"ddca_e",
"name":"dodecanoate",
"compartment":"e",
"charge":-1.0,
"formula":"C12H23O2",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"udpLa4n_c",
"name":"UDP-4-amino-4-deoxy-beta-L-arabinopyranose(1-)",
"compartment":"c",
"charge":-1.0,
"formula":"C14H22N3O15P2",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"tartr__L_p",
"name":"L-tartrate(2-)",
"compartment":"p",
"charge":-2.0,
"formula":"C4H4O6",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__octeACP_c",
"name":"Cis-octadec-11-enoyl-[acyl-carrier protein] (n-C18:1)",
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"charge":-1.0,
"formula":"C29H53N2O8PRS",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"26dap__M_p",
"name":"meso-2,6-diaminopimelic acid dizwitterion",
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"charge":0.0,
"formula":"C7H14N2O4",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__hacolipa_e",
"name":"Hepta-acylated core oligosaccharide lipid A (E. coli)",
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"charge":-11.0,
"formula":"C192H333N2O101P4",
"annotation":{
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}
},
{
"id":"gtspmd_c",
"name":"glutathionylspermidinium(2+)",
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"charge":2.0,
"formula":"C17H36N6O5S",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__o16aund_c",
"name":"O16 antigen undecaprenyl diphosphate",
"compartment":"c",
"charge":-2.0,
"formula":"C89H145N1O32P2",
"annotation":{
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"sbo":"SBO:0000247"
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},
{
"id":"__Ecoli_panGEMs__o16aund_p",
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"charge":-2.0,
"formula":"C89H145N1O32P2",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__3hhexACP_c",
"name":"(R)-3-Hydroxyhexanoyl-[acyl-carrier protein]",
"compartment":"c",
"charge":-1.0,
"formula":"C17H31N2O9PRS",
"annotation":{
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}
},
{
"id":"adocbl_p",
"name":"cobamamide",
"compartment":"p",
"charge":0.0,
"formula":"C72H100CoN18O17P",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__acolipa_p",
"name":"4-Amino-4-deoxy-L-arabinose modified core oligosaccharide lipid A",
"compartment":"p",
"charge":-9.0,
"formula":"C181H314N3O103P4",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"butso3_p",
"name":"butane-1-sulfonate",
"compartment":"p",
"charge":-1.0,
"formula":"C4H9O3S",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"cys__L_p",
"name":"L-cysteine zwitterion",
"compartment":"p",
"charge":0.0,
"formula":"C3H7NO2S",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__cpgn_un_c",
"name":"Coprogen unloaded (no Fe(III))",
"compartment":"c",
"charge":-4.0,
"formula":"C35H52N6O13",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__ps161_c",
"name":"Phosphatidylserine (dihexadec-9-enoyl, n-C16:1)",
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"charge":-1.0,
"formula":"C38H69N1O10P1",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__t3c5ddeceACP_c",
"name":"Trans-3-cis-5-dodecenoyl-[acyl-carrier protein]",
"compartment":"c",
"charge":-1.0,
"formula":"C23H39N2O8PRS",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__ps120_c",
"name":"Phosphatidylserine (didodecanoyl, n-C12:0)",
"compartment":"c",
"charge":-1.0,
"formula":"C30H57N1O10P1",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__arbtn_fe3_p",
"name":"Aerobactin",
"compartment":"p",
"charge":0.0,
"formula":"C22H33FeN4O13",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"12dgr161_p",
"name":"1,2-di-palmitoleoyl-2-sn-glycerol",
"compartment":"p",
"charge":0.0,
"formula":"C35H64O5",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"progly_p",
"name":"L-prolinylglycine zwitterion",
"compartment":"p",
"charge":0.0,
"formula":"C7H12N2O3",
"annotation":{
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"chebi":[
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"CHEBI:61695"
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"sbo":"SBO:0000247"
}
},
{
"id":"orn__L_p",
"name":"L-ornithinium(1+)",
"compartment":"p",
"charge":1.0,
"formula":"C5H13N2O2",
"annotation":{
"biggr":"orn__L_p:1",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__pa181_p",
"name":"1,2-dioctadec-11-enoyl-sn-glycerol 3-phosphate",
"compartment":"p",
"charge":-2.0,
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{
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{
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{
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},
{
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"id":"__Ecoli_panGEMs__mococdp_c",
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{
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{
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"id":"pacald_e",
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},
{
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{
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},
{
"id":"cyan_p",
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},
{
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},
{
"id":"__Ecoli_panGEMs__LalaDgluMdapDala_p",
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},
{
"id":"mercppyr_c",
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},
{
"id":"__Ecoli_panGEMs__garagund_c",
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},
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},
{
"id":"udpg_p",
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},
{
"id":"inost_e",
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},
{
"id":"__Ecoli_panGEMs__fe3dhbzs_e",
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},
{
"id":"cytd_e",
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},
{
"id":"__Ecoli_panGEMs__o16a3und_p",
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},
{
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},
{
"id":"2dmmql8_c",
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},
{
"id":"__Ecoli_panGEMs__t3c7mrseACP_c",
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},
{
"id":"g3pe_c",
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},
{
"id":"cu2_c",
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"charge":2.0,
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},
{
"id":"__Ecoli_panGEMs__t3c11vaceACP_c",
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"charge":-1.0,
"formula":"C29H51N2O8PRS",
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},
{
"id":"tcynt_e",
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},
{
"id":"glyclt_e",
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"charge":-1.0,
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"sbo":"SBO:0000247"
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},
{
"id":"__Ecoli_panGEMs__pg180_c",
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"charge":-1.0,
"formula":"C42H82O10P1",
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},
{
"id":"12ppd__S_e",
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},
{
"id":"__Ecoli_panGEMs__14glucan_c",
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"charge":0.0,
"formula":"C36H62O31",
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},
{
"id":"__Ecoli_panGEMs__cdpdodec11eg_c",
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"charge":-2.0,
"formula":"C48H83N3O15P2",
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},
{
"id":"pyr5carb_c",
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"charge":-1.0,
"formula":"C5H6NO2",
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{
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{
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},
{
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{
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{
"id":"dump_e",
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{
"id":"3dhsk_c",
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{
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{
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},
{
"id":"urate_p",
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},
{
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},
{
"id":"h2o_c",
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},
{
"id":"__Ecoli_panGEMs__gagicolipa_c",
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},
{
"id":"__Ecoli_panGEMs__feenter_p",
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},
{
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},
{
"id":"ala__D_c",
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},
{
"id":"glcr_p",
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},
{
"id":"alac__S_c",
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},
{
"id":"2amsa_c",
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},
{
"id":"__Ecoli_panGEMs__dsbaox_p",
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"charge":0.0,
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},
{
"id":"tre_p",
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},
{
"id":"__Ecoli_panGEMs__pa161_p",
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{
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{
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{
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{
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{
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},
{
"id":"gal1p_e",
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},
{
"id":"gly_c",
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},
{
"id":"__Ecoli_panGEMs__2fe1s_c",
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},
{
"id":"__Ecoli_panGEMs__flxso_c",
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{
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{
"id":"malcoa_c",
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},
{
"id":"fru_p",
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},
{
"id":"xyl__D_e",
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{
"id":"galctn__D_e",
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},
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},
{
"id":"3odcoa_c",
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{
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},
{
"id":"__Ecoli_panGEMs__uLa4n_c",
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{
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},
{
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},
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},
{
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},
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},
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},
{
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},
{
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},
{
"id":"__Ecoli_panGEMs__2agpg141_c",
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},
{
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},
{
"id":"3hcinnm_p",
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},
{
"id":"__Ecoli_panGEMs__2agpg161_c",
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},
{
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},
{
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},
{
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},
{
"id":"fald_e",
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},
{
"id":"prlp_c",
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},
{
"id":"uacgam_p",
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},
{
"id":"2ddara_c",
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},
{
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},
{
"id":"s7p_c",
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},
{
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},
{
"id":"__Ecoli_panGEMs__murein5p5p5p_p",
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},
{
"id":"nicrnt_c",
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},
{
"id":"__Ecoli_panGEMs__murein4px4p_p",
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},
{
"id":"csn_e",
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}
},
{
"id":"__Ecoli_panGEMs__tmrs2eACP_c",
"name":"Trans-Tetradec-2-enoyl-[acyl-carrier protein]",
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"charge":-1.0,
"formula":"C25H45N2O8PRS",
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},
{
"id":"o2_e",
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},
{
"id":"pe180_c",
"name":"1,2-distearoylphosphatidylethanolamine zwitterion",
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"formula":"C41H82NO8P",
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},
{
"id":"kdo8p_c",
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},
{
"id":"succ_e",
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}
},
{
"id":"ser__L_e",
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}
},
{
"id":"__Ecoli_panGEMs__cpg180_c",
"name":"Cyclopropane phosphatidylglycerol (dioctadec-11,12-cyclo-anoyl, n-C18:0 cyclo)",
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},
{
"id":"mql8_c",
"name":"menaquinol-8",
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}
},
{
"id":"__Ecoli_panGEMs__pg120_p",
"name":"Phosphatidylglycerol (didodecanoyl, n-C12:0)",
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}
},
{
"id":"amob_c",
"name":"S-adenosyl-4-methylthio-2-oxobutanoate",
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}
},
{
"id":"xtsn_e",
"name":"xanthosine",
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"charge":0.0,
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}
},
{
"id":"ttdca_e",
"name":"tetradecanoate",
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}
},
{
"id":"__Ecoli_panGEMs__2hdec9eg3p_c",
"name":"2-hexadec-9-enoyl-sn-glycerol 3-phosphate",
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}
},
{
"id":"5dglcn_c",
"name":"5-dehydro-D-gluconate",
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},
{
"id":"cl_c",
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}
},
{
"id":"2oxpaccoa_c",
"name":"2-oxepin-2(3H)-ylideneacetyl-CoA(4-)",
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}
},
{
"id":"mmcoa__S_c",
"name":"(S)-methylmalonyl-CoA(5-)",
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}
},
{
"id":"glyc__R_c",
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"charge":-1.0,
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}
},
{
"id":"mmet_e",
"name":"S-methyl-L-methionine",
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"charge":1.0,
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}
},
{
"id":"dms_c",
"name":"dimethyl sulfide",
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"charge":0.0,
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],
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}
},
{
"id":"g6p_c",
"name":"D-glucopyranose 6-phosphate(2-)",
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}
},
{
"id":"N1aspmd_c",
"name":"N(1)-acetylspermidinium(2+)",
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}
},
{
"id":"__Ecoli_panGEMs__trdrd_c",
"name":"Reduced thioredoxin",
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"charge":0.0,
"formula":"XH2",
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}
},
{
"id":"2dh3dgal_c",
"name":"2-dehydro-3-deoxy-D-galactonate",
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}
},
{
"id":"methf_c",
"name":"(6R)-5,10-methenyltetrahydrofolate",
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}
},
{
"id":"__Ecoli_panGEMs__ddcaACP_c",
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}
},
{
"id":"mnl1p_c",
"name":"D-mannitol 1-phosphate(2-)",
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}
},
{
"id":"agm_c",
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"charge":2.0,
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}
},
{
"id":"ala__L_p",
"name":"L-alanine",
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"charge":0.0,
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}
},
{
"id":"prpp_c",
"name":"5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)",
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},
{
"id":"hkndd_c",
"name":"2-hydroxy-6-oxonona-2,4-dienedioate",
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}
},
{
"id":"galur_p",
"name":"aldehydo-D-galacturonate",
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}
},
{
"id":"all6p_c",
"name":"D-allose 6-phosphate(2-)",
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},
{
"id":"allul6p_c",
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}
},
{
"id":"histd_c",
"name":"L-histidinol(1+)",
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},
{
"id":"for_p",
"name":"formate",
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},
{
"id":"orot_c",
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},
{
"id":"galt_p",
"name":"galactitol",
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}
},
{
"id":"__Ecoli_panGEMs__fecrm_e",
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"charge":0.0,
"formula":"C27H42FeN9O12",
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{
"id":"glc__D_p",
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{
"id":"damp_c",
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},
{
"id":"__Ecoli_panGEMs__fmn_c",
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},
{
"id":"mal__D_e",
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},
{
"id":"3oddcoa_c",
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},
{
"id":"phe__L_p",
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},
{
"id":"g3pg_p",
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},
{
"id":"__Ecoli_panGEMs__tsul_p",
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},
{
"id":"__Ecoli_panGEMs__trnaglu_c",
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},
{
"id":"ppgpp_c",
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},
{
"id":"ins_e",
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},
{
"id":"thm_p",
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}
},
{
"id":"eths_c",
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"formula":"C2H5O3S",
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}
},
{
"id":"__Ecoli_panGEMs__arbtn_fe3_e",
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"charge":0.0,
"formula":"C22H33FeN4O13",
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},
{
"id":"q8_c",
"name":"ubiquinone-8",
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},
{
"id":"acgam1p_p",
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}
},
{
"id":"orn__L_c",
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},
{
"id":"cl_e",
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},
{
"id":"stcoa_c",
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}
},
{
"id":"2ombzl_c",
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}
},
{
"id":"__Ecoli_panGEMs__murein5px4p_p",
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"charge":-4.0,
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},
{
"id":"gthox_e",
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}
},
{
"id":"damp_p",
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"formula":"C10H12N5O6P",
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}
},
{
"id":"__Ecoli_panGEMs__dcaACP_c",
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"charge":-1.0,
"formula":"C21H39N2O8PRS",
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},
{
"id":"3gmp_e",
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"formula":"C10H12N5O8P",
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}
},
{
"id":"etha_c",
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"formula":"C2H8NO",
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}
},
{
"id":"__Ecoli_panGEMs__3hcddec5eACP_c",
"name":"(R)-3-hydroxy-cis-dodec-5-enoyl-[acyl-carrier protein]",
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"charge":-1.0,
"formula":"C23H41N2O9PRS",
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},
{
"id":"betald_c",
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"charge":1.0,
"formula":"C5H12NO",
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}
},
{
"id":"udpglcur_p",
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"charge":-3.0,
"formula":"C15H19N2O18P2",
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}
},
{
"id":"__Ecoli_panGEMs__2agpg140_p",
"name":"2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:0)",
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"charge":-1.0,
"formula":"C20H40O9P1",
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}
},
{
"id":"__Ecoli_panGEMs__tddec2eACP_c",
"name":"Trans-Dodec-2-enoyl-[acyl-carrier protein]",
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"charge":-1.0,
"formula":"C23H41N2O8PRS",
"annotation":{
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}
},
{
"id":"hdca_c",
"name":"hexadecanoate",
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"charge":-1.0,
"formula":"C16H31O2",
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}
},
{
"id":"1agpe180_p",
"name":"1-stearoyl-sn-glycero-3-phosphoethanolamine",
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"charge":0.0,
"formula":"C23H48NO7P",
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"sbo":"SBO:0000247"
}
},
{
"id":"fgam_c",
"name":"N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide(2-)",
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"charge":-2.0,
"formula":"C8H13N2O9P",
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"sbo":"SBO:0000247"
}
},
{
"id":"pe180_p",
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"charge":0.0,
"formula":"C41H82NO8P",
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}
},
{
"id":"__Ecoli_panGEMs__1agpg141_p",
"name":"1-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1)",
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"charge":-1.0,
"formula":"C20H38O9P1",
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}
},
{
"id":"__Ecoli_panGEMs__2agpe181_c",
"name":"2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:1)",
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"charge":0.0,
"formula":"C23H46NO7P1",
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}
},
{
"id":"dd2coa_c",
"name":"trans-dodec-2-enoyl-CoA(4-)",
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"charge":-4.0,
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],
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}
},
{
"id":"__Ecoli_panGEMs__sufbcd_c",
"name":"SufBCD scaffold complex",
"compartment":"c",
"charge":0.0,
"formula":"H8O2S6R",
"annotation":{
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}
},
{
"id":"iasp_c",
"name":"iminoaspartate",
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"charge":-2.0,
"formula":"C4H3NO4",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"3hpp_e",
"name":"3-hydroxypropionate",
"compartment":"e",
"charge":-1.0,
"formula":"C3H5O3",
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"chebi":[
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],
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}
},
{
"id":"nadphx__R_c",
"name":"(R)-NADPHX(4-)",
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"charge":-4.0,
"formula":"C21H28N7O18P3",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__opmeACP_c",
"name":"3-Oxo-pimeloyl-[acyl-carrier protein] methyl ester",
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"charge":-1.0,
"formula":"C19H31N2O11PRS",
"annotation":{
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}
},
{
"id":"meoh_p",
"name":"methanol",
"compartment":"p",
"charge":0.0,
"formula":"CH4O",
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__bwco1gdp_c",
"name":"Tungsten bispterin cofactor mono-guanine dinucleotide",
"compartment":"c",
"charge":-4.0,
"formula":"C30H32N15O20P3S4W",
"annotation":{
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}
},
{
"id":"cit_c",
"name":"citrate(3-)",
"compartment":"c",
"charge":-3.0,
"formula":"C6H5O7",
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"chebi":[
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],
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}
},
{
"id":"skm5p_c",
"name":"3-phosphonatoshikimate(3-)",
"compartment":"c",
"charge":-3.0,
"formula":"C7H8O8P",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"oaa_c",
"name":"oxaloacetate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C4H2O5",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"td2coa_c",
"name":"trans-tetradec-2-enoyl-CoA(4-)",
"compartment":"c",
"charge":-4.0,
"formula":"C35H56N7O17P3S",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"acmet__L_c",
"name":"N-acetyl-L-methionine(1-)",
"compartment":"c",
"charge":-1.0,
"formula":"C7H12NO3S",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"nadhx__S_c",
"name":"(S)-NADHX(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C21H29N7O15P2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"tre6p_c",
"name":"alpha,alpha-trehalose 6-phosphate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C12H21O14P",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"23dhmp_c",
"name":"(2R,3R)-2,3-dihydroxy-3-methylpentanoate",
"compartment":"c",
"charge":-1.0,
"formula":"C6H11O4",
"annotation":{
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"chebi":[
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],
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}
},
{
"id":"tagur_c",
"name":"D-tagaturonate",
"compartment":"c",
"charge":-1.0,
"formula":"C6H9O7",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"man6p_c",
"name":"alpha-D-mannose 6-phosphate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C6H11O9P",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"acgam_e",
"name":"N-acetyl-D-glucosamine",
"compartment":"e",
"charge":0.0,
"formula":"C8H15NO6",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"hmbil_c",
"name":"preuroporphyrinogen(8-)",
"compartment":"c",
"charge":-8.0,
"formula":"C40H38N4O17",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"no3_e",
"name":"nitrate",
"compartment":"e",
"charge":-1.0,
"formula":"NO3",
"annotation":{
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"chebi":[
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],
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}
},
{
"id":"fprica_c",
"name":"5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C10H13N4O9P",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"ara5p_c",
"name":"aldehydo-D-arabinose 5-phosphate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C5H9O8P",
"annotation":{
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}
},
{
"id":"pnto__R_e",
"name":"(R)-pantothenate",
"compartment":"e",
"charge":-1.0,
"formula":"C9H16NO5",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"dtdprmn_c",
"name":"dTDP-6-deoxy-beta-L-mannose(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C16H24N2O15P2",
"annotation":{
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}
},
{
"id":"mana_c",
"name":"D-mannonate",
"compartment":"c",
"charge":-1.0,
"formula":"C6H11O7",
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"chebi":[
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],
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}
},
{
"id":"3dhguln_c",
"name":"3-dehydro-L-gulonate",
"compartment":"c",
"charge":-1.0,
"formula":"C6H9O7",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"kdo_c",
"name":"3-deoxy-alpha-D-manno-oct-2-ulosonate",
"compartment":"c",
"charge":-1.0,
"formula":"C8H13O8",
"annotation":{
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}
},
{
"id":"glcn_e",
"name":"D-gluconate",
"compartment":"e",
"charge":-1.0,
"formula":"C6H11O7",
"annotation":{
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"chebi":[
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],
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}
},
{
"id":"duri_e",
"name":"2'-deoxyuridine",
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"charge":0.0,
"formula":"C9H12N2O5",
"annotation":{
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"chebi":[
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],
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}
},
{
"id":"hqn_c",
"name":"hydroquinone",
"compartment":"c",
"charge":0.0,
"formula":"C6H6O2",
"annotation":{
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"chebi":[
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],
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}
},
{
"id":"lipidA_c",
"name":"lipid IVA(4-)",
"compartment":"c",
"charge":-4.0,
"formula":"C68H126N2O23P2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"glucys_c",
"name":"L-gamma-glutamyl-L-cysteinate(1-)",
"compartment":"c",
"charge":-1.0,
"formula":"C8H13N2O5S",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"2omph_c",
"name":"2-methoxy-6-(all-trans-octaprenyl)phenol",
"compartment":"c",
"charge":0.0,
"formula":"C47H72O2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"sbt6p_c",
"name":"D-glucitol 6-phosphate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C6H13O9P",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__scl_c",
"name":"Sirohydrochlorin",
"compartment":"c",
"charge":-7.0,
"formula":"C42H39N4O16",
"annotation":{
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}
},
{
"id":"minohp_e",
"name":"myo-inositol hexakisphosphate(12-)",
"compartment":"e",
"charge":-12.0,
"formula":"C6H6O24P6",
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}
},
{
"id":"pppg9_c",
"name":"protoporphyrinogen(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C34H38N4O4",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"csn_c",
"name":"cytosine",
"compartment":"c",
"charge":0.0,
"formula":"C4H5N3O",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"acnam_e",
"name":"N-acetyl-beta-neuraminate",
"compartment":"e",
"charge":-1.0,
"formula":"C11H18NO9",
"annotation":{
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"chebi":[
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],
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}
},
{
"id":"ac_p",
"name":"acetate",
"compartment":"p",
"charge":-1.0,
"formula":"C2H3O2",
"annotation":{
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"chebi":[
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],
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}
},
{
"id":"ap5a_c",
"name":"P(1),P(5)-bis(5'-adenosyl) pentaphosphate(5-)",
"compartment":"c",
"charge":-5.0,
"formula":"C20H24N10O22P5",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__malthx_p",
"name":"Maltohexaose",
"compartment":"p",
"charge":0.0,
"formula":"C36H62O31",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"cgly_e",
"name":"L-cysteinylglycine zwitterion",
"compartment":"e",
"charge":0.0,
"formula":"C5H10N2O3S",
"annotation":{
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}
},
{
"id":"inost_c",
"name":"myo-inositol",
"compartment":"c",
"charge":0.0,
"formula":"C6H12O6",
"annotation":{
"biggr":"inost_c:0",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"seln_c",
"name":"selanide",
"compartment":"c",
"charge":-1.0,
"formula":"HSe",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"gmhep1p_c",
"name":"D-glycero-beta-D-manno-heptose 1-phosphate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C7H13O10P",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__fecrm_un_p",
"name":"Ferrichrome minus Fe(III)",
"compartment":"p",
"charge":-3.0,
"formula":"C27H42N9O12",
"annotation":{
"biggr":"__Ecoli_panGEMs__fecrm_un_p:-3",
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__apoACP_c",
"name":"Apoprotein [acyl carrier protein]",
"compartment":"c",
"charge":0.0,
"formula":"RHO",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__o16a4colipa_p",
"name":"(O16 antigen)x4 core oligosaccharide lipid A",
"compartment":"p",
"charge":-11.0,
"formula":"C312H523N6O200P4",
"annotation":{
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}
},
{
"id":"ttdcea_c",
"name":"myristoleate",
"compartment":"c",
"charge":-1.0,
"formula":"C14H25O2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"ump_e",
"name":"uridine 5'-monophosphate(2-)",
"compartment":"e",
"charge":-2.0,
"formula":"C9H11N2O9P",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"ni2_e",
"name":"nickel(2+)",
"compartment":"e",
"charge":2.0,
"formula":"Ni",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"aso3_p",
"name":"arsenite(3-)",
"compartment":"p",
"charge":-3.0,
"formula":"AsO3",
"annotation":{
"biggr":"aso3_p:-3",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"enter_p",
"name":"enterobactin",
"compartment":"p",
"charge":0.0,
"formula":"C30H27N3O15",
"annotation":{
"biggr":"enter_p:0",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"thrp_p",
"name":"O-phosphonato-L-threonine(2-)",
"compartment":"p",
"charge":-2.0,
"formula":"C4H8NO6P",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"cys__D_p",
"name":"D-cysteine zwitterion",
"compartment":"p",
"charge":0.0,
"formula":"C3H7NO2S",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"ch4_e",
"name":"methane",
"compartment":"e",
"charge":0.0,
"formula":"CH4",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"o2s_e",
"name":"superoxide",
"compartment":"e",
"charge":-1.0,
"formula":"O2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__murein5px4px4p_p",
"name":"Three disacharide linked murein units (pentapeptide crosslinked tetrapeptide (A2pm->D-ala) tetrapeptide corsslinked tetrapeptide (A2pm->D-ala)) (middle of chain)",
"compartment":"p",
"charge":-6.0,
"formula":"C114H172N22O59",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"ag_c",
"name":"silver(1+)",
"compartment":"c",
"charge":1.0,
"formula":"Ag",
"annotation":{
"biggr":"ag_c:1",
"chebi":[
"CHEBI:49468"
],
"sbo":"SBO:0000247"
}
},
{
"id":"3cmp_p",
"name":"3'-CMP(2-)",
"compartment":"p",
"charge":-2.0,
"formula":"C9H12N3O8P",
"annotation":{
"biggr":"3cmp_p:-2",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"1ddecg3p_c",
"name":"1-lauroyl-sn-glycerol 3-phosphate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C15H29O7P",
"annotation":{
"biggr":"1ddecg3p_c:-2",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__pg141_c",
"name":"Phosphatidylglycerol (ditetradec-7-enoyl, n-C14:1)",
"compartment":"c",
"charge":-1.0,
"formula":"C34H62O10P1",
"annotation":{
"biggr":"__Ecoli_panGEMs__pg141_c:-1",
"sbo":"SBO:0000247"
}
},
{
"id":"crn__D_c",
"name":"(S)-carnitine",
"compartment":"c",
"charge":0.0,
"formula":"C7H15NO3",
"annotation":{
"biggr":"crn__D_c:0",
"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__pa120_c",
"name":"1,2-didodecanoyl-sn-glycerol 3-phosphate",
"compartment":"c",
"charge":-2.0,
"formula":"C27H51O8P1",
"annotation":{
"biggr":"__Ecoli_panGEMs__pa120_c:-2",
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__pe161_p",
"name":"Phosphatidylethanolamine (dihexadec-9enoyl, n-C16:1)",
"compartment":"p",
"charge":0.0,
"formula":"C37H70N1O8P1",
"annotation":{
"biggr":"__Ecoli_panGEMs__pe161_p:0",
"sbo":"SBO:0000247"
}
},
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},
{
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},
{
"id":"__Ecoli_panGEMs__2agpe161_c",
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{
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{
"id":"udpacgal_p",
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},
{
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{
"id":"12ppd__R_e",
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{
"id":"forcoa_c",
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},
{
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},
{
"id":"__Ecoli_panGEMs__moadcosh_c",
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},
{
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}
},
{
"id":"__Ecoli_panGEMs__murein5p3p_p",
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"id":"rephaccoa_c",
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}
},
{
"id":"ttrcyc_e",
"name":"tetracycline zwitterion",
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}
},
{
"id":"__Ecoli_panGEMs__pa180_c",
"name":"1,2-dioctadecanoyl-sn-glycerol 3-phosphate",
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}
},
{
"id":"his__L_c",
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}
},
{
"id":"2fe2s_c",
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}
},
{
"id":"didp_c",
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}
},
{
"id":"23doguln_p",
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{
"id":"ribflv_c",
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"charge":0.0,
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{
"id":"__Ecoli_panGEMs__pg161_p",
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"id":"so4_c",
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},
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{
"id":"__Ecoli_panGEMs__2agpg141_p",
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"id":"ptrc_c",
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},
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"id":"2dda7p_c",
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},
{
"id":"__Ecoli_panGEMs__1hdec9eg3p_p",
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"id":"2mcit_c",
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"id":"sl2a6o_c",
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},
{
"id":"__Ecoli_panGEMs__iscu_4fe4s_c",
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"id":"cmp_c",
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{
"id":"dtdpglu_c",
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},
{
"id":"cm_p",
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},
{
"id":"g3pi_c",
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{
"id":"gtp_c",
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},
{
"id":"cur_c",
"name":"curcumin",
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"charge":0.0,
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},
{
"id":"uacgam_c",
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},
{
"id":"uaccg_c",
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},
{
"id":"lipidAds_c",
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},
{
"id":"h2mb4p_c",
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},
{
"id":"galct__D_p",
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},
{
"id":"glcur_p",
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},
{
"id":"prcp_c",
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},
{
"id":"__Ecoli_panGEMs__maltpt_p",
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"charge":0.0,
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},
{
"id":"fc1p_c",
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},
{
"id":"btn_c",
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},
{
"id":"so4_p",
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},
{
"id":"succ_c",
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},
{
"id":"__Ecoli_panGEMs__feoxam_un_c",
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"charge":-2.0,
"formula":"C25H46N6O8",
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},
{
"id":"cbl1_e",
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},
{
"id":"gam6p_c",
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},
{
"id":"xylu__L_c",
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},
{
"id":"mso3_c",
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"charge":-1.0,
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},
{
"id":"aps_c",
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},
{
"id":"Sfglutth_c",
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},
{
"id":"xylu__L_e",
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},
{
"id":"arg__L_p",
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},
{
"id":"thdp_c",
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"charge":-2.0,
"formula":"C7H7NO4",
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},
{
"id":"gam_p",
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"charge":1.0,
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},
{
"id":"__Ecoli_panGEMs__pe140_c",
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"charge":0.0,
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},
{
"id":"__Ecoli_panGEMs__pgp120_c",
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{
"id":"cdp_c",
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},
{
"id":"__Ecoli_panGEMs__clpn180_p",
"name":"Cardiolipin (tetraoctadecanoyl, n-C18:0)",
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"charge":-2.0,
"formula":"C81H156O17P2",
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},
{
"id":"glyb_p",
"name":"glycine betaine",
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"charge":0.0,
"formula":"C5H11NO2",
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},
{
"id":"ipdp_c",
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},
{
"id":"lac__L_p",
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},
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},
{
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},
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},
{
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},
{
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},
{
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{
"id":"hmgth_c",
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},
{
"id":"__Ecoli_panGEMs__fe3dcit_c",
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{
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},
{
"id":"4hthr_c",
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{
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},
{
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},
{
"id":"glyc__R_e",
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},
{
"id":"2ohph_c",
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}
},
{
"id":"__Ecoli_panGEMs__eca4colipa_e",
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},
{
"id":"2dglc_p",
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}
},
{
"id":"sucglu_c",
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},
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"id":"no_c",
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},
{
"id":"cyan_e",
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}
},
{
"id":"op4en_c",
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}
},
{
"id":"hom__L_p",
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},
{
"id":"nadph_c",
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},
{
"id":"dmso_c",
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},
{
"id":"acglu_c",
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}
},
{
"id":"__Ecoli_panGEMs__3hddecACP_c",
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},
{
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{
"id":"dmpp_c",
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},
{
"id":"__Ecoli_panGEMs__cddec5eACP_c",
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},
{
"id":"__Ecoli_panGEMs__malttr_c",
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},
{
"id":"__Ecoli_panGEMs__1odec11eg3p_p",
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"id":"rbflvrd_c",
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},
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"id":"sucarg_c",
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},
{
"id":"tagdp__D_c",
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},
{
"id":"__Ecoli_panGEMs__iscu_c",
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"charge":0.0,
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},
{
"id":"arab__L_p",
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},
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"id":"cxsam_c",
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},
{
"id":"crn_c",
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},
{
"id":"gsn_p",
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},
{
"id":"dnad_c",
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},
{
"id":"mteo2_c",
"name":"methanetelluronate(1-)",
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"charge":-1.0,
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},
{
"id":"glyc_c",
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},
{
"id":"no3_p",
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"charge":-1.0,
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},
{
"id":"val__L_c",
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"charge":0.0,
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}
},
{
"id":"pro__L_c",
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"charge":0.0,
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},
{
"id":"ddca_p",
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"charge":-1.0,
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},
{
"id":"ala_B_e",
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"charge":0.0,
"formula":"C3H7NO2",
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}
},
{
"id":"cbasp_c",
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}
},
{
"id":"mobd_c",
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"charge":-2.0,
"formula":"MoO4",
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},
{
"id":"mqn8_c",
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"charge":0.0,
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},
{
"id":"lac__D_p",
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"charge":-1.0,
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}
},
{
"id":"__Ecoli_panGEMs__fecrm_un_e",
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"charge":-3.0,
"formula":"C27H42N9O12",
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},
{
"id":"ala__D_p",
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}
},
{
"id":"fuc__L_e",
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},
{
"id":"__Ecoli_panGEMs__malACP_c",
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"charge":-2.0,
"formula":"C14H22N2O10PRS",
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},
{
"id":"__Ecoli_panGEMs__malthp_c",
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"formula":"C42H72O36",
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},
{
"id":"__Ecoli_panGEMs__tsul_e",
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"charge":-2.0,
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},
{
"id":"__Ecoli_panGEMs__lipa_cold_c",
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"charge":-6.0,
"formula":"C114H202N2O39P2",
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},
{
"id":"3cmp_e",
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"formula":"C9H12N3O8P",
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},
{
"id":"sarcs_c",
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"charge":0.0,
"formula":"C3H7NO2",
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},
{
"id":"butso3_e",
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},
{
"id":"ptrc_e",
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"charge":2.0,
"formula":"C4H14N2",
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},
{
"id":"acgal1p_p",
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"charge":-2.0,
"formula":"C8H14NO9P",
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},
{
"id":"hxa_e",
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"charge":-1.0,
"formula":"C6H11O2",
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},
{
"id":"3hpppn_c",
"name":"3-(3-hydroxyphenyl)propanoate",
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"charge":-1.0,
"formula":"C9H9O3",
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}
},
{
"id":"__Ecoli_panGEMs__fe3hox_c",
"name":"Fe(III)hydroxamate",
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"charge":0.0,
"formula":"C9H18O6N3Fe",
"annotation":{
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},
{
"id":"acgal1p_e",
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"charge":-2.0,
"formula":"C8H14NO9P",
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}
},
{
"id":"leu__L_p",
"name":"L-leucine zwitterion",
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"charge":0.0,
"formula":"C6H13NO2",
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__malthx_e",
"name":"Maltohexaose",
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}
},
{
"id":"lyx__L_p",
"name":"L-lyxopyranose",
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"charge":0.0,
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}
},
{
"id":"3sala_c",
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"charge":-2.0,
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}
},
{
"id":"__Ecoli_panGEMs__feoxam_p",
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"charge":1.0,
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}
},
{
"id":"__Ecoli_panGEMs__3hdecACP_c",
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},
{
"id":"taur_p",
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}
},
{
"id":"__Ecoli_panGEMs__cdec3eACP_c",
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},
{
"id":"__Ecoli_panGEMs__3hcmrs7eACP_c",
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},
{
"id":"h2o2_p",
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},
{
"id":"glu__L_p",
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}
},
{
"id":"dimp_e",
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}
},
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}
},
{
"id":"__Ecoli_panGEMs__pe161_c",
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},
{
"id":"__Ecoli_panGEMs__2odecg3p_p",
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}
},
{
"id":"__Ecoli_panGEMs__1tdecg3p_p",
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}
},
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"id":"__Ecoli_panGEMs__anhgm_p",
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},
{
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}
},
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},
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}
},
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}
},
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}
},
{
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}
},
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}
},
{
"id":"__Ecoli_panGEMs__pg181_c",
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},
{
"id":"12dgr141_c",
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},
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}
},
{
"id":"__Ecoli_panGEMs__3ooctdACP_c",
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},
{
"id":"__Ecoli_panGEMs__but2eACP_c",
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},
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},
{
"id":"__Ecoli_panGEMs__fe3dhbzs3_c",
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},
{
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},
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},
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},
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"id":"xdp_c",
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"charge":-3.0,
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},
{
"id":"dump_c",
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},
{
"id":"acon_c",
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"charge":-3.0,
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}
},
{
"id":"__Ecoli_panGEMs__dsbgrd_p",
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"charge":0.0,
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},
{
"id":"23dhacoa_c",
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},
{
"id":"4mpetz_c",
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},
{
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"charge":0.0,
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},
{
"id":"ru5p__L_c",
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},
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},
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},
{
"id":"__Ecoli_panGEMs__ocdcap_c",
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"charge":-1.0,
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},
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}
},
{
"id":"__Ecoli_panGEMs__acolipa_e",
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"charge":-9.0,
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},
{
"id":"anhm_c",
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"charge":-1.0,
"formula":"C11H16NO7",
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}
},
{
"id":"urea_e",
"name":"carbamimidic acid",
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"charge":0.0,
"formula":"CH4N2O",
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}
},
{
"id":"4fe4s_c",
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"charge":2.0,
"formula":"Fe4S4",
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"chebi":[
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},
{
"id":"gcald_c",
"name":"(Z)-1,2-ethenediol",
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"charge":0.0,
"formula":"C2H4O2",
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}
},
{
"id":"fe3_p",
"name":"iron(3+)",
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"charge":3.0,
"formula":"Fe",
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__fusa_e",
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"charge":0.0,
"formula":"C31H48O5",
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}
},
{
"id":"tyrp_e",
"name":"O(4)-phosphonatotyrosine(2-)",
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"charge":-2.0,
"formula":"C9H10NO6P",
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},
{
"id":"hdcea_e",
"name":"palmitoleate",
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"charge":-1.0,
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__gdpofuc_DUP1_c",
"name":"",
"compartment":"c",
"charge":-2.0,
"formula":"C16H21N5O15P2",
"annotation":{
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}
},
{
"id":"__Ecoli_panGEMs__dhptdn_c",
"name":"6,7-Dihydropteridine",
"compartment":"c",
"charge":0.0,
"formula":"C6H6N4",
"annotation":{
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},
{
"id":"galct__D_c",
"name":"galactarate(2-)",
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"charge":-2.0,
"formula":"C6H8O8",
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__grxox_c",
"name":"Glutaredoxin (oxidized)",
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"charge":0.0,
"formula":"X",
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},
{
"id":"4hbz_p",
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"charge":-1.0,
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__1tdec7eg3p_c",
"name":"1-tetradec-7-enoyl-sn-glycerol 3-phosphate",
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"charge":-2.0,
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{
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{
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},
{
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},
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},
{
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},
{
"id":"__Ecoli_panGEMs__2hdec9eg3p_p",
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{
"id":"__Ecoli_panGEMs__3fe4s_c",
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"id":"__Ecoli_panGEMs__lipoamp_c",
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},
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"id":"urate_c",
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},
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"id":"pi_e",
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},
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"id":"__Ecoli_panGEMs__14glucan_e",
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},
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},
{
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},
{
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},
{
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},
{
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{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
"id":"adocbip_c",
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{
"id":"etha_e",
"name":"ethanolaminium(1+)",
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"charge":1.0,
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],
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}
},
{
"id":"gdpfuc_c",
"name":"GDP-beta-L-fucose(2-)",
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"charge":-2.0,
"formula":"C16H23N5O15P2",
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}
},
{
"id":"glyc3p_p",
"name":"sn-glycerol 3-phosphate(2-)",
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"charge":-2.0,
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"sbo":"SBO:0000247"
}
},
{
"id":"unaga_c",
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"charge":-2.0,
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"chebi":[
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],
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}
},
{
"id":"k_p",
"name":"potassium(1+)",
"compartment":"p",
"charge":1.0,
"formula":"K",
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],
"sbo":"SBO:0000247"
}
},
{
"id":"gtp_p",
"name":"GTP(4-)",
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"charge":-4.0,
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],
"sbo":"SBO:0000247"
}
},
{
"id":"xylu__L_p",
"name":"L-xylulose",
"compartment":"p",
"charge":0.0,
"formula":"C5H10O5",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__maltttr_e",
"name":"Maltotetraose",
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"charge":0.0,
"formula":"C24H42O21",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"glcur_e",
"name":"D-glucopyranuronate",
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"charge":-1.0,
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],
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}
},
{
"id":"metsox_S__L_c",
"name":"L-methionine (S)-S-oxide",
"compartment":"c",
"charge":0.0,
"formula":"C5H11NO3S",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"crncoa_c",
"name":"(R)-carnitinyl-CoA(3-)",
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"charge":-3.0,
"formula":"C28H46N8O18P3S",
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],
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}
},
{
"id":"__Ecoli_panGEMs__fe3hox_e",
"name":"Fe(III)hydroxamate",
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"charge":0.0,
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"sbo":"SBO:0000247"
}
},
{
"id":"3ump_p",
"name":"3'-UMP(2-)",
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"charge":-2.0,
"formula":"C9H11N2O9P",
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],
"sbo":"SBO:0000247"
}
},
{
"id":"g3ps_p",
"name":"sn-glycero-3-phosphoserine(1-)",
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"charge":-1.0,
"formula":"C6H13NO8P",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"ggbutal_c",
"name":"gamma-glutamyl-gamma-aminobutyraldehyde",
"compartment":"c",
"charge":0.0,
"formula":"C9H16N2O4",
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"chebi":[
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],
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}
},
{
"id":"gbbtn_e",
"name":"4-(trimethylammonio)butanoate",
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"charge":0.0,
"formula":"C7H15NO2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__pg140_c",
"name":"Phosphatidylglycerol (ditetradecanoyl, n-C14:0)",
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"charge":-1.0,
"formula":"C34H66O10P1",
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"sbo":"SBO:0000247"
}
},
{
"id":"4abz_c",
"name":"4-aminobenzoate",
"compartment":"c",
"charge":-1.0,
"formula":"C7H6NO2",
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],
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}
},
{
"id":"mso3_p",
"name":"methanesulfonate",
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"charge":-1.0,
"formula":"CH3O3S",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"pa140_p",
"name":"1,2-dimyrsitoylphosphatidate(2-)",
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"charge":-2.0,
"formula":"C31H59O8P",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__LalaDgluMdap_c",
"name":"L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate",
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"charge":-1.0,
"formula":"C15H25N4O8",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"cbl1_p",
"name":"cob(I)alamin(1-)",
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"charge":-1.0,
"formula":"C62H88CoN13O14P",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"enter_e",
"name":"enterobactin",
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"charge":0.0,
"formula":"C30H27N3O15",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__apg180_c",
"name":"Acyl phosphatidylglycerol (n-C18:0)",
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"charge":-1.0,
"formula":"C60H116O11P",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__colipa_c",
"name":"Core oligosaccharide lipid A",
"compartment":"c",
"charge":-11.0,
"formula":"C176H303N2O100P4",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"LalaLglu_c",
"name":"L-alanyl-L-glutamate(1-)",
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"charge":-1.0,
"formula":"C8H13N2O5",
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],
"sbo":"SBO:0000247"
}
},
{
"id":"appl_c",
"name":"(2R)-2-hydroxypropylammonium",
"compartment":"c",
"charge":1.0,
"formula":"C3H10NO",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__aragund_c",
"name":"O-acetyl-rhamanosyl-N-acetylglucosamyl-undecaprenyl diphosphate",
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"charge":-2.0,
"formula":"C71H115N1O17P2",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"2dglc_c",
"name":"2-deoxy-D-glucopyranose",
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"charge":0.0,
"formula":"C6H12O5",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"14dhncoa_c",
"name":"1,4-dihydroxy-2-naphthoyl-CoA(4-)",
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"charge":-4.0,
"formula":"C32H38N7O19P3S",
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__3omrsACP_c",
"name":"3-Oxotetradecanoyl-[acyl-carrier protein]",
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"charge":-1.0,
"formula":"C25H45N2O9PRS",
"annotation":{
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}
},
{
"id":"__Ecoli_panGEMs__o16a2und_p",
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"charge":-2.0,
"formula":"C123H200N2O57P2",
"annotation":{
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}
},
{
"id":"mmet_c",
"name":"S-methyl-L-methionine",
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"charge":1.0,
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__pgp181_c",
"name":"Phosphatidylglycerophosphate (dioctadec-11-enoyl, n-C18:1)",
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"charge":-3.0,
"formula":"C42H77O13P2",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"acald_c",
"name":"acetaldehyde",
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"charge":0.0,
"formula":"C2H4O",
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__cpe180_c",
"name":"Cyclopropane phosphatidylethanolamine (dioctadec-11,12-cyclo-anoyl, n-C18:0 cyclo)",
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"charge":0.0,
"formula":"C43H82N1O8P1",
"annotation":{
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}
},
{
"id":"acgam1p_e",
"name":"N-acetyl-alpha-D-glucosamine 1-phosphate(2-)",
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"charge":-2.0,
"formula":"C8H14NO9P",
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"sbo":"SBO:0000247"
}
},
{
"id":"5aprbu_c",
"name":"5-amino-6-(5-phosphoribitylamino)uracil(2-)",
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"charge":-2.0,
"formula":"C9H15N4O9P",
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__pa141_p",
"name":"1,2-ditetradec-7-enoyl-sn-glycerol 3-phosphate",
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"charge":-2.0,
"formula":"C31H55O8P1",
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}
},
{
"id":"5aop_c",
"name":"5-aminolevulinic acid",
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"charge":0.0,
"formula":"C5H9NO3",
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}
},
{
"id":"12dgr141_p",
"name":"1,2-di-(7Z-tetradecenoyl)-sn-glycerol",
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"charge":0.0,
"formula":"C31H56O5",
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__pa180_p",
"name":"1,2-dioctadecanoyl-sn-glycerol 3-phosphate",
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"charge":-2.0,
"formula":"C39H75O8P1",
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}
},
{
"id":"oc2coa_c",
"name":"trans-oct-2-enoyl-CoA(4-)",
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"charge":-4.0,
"formula":"C29H44N7O17P3S",
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}
},
{
"id":"__Ecoli_panGEMs__2agpe141_c",
"name":"2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:1)",
"compartment":"c",
"charge":0.0,
"formula":"C19H38NO7P1",
"annotation":{
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}
},
{
"id":"rdmbzi_c",
"name":"alpha-ribazole",
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"charge":0.0,
"formula":"C14H18N2O4",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__1agpe141_p",
"name":"1-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:1)",
"compartment":"p",
"charge":0.0,
"formula":"C19H38NO7P1",
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}
},
{
"id":"ctbtcoa_c",
"name":"(E)-4-(trimethylammonio)but-2-enoyl-CoA(3-)",
"compartment":"c",
"charge":-3.0,
"formula":"C28H44N8O17P3S",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__1agpg161_p",
"name":"1-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1)",
"compartment":"p",
"charge":-1.0,
"formula":"C22H42O9P1",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__3hmrsACP_c",
"name":"(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]",
"compartment":"c",
"charge":-1.0,
"formula":"C25H47N2O9PRS",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"LalaDglu_e",
"name":"L-alanyl-D-glutamate(1-)",
"compartment":"e",
"charge":-1.0,
"formula":"C8H13N2O5",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"pram_c",
"name":"5-phospho-beta-D-ribosylaminium(1-)",
"compartment":"c",
"charge":-1.0,
"formula":"C5H11NO7P",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__sufbcd_2fe2s2_c",
"name":"SufBCD with two bound [2Fe-2S] clusters",
"compartment":"c",
"charge":-4.0,
"formula":"O2S10Fe4R",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"urate_e",
"name":"7H-purine-2,6,8-triol",
"compartment":"e",
"charge":0.0,
"formula":"C5H4N4O3",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"oxur_c",
"name":"oxalurate",
"compartment":"c",
"charge":-1.0,
"formula":"C3H3N2O4",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__ocdceap_c",
"name":"Octadecanoyl-phosphate (n-C18:1)",
"compartment":"c",
"charge":-1.0,
"formula":"C18H34O5P",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"cm_e",
"name":"chloramphenicol",
"compartment":"e",
"charge":0.0,
"formula":"C11H12Cl2N2O5",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"agm_e",
"name":"agmatinium(2+)",
"compartment":"e",
"charge":2.0,
"formula":"C5H16N4",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"cdg_c",
"name":"7-carboxylato-7-deazaguanine",
"compartment":"c",
"charge":-1.0,
"formula":"C7H5N4O3",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__feenter_c",
"name":"Fe-enterobactin",
"compartment":"c",
"charge":3.0,
"formula":"C30H27FeN3O15",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__iscs_c",
"name":"IscS sulfur acceptor protein",
"compartment":"c",
"charge":0.0,
"formula":"HSR",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__fe3dhbzs3_p",
"name":"2-3-dihydroxybenzoylserine trimer-Fe-III",
"compartment":"p",
"charge":3.0,
"formula":"C30H29FeN3O16",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"na1_c",
"name":"sodium(1+)",
"compartment":"c",
"charge":1.0,
"formula":"Na",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"3c4mop_c",
"name":"(2S)-2-isopropyl-3-oxosuccinate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C7H8O5",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"dxylnt_c",
"name":"D-xylonate",
"compartment":"c",
"charge":-1.0,
"formula":"C5H9O6",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"lys__L_p",
"name":"L-lysinium(1+)",
"compartment":"p",
"charge":1.0,
"formula":"C6H15N2O2",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"urdgci_c",
"name":"(S)-2-ureidoglycine zwitterion",
"compartment":"c",
"charge":0.0,
"formula":"C3H7N3O3",
"annotation":{
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"chebi":[
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"CHEBI:59945"
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"sbo":"SBO:0000247"
}
},
{
"id":"hcys__L_c",
"name":"L-homocysteine zwitterion",
"compartment":"c",
"charge":0.0,
"formula":"C4H9NO2S",
"annotation":{
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"chebi":[
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"CHEBI:17588"
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"sbo":"SBO:0000247"
}
},
{
"id":"no3_c",
"name":"nitrate",
"compartment":"c",
"charge":-1.0,
"formula":"NO3",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
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}
},
{
"id":"co2_c",
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}
},
{
"id":"4ppcys_c",
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}
},
{
"id":"phe__L_e",
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}
},
{
"id":"__Ecoli_panGEMs__cpgn_e",
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},
{
"id":"pi_p",
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},
{
"id":"alltt_c",
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}
},
{
"id":"fum_e",
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}
},
{
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{
"id":"acald_e",
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},
{
"id":"h2_p",
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},
{
"id":"tym_p",
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},
{
"id":"etoh_p",
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}
},
{
"id":"25drapp_c",
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}
},
{
"id":"gthox_c",
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}
},
{
"id":"peamn_e",
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}
},
{
"id":"gar_c",
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},
{
"id":"tungs_c",
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},
{
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},
{
"id":"arbtn_c",
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},
{
"id":"enter_c",
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},
{
"id":"cu_p",
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}
},
{
"id":"__Ecoli_panGEMs__fe3hox_p",
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},
{
"id":"__Ecoli_panGEMs__feoxam_un_e",
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{
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},
{
"id":"ump_p",
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},
{
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},
{
"id":"cmp_p",
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},
{
"id":"__Ecoli_panGEMs__fe3hox_un_e",
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},
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},
{
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},
{
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},
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"id":"tym_e",
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},
{
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},
{
"id":"__Ecoli_panGEMs__3ooctACP_c",
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},
{
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},
{
"id":"__Ecoli_panGEMs__3ocmrs7eACP_c",
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},
{
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},
{
"id":"poaac_c",
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},
{
"id":"__Ecoli_panGEMs__2agpe120_p",
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},
{
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},
{
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},
{
"id":"hdcea_p",
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},
{
"id":"__Ecoli_panGEMs__2agpg160_p",
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},
{
"id":"2agpe180_c",
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},
{
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},
{
"id":"__Ecoli_panGEMs__moco_c",
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},
{
"id":"__Ecoli_panGEMs__1tdec7eg3p_p",
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},
{
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},
{
"id":"2ddg6p_c",
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},
{
"id":"mincyc_e",
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},
{
"id":"1tdecg3p_p",
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},
{
"id":"arab__L_c",
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},
{
"id":"__Ecoli_panGEMs__sufbcd_4fe4s_c",
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},
{
"id":"dhcur_c",
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},
{
"id":"ade_c",
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},
{
"id":"rml_c",
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},
{
"id":"rfamp_e",
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},
{
"id":"acg5p_c",
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},
{
"id":"rfamp_p",
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},
{
"id":"4pasp_c",
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},
{
"id":"glu5p_c",
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},
{
"id":"h2o_e",
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},
{
"id":"ch4_c",
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"charge":0.0,
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},
{
"id":"23dhdp_c",
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"charge":-2.0,
"formula":"C7H5NO4",
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},
{
"id":"3mop_c",
"name":"(S)-3-methyl-2-oxovalerate",
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"charge":-1.0,
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},
{
"id":"3htdcoa_c",
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}
},
{
"id":"dgtp_c",
"name":"dGTP(4-)",
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}
},
{
"id":"rib__D_e",
"name":"D-ribofuranose",
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"charge":0.0,
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__fad_c",
"name":"Flavin adenine dinucleotide oxidized",
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"charge":-2.0,
"formula":"C27H31N9O15P2",
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}
},
{
"id":"uri_e",
"name":"uridine",
"compartment":"e",
"charge":0.0,
"formula":"C9H12N2O6",
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"chebi":[
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}
},
{
"id":"4ahmmp_c",
"name":"4-amino-5-hydroxymethyl-2-methylpyrimidine",
"compartment":"c",
"charge":0.0,
"formula":"C6H9N3O",
"annotation":{
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"chebi":[
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],
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}
},
{
"id":"trp__L_e",
"name":"L-tryptophan zwitterion",
"compartment":"e",
"charge":0.0,
"formula":"C11H12N2O2",
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}
},
{
"id":"dpcoa_c",
"name":"3'-dephospho-CoA(2-)",
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"charge":-2.0,
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}
},
{
"id":"2ommbl_c",
"name":"5-methoxy-2-methyl-3-octaprenylhydroquinone",
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"charge":0.0,
"formula":"C48H74O3",
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"chebi":[
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}
},
{
"id":"23ddhb_c",
"name":"2,3-dihydroxy-2,3-dihydrobenzoate",
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"charge":-1.0,
"formula":"C7H7O4",
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"chebi":[
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}
},
{
"id":"din_e",
"name":"2'-deoxyinosine",
"compartment":"e",
"charge":0.0,
"formula":"C10H12N4O4",
"annotation":{
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"chebi":[
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}
},
{
"id":"36dahx_c",
"name":"(3S)-3,6-diammoniohexanoate",
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"charge":1.0,
"formula":"C6H15N2O2",
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"chebi":[
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}
},
{
"id":"melib_c",
"name":"melibiose",
"compartment":"c",
"charge":0.0,
"formula":"C12H22O11",
"annotation":{
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"chebi":[
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],
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}
},
{
"id":"udcpp_c",
"name":"ditrans,polycis-undecaprenyl phosphate(2-)",
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"charge":-2.0,
"formula":"C55H89O4P",
"annotation":{
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}
},
{
"id":"dcamp_c",
"name":"N(6)-(1,2-dicarboxylatoethyl)-AMP(4-)",
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"charge":-4.0,
"formula":"C14H14N5O11P",
"annotation":{
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"chebi":[
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}
},
{
"id":"kdo2lipid4_c",
"name":"(KDO)2-lipid IVA(6-)",
"compartment":"c",
"charge":-6.0,
"formula":"C84H148N2O37P2",
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}
},
{
"id":"galct__D_e",
"name":"galactarate(2-)",
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"charge":-2.0,
"formula":"C6H8O8",
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"chebi":[
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}
},
{
"id":"udpglcur_c",
"name":"UDP-alpha-D-glucuronate(3-)",
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"charge":-3.0,
"formula":"C15H19N2O18P2",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"4h2opntn_c",
"name":"(S)-4-hydroxy-2-oxopentanoate",
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"charge":-1.0,
"formula":"C5H7O4",
"annotation":{
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"chebi":[
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}
},
{
"id":"btnso_c",
"name":"biotinate sulfoxide(1-)",
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"charge":-1.0,
"formula":"C10H15N2O4S",
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"chebi":[
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}
},
{
"id":"__Ecoli_panGEMs__myrsACP_c",
"name":"Myristoyl-ACP (n-C14:0ACP)",
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"charge":-1.0,
"formula":"C25H47N2O8PRS",
"annotation":{
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}
},
{
"id":"__Ecoli_panGEMs__selnp_c",
"name":"Selenophosphate",
"compartment":"c",
"charge":-1.0,
"formula":"H2O3PSe",
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}
},
{
"id":"camp_c",
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}
},
{
"id":"dtbt_c",
"name":"(4R,5S)-dethiobiotin(1-)",
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"charge":-1.0,
"formula":"C10H17N2O3",
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}
},
{
"id":"galur_e",
"name":"aldehydo-D-galacturonate",
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"charge":-1.0,
"formula":"C6H9O7",
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}
},
{
"id":"gmhep17bp_c",
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"charge":-4.0,
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}
},
{
"id":"__Ecoli_panGEMs__ACP_c",
"name":"Acyl carrier protein",
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"charge":-1.0,
"formula":"C11H21N2O7PRS",
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},
{
"id":"__Ecoli_panGEMs__met__D_p",
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"charge":0.0,
"formula":"C5H10NO2S",
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}
},
{
"id":"__Ecoli_panGEMs__palmACP_c",
"name":"Palmitoyl-ACP (n-C16:0ACP)",
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"charge":-1.0,
"formula":"C27H51N2O8PRS",
"annotation":{
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},
{
"id":"alltn_p",
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"charge":0.0,
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}
},
{
"id":"dad_2_p",
"name":"2'-deoxyadenosine",
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"formula":"C10H13N5O3",
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}
},
{
"id":"suc6p_c",
"name":"sucrose 6(F)-phosphate(2-)",
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"charge":-2.0,
"formula":"C12H21O14P",
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}
},
{
"id":"etha_p",
"name":"ethanolaminium(1+)",
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"charge":1.0,
"formula":"C2H8NO",
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},
{
"id":"dgmp_p",
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},
{
"id":"__Ecoli_panGEMs__23dappa_p",
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"charge":1.0,
"formula":"C3H9N2O2",
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},
{
"id":"g3pi_p",
"name":"1-(sn-glycero-3-O-phosphonato)-1D-myo-inositol",
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"charge":-1.0,
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},
{
"id":"23camp_e",
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}
},
{
"id":"__Ecoli_panGEMs__uLa4n_p",
"name":"Undecaprenyl phosphate-4-amino-4-deoxy-L-arabinose",
"compartment":"p",
"charge":0.0,
"formula":"C60H100N1O7P1",
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},
{
"id":"cu_c",
"name":"copper(1+)",
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"charge":1.0,
"formula":"Cu",
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}
},
{
"id":"__Ecoli_panGEMs__cpgn_un_p",
"name":"Coprogen unloaded (no Fe(III))",
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"charge":-4.0,
"formula":"C35H52N6O13",
"annotation":{
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}
},
{
"id":"__Ecoli_panGEMs__ps141_c",
"name":"Phosphatidylserine (ditetradec-7-enoyl, n-C14:1)",
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"charge":-1.0,
"formula":"C34H61N1O10P1",
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},
{
"id":"__Ecoli_panGEMs__pgp141_p",
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"charge":-3.0,
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},
{
"id":"__Ecoli_panGEMs__pgp180_p",
"name":"Phosphatidylglycerophosphate (dioctadecanoyl, n-C18:0)",
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"charge":-3.0,
"formula":"C42H81O13P2",
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},
{
"id":"psclys_p",
"name":"psicosyllysine(1+)",
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"formula":"C12H25N2O7",
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}
},
{
"id":"4abzglu_c",
"name":"N-(4-aminobenzoyl)-L-glutamate",
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"charge":-2.0,
"formula":"C12H12N2O5",
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}
},
{
"id":"dhps_e",
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"charge":-1.0,
"formula":"C3H7O5S",
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}
},
{
"id":"erthrs_c",
"name":"D-erythrose",
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"charge":0.0,
"formula":"C4H8O4",
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}
},
{
"id":"succoa_c",
"name":"succinyl-CoA(5-)",
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"charge":-5.0,
"formula":"C25H35N7O19P3S",
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}
},
{
"id":"xyl__D_c",
"name":"D-xylopyranose",
"compartment":"c",
"charge":0.0,
"formula":"C5H10O5",
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"chebi":[
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}
},
{
"id":"sucsal_c",
"name":"4-oxobutanoate",
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"charge":-1.0,
"formula":"C4H5O3",
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}
},
{
"id":"alltn_c",
"name":"1-(5-hydroxy-2-oxo-2,3-dihydroimidazol-4-yl)urea",
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"charge":0.0,
"formula":"C4H6N4O3",
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}
},
{
"id":"3hdcoa_c",
"name":"(S)-3-hydroxydecanoyl-CoA(4-)",
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"charge":-4.0,
"formula":"C31H50N7O18P3S",
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}
},
{
"id":"mnl_e",
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"charge":0.0,
"formula":"C6H14O6",
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}
},
{
"id":"for_e",
"name":"formate",
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"charge":-1.0,
"formula":"CHO2",
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}
},
{
"id":"kdolipid4_c",
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"charge":-5.0,
"formula":"C76H137N2O30P2",
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}
},
{
"id":"seramp_c",
"name":"L-seryl-AMP",
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"charge":0.0,
"formula":"C13H19N6O9P",
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}
},
{
"id":"ade_p",
"name":"adenine",
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"charge":0.0,
"formula":"C5H5N5",
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],
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}
},
{
"id":"sbt__D_p",
"name":"D-glucitol",
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"charge":0.0,
"formula":"C6H14O6",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"12ppd__S_p",
"name":"(S)-propane-1,2-diol",
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"charge":0.0,
"formula":"C3H8O2",
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"dca_p",
"name":"decanoate",
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"charge":-1.0,
"formula":"C10H19O2",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__fe3dcit_p",
"name":"Fe(III)dicitrate",
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"charge":-3.0,
"formula":"C12H10FeO14",
"annotation":{
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}
},
{
"id":"h2o2_e",
"name":"hydrogen peroxide",
"compartment":"e",
"charge":0.0,
"formula":"H2O2",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"23cump_e",
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"compartment":"e",
"charge":-1.0,
"formula":"C9H10N2O8P",
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__eca2und_p",
"name":"(enterobacterial common antigen)x2 undecaprenyl-diphosphate",
"compartment":"p",
"charge":-4.0,
"formula":"C103H162N6O37P2",
"annotation":{
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},
{
"id":"cl_p",
"name":"chloride",
"compartment":"p",
"charge":-1.0,
"formula":"Cl",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__murein4p3p_p",
"name":"Two linked disacharide tetrapeptide and tripeptide murein units (uncrosslinked, middle of chain)",
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"charge":-4.0,
"formula":"C71H109N13O39",
"annotation":{
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}
},
{
"id":"12dgr160_p",
"name":"1,2-dipalmitoyl-sn-glycerol",
"compartment":"p",
"charge":0.0,
"formula":"C35H68O5",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
},
{
"id":"__Ecoli_panGEMs__1agpg120_p",
"name":"1-Acyl-sn-glycero-3-phosphoglycerol (n-C12:0)",
"compartment":"p",
"charge":-1.0,
"formula":"C18H36O9P1",
"annotation":{
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"sbo":"SBO:0000247"
}
},
{
"id":"tungs_e",
"name":"tungstate",
"compartment":"e",
"charge":-2.0,
"formula":"O4W",
"annotation":{
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"chebi":[
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],
"sbo":"SBO:0000247"
}
},
{
"id":"5fthf_c",
"name":"(6S)-5-formyltetrahydrofolate(2-)",
"compartment":"c",
"charge":-2.0,
"formula":"C20H21N7O7",
"annotation":{
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"chebi":[
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"sbo":"SBO:0000247"
}
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{
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{
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{
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{
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{
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{
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},
{
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},
{
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},
{
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},
{
"id":"EX_met__L_e",
"name":"Exchange of L-methionine zwitterion.",
"metabolites":{
"met__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_met__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GTHOr",
"name":"glutathione oxidoreductase",
"metabolites":{
"gthox_c":-1.0,
"gthrd_c":2.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03602",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"GTHOr",
"rhea":"RHEA:11740",
"sbo":"SBO:0000176"
}
},
{
"id":"ILETA",
"name":"isoleucine transaminase",
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"3mop_c":1.0,
"akg_c":-1.0,
"glu__L_c":1.0,
"ile__L_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03899",
"subsystem":"Valine, Leucine, and Isoleucine Metabolism",
"annotation":{
"biggr":"ILETA",
"rhea":"RHEA:24801",
"sbo":"SBO:0000176"
}
},
{
"id":"DHORD5",
"name":"dihydroorotic acid (menaquinone-8)",
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"dhor__S_c":-1.0,
"mql8_c":1.0,
"mqn8_c":-1.0,
"orot_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00966",
"subsystem":"Purine and Pyrimidine Biosynthesis",
"annotation":{
"biggr":"DHORD5",
"rhea":"RHEA:29199",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_metsox_S__L_e",
"name":"Exchange of L-methionine (S)-S-oxide zwitterion.",
"metabolites":{
"metsox_S__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_metsox_S__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"VALTA",
"name":"valine transaminase",
"metabolites":{
"3mob_c":1.0,
"akg_c":-1.0,
"glu__L_c":1.0,
"val__L_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03899",
"subsystem":"Valine, Leucine, and Isoleucine Metabolism",
"annotation":{
"biggr":"VALTA",
"rhea":"RHEA:24813",
"sbo":"SBO:0000176"
}
},
{
"id":"IPPMIb",
"name":"2-isopropylmalate hydratase",
"metabolites":{
"2ippm_c":-1.0,
"3c3hmp_c":1.0,
"h2o_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00072 and HFPHFOGF_00073",
"subsystem":"Valine, Leucine, and Isoleucine Metabolism",
"annotation":{
"biggr":"IPPMIb",
"rhea":"RHEA:16293",
"sbo":"SBO:0000176"
}
},
{
"id":"ORPT",
"name":"orotate phosphoribosyltransferase",
"metabolites":{
"orot5p_c":-1.0,
"orot_c":1.0,
"ppi_c":-1.0,
"prpp_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03752",
"subsystem":"Purine and Pyrimidine Biosynthesis",
"annotation":{
"biggr":"ORPT",
"rhea":"RHEA:10380",
"sbo":"SBO:0000176"
}
},
{
"id":"RBFSa_1",
"name":"riboflavin synthase",
"metabolites":{
"4r5au_c":-1.0,
"db4p_c":-1.0,
"dmlz_c":1.0,
"h2o_c":2.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00445",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"RBFSa_1:2",
"rhea":"RHEA:26152",
"sbo":"SBO:0000176"
}
},
{
"id":"ACHBS",
"name":"2-aceto-2-hydroxybutanoate synthase",
"metabolites":{
"2ahbut_c":1.0,
"2obut_c":-1.0,
"co2_c":1.0,
"h_c":-1.0,
"pyr_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_03797 and HFPHFOGF_03798) or (HFPHFOGF_00077 and HFPHFOGF_00078)",
"subsystem":"Valine, Leucine, and Isoleucine Metabolism",
"annotation":{
"biggr":"ACHBS",
"rhea":"RHEA:27654",
"sbo":"SBO:0000176"
}
},
{
"id":"PFK_3",
"name":"phosphofructokinase (s7p)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"s17bp_c":1.0,
"s7p_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04045",
"subsystem":"Pentose Phosphate Pathway",
"annotation":{
"biggr":"PFK_3",
"rhea":"RHEA:31443",
"sbo":"SBO:0000176"
}
},
{
"id":"DHAD2",
"name":"Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)",
"metabolites":{
"23dhmp_c":-1.0,
"3mop_c":1.0,
"h2o_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03900",
"subsystem":"Valine, Leucine, and Isoleucine Metabolism",
"annotation":{
"biggr":"DHAD2",
"rhea":"RHEA:27694",
"sbo":"SBO:0000176"
}
},
{
"id":"ACLS",
"name":"acetolactate synthase",
"metabolites":{
"alac__S_c":1.0,
"co2_c":1.0,
"h_c":-1.0,
"pyr_c":-2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00077 and HFPHFOGF_00078) or (HFPHFOGF_03797 and HFPHFOGF_03798)",
"subsystem":"Valine, Leucine, and Isoleucine Metabolism",
"annotation":{
"biggr":"ACLS",
"rhea":"RHEA:25249",
"sbo":"SBO:0000176"
}
},
{
"id":"TRPS2",
"name":"tryptophan synthase (indole)",
"metabolites":{
"h2o_c":1.0,
"indole_c":-1.0,
"ser__L_c":-1.0,
"trp__L_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01369 and HFPHFOGF_01370",
"subsystem":"Tyrosine, Tryptophan, and Phenylalanine Metabolism",
"annotation":{
"biggr":"TRPS2",
"sbo":"SBO:0000176"
}
},
{
"id":"PSCVT",
"name":"3-phosphoshikimate 1-carboxyvinyltransferase",
"metabolites":{
"3psme_c":1.0,
"pep_c":-1.0,
"pi_c":1.0,
"skm5p_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00928",
"subsystem":"Tyrosine, Tryptophan, and Phenylalanine Metabolism",
"annotation":{
"biggr":"PSCVT",
"rhea":"RHEA:21256",
"sbo":"SBO:0000176"
}
},
{
"id":"G3PD5",
"name":"glycerol-3-phosphate dehydrogenase (ubiquinone-8)",
"metabolites":{
"dhap_c":1.0,
"glyc3p_c":-1.0,
"q8_c":-1.0,
"q8h2_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_02329 and HFPHFOGF_02328 and HFPHFOGF_02327) or HFPHFOGF_03529",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"G3PD5",
"rhea":"RHEA:28751",
"sbo":"SBO:0000176"
}
},
{
"id":"G1PP",
"name":"Glucose-1-phosphatase",
"metabolites":{
"g1p_c":-1.0,
"glc__D_c":1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02379 or HFPHFOGF_04011 or HFPHFOGF_03825",
"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
"biggr":"G1PP",
"sbo":"SBO:0000176"
}
},
{
"id":"PFL",
"name":"pyruvate formate lyase",
"metabolites":{
"accoa_c":1.0,
"coa_c":-1.0,
"for_c":1.0,
"pyr_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00922 and HFPHFOGF_00923) or (HFPHFOGF_00922 and HFPHFOGF_03220) or (HFPHFOGF_04079 and HFPHFOGF_04080) or ((HFPHFOGF_00922 and HFPHFOGF_00923) and HFPHFOGF_02662)",
"subsystem":"Pyruvate Metabolism",
"annotation":{
"biggr":"PFL",
"rhea":"RHEA:11844",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_acgam_e",
"name":"Exchange of N-acetyl-D-glucosamine.",
"metabolites":{
"acgam_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_acgam_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ANS",
"name":"anthranilate synthase",
"metabolites":{
"anth_c":1.0,
"chor_c":-1.0,
"gln__L_c":-1.0,
"glu__L_c":1.0,
"h_c":1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01372 and HFPHFOGF_01373",
"subsystem":"Tyrosine, Tryptophan, and Phenylalanine Metabolism",
"annotation":{
"biggr":"ANS",
"rhea":"RHEA:21732",
"sbo":"SBO:0000176"
}
},
{
"id":"FRD2",
"name":"fumarate reductase",
"metabolites":{
"fum_c":-1.0,
"mql8_c":-1.0,
"mqn8_c":1.0,
"succ_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04293 and HFPHFOGF_04292 and HFPHFOGF_04294 and HFPHFOGF_04295",
"subsystem":"Citric Acid Cycle",
"annotation":{
"biggr":"FRD2",
"rhea":"RHEA:29215",
"sbo":"SBO:0000176"
}
},
{
"id":"FRD3",
"name":"fumarate reductase",
"metabolites":{
"2dmmq8_c":1.0,
"2dmmql8_c":-1.0,
"fum_c":-1.0,
"succ_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04293 and HFPHFOGF_04292 and HFPHFOGF_04294 and HFPHFOGF_04295",
"subsystem":"Citric Acid Cycle",
"annotation":{
"biggr":"FRD3",
"sbo":"SBO:0000176"
}
},
{
"id":"ANPRT",
"name":"anthranilate phosphoribosyltransferase",
"metabolites":{
"anth_c":-1.0,
"ppi_c":1.0,
"pran_c":1.0,
"prpp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01372",
"subsystem":"Tyrosine, Tryptophan, and Phenylalanine Metabolism",
"annotation":{
"biggr":"ANPRT",
"rhea":"RHEA:11768",
"sbo":"SBO:0000176"
}
},
{
"id":"POX",
"name":"pyruvate oxidase",
"metabolites":{
"ac_c":1.0,
"co2_c":1.0,
"h2o_c":-1.0,
"pyr_c":-1.0,
"q8_c":-1.0,
"q8h2_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00891",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"POX",
"sbo":"SBO:0000176"
}
},
{
"id":"CHORM",
"name":"chorismate mutase",
"metabolites":{
"chor_c":-1.0,
"pphn_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02682 or HFPHFOGF_02683",
"subsystem":"Tyrosine, Tryptophan, and Phenylalanine Metabolism",
"annotation":{
"biggr":"CHORM",
"sbo":"SBO:0000176"
}
},
{
"id":"PTAr",
"name":"phosphotransacetylase",
"metabolites":{
"accoa_c":-1.0,
"actp_c":1.0,
"coa_c":1.0,
"pi_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02383 or HFPHFOGF_02535",
"subsystem":"Pyruvate Metabolism",
"annotation":{
"biggr":"PTAr",
"rhea":"RHEA:19521",
"sbo":"SBO:0000176"
}
},
{
"id":"CHORS",
"name":"chorismate synthase",
"metabolites":{
"3psme_c":-1.0,
"chor_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02415",
"subsystem":"Tyrosine, Tryptophan, and Phenylalanine Metabolism",
"annotation":{
"biggr":"CHORS",
"rhea":"RHEA:21020",
"sbo":"SBO:0000176"
}
},
{
"id":"IGPS",
"name":"indole-3-glycerol-phosphate synthase",
"metabolites":{
"2cpr5p_c":-1.0,
"3ig3p_c":1.0,
"co2_c":1.0,
"h2o_c":1.0,
"h_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01371",
"subsystem":"Tyrosine, Tryptophan, and Phenylalanine Metabolism",
"annotation":{
"biggr":"IGPS",
"rhea":"RHEA:23476",
"sbo":"SBO:0000176"
}
},
{
"id":"ACKr",
"name":"acetate kinase",
"metabolites":{
"ac_c":-1.0,
"actp_c":1.0,
"adp_c":1.0,
"atp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02382 or HFPHFOGF_01909 or HFPHFOGF_03221",
"subsystem":"Pyruvate Metabolism",
"annotation":{
"biggr":"ACKr",
"rhea":"RHEA:11352",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_cellb_e",
"name":"Exchange of cellobiose.",
"metabolites":{
"cellb_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cellb_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_crn_e",
"name":"Exchange of (R)-carnitine.",
"metabolites":{
"crn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_crn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_hxan_e",
"name":"Exchange of hypoxanthine.",
"metabolites":{
"hxan_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_hxan_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_ile__L_e",
"name":"Exchange of L-isoleucine zwitterion.",
"metabolites":{
"ile__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ile__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_chol_e",
"name":"Exchange of choline.",
"metabolites":{
"chol_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_chol_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_fe3_e",
"name":"Exchange of iron(3+).",
"metabolites":{
"fe3_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_fe3_e",
"sbo":"SBO:0000627"
}
},
{
"id":"LEUTAi",
"name":"leucine transaminase (irreversible)",
"metabolites":{
"4mop_c":-1.0,
"akg_c":1.0,
"glu__L_c":-1.0,
"leu__L_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03899 or HFPHFOGF_04188",
"subsystem":"Valine, Leucine, and Isoleucine Metabolism",
"annotation":{
"biggr":"LEUTAi",
"rhea":"RHEA:18321",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_lac__L_e",
"name":"Exchange of (S)-lactate.",
"metabolites":{
"lac__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_lac__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_leu__L_e",
"name":"Exchange of L-leucine zwitterion.",
"metabolites":{
"leu__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_leu__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_glcn_e",
"name":"Exchange of D-gluconate.",
"metabolites":{
"glcn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_glcn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_no3_e",
"name":"Exchange of nitrate.",
"metabolites":{
"no3_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_no3_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_h_e",
"name":"Exchange of hydron.",
"metabolites":{
"h_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_h_e",
"sbo":"SBO:0000627"
}
},
{
"id":"DMATT",
"name":"dimethylallyltranstransferase",
"metabolites":{
"dmpp_c":-1.0,
"grdp_c":1.0,
"ipdp_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00451",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"DMATT",
"rhea":"RHEA:22408",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_orn__L_e",
"name":"Exchange of L-ornithinium(1+).",
"metabolites":{
"orn__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_orn__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GRTT",
"name":"geranyltranstransferase",
"metabolites":{
"frdp_c":1.0,
"grdp_c":-1.0,
"ipdp_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00451",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"GRTT",
"rhea":"RHEA:19361",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_gln__L_e",
"name":"Exchange of L-glutamine zwitterion.",
"metabolites":{
"gln__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_gln__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"UPP3S",
"name":"uroporphyrinogen-III synthase",
"metabolites":{
"h2o_c":1.0,
"hmbil_c":-1.0,
"uppg3_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03933",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"UPP3S",
"rhea":"RHEA:18965",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_pro__L_e",
"name":"Exchange of L-proline zwitterion.",
"metabolites":{
"pro__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_pro__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_glyc_e",
"name":"Exchange of glycerol.",
"metabolites":{
"glyc_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_glyc_e",
"sbo":"SBO:0000627"
}
},
{
"id":"UPPDC1",
"name":"uroporphyrinogen decarboxylase (uroporphyrinogen III)",
"metabolites":{
"co2_c":4.0,
"cpppg3_c":1.0,
"h_c":-4.0,
"uppg3_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04125",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"UPPDC1",
"rhea":"RHEA:19865",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_man_e",
"name":"Exchange of D-mannopyranose.",
"metabolites":{
"man_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_man_e",
"sbo":"SBO:0000627"
}
},
{
"id":"TMDPP",
"name":"thymidine phosphorylase",
"metabolites":{
"2dr1p_c":1.0,
"pi_c":-1.0,
"thym_c":1.0,
"thymd_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04521",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"TMDPP",
"rhea":"RHEA:16037",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_ade_e",
"name":"Exchange of adenine.",
"metabolites":{
"ade_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ade_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_mn2_e",
"name":"Exchange of manganese(2+).",
"metabolites":{
"mn2_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_mn2_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_4abut_e",
"name":"Exchange of gamma-aminobutyric acid zwitterion.",
"metabolites":{
"4abut_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_4abut_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_ac_e",
"name":"Exchange of acetate.",
"metabolites":{
"ac_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ac_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_akg_e",
"name":"Exchange of 2-oxoglutarate(2-).",
"metabolites":{
"akg_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_akg_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_ala__L_e",
"name":"Exchange of L-alanine zwitterion.",
"metabolites":{
"ala__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ala__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_arg__L_e",
"name":"Exchange of L-argininium(1+).",
"metabolites":{
"arg__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_arg__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_asp__L_e",
"name":"Exchange of L-aspartate(1-).",
"metabolites":{
"asp__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_asp__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_pyr_e",
"name":"Exchange of pyruvate.",
"metabolites":{
"pyr_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_pyr_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_succ_e",
"name":"Exchange of succinate(2-).",
"metabolites":{
"succ_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_succ_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_thymd_e",
"name":"Exchange of thymidine.",
"metabolites":{
"thymd_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_thymd_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_rib__D_e",
"name":"Exchange of D-ribofuranose.",
"metabolites":{
"rib__D_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_rib__D_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_tyr__L_e",
"name":"Exchange of L-tyrosine zwitterion.",
"metabolites":{
"tyr__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_tyr__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_cytd_e",
"name":"Exchange of cytidine.",
"metabolites":{
"cytd_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cytd_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_dcyt_e",
"name":"Exchange of 2'-deoxycytidine.",
"metabolites":{
"dcyt_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_dcyt_e",
"sbo":"SBO:0000627"
}
},
{
"id":"MOAT",
"name":"3-deoxy-D-manno-octulosonic acid transferase",
"metabolites":{
"ckdo_c":-1.0,
"cmp_c":1.0,
"h_c":1.0,
"kdolipid4_c":1.0,
"lipidA_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03743",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"MOAT",
"rhea":"RHEA:28066",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_fum_e",
"name":"Exchange of fumarate(2-).",
"metabolites":{
"fum_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_fum_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_sbt__D_e",
"name":"Exchange of D-glucitol.",
"metabolites":{
"sbt__D_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_sbt__D_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_glu__L_e",
"name":"Exchange of L-glutamate(1-).",
"metabolites":{
"glu__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_glu__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"UDCPDPS",
"name":"Undecaprenyl diphosphate synthase",
"metabolites":{
"frdp_c":-1.0,
"ipdp_c":-8.0,
"ppi_c":8.0,
"udcpdp_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00170",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"UDCPDPS",
"rhea":"RHEA:27551",
"sbo":"SBO:0000176"
}
},
{
"id":"ECOAH6",
"name":"3-hydroxyacyl-CoA dehydratase (3-hydroxytetradecanoyl-CoA)",
"metabolites":{
"3htdcoa_c":-1.0,
"h2o_c":1.0,
"td2coa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02426 or HFPHFOGF_03972",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"ECOAH6",
"rhea":"RHEA:31171",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__USHD",
"name":"UDP-sugar hydrolase",
"metabolites":{
"__Ecoli_panGEMs__u23ga_c":-1.0,
"h2o_c":-1.0,
"h_c":2.0,
"lipidX_c":1.0,
"ump_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00551",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__USHD",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_gua_e",
"name":"Exchange of guanine.",
"metabolites":{
"gua_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_gua_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ENO",
"name":"enolase",
"metabolites":{
"2pg_c":-1.0,
"h2o_c":1.0,
"pep_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02884",
"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
"biggr":"ENO",
"rhea":"RHEA:10164",
"sbo":"SBO:0000176"
}
},
{
"id":"FBA",
"name":"fructose-bisphosphate aldolase",
"metabolites":{
"dhap_c":1.0,
"fdp_c":-1.0,
"g3p_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03056 or HFPHFOGF_02185",
"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
"biggr":"FBA",
"sbo":"SBO:0000176"
}
},
{
"id":"H2CO3D",
"name":"HCO3 equilibration reaction",
"metabolites":{
"co2_c":-1.0,
"h2co3_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00123 or HFPHFOGF_00373",
"subsystem":"Unassigned",
"annotation":{
"biggr":"H2CO3D",
"rhea":"RHEA:10748",
"sbo":"SBO:0000176"
}
},
{
"id":"MGSA",
"name":"methylglyoxal synthase",
"metabolites":{
"dhap_c":-1.0,
"mthgxl_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00984",
"subsystem":"Methylglyoxal Metabolism",
"annotation":{
"biggr":"MGSA",
"rhea":"RHEA:17937",
"sbo":"SBO:0000176"
}
},
{
"id":"IMPC",
"name":"IMP cyclohydrolase",
"metabolites":{
"fprica_c":1.0,
"h2o_c":-1.0,
"imp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04134",
"subsystem":"Purine and Pyrimidine Biosynthesis",
"annotation":{
"biggr":"IMPC",
"rhea":"RHEA:18445",
"sbo":"SBO:0000176"
}
},
{
"id":"IMPD",
"name":"IMP dehydrogenase",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"imp_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"xmp_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02588",
"subsystem":"Purine and Pyrimidine Biosynthesis",
"annotation":{
"biggr":"IMPD",
"rhea":"RHEA:11708",
"sbo":"SBO:0000176"
}
},
{
"id":"PPS",
"name":"phosphoenolpyruvate synthase",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":2.0,
"pep_c":1.0,
"pi_c":1.0,
"pyr_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01759",
"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
"biggr":"PPS",
"rhea":"RHEA:11364",
"sbo":"SBO:0000176"
}
},
{
"id":"ECOAH4",
"name":"3-hydroxyacyl-CoA dehydratase (3-hydroxydecanoyl-CoA)",
"metabolites":{
"3hdcoa_c":-1.0,
"dc2coa_c":1.0,
"h2o_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02426 or HFPHFOGF_03972",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"ECOAH4",
"rhea":"RHEA:31191",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPADSS",
"name":"Lipid A disaccaride synthase",
"metabolites":{
"__Ecoli_panGEMs__u23ga_c":-1.0,
"h_c":1.0,
"lipidAds_c":1.0,
"lipidX_c":-1.0,
"udp_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00179",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPADSS",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__GLUTRS",
"name":"Glutamyl-tRNA synthetase",
"metabolites":{
"__Ecoli_panGEMs__glutrna_c":1.0,
"__Ecoli_panGEMs__trnaglu_c":-1.0,
"amp_c":1.0,
"atp_c":-1.0,
"glu__L_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02485",
"subsystem":"tRNA Charging",
"annotation":{
"biggr":"__Ecoli_panGEMs__GLUTRS",
"sbo":"SBO:0000176"
}
},
{
"id":"TDSK",
"name":"Tetraacyldisaccharide 4'kinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"lipidA_c":1.0,
"lipidAds_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00936",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"TDSK",
"rhea":"RHEA:20700",
"sbo":"SBO:0000176"
}
},
{
"id":"PGI",
"name":"glucose-6-phosphate isomerase",
"metabolites":{
"f6p_c":1.0,
"g6p_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04153",
"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
"biggr":"PGI",
"sbo":"SBO:0000176"
}
},
{
"id":"TMPPP",
"name":"thiamine-phosphate diphosphorylase",
"metabolites":{
"2mahmp_c":-1.0,
"4mpetz_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0,
"thmmp_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04121",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"TMPPP",
"rhea":"RHEA:22328",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_btn_e",
"name":"Exchange of biotinate.",
"metabolites":{
"btn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_btn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"PGK",
"name":"phosphoglycerate kinase",
"metabolites":{
"13dpg_c":1.0,
"3pg_c":-1.0,
"adp_c":1.0,
"atp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03057",
"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
"biggr":"PGK",
"rhea":"RHEA:14801",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_ptrc_e",
"name":"Exchange of 1,4-butanediammonium.",
"metabolites":{
"ptrc_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ptrc_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EDA",
"name":"2-dehydro-3-deoxy-phosphogluconate aldolase",
"metabolites":{
"2ddg6p_c":-1.0,
"g3p_c":1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01910",
"subsystem":"Pentose Phosphate Pathway",
"annotation":{
"biggr":"EDA",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_spmd_e",
"name":"Exchange of spermidine(3+).",
"metabolites":{
"spmd_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_spmd_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_thym_e",
"name":"Exchange of thymine.",
"metabolites":{
"thym_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_thym_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_xtsn_e",
"name":"Exchange of xanthosine.",
"metabolites":{
"xtsn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_xtsn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"NTPP1",
"name":"Nucleoside triphosphate pyrophosphorylase (dgtp)",
"metabolites":{
"dgmp_c":1.0,
"dgtp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00098 or HFPHFOGF_02886",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTPP1",
"rhea":"RHEA:28362",
"sbo":"SBO:0000176"
}
},
{
"id":"URIK1_1",
"name":"uridine kinase (ATP:Uridine)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"ump_c":1.0,
"uri_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02157",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"URIK1_1",
"rhea":"RHEA:16825",
"sbo":"SBO:0000176"
}
},
{
"id":"URIK2",
"name":"uridine kinase (GTP:Uridine)",
"metabolites":{
"gdp_c":1.0,
"gtp_c":-1.0,
"h_c":1.0,
"ump_c":1.0,
"uri_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02157",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"URIK2",
"rhea":"RHEA:27650",
"sbo":"SBO:0000176"
}
},
{
"id":"NTPP2_1",
"name":"Nucleoside triphosphate pyrophosphorylase (gtp)",
"metabolites":{
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"gtp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00098 or HFPHFOGF_02886",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTPP2_1",
"rhea":"RHEA:29391",
"sbo":"SBO:0000176"
}
},
{
"id":"PGL",
"name":"6-phosphogluconolactonase",
"metabolites":{
"6pgc_c":1.0,
"6pgl_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00787",
"subsystem":"Pentose Phosphate Pathway",
"annotation":{
"biggr":"PGL",
"rhea":"RHEA:12556",
"sbo":"SBO:0000176"
}
},
{
"id":"NTPTP1",
"name":"Nucleoside triphosphate tripolyhydrolase",
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"h2o_c":-1.0,
"pppi_c":1.0
},
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"rhea":"RHEA:15193",
"sbo":"SBO:0000176"
}
},
{
"id":"NTPTP2",
"name":"Nucleoside triphosphate tripolyhydrolase",
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},
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"sbo":"SBO:0000176"
}
},
{
"id":"CYTDK1",
"name":"cytidine kinase (ATP)",
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"h_c":1.0
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"rhea":"RHEA:24674",
"sbo":"SBO:0000176"
}
},
{
"id":"RPE",
"name":"ribulose 5-phosphate 3-epimerase",
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},
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"sbo":"SBO:0000176"
}
},
{
"id":"DHQTi",
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},
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"sbo":"SBO:0000176"
}
},
{
"id":"IPMD",
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"rhea":"RHEA:10892",
"sbo":"SBO:0000176"
}
},
{
"id":"AIRC3",
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},
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"sbo":"SBO:0000176"
}
},
{
"id":"TALA",
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},
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"sbo":"SBO:0000176"
}
},
{
"id":"PUNP1",
"name":"purine-nucleoside phosphorylase (Adenosine)",
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},
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"rhea":"RHEA:27642",
"sbo":"SBO:0000176"
}
},
{
"id":"PUNP2_1",
"name":"purine-nucleoside phosphorylase (Deoxyadenosine)",
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"rhea":"RHEA:27742",
"sbo":"SBO:0000176"
}
},
{
"id":"PUNP3",
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},
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"rhea":"RHEA:13233",
"sbo":"SBO:0000176"
}
},
{
"id":"ADSL2r",
"name":"adenylosuccinate lyase",
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},
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"rhea":"RHEA:23920",
"sbo":"SBO:0000176"
}
},
{
"id":"TKT1",
"name":"transketolase",
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"sbo":"SBO:0000176"
}
},
{
"id":"EX_fe2_e",
"name":"Exchange of iron(2+).",
"metabolites":{
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"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
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"sbo":"SBO:0000627"
}
},
{
"id":"PUNP5",
"name":"purine-nucleoside phosphorylase (Inosine)",
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},
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"subsystem":"Nucleotide Salvage Pathway",
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"rhea":"RHEA:27646",
"sbo":"SBO:0000176"
}
},
{
"id":"PUNP6",
"name":"purine-nucleoside phosphorylase (Deoxyinosine)",
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},
"lower_bound":-1000.0,
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"subsystem":"Nucleotide Salvage Pathway",
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"rhea":"RHEA:27750",
"sbo":"SBO:0000176"
}
},
{
"id":"PUNP7",
"name":"purine-nucleoside phosphorylase (Xanthosine)",
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},
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"sbo":"SBO:0000176"
}
},
{
"id":"G6PDA",
"name":"glucosamine-6-phosphate deaminase",
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"rhea":"RHEA:12172",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__RNDR1",
"name":"Ribonucleoside-diphosphate reductase (ADP)",
"metabolites":{
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}
},
{
"id":"ALCD2x",
"name":"alcohol dehydrogenase (ethanol)",
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"rhea":"RHEA:25290",
"sbo":"SBO:0000176"
}
},
{
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}
},
{
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}
},
{
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"sbo":"SBO:0000176"
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},
{
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"rhea":"RHEA:12104",
"sbo":"SBO:0000176"
}
},
{
"id":"RMI",
"name":"L-rhamnose isomerase",
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"sbo":"SBO:0000176"
}
},
{
"id":"TMDK1",
"name":"thymidine kinase (ATP:thymidine)",
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"sbo":"SBO:0000176"
}
},
{
"id":"LYSAM",
"name":"lysine 2,3-aminomutase",
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"rhea":"RHEA:19177",
"sbo":"SBO:0000176"
}
},
{
"id":"PPCDC",
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"sbo":"SBO:0000176"
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},
{
"id":"FTHFD",
"name":"formyltetrahydrofolate deformylase",
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"rhea":"RHEA:19833",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_glc__D_e",
"name":"Exchange of D-glucopyranose.",
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"lower_bound":-20.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
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"sbo":"SBO:0000627"
}
},
{
"id":"DHAD1",
"name":"dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate)",
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"h2o_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03900",
"subsystem":"Valine, Leucine, and Isoleucine Metabolism",
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"rhea":"RHEA:24809",
"sbo":"SBO:0000176"
}
},
{
"id":"IPPMIa",
"name":"3-isopropylmalate dehydratase",
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"h2o_c":1.0
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"subsystem":"Valine, Leucine, and Isoleucine Metabolism",
"annotation":{
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"rhea":"RHEA:10676",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_alltn_e",
"name":"Allantoin exchange",
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"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_alltn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"G3PD7",
"name":"glycerol-3-phosphate dehydrogenase (demethylmenaquinone-8)",
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"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"G3PD7",
"sbo":"SBO:0000176"
}
},
{
"id":"EDD",
"name":"6-phosphogluconate dehydratase",
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"h2o_c":1.0
},
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"gene_reaction_rule":"HFPHFOGF_01911",
"subsystem":"Pentose Phosphate Pathway",
"annotation":{
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"rhea":"RHEA:17277",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_ura_e",
"name":"Exchange of uracil.",
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"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ura_e",
"sbo":"SBO:0000627"
}
},
{
"id":"NADH9",
"name":"NADH dehydrogenase (demethylmenaquinone-8 & 0 protons)",
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"2dmmql8_c":1.0,
"h_c":-1.0,
"nad_c":1.0,
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"gene_reaction_rule":"HFPHFOGF_01127 or HFPHFOGF_01024 or HFPHFOGF_00047 or HFPHFOGF_03840",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"NADH9",
"rhea":"RHEA:30507",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_val__L_e",
"name":"Exchange of L-valine zwitterion.",
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_val__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"NADH10",
"name":"NADH dehydrogenase (menaquinone-8 & 0 protons)",
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"mqn8_c":-1.0,
"nad_c":1.0,
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_01127 or HFPHFOGF_03840 or HFPHFOGF_00047 or HFPHFOGF_01024",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"NADH10",
"rhea":"RHEA:29243",
"sbo":"SBO:0000176"
}
},
{
"id":"ADK4",
"name":"adentylate kinase (ITP)",
"metabolites":{
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"amp_c":-1.0,
"idp_c":1.0,
"itp_c":-1.0
},
"lower_bound":-1000.0,
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"gene_reaction_rule":"HFPHFOGF_00503",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
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"rhea":"RHEA:29867",
"sbo":"SBO:0000176"
}
},
{
"id":"INSK",
"name":"insosine kinase",
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"h_c":1.0,
"imp_c":1.0,
"ins_c":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00506",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
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"rhea":"RHEA:21140",
"sbo":"SBO:0000176"
}
},
{
"id":"MDHi2",
"name":"malate dehydrogenase",
"metabolites":{
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"mal__L_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"oaa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03339",
"subsystem":"Citric Acid Cycle",
"annotation":{
"biggr":"MDHi2",
"rhea":"RHEA:21432",
"sbo":"SBO:0000176"
}
},
{
"id":"ABTA",
"name":"4-aminobutyrate transaminase",
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"akg_c":-1.0,
"glu__L_c":1.0,
"sucsal_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02754 or HFPHFOGF_01416",
"subsystem":"Arginine and Proline Metabolism",
"annotation":{
"biggr":"ABTA",
"rhea":"RHEA:23352",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_xan_e",
"name":"Xanthine exchange",
"metabolites":{
"xan_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_xan_e",
"sbo":"SBO:0000627"
}
},
{
"id":"FUM",
"name":"fumarase",
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"h2o_c":-1.0,
"mal__L_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01666 or HFPHFOGF_04260 or HFPHFOGF_01665",
"subsystem":"Citric Acid Cycle",
"annotation":{
"biggr":"FUM",
"rhea":"RHEA:12460",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FMNAT",
"name":"FMN adenylyltransferase",
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"__Ecoli_panGEMs__fmn_c":-1.0,
"atp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00025",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__FMNAT",
"sbo":"SBO:0000176"
}
},
{
"id":"PYDXNK",
"name":"pyridoxine kinase",
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"atp_c":-1.0,
"h_c":1.0,
"pdx5p_c":1.0,
"pydxn_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02504",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
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"biggr":"PYDXNK",
"rhea":"RHEA:25108",
"sbo":"SBO:0000176"
}
},
{
"id":"PYAM5PO",
"name":"pyridoxamine 5'-phosphate oxidase",
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"h2o_c":-1.0,
"nh4_c":1.0,
"o2_c":-1.0,
"pyam5p_c":-1.0,
"pydx5p_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01694",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"PYAM5PO",
"rhea":"RHEA:15817",
"sbo":"SBO:0000176"
}
},
{
"id":"SSALx",
"name":"succinate-semialdehyde dehydrogenase (NAD)",
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"h2o_c":-1.0,
"h_c":2.0,
"nad_c":-1.0,
"nadh_c":1.0,
"succ_c":1.0,
"sucsal_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01614",
"subsystem":"Arginine and Proline Metabolism",
"annotation":{
"biggr":"SSALx",
"rhea":"RHEA:13217",
"sbo":"SBO:0000176"
}
},
{
"id":"ASPT",
"name":"L-aspartase",
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"fum_c":1.0,
"nh4_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04278",
"subsystem":"Alanine and Aspartate Metabolism",
"annotation":{
"biggr":"ASPT",
"rhea":"RHEA:16601",
"sbo":"SBO:0000176"
}
},
{
"id":"OHPBAT",
"name":"O-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferase",
"metabolites":{
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"glu__L_c":-1.0,
"ohpb_c":-1.0,
"phthr_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00927",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"OHPBAT",
"rhea":"RHEA:16573",
"sbo":"SBO:0000176"
}
},
{
"id":"SERD_L",
"name":"L-serine deaminase",
"metabolites":{
"nh4_c":1.0,
"pyr_c":1.0,
"ser__L_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03218 or HFPHFOGF_01873 or HFPHFOGF_02902 or HFPHFOGF_03835 or HFPHFOGF_03223",
"subsystem":"Glycine and Serine Metabolism",
"annotation":{
"biggr":"SERD_L",
"rhea":"RHEA:19169",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_dgsn_e",
"name":"Exchange of 2'-deoxyguanosine.",
"metabolites":{
"dgsn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_dgsn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"NPH",
"name":"NAD diphosphatase",
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"h2o_c":-1.0,
"h_c":2.0,
"nad_c":-1.0,
"nmn_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04124 or HFPHFOGF_02497",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"NPH",
"rhea":"RHEA:11800",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_arab__L_e",
"name":"L-Arabinose exchange",
"metabolites":{
"arab__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_arab__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_fru_e",
"name":"Exchange of beta-D-fructofuranose.",
"metabolites":{
"fru_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_fru_e",
"sbo":"SBO:0000627"
}
},
{
"id":"THRD",
"name":"L-threonine dehydrogenase",
"metabolites":{
"2aobut_c":1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"thr__L_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03727 or HFPHFOGF_03699",
"subsystem":"Glycine and Serine Metabolism",
"annotation":{
"biggr":"THRD",
"rhea":"RHEA:13161",
"sbo":"SBO:0000176"
}
},
{
"id":"HEX4",
"name":"hexokinase (D-mannose:ATP)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"man6p_c":1.0,
"man_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"HEX4",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_gal_e",
"name":"Exchange of alpha-D-galactose.",
"metabolites":{
"gal_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_gal_e",
"sbo":"SBO:0000627"
}
},
{
"id":"NMNAT",
"name":"nicotinamide-nucleotide adenylyltransferase",
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"h_c":-1.0,
"nad_c":1.0,
"nmn_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04529 or HFPHFOGF_00658",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"NMNAT",
"rhea":"RHEA:21360",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_xyl__D_e",
"name":"Exchange of D-xylopyranose.",
"metabolites":{
"xyl__D_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_xyl__D_e",
"sbo":"SBO:0000627"
}
},
{
"id":"KARA1",
"name":"ketol-acid reductoisomerase (2,3-dihydroxy-3-methylbutanoate)",
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"alac__S_c":1.0,
"h_c":1.0,
"nadp_c":-1.0,
"nadph_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03903",
"subsystem":"Valine, Leucine, and Isoleucine Metabolism",
"annotation":{
"biggr":"KARA1",
"rhea":"RHEA:22068",
"sbo":"SBO:0000176"
}
},
{
"id":"HMPK1",
"name":"hydroxymethylpyrimidine kinase (ATP)",
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"4ampm_c":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02191 or HFPHFOGF_02504",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"HMPK1",
"rhea":"RHEA:23096",
"sbo":"SBO:0000176"
}
},
{
"id":"KARA2",
"name":"ketol-acid reductoisomerase (2-Acetolactate)",
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"2ahbut_c":-1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03903",
"subsystem":"Valine, Leucine, and Isoleucine Metabolism",
"annotation":{
"biggr":"KARA2",
"rhea":"RHEA:13493",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_duri_e",
"name":"Exchange of 2'-deoxyuridine.",
"metabolites":{
"duri_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_duri_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_for_e",
"name":"Exchange of formate.",
"metabolites":{
"for_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_for_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_gly_e",
"name":"Exchange of glycine zwitterion.",
"metabolites":{
"gly_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_gly_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_h2_e",
"name":"Exchange of dihydrogen.",
"metabolites":{
"h2_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_h2_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_lys__L_e",
"name":"Exchange of L-lysinium(1+).",
"metabolites":{
"lys__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_lys__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ACCOAC",
"name":"acetyl-CoA carboxylase",
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"adp_c":1.0,
"atp_c":-1.0,
"h2co3_c":-1.0,
"h_c":1.0,
"malcoa_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02402 and HFPHFOGF_03356 and HFPHFOGF_03357 and HFPHFOGF_00182",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"ACCOAC",
"rhea":"RHEA:11308",
"sbo":"SBO:0000176"
}
},
{
"id":"NADK",
"name":"NAD kinase",
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"atp_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadp_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02697",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"NADK",
"rhea":"RHEA:18629",
"sbo":"SBO:0000176"
}
},
{
"id":"GLXCL",
"name":"glyoxalate carboligase",
"metabolites":{
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"co2_c":1.0,
"glx_c":-2.0,
"h_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00535",
"subsystem":"Glyoxylate Metabolism",
"annotation":{
"biggr":"GLXCL",
"rhea":"RHEA:10136",
"sbo":"SBO:0000176"
}
},
{
"id":"ICHORS",
"name":"isochorismate synthase",
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"chor_c":-1.0,
"ichor_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02353",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"ICHORS",
"rhea":"RHEA:18985",
"sbo":"SBO:0000176"
}
},
{
"id":"SUCBZS",
"name":"O-succinylbenzoate-CoA synthase",
"metabolites":{
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"h2o_c":1.0,
"sucbz_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02349",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"SUCBZS",
"rhea":"RHEA:10196",
"sbo":"SBO:0000176"
}
},
{
"id":"DHBD",
"name":"2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase",
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"23dhb_c":1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00614",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"DHBD",
"sbo":"SBO:0000176"
}
},
{
"id":"ICHORT",
"name":"isochorismatase",
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"h2o_c":-1.0,
"ichor_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00613",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"ICHORT",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_ser__L_e",
"name":"Exchange of L-serine zwitterion.",
"metabolites":{
"ser__L_e":-1.0
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"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ser__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_thm_e",
"name":"Exchange of thiamine(1+).",
"metabolites":{
"thm_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_thm_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_trp__L_e",
"name":"Exchange of L-tryptophan zwitterion.",
"metabolites":{
"trp__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_trp__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__GLUTRR",
"name":"Glutamyl-tRNA reductase",
"metabolites":{
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"glu1sa_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
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"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01314",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__GLUTRR",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__GLCS1",
"name":"Glycogen synthase (ADPGlc)",
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"adp_c":1.0,
"adpglc_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03532",
"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__GLCS1",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__GLCP",
"name":"Glycogen phosphorylase",
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"g1p_c":1.0,
"pi_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03531 or HFPHFOGF_03521",
"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__GLCP",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_din_e",
"name":"Exchange of 2'-deoxyinosine.",
"metabolites":{
"din_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_din_e",
"sbo":"SBO:0000627"
}
},
{
"id":"RBK_L1",
"name":"L-ribulokinase (L-ribulose)",
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"h_c":1.0,
"rbl__L_c":-1.0,
"ru5p__L_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00063",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"RBK_L1",
"rhea":"RHEA:22072",
"sbo":"SBO:0000176"
}
},
{
"id":"RBP4E",
"name":"L-ribulose-phosphate 4-epimerase",
"metabolites":{
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"xu5p__D_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00061 or HFPHFOGF_04347 or HFPHFOGF_03692",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"RBP4E",
"rhea":"RHEA:22368",
"sbo":"SBO:0000176"
}
},
{
"id":"TARTD",
"name":"L(+)-tartrate dehydratase",
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"oaa_c":1.0,
"tartr__L_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03172 and HFPHFOGF_03171",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"TARTD",
"rhea":"RHEA:15413",
"sbo":"SBO:0000176"
}
},
{
"id":"NTD2",
"name":"5'-nucleotidase (UMP)",
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"pi_c":1.0,
"ump_c":-1.0,
"uri_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02844 or HFPHFOGF_04512 or HFPHFOGF_00689",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD2",
"rhea":"RHEA:29359",
"sbo":"SBO:0000176"
}
},
{
"id":"GLCRAL",
"name":"5-dehydro-4-deoxyglucarate aldolase",
"metabolites":{
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"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03229",
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"annotation":{
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"rhea":"RHEA:27726",
"sbo":"SBO:0000176"
}
},
{
"id":"NTD4",
"name":"5'-nucleotidase (CMP)",
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"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02844 or HFPHFOGF_00689",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
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"rhea":"RHEA:29367",
"sbo":"SBO:0000176"
}
},
{
"id":"NTD5",
"name":"5'-nucleotidase (dTMP)",
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"thymd_c":1.0
},
"lower_bound":0.0,
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"subsystem":"Nucleotide Salvage Pathway",
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"sbo":"SBO:0000176"
}
},
{
"id":"EX___Ecoli_panGEMs__fmn_e",
"name":"FMN exchange",
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"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
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"sbo":"SBO:0000627"
}
},
{
"id":"EX_gthox_e",
"name":"Exchange of glutathione disulfide(2-).",
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"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
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}
},
{
"id":"__Ecoli_panGEMs__KAS14",
"name":"Beta-ketoacyl-ACP synthase",
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}
},
{
"id":"__Ecoli_panGEMs__HEMEOS",
"name":"Heme O synthase",
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"pheme_c":-1.0,
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}
},
{
"id":"ADMDC",
"name":"adenosylmethionine decarboxylase",
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"h_c":-1.0
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}
},
{
"id":"AGMT",
"name":"agmatinase",
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}
},
{
"id":"NTD6",
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},
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}
},
{
"id":"LGTHL",
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"sbo":"SBO:0000176"
}
},
{
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"name":"Pyridoxal 5-phosphate phosphatase",
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}
},
{
"id":"PDXPP",
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}
},
{
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}
},
{
"id":"HACD6i",
"name":"3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA)",
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"rhea":"RHEA:31167",
"sbo":"SBO:0000176"
}
},
{
"id":"ECOAH1",
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}
},
{
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}
},
{
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"sbo":"SBO:0000176"
}
},
{
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}
},
{
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"sbo":"SBO:0000176"
}
},
{
"id":"G1SAT",
"name":"glutamate-1-semialdehyde aminotransferase",
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}
},
{
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"sbo":"SBO:0000176"
}
},
{
"id":"ECOAH3",
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},
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}
},
{
"id":"UGLT",
"name":"UDPglucose--hexose-1-phosphate uridylyltransferase",
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}
},
{
"id":"__Ecoli_panGEMs__EDTXS1",
"name":"Endotoxin Synthesis (lauroyl transferase)",
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}
},
{
"id":"DXPS",
"name":"1-deoxy-D-xylulose 5-phosphate synthase",
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},
{
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"rhea":"RHEA:15641",
"sbo":"SBO:0000176"
}
},
{
"id":"MNNH",
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}
},
{
"id":"CDPMEK",
"name":"4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase",
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}
},
{
"id":"__Ecoli_panGEMs__EDTXS2",
"name":"Endotoxin Synthesis (myristoyl transferase)",
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}
},
{
"id":"ALTRH",
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"sbo":"SBO:0000176"
}
},
{
"id":"MECDPS",
"name":"2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase",
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"sbo":"SBO:0000176"
}
},
{
"id":"GUI1",
"name":"glucuronate isomerase (D-glucuronate)",
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},
"lower_bound":-1000.0,
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EDTXS3",
"name":"Endotoxin Synthesis (palmitoleoyl ACP)",
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}
},
{
"id":"PGAMT",
"name":"phosphoglucosamine mutase",
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},
"lower_bound":-1000.0,
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}
},
{
"id":"DDGLK",
"name":"2-dehydro-3-deoxygluconokinase",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EDTXS4",
"name":"Endotoxin Synthesis (myristoyl transferase)",
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},
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"sbo":"SBO:0000176"
}
},
{
"id":"XYLI2",
"name":"xylose isomerase",
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},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03674",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"XYLI2",
"sbo":"SBO:0000176"
}
},
{
"id":"ICL",
"name":"Isocitrate lyase",
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"icit_c":-1.0,
"succ_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04143",
"subsystem":"Anaplerotic Reactions",
"annotation":{
"biggr":"ICL",
"sbo":"SBO:0000176"
}
},
{
"id":"UAGDP",
"name":"UDP-N-acetylglucosamine diphosphorylase",
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"h_c":-1.0,
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"uacgam_c":1.0,
"utp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03861",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"UAGDP",
"rhea":"RHEA:13509",
"sbo":"SBO:0000176"
}
},
{
"id":"UAGCVT_1",
"name":"UDP-N-acetylglucosamine 1-carboxyvinyltransferase",
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"pi_c":1.0,
"uaccg_c":1.0,
"uacgam_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03290",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"UAGCVT_1",
"rhea":"RHEA:18681",
"sbo":"SBO:0000176"
}
},
{
"id":"GLUR",
"name":"glutamate racemase",
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"glu__L_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04095",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"GLUR",
"rhea":"RHEA:12813",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_tmao_e",
"name":"Exchange of trimethylamine N-oxide.",
"metabolites":{
"tmao_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_tmao_e",
"sbo":"SBO:0000627"
}
},
{
"id":"UAG2E",
"name":"UDP-N-acetylglucosamine 2-epimerase",
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"uacmam_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03914",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"UAG2E",
"rhea":"RHEA:17213",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_acald_e",
"name":"Exchange of acetaldehyde.",
"metabolites":{
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_acald_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GLYCL",
"name":"Glycine Cleavage System",
"metabolites":{
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"gly_c":-1.0,
"mlthf_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"nh4_c":1.0,
"thf_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03036 and HFPHFOGF_03035 and HFPHFOGF_00113 and HFPHFOGF_03037",
"subsystem":"Folate Metabolism",
"annotation":{
"biggr":"GLYCL",
"rhea":"RHEA:27758",
"sbo":"SBO:0000176"
}
},
{
"id":"CMPN",
"name":"CMP nucleosidase",
"metabolites":{
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"csn_c":1.0,
"h2o_c":-1.0,
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},
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},
{
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},
{
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},
{
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},
{
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{
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},
{
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{
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},
{
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},
{
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},
{
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},
{
"id":"G3PT",
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},
{
"id":"CINNDO",
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{
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},
{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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},
{
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{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
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},
{
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},
{
"id":"BUTCT",
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},
{
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},
{
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},
{
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{
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{
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},
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}
},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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{
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{
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{
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{
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{
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},
{
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{
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},
{
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},
{
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},
{
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},
{
"id":"GMHEPPA",
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},
{
"id":"S7PI",
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},
{
"id":"TRPS3",
"name":"tryptophan synthase (indoleglycerol phosphate)",
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},
"lower_bound":0.0,
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},
{
"id":"EX_ttdcea_e",
"name":"Exchange of myristoleate.",
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}
},
{
"id":"F6PA",
"name":"fructose 6-phosphate aldolase",
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}
},
{
"id":"AGMHE",
"name":"ADP-D-glycero-D-manno-heptose epimerase",
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},
"lower_bound":0.0,
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"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
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"sbo":"SBO:0000176"
}
},
{
"id":"CRNBTCT",
"name":"gamma-butyrobetainyl-CoA: carnitine CoA transferase",
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"crncoa_c":1.0,
"gbbtn_c":1.0
},
"lower_bound":-1000.0,
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"gene_reaction_rule":"HFPHFOGF_00039",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"CRNBTCT",
"rhea":"RHEA:28418",
"sbo":"SBO:0000176"
}
},
{
"id":"CRNCBCT",
"name":"crotonobetainyl-CoA: carnitine CoA transferase",
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{
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"sbo":"SBO:0000176"
}
},
{
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"sbo":"SBO:0000176"
}
},
{
"id":"GSPMDA",
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},
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}
},
{
"id":"GSPMDS",
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}
},
{
"id":"GUAD_1",
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},
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"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"GUAD_1",
"sbo":"SBO:0000176"
}
},
{
"id":"THRS_2",
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},
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}
},
{
"id":"EX_amp_e",
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}
},
{
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"sbo":"SBO:0000176"
}
},
{
"id":"PPNDH",
"name":"prephenate dehydratase",
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}
},
{
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"rhea":"RHEA:29279",
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}
},
{
"id":"TMAOR2",
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"biggr":"TMAOR2",
"rhea":"RHEA:30583",
"sbo":"SBO:0000176"
}
},
{
"id":"DGK1",
"name":"deoxyguanylate kinase (dGMP:ATP)",
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},
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"rhea":"RHEA:12697",
"sbo":"SBO:0000176"
}
},
{
"id":"DTMPK",
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},
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"biggr":"DTMPK",
"rhea":"RHEA:13517",
"sbo":"SBO:0000176"
}
},
{
"id":"NDPK1",
"name":"nucleoside-diphosphate kinase (ATP:GDP)",
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},
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__TRDR",
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"sbo":"SBO:0000176"
}
},
{
"id":"DDPA",
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"sbo":"SBO:0000176"
}
},
{
"id":"NMNDA",
"name":"nicotinamide-nucleotide amidase",
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"nicrnt_c":1.0,
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},
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"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
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"rhea":"RHEA:12400",
"sbo":"SBO:0000176"
}
},
{
"id":"NNAM",
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"biggr":"NNAM",
"rhea":"RHEA:14545",
"sbo":"SBO:0000176"
}
},
{
"id":"P5CD",
"name":"1-pyrroline-5-carboxylate dehydrogenase",
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},
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"gene_reaction_rule":"HFPHFOGF_01034",
"subsystem":"Arginine and Proline Metabolism",
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"biggr":"P5CD",
"rhea":"RHEA:16417",
"sbo":"SBO:0000176"
}
},
{
"id":"PGMT",
"name":"phosphoglucomutase",
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"g6p_c":1.0
},
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"upper_bound":1000.0,
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"subsystem":"Alternate Carbon Metabolism",
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"sbo":"SBO:0000176"
}
},
{
"id":"FRUK",
"name":"fructose-1-phosphate kinase",
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"h_c":1.0
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"rhea":"RHEA:14213",
"sbo":"SBO:0000176"
}
},
{
"id":"SPMDAT1",
"name":"Spermidine acetyltransferase",
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"h_c":1.0,
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"sbo":"SBO:0000176"
}
},
{
"id":"RHCCE",
"name":"S-ribosylhomocysteine cleavage enzyme",
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"hcys__L_c":1.0,
"rhcys_c":-1.0
},
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"gene_reaction_rule":"HFPHFOGF_02778",
"subsystem":"Methionine Metabolism",
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"rhea":"RHEA:17753",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_dha_e",
"name":"Exchange of dihydroxyacetone.",
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"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
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"sbo":"SBO:0000627"
}
},
{
"id":"KG6PDC",
"name":"3-keto-L-gulonate 6-phosphate decarboxylase",
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"h_c":-1.0,
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},
"lower_bound":0.0,
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"rhea":"RHEA:14353",
"sbo":"SBO:0000176"
}
},
{
"id":"SPMDAT2",
"name":"Spermidine acetyltransferase (N8)",
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"h_c":1.0,
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"spmd_c":-1.0
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"subsystem":"Arginine and Proline Metabolism",
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"rhea":"RHEA:28270",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__TDPADGAT",
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"h_c":1.0
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"gene_reaction_rule":"HFPHFOGF_03918",
"subsystem":"Cell Envelope Biosynthesis",
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"sbo":"SBO:0000176"
}
},
{
"id":"MALS",
"name":"malate synthase",
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"h2o_c":-1.0,
"h_c":1.0,
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"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_04142",
"subsystem":"Anaplerotic Reactions",
"annotation":{
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"rhea":"RHEA:18181",
"sbo":"SBO:0000176"
}
},
{
"id":"X5PL3E",
"name":"L-xylulose 5-phosphate 3-epimerase",
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"rhea":"RHEA:18497",
"sbo":"SBO:0000176"
}
},
{
"id":"DOGULNR",
"name":"2,3 dioxo-L-gulonate reductase",
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"3dhguln_c":1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03684",
"subsystem":"Alternate Carbon Metabolism",
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"rhea":"RHEA:21924",
"sbo":"SBO:0000176"
}
},
{
"id":"TRE6PP",
"name":"trehalose-phosphatase",
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"tre6p_c":-1.0,
"tre_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01956",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"TRE6PP",
"rhea":"RHEA:23420",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_fuc__L_e",
"name":"Exchange of alpha-L-fucose.",
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"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
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"sbo":"SBO:0000627"
}
},
{
"id":"EX___Ecoli_panGEMs__met__D_e",
"name":"D-Methionine exchange",
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"lower_bound":0.0,
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"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
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"sbo":"SBO:0000627"
}
},
{
"id":"EX_tartr__L_e",
"name":"Exchange of L-tartrate(2-).",
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"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
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"sbo":"SBO:0000627"
}
},
{
"id":"BETALDHx",
"name":"betaine-aldehyde dehydrogenase",
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"glyb_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
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"nadh_c":1.0
},
"lower_bound":0.0,
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"rhea":"RHEA:15305",
"sbo":"SBO:0000176"
}
},
{
"id":"BETALDHy",
"name":"betaine-aldehyde dehydrogenase",
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"h2o_c":-1.0,
"h_c":2.0,
"nadp_c":-1.0,
"nadph_c":1.0
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"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00346",
"subsystem":"Unassigned",
"annotation":{
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"rhea":"RHEA:30067",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MLTG3",
"name":"Maltodextrin glucosidase (maltopentaose)",
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"h2o_c":-1.0
},
"lower_bound":0.0,
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"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"EX_taur_e",
"name":"Exchange of taurine zwitterion.",
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"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
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}
},
{
"id":"EX___Ecoli_panGEMs__maltpt_e",
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"lower_bound":0.0,
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"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
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"sbo":"SBO:0000627"
}
},
{
"id":"EX_glyald_e",
"name":"Exchange of D-glyceraldehyde.",
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"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_glyald_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_glcur_e",
"name":"Exchange of D-glucopyranuronate.",
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"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_glcur_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ADPRDP_1",
"name":"ADPribose diphosphatase",
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"amp_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"r5p_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03501 or HFPHFOGF_03146",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
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"rhea":"RHEA:10412",
"sbo":"SBO:0000176"
}
},
{
"id":"DKGLCNR1",
"name":"2,5-diketo-D-gluconate reductase",
"metabolites":{
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"2dhguln_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03126 or HFPHFOGF_00205",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
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"rhea":"RHEA:35111",
"sbo":"SBO:0000176"
}
},
{
"id":"NADTRHD",
"name":"NAD transhydrogenase",
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"nadh_c":1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04090",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"NADTRHD",
"rhea":"RHEA:11692",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AACPS2",
"name":"Acyl-[acyl-carrier-protein] synthetase  (n-C14:1)",
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"__Ecoli_panGEMs__tdeACP_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"ppi_c":1.0,
"ttdcea_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01112 and HFPHFOGF_02953",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__AACPS2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FMNRx2",
"name":"FMN reductase",
"metabolites":{
"__Ecoli_panGEMs__fmn_c":-1.0,
"fmnh2_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03970 or HFPHFOGF_00958 or (HFPHFOGF_02867 and HFPHFOGF_02866)",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__FMNRx2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ACPS1",
"name":"Acyl-carrier protein synthase",
"metabolites":{
"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__apoACP_c":-1.0,
"coa_c":-1.0,
"h_c":1.0,
"pap_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02646 or HFPHFOGF_03577",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__ACPS1",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_nmn_e",
"name":"Exchange of NMN(-).",
"metabolites":{
"nmn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_nmn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_urea_e",
"name":"Exchange of urea.",
"metabolites":{
"urea_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_urea_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ARAI",
"name":"L-arabinose isomerase",
"metabolites":{
"arab__L_c":-1.0,
"rbl__L_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00062",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"ARAI",
"sbo":"SBO:0000176"
}
},
{
"id":"M1PD",
"name":"mannitol-1-phosphate 5-dehydrogenase",
"metabolites":{
"f6p_c":1.0,
"h_c":1.0,
"mnl1p_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03710",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"M1PD",
"rhea":"RHEA:19661",
"sbo":"SBO:0000176"
}
},
{
"id":"G3PD2",
"name":"glycerol-3-phosphate dehydrogenase (NADP)",
"metabolites":{
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"glyc3p_c":-1.0,
"h_c":1.0,
"nadp_c":-1.0,
"nadph_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03719",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"G3PD2",
"rhea":"RHEA:11096",
"sbo":"SBO:0000176"
}
},
{
"id":"DGGH",
"name":"a-galactosidase (melibiose)",
"metabolites":{
"gal_c":1.0,
"glc__D_c":1.0,
"h2o_c":-1.0,
"melib_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04257",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"DGGH",
"sbo":"SBO:0000176"
}
},
{
"id":"FCI",
"name":"L-fucose isomerase",
"metabolites":{
"fcl__L_c":1.0,
"fuc__L_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02911",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"FCI",
"sbo":"SBO:0000176"
}
},
{
"id":"FCLK",
"name":"L-fuculokinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"fc1p_c":1.0,
"fcl__L_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02912",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"FCLK",
"rhea":"RHEA:12376",
"sbo":"SBO:0000176"
}
},
{
"id":"FCLPA",
"name":"L-fuculose 1-phosphate aldolase",
"metabolites":{
"dhap_c":1.0,
"fc1p_c":-1.0,
"lald__L_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02834 or HFPHFOGF_02905",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"FCLPA",
"rhea":"RHEA:12933",
"sbo":"SBO:0000176"
}
},
{
"id":"GMPS2",
"name":"GMP synthase",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"gln__L_c":-1.0,
"glu__L_c":1.0,
"gmp_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"ppi_c":1.0,
"xmp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02587",
"subsystem":"Purine and Pyrimidine Biosynthesis",
"annotation":{
"biggr":"GMPS2",
"rhea":"RHEA:11680",
"sbo":"SBO:0000176"
}
},
{
"id":"AMPN",
"name":"AMP nucleosidase",
"metabolites":{
"ade_c":1.0,
"amp_c":-1.0,
"h2o_c":-1.0,
"r5p_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02063",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"AMPN",
"rhea":"RHEA:20129",
"sbo":"SBO:0000176"
}
},
{
"id":"GSNK",
"name":"guanosine kinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"gmp_c":1.0,
"gsn_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00506",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"GSNK",
"rhea":"RHEA:27710",
"sbo":"SBO:0000176"
}
},
{
"id":"ACCOAL",
"name":"acetate-CoA ligase (ADP-forming)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"pi_c":1.0,
"ppcoa_c":1.0,
"prpnte_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04204 or HFPHFOGF_00369",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"ACCOAL",
"rhea":"RHEA:29843",
"sbo":"SBO:0000176"
}
},
{
"id":"GALUi",
"name":"UTP-glucose-1-phosphate uridylyltransferase (irreversible)",
"metabolites":{
"g1p_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0,
"udpg_c":1.0,
"utp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00579 and HFPHFOGF_02152",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"GALUi",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AACPS3",
"name":"Acyl-[acyl-carrier-protein] synthetase  (n-C16:0)",
"metabolites":{
"__Ecoli_panGEMs__ACP_c":-1.0,
"__Ecoli_panGEMs__palmACP_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"hdca_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01112 and HFPHFOGF_02953",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__AACPS3",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__U23GAAT",
"name":"UDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferase",
"metabolites":{
"__Ecoli_panGEMs__3hmrsACP_c":-1.0,
"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__u23ga_c":1.0,
"h_c":1.0,
"u3hga_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00176",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__U23GAAT",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_f6p_e",
"name":"Exchange of beta-D-fructofuranose 6-phosphate(2-).",
"metabolites":{
"f6p_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_f6p_e",
"sbo":"SBO:0000627"
}
},
{
"id":"UAAGDS",
"name":"UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase",
"metabolites":{
"26dap__M_c":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"uamag_c":-1.0,
"ugmd_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00084",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"UAAGDS",
"rhea":"RHEA:23676",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AACPS4",
"name":"Acyl-[acyl-carrier-protein] synthetase  (n-C16:1)",
"metabolites":{
"__Ecoli_panGEMs__ACP_c":-1.0,
"__Ecoli_panGEMs__hdeACP_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"hdcea_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02953 and HFPHFOGF_01112",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__AACPS4",
"sbo":"SBO:0000176"
}
},
{
"id":"UAMAS",
"name":"UDP-N-acetylmuramoyl-L-alanine synthetase",
"metabolites":{
"adp_c":1.0,
"ala__L_c":-1.0,
"atp_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"uama_c":1.0,
"uamr_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00090",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"UAMAS",
"sbo":"SBO:0000176"
}
},
{
"id":"UAMAGS",
"name":"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase",
"metabolites":{
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"atp_c":-1.0,
"glu__D_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"uama_c":-1.0,
"uamag_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00087",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"UAMAGS",
"sbo":"SBO:0000176"
}
},
{
"id":"UGLYCH",
"name":"Ureidoglycolate hydrolase",
"metabolites":{
"co2_c":1.0,
"glx_c":1.0,
"h2o_c":-1.0,
"h_c":-2.0,
"nh4_c":2.0,
"urdglyc_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00533",
"subsystem":"Nitrogen Metabolism",
"annotation":{
"biggr":"UGLYCH",
"rhea":"RHEA:19809",
"sbo":"SBO:0000176"
}
},
{
"id":"NTPP3",
"name":"Nucleoside triphosphate pyrophosphorylase (dctp)",
"metabolites":{
"dcmp_c":1.0,
"dctp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02338 or HFPHFOGF_02886 or HFPHFOGF_01818",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTPP3",
"rhea":"RHEA:22636",
"sbo":"SBO:0000176"
}
},
{
"id":"NTPP6",
"name":"Nucleoside triphosphate pyrophosphorylase (atp)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02886 or HFPHFOGF_00925",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTPP6",
"rhea":"RHEA:14245",
"sbo":"SBO:0000176"
}
},
{
"id":"NTPP7",
"name":"Nucleoside triphosphate pyrophosphorylase (dttp)",
"metabolites":{
"dtmp_c":1.0,
"dttp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02886 or HFPHFOGF_02338 or HFPHFOGF_03350",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTPP7",
"rhea":"RHEA:28534",
"sbo":"SBO:0000176"
}
},
{
"id":"OP4ENH",
"name":"2-oxopent-4-enoate hydratase",
"metabolites":{
"4h2opntn_c":1.0,
"h2o_c":-1.0,
"op4en_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00384",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"OP4ENH",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_rmn_e",
"name":"Exchange of L-rhamnopyranose.",
"metabolites":{
"rmn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_rmn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"HOPNTAL",
"name":"4-hydroxy-2-oxopentanoate aldolase",
"metabolites":{
"4h2opntn_c":-1.0,
"acald_c":1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00386",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"HOPNTAL",
"rhea":"RHEA:22624",
"sbo":"SBO:0000176"
}
},
{
"id":"NTPP8",
"name":"Nucleoside triphosphate pyrophosphorylase (utp)",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0,
"ump_c":1.0,
"utp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02886 or HFPHFOGF_03350",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTPP8",
"rhea":"RHEA:29395",
"sbo":"SBO:0000176"
}
},
{
"id":"P5CR",
"name":"pyrroline-5-carboxylate reductase",
"metabolites":{
"h_c":-2.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"pro__L_c":1.0,
"pyr5carb_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00417",
"subsystem":"Arginine and Proline Metabolism",
"annotation":{
"biggr":"P5CR",
"rhea":"RHEA:14109",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CYANST",
"name":"Cyanide sulfurtransferase",
"metabolites":{
"__Ecoli_panGEMs__tsul_c":-1.0,
"cyan_c":-1.0,
"h_c":1.0,
"so3_c":1.0,
"tcynt_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03528 or HFPHFOGF_02760 or HFPHFOGF_02604",
"subsystem":"Unassigned",
"annotation":{
"biggr":"__Ecoli_panGEMs__CYANST",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_ttdca_e",
"name":"Exchange of tetradecanoate.",
"metabolites":{
"ttdca_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ttdca_e",
"sbo":"SBO:0000627"
}
},
{
"id":"DHPPDA2",
"name":"diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)",
"metabolites":{
"25drapp_c":-1.0,
"5apru_c":1.0,
"h2o_c":-1.0,
"h_c":-1.0,
"nh4_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00444",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"DHPPDA2",
"sbo":"SBO:0000176"
}
},
{
"id":"3HPPPNH",
"name":"3-(3-hydroxy-phenyl)propionate hydroxylase",
"metabolites":{
"3hpppn_c":-1.0,
"dhpppn_c":1.0,
"h2o_c":1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0,
"o2_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00381",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"3HPPPNH",
"rhea":"RHEA:24785",
"sbo":"SBO:0000176"
}
},
{
"id":"PPCSCT",
"name":"Propanoyl-CoA: succinate CoA-transferase",
"metabolites":{
"ppcoa_c":-1.0,
"prpnte_c":1.0,
"succ_c":-1.0,
"succoa_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03051",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"PPCSCT",
"rhea":"RHEA:28010",
"sbo":"SBO:0000176"
}
},
{
"id":"CYTD",
"name":"cytidine deaminase",
"metabolites":{
"cytd_c":-1.0,
"h2o_c":-1.0,
"h_c":-1.0,
"nh4_c":1.0,
"uri_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02228",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"CYTD",
"rhea":"RHEA:16069",
"sbo":"SBO:0000176"
}
},
{
"id":"AKGDH",
"name":"2-Oxogluterate dehydrogenase",
"metabolites":{
"akg_c":-1.0,
"co2_c":1.0,
"coa_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"succoa_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00746 and HFPHFOGF_00113 and HFPHFOGF_00745",
"subsystem":"Citric Acid Cycle",
"annotation":{
"biggr":"AKGDH",
"rhea":"RHEA:27786",
"sbo":"SBO:0000176"
}
},
{
"id":"HPYRRx",
"name":"Hydroxypyruvate reductase (NADH)",
"metabolites":{
"glyc__R_c":1.0,
"h_c":-1.0,
"hpyr_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01051 or HFPHFOGF_03660",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"HPYRRx",
"rhea":"RHEA:17905",
"sbo":"SBO:0000176"
}
},
{
"id":"GLYCDx",
"name":"Glycerol dehydrogenase",
"metabolites":{
"dha_c":1.0,
"glyc_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
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},
{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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},
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},
{
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{
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},
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{
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{
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{
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{
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{
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{
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},
{
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{
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},
{
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},
{
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},
{
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},
{
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},
{
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"biggr":"ETHAAL",
"rhea":"RHEA:15313",
"sbo":"SBO:0000176"
}
},
{
"id":"PSERT",
"name":"phosphoserine transaminase",
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"akg_c":1.0,
"glu__L_c":-1.0,
"pser_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00927",
"subsystem":"Glycine and Serine Metabolism",
"annotation":{
"biggr":"PSERT",
"rhea":"RHEA:14329",
"sbo":"SBO:0000176"
}
},
{
"id":"AP4AH",
"name":"Ap4A hydrolase",
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"ap4a_c":-1.0,
"h2o_c":-1.0,
"h_c":2.0
},
"lower_bound":0.0,
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"biggr":"AP4AH",
"rhea":"RHEA:24252",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_acmana_e",
"name":"Exchange of N-acetyl-D-mannosamine.",
"metabolites":{
"acmana_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_acmana_e",
"sbo":"SBO:0000627"
}
},
{
"id":"AP5AH",
"name":"Ap5A hydrolase",
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"ap5a_c":-1.0,
"atp_c":1.0,
"h2o_c":-1.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00050",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"AP5AH",
"rhea":"RHEA:30527",
"sbo":"SBO:0000176"
}
},
{
"id":"ADNCYC",
"name":"adenylate cyclase",
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"atp_c":-1.0,
"camp_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03935",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"ADNCYC",
"rhea":"RHEA:15389",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AIRC2",
"name":"Phosphoribosylaminoimidazole carboxylase",
"metabolites":{
"5caiz_c":1.0,
"__Ecoli_panGEMs__air_c":-1.0,
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"atp_c":-1.0,
"h2co3_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00549",
"subsystem":"Purine and Pyrimidine Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__AIRC2",
"sbo":"SBO:0000176"
}
},
{
"id":"GAPD",
"name":"glyceraldehyde-3-phosphate dehydrogenase",
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"g3p_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
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},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01838 or HFPHFOGF_01502",
"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
"biggr":"GAPD",
"sbo":"SBO:0000176"
}
},
{
"id":"MI1PP",
"name":"myo-inositol 1-phosphatase",
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"h2o_c":-1.0,
"inost_c":1.0,
"mi1p__D_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02616",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"MI1PP",
"rhea":"RHEA:27670",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_galur_e",
"name":"Exchange of aldehydo-D-galacturonate.",
"metabolites":{
"galur_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_galur_e",
"sbo":"SBO:0000627"
}
},
{
"id":"MCITS",
"name":"2-methylcitrate synthase",
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"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"oaa_c":-1.0,
"ppcoa_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00367",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"MCITS",
"rhea":"RHEA:57492",
"sbo":"SBO:0000176"
}
},
{
"id":"PPAKr",
"name":"Propionate kinase",
"metabolites":{
"adp_c":-1.0,
"atp_c":1.0,
"ppap_c":-1.0,
"prpnte_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03221",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"PPAKr",
"rhea":"RHEA:23148",
"sbo":"SBO:0000176"
}
},
{
"id":"HEX1",
"name":"hexokinase (D-glucose:ATP)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"g6p_c":1.0,
"glc__D_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02475",
"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
"biggr":"HEX1",
"rhea":"RHEA:17825",
"sbo":"SBO:0000176"
}
},
{
"id":"GND",
"name":"phosphogluconate dehydrogenase",
"metabolites":{
"6pgc_c":-1.0,
"co2_c":1.0,
"nadp_c":-1.0,
"nadph_c":1.0,
"ru5p__D_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02134",
"subsystem":"Pentose Phosphate Pathway",
"annotation":{
"biggr":"GND",
"rhea":"RHEA:10116",
"sbo":"SBO:0000176"
}
},
{
"id":"TAUDO",
"name":"Taurine dioxygenase",
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"akg_c":-1.0,
"co2_c":1.0,
"h_c":1.0,
"o2_c":-1.0,
"so3_c":1.0,
"succ_c":1.0,
"taur_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00398",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"TAUDO:2",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_amob_c",
"name":"Exchange of S-adenosyl-4-methylthio-2-oxobutanoate.",
"metabolites":{
"amob_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Intracellular demand",
"annotation":{
"biggr":"EX_amob_c",
"sbo":"SBO:0000627"
}
},
{
"id":"NTP3",
"name":"nucleoside-triphosphatase (GTP)",
"metabolites":{
"gdp_c":1.0,
"gtp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04302 or HFPHFOGF_04489 or HFPHFOGF_02821 or HFPHFOGF_03049 or HFPHFOGF_02259 or HFPHFOGF_03700 or HFPHFOGF_04314",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTP3",
"rhea":"RHEA:19669",
"sbo":"SBO:0000176"
}
},
{
"id":"PPM2",
"name":"phosphopentomutase 2 (deoxyribose)",
"metabolites":{
"2dr1p_c":-1.0,
"2dr5p_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04522",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"PPM2",
"rhea":"RHEA:27658",
"sbo":"SBO:0000176"
}
},
{
"id":"MOAT2",
"name":"3-deoxy-D-manno-octulosonic acid transferase",
"metabolites":{
"ckdo_c":-1.0,
"cmp_c":1.0,
"h_c":1.0,
"kdo2lipid4_c":1.0,
"kdolipid4_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03743",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"MOAT2",
"rhea":"RHEA:28062",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_adn_e",
"name":"Exchange of adenosine.",
"metabolites":{
"adn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_adn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_ins_e",
"name":"Exchange of inosine.",
"metabolites":{
"ins_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ins_e",
"sbo":"SBO:0000627"
}
},
{
"id":"G6PDH2r",
"name":"glucose 6-phosphate dehydrogenase",
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"g6p_c":-1.0,
"h_c":1.0,
"nadp_c":-1.0,
"nadph_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01912",
"subsystem":"Pentose Phosphate Pathway",
"annotation":{
"biggr":"G6PDH2r",
"rhea":"RHEA:15841",
"sbo":"SBO:0000176"
}
},
{
"id":"ME2",
"name":"malic enzyme (NADP)",
"metabolites":{
"co2_c":1.0,
"mal__L_c":-1.0,
"nadp_c":-1.0,
"nadph_c":1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02540",
"subsystem":"Anaplerotic Reactions",
"annotation":{
"biggr":"ME2",
"rhea":"RHEA:18253",
"sbo":"SBO:0000176"
}
},
{
"id":"ARGSL",
"name":"argininosuccinate lyase",
"metabolites":{
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"argsuc_c":-1.0,
"fum_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04088",
"subsystem":"Arginine and Proline Metabolism",
"annotation":{
"biggr":"ARGSL",
"rhea":"RHEA:24020",
"sbo":"SBO:0000176"
}
},
{
"id":"CBPS",
"name":"carbamoyl-phosphate synthase (glutamine-hydrolysing)",
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"atp_c":-2.0,
"cbp_c":1.0,
"gln__L_c":-1.0,
"glu__L_c":1.0,
"h2co3_c":-1.0,
"h2o_c":-1.0,
"h_c":2.0,
"pi_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00032 and HFPHFOGF_00033",
"subsystem":"Arginine and Proline Metabolism",
"annotation":{
"biggr":"CBPS",
"rhea":"RHEA:18633",
"sbo":"SBO:0000176"
}
},
{
"id":"GLU5K",
"name":"glutamate 5-kinase",
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"atp_c":-1.0,
"glu5p_c":1.0,
"glu__L_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00263",
"subsystem":"Arginine and Proline Metabolism",
"annotation":{
"biggr":"GLU5K",
"rhea":"RHEA:14877",
"sbo":"SBO:0000176"
}
},
{
"id":"IPPS",
"name":"2-isopropylmalate synthase",
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"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00075",
"subsystem":"Valine, Leucine, and Isoleucine Metabolism",
"annotation":{
"biggr":"IPPS",
"rhea":"RHEA:21524",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_mg2_e",
"name":"Exchange of magnesium(2+).",
"metabolites":{
"mg2_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_mg2_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__ACOATA",
"name":"Acetyl-CoA ACP transacylase",
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"accoa_c":-1.0,
"coa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01112 and HFPHFOGF_01109",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__ACOATA",
"sbo":"SBO:0000176"
}
},
{
"id":"NADH5",
"name":"NADH dehydrogenase (ubiquinone-8 )",
"metabolites":{
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"nad_c":1.0,
"nadh_c":-1.0,
"q8_c":-1.0,
"q8h2_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01127 or HFPHFOGF_00047 or HFPHFOGF_03840 or HFPHFOGF_01024",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"NADH5",
"rhea":"RHEA:29107",
"sbo":"SBO:0000176"
}
},
{
"id":"MOHMT",
"name":"3-methyl-2-oxobutanoate hydroxymethyltransferase",
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"3mob_c":-1.0,
"h2o_c":-1.0,
"mlthf_c":-1.0,
"thf_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00131",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"MOHMT",
"rhea":"RHEA:11824",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_glyc3p_e",
"name":"Exchange of sn-glycerol 3-phosphate(2-).",
"metabolites":{
"glyc3p_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_glyc3p_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__MLTG2",
"name":"Maltodextrin glucosidase (maltotetraose)",
"metabolites":{
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"__Ecoli_panGEMs__maltttr_c":-1.0,
"glc__D_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00433",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__MLTG2",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_but_e",
"name":"Exchange of butyrate.",
"metabolites":{
"but_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_but_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__MLTG1",
"name":"Maltodextrin glucosidase (maltotriose)",
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"glc__D_c":1.0,
"h2o_c":-1.0,
"malt_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00433",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__MLTG1",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AMALT3",
"name":"Amylomaltase (maltopentaose)",
"metabolites":{
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"glc__D_c":1.0,
"malt_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03520",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__AMALT3",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MLTP3",
"name":"Maltodextrin phosphorylase (maltoheptaose)",
"metabolites":{
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"__Ecoli_panGEMs__malthx_c":1.0,
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},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03521",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__MLTP3",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_lcts_e",
"name":"Exchange of lactose.",
"metabolites":{
"lcts_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_lcts_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_ocdca_e",
"name":"Exchange of octadecanoate.",
"metabolites":{
"ocdca_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ocdca_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_cbl1_e",
"name":"Exchange of cob(I)alamin(1-).",
"metabolites":{
"cbl1_e":-1.0
},
"lower_bound":-0.01,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cbl1_e",
"sbo":"SBO:0000627"
}
},
{
"id":"SPODM_1",
"name":"superoxide dismutase",
"metabolites":{
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"h_c":-2.0,
"o2_c":1.0,
"o2s_c":-2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04037 or HFPHFOGF_01712",
"subsystem":"Unassigned",
"annotation":{
"biggr":"SPODM_1",
"rhea":"RHEA:20696",
"sbo":"SBO:0000176"
}
},
{
"id":"AHCYSNS",
"name":"S-adenosylhomocysteine nucleosidase",
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"ahcys_c":-1.0,
"h2o_c":-1.0,
"rhcys_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00156",
"subsystem":"Methionine Metabolism",
"annotation":{
"biggr":"AHCYSNS",
"rhea":"RHEA:17805",
"sbo":"SBO:0000176"
}
},
{
"id":"ACNML",
"name":"N-Acetylneuraminate lyase",
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"acnam_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03328",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"ACNML",
"sbo":"SBO:0000176"
}
},
{
"id":"TMK",
"name":"thiamine kinase",
"metabolites":{
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"atp_c":-1.0,
"h_c":1.0,
"thm_c":-1.0,
"thmmp_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01124",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"TMK",
"rhea":"RHEA:12012",
"sbo":"SBO:0000176"
}
},
{
"id":"NTPP4",
"name":"Nucleoside triphosphate pyrophosphorylase (ctp)",
"metabolites":{
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"ctp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01818 or HFPHFOGF_02886",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTPP4",
"rhea":"RHEA:27762",
"sbo":"SBO:0000176"
}
},
{
"id":"GMPS",
"name":"GMP synthase",
"metabolites":{
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"atp_c":-1.0,
"gmp_c":1.0,
"h_c":2.0,
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"sbo":"SBO:0000176"
}
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{
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{
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},
{
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{
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{
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{
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}
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}
},
{
"id":"FBA3",
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"sbo":"SBO:0000176"
}
},
{
"id":"PMPK",
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"sbo":"SBO:0000176"
}
},
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"sbo":"SBO:0000176"
}
},
{
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},
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}
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},
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}
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},
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}
},
{
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},
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"sbo":"SBO:0000176"
}
},
{
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}
},
{
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},
{
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"sbo":"SBO:0000176"
}
},
{
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"sbo":"SBO:0000176"
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},
{
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}
},
{
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},
{
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"name":"acetyl-CoA C-acyltransferase (octanoyl-CoA) (r)",
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"subsystem":"Membrane Lipid Metabolism",
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"rhea":"RHEA:31087",
"sbo":"SBO:0000176"
}
},
{
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},
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"sbo":"SBO:0000655"
}
},
{
"id":"SUCFUMtpp",
"name":"succinate:fumarate antiporter (periplasm)",
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}
},
{
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"sbo":"SBO:0000176"
}
},
{
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"annotation":{
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"rhea":"RHEA:13965",
"sbo":"SBO:0000176"
}
},
{
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},
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"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
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"rhea":"RHEA:28366",
"sbo":"SBO:0000176"
}
},
{
"id":"SHSL1",
"name":"O-succinylhomoserine lyase (L-cysteine)",
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"h_c":1.0,
"succ_c":1.0,
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},
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"subsystem":"Methionine Metabolism",
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"rhea":"RHEA:20397",
"sbo":"SBO:0000176"
}
},
{
"id":"SSALy",
"name":"succinate-semialdehyde dehydrogenase (NADP)",
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"h_c":2.0,
"nadp_c":-1.0,
"nadph_c":1.0,
"succ_c":1.0,
"sucsal_c":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_01614 or HFPHFOGF_02753",
"subsystem":"Arginine and Proline Metabolism",
"annotation":{
"biggr":"SSALy",
"rhea":"RHEA:13213",
"sbo":"SBO:0000176"
}
},
{
"id":"SUCptspp",
"name":"sucrose transport via PEP:Pyr  (periplasm)",
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"pyr_c":1.0,
"suc6p_c":1.0,
"sucr_p":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02503 and HFPHFOGF_02501 and HFPHFOGF_02502 and HFPHFOGF_02514",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"SUCptspp",
"sbo":"SBO:0000655"
}
},
{
"id":"SULabcpp",
"name":"sulfate transport via ABC system (periplasm)",
"metabolites":{
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"atp_c":-1.0,
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"pi_c":1.0,
"so4_c":1.0,
"so4_p":-1.0
},
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"gene_reaction_rule":"(HFPHFOGF_02508 and HFPHFOGF_02509 and HFPHFOGF_02507 and HFPHFOGF_02510) or (HFPHFOGF_00784 and HFPHFOGF_00785 and HFPHFOGF_00783) or (HFPHFOGF_02507 and HFPHFOGF_02508 and HFPHFOGF_02509 and HFPHFOGF_04046)",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"SULabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__TSULabcpp",
"name":"Thiosulfate transport via ABC system (periplasm)",
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},
"lower_bound":0.0,
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"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__TSULabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"TARTRt7pp",
"name":"Tartrate/succinate antiporter (periplasm)",
"metabolites":{
"succ_c":-1.0,
"succ_p":1.0,
"tartr__L_c":1.0,
"tartr__L_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03173",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"TARTRt7pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_dad_2_e",
"name":"Exchange of 2'-deoxyadenosine.",
"metabolites":{
"dad_2_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_dad_2_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_ser__D_e",
"name":"Exchange of D-serine zwitterion.",
"metabolites":{
"ser__D_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ser__D_e",
"sbo":"SBO:0000627"
}
},
{
"id":"DDGALK",
"name":"2-dehydro-3-deoxygalactonokinase",
"metabolites":{
"2dh3dgal6p_c":1.0,
"2dh3dgal_c":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03822",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"DDGALK",
"rhea":"RHEA:16525",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_gam6p_e",
"name":"Exchange of alpha-D-glucosamine 6-phosphate(1-).",
"metabolites":{
"gam6p_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_gam6p_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_15dap_e",
"name":"Exchange of cadaverine(2+).",
"metabolites":{
"15dap_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_15dap_e",
"sbo":"SBO:0000627"
}
},
{
"id":"AB6PGH",
"name":"Arbutin 6-phosphate glucohydrolase",
"metabolites":{
"arbt6p_c":-1.0,
"g6p_c":1.0,
"h2o_c":-1.0,
"hqn_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03034 or HFPHFOGF_03852 or HFPHFOGF_02808",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"AB6PGH",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_ocdcea_e",
"name":"Exchange of oleate.",
"metabolites":{
"ocdcea_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ocdcea_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_cynt_e",
"name":"Cyanate exchange",
"metabolites":{
"cynt_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cynt_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_galctn__D_e",
"name":"Exchange of D-galactonate.",
"metabolites":{
"galctn__D_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_galctn__D_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__AMALT1",
"name":"Amylomaltase (maltotriose)",
"metabolites":{
"__Ecoli_panGEMs__malttr_c":-1.0,
"__Ecoli_panGEMs__maltttr_c":1.0,
"glc__D_c":1.0,
"malt_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03520",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__AMALT1",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_glyb_e",
"name":"Exchange of glycine betaine.",
"metabolites":{
"glyb_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_glyb_e",
"sbo":"SBO:0000627"
}
},
{
"id":"AHGDx",
"name":"(S)-alpha-hydroxyglutarate dehydrogenase",
"metabolites":{
"akg_c":1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"s2hydog_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03044",
"subsystem":"Glycine and Serine Metabolism",
"annotation":{
"biggr":"AHGDx",
"rhea":"RHEA:57172",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MLTP2",
"name":"Maltodextrin phosphorylase (maltohexaose)",
"metabolites":{
"__Ecoli_panGEMs__malthx_c":-1.0,
"__Ecoli_panGEMs__maltpt_c":1.0,
"g1p_c":1.0,
"pi_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03521",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__MLTP2",
"sbo":"SBO:0000176"
}
},
{
"id":"TAURabcpp",
"name":"taurine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"taur_c":1.0,
"taur_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00395 and HFPHFOGF_00397 and HFPHFOGF_00396",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"TAURabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"THMDt2pp",
"name":"thymidine transport in via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"thymd_c":1.0,
"thymd_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03092 or HFPHFOGF_02479",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"THMDt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"3HCINNMH",
"name":"3-hydroxycinnamate hydroxylase",
"metabolites":{
"34dhcinm_c":1.0,
"3hcinnm_c":-1.0,
"h2o_c":1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0,
"o2_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00381",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"3HCINNMH",
"sbo":"SBO:0000176"
}
},
{
"id":"BSORx",
"name":"Biotin sulfoxide reductase",
"metabolites":{
"btn_c":1.0,
"btnso_c":-1.0,
"h2o_c":1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03658",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"BSORx",
"rhea":"RHEA:30531",
"sbo":"SBO:0000176"
}
},
{
"id":"PACCOAL",
"name":"phenylacetate-CoA ligase",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"pac_c":-1.0,
"phaccoa_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01484",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"PACCOAL",
"rhea":"RHEA:20956",
"sbo":"SBO:0000176"
}
},
{
"id":"NMNt7pp",
"name":"NMN transport via NMN glycohydrolase (periplasm)",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"ncam_c":1.0,
"nmn_p":-1.0,
"r5p_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"NMNt7pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_ca2_e",
"name":"Exchange of calcium(2+).",
"metabolites":{
"ca2_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ca2_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_so3_e",
"name":"Sulfite exchange",
"metabolites":{
"so3_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_so3_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GLUtex",
"name":"L-glutamate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"glu__L_e":-1.0,
"glu__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GLUtex",
"sbo":"SBO:0000655"
}
},
{
"id":"Kt2pp",
"name":"potassium transport in via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"k_c":1.0,
"k_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_03975 and HFPHFOGF_01405 and HFPHFOGF_03393) or HFPHFOGF_01359 or HFPHFOGF_03878",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"Kt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYtex",
"name":"Glycine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"gly_e":-1.0,
"gly_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GLYtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GP4GH",
"name":"Gp4G hydrolase",
"metabolites":{
"gdp_c":2.0,
"gp4g_c":-1.0,
"h2o_c":-1.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00050",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"GP4GH",
"rhea":"RHEA:30203",
"sbo":"SBO:0000176"
}
},
{
"id":"GLYALDtex",
"name":"Glyceraldehyde transport via diffusion (extracellular to periplasm)",
"metabolites":{
"glyald_e":-1.0,
"glyald_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GLYALDtex",
"sbo":"SBO:0000655"
}
},
{
"id":"AKGt2rpp",
"name":"2-oxoglutarate reversible transport via symport (periplasm)",
"metabolites":{
"akg_c":1.0,
"akg_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02670",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"AKGt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ACGAMT",
"name":"UDP-N-acetylglucosamine:undecaprenylphosphate N-acetylglucosamine -1-phosphate transferase",
"metabolites":{
"uacgam_c":-1.0,
"udcpp_c":-1.0,
"ump_c":1.0,
"unaga_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03912",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"ACGAMT",
"rhea":"RHEA:28090",
"sbo":"SBO:0000176"
}
},
{
"id":"XYLt2pp",
"name":"D-xylose transport in via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"xyl__D_c":1.0,
"xyl__D_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04159",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"XYLt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_ascb__L_e",
"name":"L-Ascorbate exchange",
"metabolites":{
"ascb__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ascb__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GLYBtex",
"name":"Glycine betaine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"glyb_e":-1.0,
"glyb_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GLYBtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYCtex",
"name":"glycerol transport via diffusion (extracellular to periplasm)",
"metabolites":{
"glyc_e":-1.0,
"glyc_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GLYCtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYC3Ptex",
"name":"Glycerol-3-phosphate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"glyc3p_e":-1.0,
"glyc3p_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GLYC3Ptex",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYCLTtex",
"name":"glycolate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"glyclt_e":-1.0,
"glyclt_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GLYCLTtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GTPtex",
"name":"GTP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"gtp_e":-1.0,
"gtp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GTPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GUAtex",
"name":"Guanine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"gua_e":-1.0,
"gua_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00441",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"GUAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"Htex",
"name":"proton transport via diffusion (extracellular to periplasm)",
"metabolites":{
"h_e":-1.0,
"h_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"Htex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_ala_B_e",
"name":"Exchange of beta-alanine zwitterion.",
"metabolites":{
"ala_B_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ala_B_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_agm_e",
"name":"Exchange of agmatinium(2+).",
"metabolites":{
"agm_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_agm_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_minohp_e",
"name":"Exchange of myo-inositol hexakisphosphate(12-).",
"metabolites":{
"minohp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_minohp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_ppt_e",
"name":"Phosphonate exchange",
"metabolites":{
"ppt_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ppt_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_hxa_e",
"name":"Exchange of hexanoate.",
"metabolites":{
"hxa_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_hxa_e",
"sbo":"SBO:0000627"
}
},
{
"id":"H2tex",
"name":"hydrogen transport via diffusion (extracellular to periplasm)",
"metabolites":{
"h2_e":-1.0,
"h2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"H2tex",
"sbo":"SBO:0000655"
}
},
{
"id":"H2Otex",
"name":"H2O transport via diffusion (extracellular to periplasm)",
"metabolites":{
"h2o_e":-1.0,
"h2o_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04001 or HFPHFOGF_01434 or HFPHFOGF_00978 or HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_01462 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"H2Otex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__AADDGT",
"name":"DTDP-N-4-acetamido-4,6-dideoxy-D-galactose transferase",
"metabolites":{
"__Ecoli_panGEMs__dtdp4aaddg_c":-1.0,
"dtdp_c":1.0,
"h_c":1.0,
"unagamu_c":-1.0,
"unagamuf_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03921",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__AADDGT",
"sbo":"SBO:0000176"
}
},
{
"id":"FACOAL160t2pp",
"name":"fatty-acid-CoA ligase (hexadecanoate transport via vectoral Co-A coupling)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"h_c":1.0,
"h_p":-1.0,
"hdca_p":-1.0,
"pmtcoa_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01758 or HFPHFOGF_01864",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAL160t2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"FACOAL180t2pp",
"name":"fatty-acid-CoA ligase (octadecanoate transport via vectoral Co-A coupling)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"h_c":1.0,
"h_p":-1.0,
"ocdca_p":-1.0,
"ppi_c":1.0,
"stcoa_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01758 or HFPHFOGF_01864",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAL180t2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"SPODMpp",
"name":"superoxide dismutase",
"metabolites":{
"h2o2_p":1.0,
"h_p":-2.0,
"o2_p":1.0,
"o2s_p":-2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01702",
"subsystem":"Unassigned",
"annotation":{
"biggr":"SPODMpp",
"rhea":"RHEA:20696",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_lyx__L_e",
"name":"Exchange of L-lyxopyranose.",
"metabolites":{
"lyx__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_lyx__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX___Ecoli_panGEMs__acmum_e",
"name":"N-Acetylmuramate exchange",
"metabolites":{
"__Ecoli_panGEMs__acmum_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__acmum_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_dca_e",
"name":"Exchange of decanoate.",
"metabolites":{
"dca_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_dca_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_all__D_e",
"name":"Exchange of aldehydo-D-allose.",
"metabolites":{
"all__D_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_all__D_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__NO3R1bpp",
"name":"Nitrate reductase (Ubiquinol-8)",
"metabolites":{
"h2o_p":1.0,
"no2_p":1.0,
"no3_p":-1.0,
"q8_c":1.0,
"q8h2_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01555",
"subsystem":"Nitrogen Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__NO3R1bpp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_octa_e",
"name":"Exchange of octanoate.",
"metabolites":{
"octa_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_octa_e",
"sbo":"SBO:0000627"
}
},
{
"id":"PHYTSpp",
"name":"Phytase (periplasm)",
"metabolites":{
"h2o_p":-6.0,
"inost_p":1.0,
"minohp_p":-1.0,
"pi_p":6.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01002",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"PHYTSpp",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_gbbtn_e",
"name":"Exchange of 4-(trimethylammonio)butanoate.",
"metabolites":{
"gbbtn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_gbbtn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"PPTHpp",
"name":"Phosphonate hydrogenase (periplasm)",
"metabolites":{
"h2_p":1.0,
"h2o_p":-1.0,
"pi_p":1.0,
"ppt_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00414",
"subsystem":"Unassigned",
"annotation":{
"biggr":"PPTHpp:2",
"sbo":"SBO:0000176"
}
},
{
"id":"PYRt2rpp",
"name":"pyruvate reversible transport via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"pyr_c":1.0,
"pyr_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PYRt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__NO3R2pp",
"name":"Nitrate reductase (Menaquinol-8) (periplasm)",
"metabolites":{
"h2o_c":1.0,
"h_c":-2.0,
"h_p":2.0,
"mql8_c":-1.0,
"mqn8_c":1.0,
"no2_c":1.0,
"no3_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_01554 and HFPHFOGF_01556 and HFPHFOGF_01553 and HFPHFOGF_01552) or (HFPHFOGF_01332 and HFPHFOGF_01335 and HFPHFOGF_01334 and HFPHFOGF_01333)",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"__Ecoli_panGEMs__NO3R2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_xylu__L_e",
"name":"Exchange of L-xylulose.",
"metabolites":{
"xylu__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_xylu__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_gdp_e",
"name":"Exchange of GDP(3-).",
"metabolites":{
"gdp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_gdp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_gtp_e",
"name":"Exchange of GTP(4-).",
"metabolites":{
"gtp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_gtp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"NTP3pp",
"name":"nucleoside-triphosphatase (GTP) (periplasm)",
"metabolites":{
"gdp_p":1.0,
"gtp_p":-1.0,
"h2o_p":-1.0,
"h_p":1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01002",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTP3pp",
"rhea":"RHEA:19669",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__NO3R2bpp",
"name":"Nitrate reductase (Menaquinol-8) (periplasm)",
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"h2o_p":1.0,
"mql8_c":-1.0,
"mqn8_c":1.0,
"no2_p":1.0,
"no3_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_02290 and HFPHFOGF_02287) and HFPHFOGF_02286",
"subsystem":"Nitrogen Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__NO3R2bpp",
"sbo":"SBO:0000655"
}
},
{
"id":"THMabcpp",
"name":"thiamine transport via ABC system (periplasm)",
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"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"thm_c":1.0,
"thm_p":-1.0
},
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"gene_reaction_rule":"HFPHFOGF_00066 and HFPHFOGF_00068 and HFPHFOGF_00067",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"THMabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"THMDt2pp:2",
"name":"thymidine transport in via proton symport (periplasm)",
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"h_c":1.0,
"h_p":-1.0,
"thymd_c":1.0,
"thymd_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02491",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"THMDt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"THRabcpp",
"name":"L-threonine transport via ABC system (periplasm)",
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"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"thr__L_c":1.0,
"thr__L_p":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03558 and HFPHFOGF_03557 and HFPHFOGF_03562 and HFPHFOGF_03559 and HFPHFOGF_03556",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"THRabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"TREptspp",
"name":"trehalose transport via PEP:Pyr PTS (periplasm)",
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"pep_c":-1.0,
"pyr_c":1.0,
"tre6p_c":1.0,
"tre_p":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02503 and HFPHFOGF_04389 and HFPHFOGF_02502 and HFPHFOGF_02501",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"TREptspp",
"sbo":"SBO:0000655"
}
},
{
"id":"THD2pp",
"name":"NAD(P) transhydrogenase (periplasm)",
"metabolites":{
"h_c":2.0,
"h_p":-2.0,
"nad_c":1.0,
"nadh_c":-1.0,
"nadp_c":-1.0,
"nadph_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01656 and HFPHFOGF_01657",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"THD2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"TMAOR1pp",
"name":"Trimethylamine N-oxide reductase (menaquinol 8) (periplasm)",
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"h2o_p":1.0,
"h_p":-1.0,
"mql8_c":-1.0,
"mqn8_c":1.0,
"tmam_p":1.0,
"tmao_p":-1.0
},
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"gene_reaction_rule":"(HFPHFOGF_01017 and HFPHFOGF_01016) or (HFPHFOGF_01933 and HFPHFOGF_01934)",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"TMAOR1pp",
"sbo":"SBO:0000655"
}
},
{
"id":"TMAOR2pp",
"name":"Trimethylamine N-oxide reductase (demethylmenaquinol 8) (periplasm)",
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"2dmmql8_c":-1.0,
"h2o_p":1.0,
"h_p":-1.0,
"tmam_p":1.0,
"tmao_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_01017 and HFPHFOGF_01016) or (HFPHFOGF_01933 and HFPHFOGF_01934)",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"TMAOR2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"XANtpp",
"name":"xanthine reversible transport (periplasm)",
"metabolites":{
"xan_c":1.0,
"xan_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"XANtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"DAPtex",
"name":"1,5-Diaminopentane transport via diffusion (extracellular to periplasm)",
"metabolites":{
"15dap_e":-1.0,
"15dap_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DAPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"TRPt2rpp",
"name":"L-tryptophan reversible transport via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"trp__L_c":1.0,
"trp__L_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03262 or HFPHFOGF_03836 or HFPHFOGF_00109",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"TRPt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"TYRt2rpp",
"name":"L-tyrosine reversible transport via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"tyr__L_c":1.0,
"tyr__L_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01965 or HFPHFOGF_00109",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"TYRt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_tmam_e",
"name":"Exchange of trimethylammonium.",
"metabolites":{
"tmam_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_tmam_e",
"sbo":"SBO:0000627"
}
},
{
"id":"URIt2pp",
"name":"uridine transport in via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"uri_c":1.0,
"uri_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02491",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"URIt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"VALabcpp",
"name":"L-valine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"val__L_c":1.0,
"val__L_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03559 and HFPHFOGF_03558 and HFPHFOGF_03562 and HFPHFOGF_03557 and HFPHFOGF_03556",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"VALabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"12PPDStex",
"name":"(S)-Propane-1,2-diol transport via diffusion (extracellular to periplasm)",
"metabolites":{
"12ppd__S_e":-1.0,
"12ppd__S_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"12PPDStex",
"sbo":"SBO:0000655"
}
},
{
"id":"DDGLCNtex",
"name":"2-dehydro-3-deoxy-D-gluconate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"2ddglcn_e":-1.0,
"2ddglcn_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DDGLCNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"XTSNt2rpp",
"name":"Xanthosine transport via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"xtsn_c":1.0,
"xtsn_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02491",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"XTSNt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"XYLabcpp",
"name":"D-xylose transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"xyl__D_c":1.0,
"xyl__D_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03677 and HFPHFOGF_03675 and HFPHFOGF_03676",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"XYLabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"GMHEPK",
"name":"D-glycero-D-manno-heptose 7-phosphate kinase",
"metabolites":{
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"atp_c":-1.0,
"gmhep17bp_c":1.0,
"gmhep7p_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03162",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"GMHEPK",
"sbo":"SBO:0000176"
}
},
{
"id":"XYLUt2pp",
"name":"L-xylulose transport in via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"xylu__L_c":1.0,
"xylu__L_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03686 and HFPHFOGF_03687 and HFPHFOGF_03688",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"XYLUt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"THRt4pp",
"name":"L-threonine  via sodium symport (periplasm)",
"metabolites":{
"na1_c":1.0,
"na1_p":-1.0,
"thr__L_c":1.0,
"thr__L_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03197",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"THRt4pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GALURtex",
"name":"D-galacturonate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"galur_e":-1.0,
"galur_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GALURtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GTPCI",
"name":"GTP cyclohydrolase I",
"metabolites":{
"ahdt_c":1.0,
"for_c":1.0,
"gtp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02238",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"GTPCI",
"rhea":"RHEA:17473",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FDMO",
"name":"FMNH2-dependent monooxygenase",
"metabolites":{
"__Ecoli_panGEMs__fmn_c":1.0,
"fmnh2_c":-1.0,
"gcald_c":1.0,
"h2o_c":1.0,
"h_c":1.0,
"isetac_c":-1.0,
"o2_c":-1.0,
"so3_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00956",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FDMO",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FEOXAMabcpp",
"name":"Ferroxamine transport via ABC system (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__feoxam_c":1.0,
"__Ecoli_panGEMs__feoxam_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00149 and HFPHFOGF_00150 and HFPHFOGF_00148",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FEOXAMabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_fruur_e",
"name":"Exchange of D-fructofuranuronate.",
"metabolites":{
"fruur_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_fruur_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GALtex",
"name":"D-galactose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"gal_e":-1.0,
"gal_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GALtex",
"sbo":"SBO:0000655"
}
},
{
"id":"CBL1abcpp",
"name":"Cob(1)alamin transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"cbl1_c":1.0,
"cbl1_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01766 and HFPHFOGF_00155 and HFPHFOGF_01768",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CBL1abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX___Ecoli_panGEMs__malttr_e",
"name":"Maltotriose exchange",
"metabolites":{
"__Ecoli_panGEMs__malttr_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__malttr_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ACACt2pp",
"name":"acetoacetate transport via proton symport  (periplasm)",
"metabolites":{
"acac_c":1.0,
"acac_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02309",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ACACt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"ACGAptspp",
"name":"N-Acetyl-D-glucosamine transport via PEP:Pyr PTS  (periplasm)",
"metabolites":{
"acgam6p_c":1.0,
"acgam_p":-1.0,
"pep_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_02502 and HFPHFOGF_02503 and HFPHFOGF_02501 and HFPHFOGF_01119) or (HFPHFOGF_02501 and HFPHFOGF_02502 and HFPHFOGF_00693)",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ACGAptspp",
"sbo":"SBO:0000655"
}
},
{
"id":"ACMANAptspp",
"name":"N-acetyl-D-mannosamine transport via PTS  (periplasm)",
"metabolites":{
"acmana_p":-1.0,
"acmanap_c":1.0,
"pep_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02501 and HFPHFOGF_01878 and HFPHFOGF_02502 and HFPHFOGF_01877 and HFPHFOGF_01879",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ACMANAptspp",
"sbo":"SBO:0000655"
}
},
{
"id":"ACNAMt2pp",
"name":"N-acetylneuraminate proton symport (periplasm)",
"metabolites":{
"acnam_c":1.0,
"acnam_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03327",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ACNAMt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GALCTtex",
"name":"D-galactarte transport via diffusion (extracellular to periplasm)",
"metabolites":{
"galct__D_e":-1.0,
"galct__D_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GALCTtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GALCTNtex",
"name":"D-galactonate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"galctn__D_e":-1.0,
"galctn__D_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GALCTNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GALTtex",
"name":"Galactitol transport via diffusion (extracellular to periplasm)",
"metabolites":{
"galt_e":-1.0,
"galt_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GALTtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_cbi_e",
"name":"Cobinamide exchange",
"metabolites":{
"cbi_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cbi_e",
"sbo":"SBO:0000627"
}
},
{
"id":"CHOLD",
"name":"choline dehydrogenase",
"metabolites":{
"betald_c":1.0,
"chol_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00345",
"subsystem":"Unassigned",
"annotation":{
"biggr":"CHOLD",
"rhea":"RHEA:33051",
"sbo":"SBO:0000176"
}
},
{
"id":"TRE6PS",
"name":"alpha,alpha-trehalose-phosphate synthase (UDP-forming)",
"metabolites":{
"g6p_c":-1.0,
"h_c":1.0,
"tre6p_c":1.0,
"udp_c":1.0,
"udpg_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01955",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"TRE6PS",
"rhea":"RHEA:18889",
"sbo":"SBO:0000176"
}
},
{
"id":"DRPA",
"name":"deoxyribose-phosphate aldolase",
"metabolites":{
"2dr5p_c":-1.0,
"acald_c":1.0,
"g3p_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04520",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"DRPA",
"sbo":"SBO:0000176"
}
},
{
"id":"TKT2",
"name":"transketolase",
"metabolites":{
"e4p_c":-1.0,
"f6p_c":1.0,
"g3p_c":1.0,
"xu5p__D_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03065 or HFPHFOGF_02542",
"subsystem":"Pentose Phosphate Pathway",
"annotation":{
"biggr":"TKT2",
"sbo":"SBO:0000176"
}
},
{
"id":"EX___Ecoli_panGEMs__arbtn_fe3_e",
"name":"Aerobactin exchange",
"metabolites":{
"__Ecoli_panGEMs__arbtn_fe3_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__arbtn_fe3_e",
"sbo":"SBO:0000627"
}
},
{
"id":"UDCPDP",
"name":"undecaprenyl-diphosphatase",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"udcpdp_c":-1.0,
"udcpp_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00861 or HFPHFOGF_01391 or HFPHFOGF_03167",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"UDCPDP",
"rhea":"RHEA:28094",
"sbo":"SBO:0000176"
}
},
{
"id":"EX___Ecoli_panGEMs__cpgn_e",
"name":"Coprogen exchange",
"metabolites":{
"__Ecoli_panGEMs__cpgn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__cpgn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_ch4_e",
"name":"Exchange of methane.",
"metabolites":{
"ch4_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ch4_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__FEENTERabcpp",
"name":"Fe-enterobactin transport via ABC system (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__feenter_c":1.0,
"__Ecoli_panGEMs__feenter_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00607 and HFPHFOGF_00610 and HFPHFOGF_00608 and HFPHFOGF_00606",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FEENTERabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_adocbl_e",
"name":"Exchange of cobamamide.",
"metabolites":{
"adocbl_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_adocbl_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__FECRMabcpp",
"name":"Ferrichrome transport via ABC system (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__fecrm_c":1.0,
"__Ecoli_panGEMs__fecrm_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00150 and HFPHFOGF_00149 and HFPHFOGF_00148",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FECRMabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"TREH",
"name":"alpha,alpha-trehalase",
"metabolites":{
"glc__D_c":2.0,
"h2o_c":-1.0,
"tre_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03624",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"TREH",
"sbo":"SBO:0000176"
}
},
{
"id":"GAMtex",
"name":"D-glucosamine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"gam_e":-1.0,
"gam_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GAMtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GBBTNtex",
"name":"gamma-butyrobetaine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"gbbtn_e":-1.0,
"gbbtn_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GBBTNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ATPS4rpp",
"name":"ATP synthase (four protons for one ATP) (periplasm)",
"metabolites":{
"adp_c":-1.0,
"atp_c":1.0,
"h2o_c":1.0,
"h_c":3.0,
"h_p":-4.0,
"pi_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_03870 and (HFPHFOGF_03862 and HFPHFOGF_03864 and HFPHFOGF_03866 and HFPHFOGF_03865 and HFPHFOGF_03863) and (HFPHFOGF_03869 and HFPHFOGF_03867 and HFPHFOGF_03868)) or ((HFPHFOGF_03862 and HFPHFOGF_03864 and HFPHFOGF_03866 and HFPHFOGF_03865 and HFPHFOGF_03863) and (HFPHFOGF_03869 and HFPHFOGF_03867 and HFPHFOGF_03868))",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"ATPS4rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"INDOLEtex",
"name":"Indole transport via diffusion (extracellular to periplasm)",
"metabolites":{
"indole_e":-1.0,
"indole_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"INDOLEtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ARBt2rpp",
"name":"L-arabinose transport via proton symport (periplasm)",
"metabolites":{
"arab__L_c":1.0,
"arab__L_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02958",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ARBt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"CYTK1",
"name":"cytidylate kinase (CMP)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"cdp_c":1.0,
"cmp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00930",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"CYTK1",
"rhea":"RHEA:11600",
"sbo":"SBO:0000176"
}
},
{
"id":"DAPabcpp",
"name":"M-diaminopimelic acid ABC transport (periplasm)",
"metabolites":{
"26dap__M_c":1.0,
"26dap__M_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"DAPabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"L_LACtex",
"name":"L-lactate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"lac__L_e":-1.0,
"lac__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"L_LACtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ACt4pp",
"name":"Na+/Acetate symport (periplasm)",
"metabolites":{
"ac_c":1.0,
"ac_p":-1.0,
"na1_c":1.0,
"na1_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04202",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ACt4pp",
"sbo":"SBO:0000655"
}
},
{
"id":"ADEt2rpp",
"name":"adenine transport via proton symport (reversible) (periplasm)",
"metabolites":{
"ade_c":1.0,
"ade_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03768 or HFPHFOGF_03841 or HFPHFOGF_03791",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ADEt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"DHAtpp",
"name":"Dihydroxyacetone transport via facilitated diffusion (periplasm)",
"metabolites":{
"dha_c":1.0,
"dha_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"DHAtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"DMSOR1pp",
"name":"Dimethyl sulfoxide reductase (Menaquinol 8) (periplasm)",
"metabolites":{
"dms_p":1.0,
"dmso_p":-1.0,
"h2o_p":1.0,
"mql8_c":-1.0,
"mqn8_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01933 and HFPHFOGF_01934",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"DMSOR1pp",
"sbo":"SBO:0000655"
}
},
{
"id":"ARGabcpp",
"name":"L-arginine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"arg__L_c":1.0,
"arg__L_p":-1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_02394 and HFPHFOGF_02392 and HFPHFOGF_02396 and HFPHFOGF_02393) or (HFPHFOGF_00884 and HFPHFOGF_00880 and HFPHFOGF_00883 and HFPHFOGF_00882 and HFPHFOGF_00881)",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ARGabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ADNt2pp",
"name":"adenosine transport in via proton symport (periplasm)",
"metabolites":{
"adn_c":1.0,
"adn_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03092 or HFPHFOGF_02479",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ADNt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"ADNt2pp:2",
"name":"adenosine transport in via proton symport (periplasm)",
"metabolites":{
"adn_c":1.0,
"adn_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02491",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ADNt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"ALAabcpp",
"name":"L-alanine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"ala__L_c":1.0,
"ala__L_p":-1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03556 and HFPHFOGF_03558 and HFPHFOGF_03557 and HFPHFOGF_03562 and HFPHFOGF_03559",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ALAabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ALLabcpp",
"name":"D-allose transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"all__D_c":1.0,
"all__D_p":-1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04224 and HFPHFOGF_04225 and HFPHFOGF_04223",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ALLabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ALLTNt2rpp",
"name":"allantoin transport in via proton symport (periplasm)",
"metabolites":{
"alltn_c":1.0,
"alltn_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00538",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ALLTNt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ARBabcpp",
"name":"L-arabinose transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"arab__L_c":1.0,
"arab__L_p":-1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01957 and HFPHFOGF_01959 and HFPHFOGF_01958",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ARBabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ARGAGMt7pp",
"name":"Arginine/agmatine antiport (periplasm)",
"metabolites":{
"agm_c":-1.0,
"agm_p":1.0,
"arg__L_c":1.0,
"arg__L_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04253",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ARGAGMt7pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__ASCBptspp",
"name":"L-ascorbate transport via PEP:Pyr PTS (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__ascb6p_c":1.0,
"ascb__L_p":-1.0,
"pep_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04344 and HFPHFOGF_04342 and HFPHFOGF_02501 and HFPHFOGF_02502 and HFPHFOGF_04343",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__ASCBptspp",
"sbo":"SBO:0000655"
}
},
{
"id":"CYTK2",
"name":"cytidylate kinase (dCMP)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"dcdp_c":1.0,
"dcmp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00930",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"CYTK2",
"rhea":"RHEA:25094",
"sbo":"SBO:0000176"
}
},
{
"id":"ASNt2rpp",
"name":"L-asparagine reversible transport via proton symport (periplasm)",
"metabolites":{
"asn__L_c":1.0,
"asn__L_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01539",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ASNt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ASPabcpp",
"name":"L-aspartate transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"asp__L_c":1.0,
"asp__L_p":-1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00673 and HFPHFOGF_00671 and HFPHFOGF_00674 and HFPHFOGF_00672",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ASPabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ASPt2pp",
"name":"L-aspartate transport in via proton symport (periplasm)",
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"asp__L_c":1.0,
"asp__L_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04212",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ASPt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"ECOAH8",
"name":"3-hydroxyacyl-CoA dehydratase (3-hydroxyoctadecanoyl-CoA)",
"metabolites":{
"3hodcoa_c":-1.0,
"h2o_c":1.0,
"od2coa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02426 or HFPHFOGF_03972",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"ECOAH8",
"rhea":"RHEA:78603",
"sbo":"SBO:0000176"
}
},
{
"id":"GLCDpp",
"name":"Glucose dehydrogenase (ubiquinone-8 as acceptor) (periplasm)",
"metabolites":{
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"glcn_p":1.0,
"h2o_p":-1.0,
"h_p":1.0,
"q8_c":-1.0,
"q8h2_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00121 or HFPHFOGF_00857",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"GLCDpp",
"sbo":"SBO:0000655"
}
},
{
"id":"GUAtpp",
"name":"Guanine transport via diffusion (periplasm)",
"metabolites":{
"gua_c":1.0,
"gua_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03017 or HFPHFOGF_04199",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GUAtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ASPt2_2pp",
"name":"Aspartate transport via proton symport (2 H) (periplasm)",
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"asp__L_c":1.0,
"asp__L_p":-1.0,
"h_c":2.0,
"h_p":-2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03633",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ASPt2_2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"HYD2pp",
"name":"Hydrogenase (menaquinone8: 2 protons) (periplasm)",
"metabolites":{
"h2_c":-1.0,
"h_c":-2.0,
"h_p":2.0,
"mql8_c":1.0,
"mqn8_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00994 and HFPHFOGF_00995 and HFPHFOGF_00993) or (HFPHFOGF_03109 and HFPHFOGF_03112 and HFPHFOGF_03111 and HFPHFOGF_03110)",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"HYD2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GK1",
"name":"guanylate kinase (GMP:ATP)",
"metabolites":{
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"atp_c":-1.0,
"gdp_c":1.0,
"gmp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03762",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"GK1",
"rhea":"RHEA:20780",
"sbo":"SBO:0000176"
}
},
{
"id":"HYXNtpp",
"name":"Hypoxanthine transport (periplasm)",
"metabolites":{
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"hxan_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04199 or HFPHFOGF_03017",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"HYXNtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"NACtpp",
"name":"Nicotinic acid uptake (periplasm)",
"metabolites":{
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"nac_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"NACtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ASPt2_3pp",
"name":"L-asparate transport via proton symport (3 H) (periplasm)",
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"asp__L_p":-1.0,
"h_c":3.0,
"h_p":-3.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_04277 or HFPHFOGF_04261",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ASPt2_3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"HIStex",
"name":"L-histidine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"his__L_e":-1.0,
"his__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"HIStex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FE3DCITabcpp",
"name":"Iron transport from ferric-dicitrate via ABC system (periplasm)",
"metabolites":{
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"adp_c":1.0,
"atp_c":-1.0,
"cit_c":2.0,
"fe3_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04444 and HFPHFOGF_04445 and HFPHFOGF_04446 and HFPHFOGF_04447",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FE3DCITabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"HXAtex",
"name":"Hexanoate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"hxa_e":-1.0,
"hxa_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"HXAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"HACD1i",
"name":"3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)",
"metabolites":{
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"aacoa_c":-1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03972 or HFPHFOGF_02426",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"HACD1i",
"rhea":"RHEA:30799",
"sbo":"SBO:0000176"
}
},
{
"id":"HYXNtex",
"name":"Hypoxanthine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"hxan_e":-1.0,
"hxan_p":1.0
},
"lower_bound":-1000.0,
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"gene_reaction_rule":"HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"HYXNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"IDONtex",
"name":"L-idonate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"idon__L_e":-1.0,
"idon__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"IDONtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ILEtex",
"name":"L-isoleucine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"ile__L_e":-1.0,
"ile__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ILEtex",
"sbo":"SBO:0000655"
}
},
{
"id":"INSTtex",
"name":"inositol transport via diffusion (extracellular to periplasm)",
"metabolites":{
"inost_e":-1.0,
"inost_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"INSTtex",
"sbo":"SBO:0000655"
}
},
{
"id":"INStex",
"name":"inosine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"ins_e":-1.0,
"ins_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00441",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"INStex",
"sbo":"SBO:0000655"
}
},
{
"id":"Ktex",
"name":"potassium transport via diffusion (extracellular to periplasm)",
"metabolites":{
"k_e":-1.0,
"k_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"Ktex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__CPGNtonex",
"name":"Coprogen transport via ton system (extracellular)",
"metabolites":{
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"__Ecoli_panGEMs__cpgn_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01120 and (HFPHFOGF_01361 and HFPHFOGF_03120 and HFPHFOGF_03121)",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__CPGNtonex",
"sbo":"SBO:0000655"
}
},
{
"id":"GLCRtex",
"name":"D-glucarate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"glcr_e":-1.0,
"glcr_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GLCRtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GLCNtex",
"name":"D-gluconate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"glcn_e":-1.0,
"glcn_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GLCNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GLCURtex",
"name":"D-glucuronat transport via diffusion (extracellular to periplasm)",
"metabolites":{
"glcur_e":-1.0,
"glcur_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GLCURtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GLNtex",
"name":"L-glutamine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"gln__L_e":-1.0,
"gln__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GLNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"O2tex",
"name":"oxygen transport via diffusion (extracellular to periplasm)",
"metabolites":{
"o2_e":-1.0,
"o2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"O2tex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_prpnte_e",
"name":"Exchange of propionate.",
"metabolites":{
"prpnte_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_prpnte_e",
"sbo":"SBO:0000627"
}
},
{
"id":"HACD2i",
"name":"3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA)",
"metabolites":{
"3hhcoa_c":1.0,
"3ohcoa_c":-1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03972 or HFPHFOGF_02426",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"HACD2i",
"rhea":"RHEA:31143",
"sbo":"SBO:0000176"
}
},
{
"id":"OCTAtex",
"name":"Octanoate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"octa_e":-1.0,
"octa_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"OCTAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"D_LACtex",
"name":"D-lactate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"lac__D_e":-1.0,
"lac__D_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"D_LACtex",
"sbo":"SBO:0000655"
}
},
{
"id":"NTD8pp",
"name":"5'-nucleotidase (dGMP)",
"metabolites":{
"dgmp_p":-1.0,
"dgsn_p":1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04190 or HFPHFOGF_00509",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD8pp",
"rhea":"RHEA:29379",
"sbo":"SBO:0000176"
}
},
{
"id":"ORNtex",
"name":"ornithine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"orn__L_e":-1.0,
"orn__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ORNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"FRULYStex",
"name":"fructoselysine transporter via diffusion (extracellular)",
"metabolites":{
"frulys_e":-1.0,
"frulys_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"FRULYStex",
"sbo":"SBO:0000655"
}
},
{
"id":"MALTtexi",
"name":"maltoseMaltotriose transport via diffusion (extracellular to periplasm) irreversible",
"metabolites":{
"malt_e":-1.0,
"malt_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04168",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"MALTtexi",
"sbo":"SBO:0000655"
}
},
{
"id":"ECOAH5",
"name":"3-hydroxyacyl-CoA dehydratase (3-hydroxydodecanoyl-CoA)",
"metabolites":{
"3hddcoa_c":-1.0,
"dd2coa_c":1.0,
"h2o_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02426 or HFPHFOGF_03972",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"ECOAH5",
"rhea":"RHEA:31075",
"sbo":"SBO:0000176"
}
},
{
"id":"DHFS",
"name":"dihydrofolate synthase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"dhf_c":1.0,
"dhpt_c":-1.0,
"glu__L_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02401",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"DHFS",
"rhea":"RHEA:23584",
"sbo":"SBO:0000176"
}
},
{
"id":"CITt7pp",
"name":"Citrate transport via succinate antiport (periplasm)",
"metabolites":{
"cit_c":1.0,
"cit_p":-1.0,
"succ_c":-1.0,
"succ_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00631",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CITt7pp",
"sbo":"SBO:0000655"
}
},
{
"id":"CRNt7pp",
"name":"Carnitine/butyrobetaine antiporter (periplasm)",
"metabolites":{
"crn_c":1.0,
"crn_p":-1.0,
"gbbtn_c":-1.0,
"gbbtn_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00041",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CRNt7pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_ni2_e",
"name":"Exchange of nickel(2+).",
"metabolites":{
"ni2_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ni2_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GLCtex",
"name":"glucose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"glc__D_e":-1.0,
"glc__D_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04168",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"GLCtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_no_e",
"name":"Exchange of nitric oxide.",
"metabolites":{
"no_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_no_e",
"sbo":"SBO:0000627"
}
},
{
"id":"CHLabcpp",
"name":"choline transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"chol_c":1.0,
"chol_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02215 and HFPHFOGF_02214 and HFPHFOGF_02217 and HFPHFOGF_02216",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CHLabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"DGSNt2pp",
"name":"deoxyguanosine transport in via proton symport (periplasm)",
"metabolites":{
"dgsn_c":1.0,
"dgsn_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03092",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"DGSNt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FE3DCITtonex",
"name":"Ferric-dicitrate transport via ton system (extracellular)",
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"__Ecoli_panGEMs__fe3dcit_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"(HFPHFOGF_01361 and HFPHFOGF_03120 and HFPHFOGF_03121) and HFPHFOGF_04448",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__FE3DCITtonex",
"sbo":"SBO:0000655"
}
},
{
"id":"DINSt2pp",
"name":"deoxyinosine transport in via proton symport (periplasm)",
"metabolites":{
"din_c":1.0,
"din_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03092",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"DINSt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"DURIt2pp",
"name":"deoxyuridine transport in via proton symport (periplasm)",
"metabolites":{
"duri_c":1.0,
"duri_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02479 or HFPHFOGF_03092",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"DURIt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"FE2abcpp",
"name":"iron (II) transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"fe2_c":1.0,
"fe2_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03513",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"FE2abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"FRUptspp",
"name":"D-fructose transport via PEP:Pyr PTS (periplasm)",
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"fru_p":-1.0,
"pep_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02501 and HFPHFOGF_02252 and HFPHFOGF_02254 and HFPHFOGF_02502",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"FRUptspp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX___Ecoli_panGEMs__fad_e",
"name":"Exchange of Flavin adenine dinucleotide oxidized",
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__fad_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GALCTt2rpp",
"name":"D-galactarte transport via proton symport, reversible (periplasm)",
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"galct__D_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02894 or HFPHFOGF_03230",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GALCTt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"GALt2pp",
"name":"D-galactose transport in via proton symport (periplasm)",
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"gal_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03071",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GALt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"ASPtex",
"name":"L-aspartate transport via diffusion (extracellular to periplasm)",
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"asp__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ASPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ABUTt2pp",
"name":"4-aminobutyrate transport in via proton symport (periplasm)",
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"4abut_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02755",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ABUTt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"FUMt2_2pp",
"name":"Fumarate transport via proton symport (2 H) (periplasm)",
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"fum_p":-1.0,
"h_c":2.0,
"h_p":-2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03633",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"FUMt2_2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"FUMt2_3pp",
"name":"Fumarate transport via proton symport (3 H) (periplasm)",
"metabolites":{
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"fum_p":-1.0,
"h_c":3.0,
"h_p":-3.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04277 or HFPHFOGF_04261 or HFPHFOGF_00640",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"FUMt2_3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"PHEtex",
"name":"L-phenylalanine transport via diffusion (extracellular to periplasm)",
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"phe__L_e":-1.0,
"phe__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"PHEtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FEENTERtonex",
"name":"Fe-enterobactin transport via ton system (extracellular)",
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"__Ecoli_panGEMs__feenter_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00601 and (HFPHFOGF_01361 and HFPHFOGF_03120 and HFPHFOGF_03121)",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__FEENTERtonex",
"sbo":"SBO:0000655"
}
},
{
"id":"CSNt2pp",
"name":"cytosine transport in via proton symport (periplasm)",
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"csn_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00370",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CSNt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"CYNTt2pp",
"name":"Cyanate transport via proton symport (periplasm)",
"metabolites":{
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"cynt_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00375",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CYNTt2pp:2",
"sbo":"SBO:0000655"
}
},
{
"id":"CYSabcpp",
"name":"L-cysteine uptake via ABC system (periplasm)",
"metabolites":{
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"atp_c":-1.0,
"cys__L_c":1.0,
"cys__L_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
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"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01993 and HFPHFOGF_01995 and HFPHFOGF_01992",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CYSabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"SBTptspp",
"name":"D-sorbitol transport via PEP:Pyr PTS (periplasm)",
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"pyr_c":1.0,
"sbt6p_c":1.0,
"sbt__D_p":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02502 and HFPHFOGF_02796 and HFPHFOGF_02795 and HFPHFOGF_02794 and HFPHFOGF_02501",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"SBTptspp",
"sbo":"SBO:0000655"
}
},
{
"id":"PItex",
"name":"phosphate transport via diffusion (extracellular to periplasm)",
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"pi_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"PItex",
"sbo":"SBO:0000655"
}
},
{
"id":"TREHpp",
"name":"alpha,alpha-trehalase (periplasm)",
"metabolites":{
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"h2o_p":-1.0,
"tre_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01300",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"TREHpp",
"sbo":"SBO:0000176"
}
},
{
"id":"CYTBDpp",
"name":"cytochrome oxidase bd (ubiquinol-8: 2 protons) (periplasm)",
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"h_c":-2.0,
"h_p":2.0,
"o2_c":-0.5,
"q8_c":1.0,
"q8h2_c":-1.0
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"gene_reaction_rule":"(HFPHFOGF_00999 and HFPHFOGF_01000) or (HFPHFOGF_00753 and HFPHFOGF_00752 and HFPHFOGF_00754)",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"CYTBDpp",
"sbo":"SBO:0000655"
}
},
{
"id":"CYTDt2pp",
"name":"cytidine transport in via proton symport (periplasm)",
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"h_c":1.0,
"h_p":-1.0
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"subsystem":"Transport, Inner Membrane",
"annotation":{
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"sbo":"SBO:0000655"
}
},
{
"id":"CYTDt2pp:2",
"name":"cytidine transport in via proton symport (periplasm)",
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"cytd_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
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"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CYTDt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"DADNt2pp",
"name":"deoxyadenosine transport in via proton symport (periplasm)",
"metabolites":{
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"dad_2_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
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"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"DADNt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"DCYTt2pp",
"name":"deoxycytidine transport in via proton symport (periplasm)",
"metabolites":{
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"dcyt_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02479 or HFPHFOGF_03092",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"DCYTt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"CYTBD2pp",
"name":"cytochrome oxidase bd (menaquinol-8: 2 protons) (periplasm)",
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"h_c":-2.0,
"h_p":2.0,
"mql8_c":-1.0,
"mqn8_c":1.0,
"o2_c":-0.5
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00999 and HFPHFOGF_01000",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"CYTBD2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"ACGAMK",
"name":"N-acetylglucosamine kinase",
"metabolites":{
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"acgam_c":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01137",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"ACGAMK",
"rhea":"RHEA:17417",
"sbo":"SBO:0000176"
}
},
{
"id":"ACt2rpp",
"name":"acetate reversible transport via proton symport (periplasm)",
"metabolites":{
"ac_c":1.0,
"ac_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00009",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ACt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"DDGLCNt2rpp",
"name":"2-dehydro-3-deoxy-D-gluconate transport via proton symport, reversible (periplasm)",
"metabolites":{
"2ddglcn_c":1.0,
"2ddglcn_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04038",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"DDGLCNt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"RMNtex",
"name":"L-rhamnose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"rmn_e":-1.0,
"rmn_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_02300 or HFPHFOGF_00950 or HFPHFOGF_01462",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"RMNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_meoh_e",
"name":"Exchange of methanol.",
"metabolites":{
"meoh_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_meoh_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX___Ecoli_panGEMs__fe3dcit_e",
"name":"Fe(III)dicitrate exchange",
"metabolites":{
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__fe3dcit_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX___Ecoli_panGEMs__fe3hox_e",
"name":"Fe(III)hydroxamate exchange",
"metabolites":{
"__Ecoli_panGEMs__fe3hox_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__fe3hox_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX___Ecoli_panGEMs__fecrm_e",
"name":"Ferrichrome exchange",
"metabolites":{
"__Ecoli_panGEMs__fecrm_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__fecrm_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX___Ecoli_panGEMs__feenter_e",
"name":"Fe-enterobactin exchange",
"metabolites":{
"__Ecoli_panGEMs__feenter_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__feenter_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX___Ecoli_panGEMs__feoxam_e",
"name":"Ferroxamine exchange",
"metabolites":{
"__Ecoli_panGEMs__feoxam_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__feoxam_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__MALTTRtexi",
"name":"Maltotriose transport via diffusion (extracellular to periplasm) irreversible",
"metabolites":{
"__Ecoli_panGEMs__malttr_e":-1.0,
"__Ecoli_panGEMs__malttr_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04168",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__MALTTRtexi",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__MALTTTRtexi",
"name":"MaltotetraoseMaltotriose transport via diffusion (extracellular to periplasm) irreversible",
"metabolites":{
"__Ecoli_panGEMs__maltttr_e":-1.0,
"__Ecoli_panGEMs__maltttr_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04168",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__MALTTTRtexi",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__MALTPTtexi",
"name":"MaltopentaoseMaltotriose transport via diffusion (extracellular to periplasm) irreversible",
"metabolites":{
"__Ecoli_panGEMs__maltpt_e":-1.0,
"__Ecoli_panGEMs__maltpt_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04168",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__MALTPTtexi",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__METS",
"name":"Methionine synthase",
"metabolites":{
"__Ecoli_panGEMs__5mthf_c":-1.0,
"h_c":1.0,
"hcys__L_c":-1.0,
"met__L_c":1.0,
"thf_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04147 or HFPHFOGF_03957",
"subsystem":"Methionine Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__METS",
"sbo":"SBO:0000176"
}
},
{
"id":"ASPO3",
"name":"L-aspartate oxidase",
"metabolites":{
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"h_c":1.0,
"iasp_c":1.0,
"q8_c":-1.0,
"q8h2_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02657",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"ASPO3:2",
"rhea":"RHEA:28683",
"sbo":"SBO:0000176"
}
},
{
"id":"ASPO5",
"name":"L-aspartate oxidase",
"metabolites":{
"asp__L_c":-1.0,
"fum_c":-1.0,
"h_c":1.0,
"iasp_c":1.0,
"succ_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02657",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"ASPO5:2",
"rhea":"RHEA:30043",
"sbo":"SBO:0000176"
}
},
{
"id":"ASPO4",
"name":"L-aspartate oxidase",
"metabolites":{
"asp__L_c":-1.0,
"h_c":1.0,
"iasp_c":1.0,
"mql8_c":1.0,
"mqn8_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02657",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"ASPO4:2",
"rhea":"RHEA:29191",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_3amp_e",
"name":"Exchange of 3'-AMP(2-).",
"metabolites":{
"3amp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_3amp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_3gmp_e",
"name":"Exchange of guanosine 3'-monophosphate(2-).",
"metabolites":{
"3gmp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_3gmp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_3ump_e",
"name":"Exchange of 3'-UMP(2-).",
"metabolites":{
"3ump_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_3ump_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ASPO6",
"name":"L-aspartate oxidase",
"metabolites":{
"asp__L_c":-1.0,
"h2o2_c":1.0,
"h_c":1.0,
"iasp_c":1.0,
"o2_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02657",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"ASPO6:2",
"rhea":"RHEA:25876",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_cu2_e",
"name":"Exchange of copper(2+).",
"metabolites":{
"cu2_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cu2_e",
"sbo":"SBO:0000627"
}
},
{
"id":"LCTStex",
"name":"Lactose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"lcts_e":-1.0,
"lcts_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"LCTStex",
"sbo":"SBO:0000655"
}
},
{
"id":"LEUtex",
"name":"L-leucine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"leu__L_e":-1.0,
"leu__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"LEUtex",
"sbo":"SBO:0000655"
}
},
{
"id":"LYStex",
"name":"L-lysine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"lys__L_e":-1.0,
"lys__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"LYStex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_glyc__R_e",
"name":"Exchange of D-glycerate.",
"metabolites":{
"glyc__R_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_glyc__R_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX___Ecoli_panGEMs__eca4colipa_e",
"name":"(enterobacterial common antigen)x4 core oligosaccharide lipid A exchange",
"metabolites":{
"__Ecoli_panGEMs__eca4colipa_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__eca4colipa_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GLYOX3",
"name":"glyoxalase III",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"lac__D_c":1.0,
"mthgxl_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02036",
"subsystem":"Methylglyoxal Metabolism",
"annotation":{
"biggr":"GLYOX3",
"rhea":"RHEA:27754",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FDMO3",
"name":"FMNH2-dependent monooxygenase (ethanesulfonate)",
"metabolites":{
"__Ecoli_panGEMs__fmn_c":1.0,
"acald_c":1.0,
"eths_c":-1.0,
"fmnh2_c":-1.0,
"h2o_c":1.0,
"h_c":1.0,
"o2_c":-1.0,
"so3_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00956",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FDMO3",
"sbo":"SBO:0000176"
}
},
{
"id":"LYXtex",
"name":"L-Lyxose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"lyx__L_e":-1.0,
"lyx__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"LYXtex",
"sbo":"SBO:0000655"
}
},
{
"id":"MANtex",
"name":"D-mannose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"man_e":-1.0,
"man_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"MANtex",
"sbo":"SBO:0000655"
}
},
{
"id":"MAN6Ptex",
"name":"Mannose 6-phosphate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"man6p_e":-1.0,
"man6p_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"MAN6Ptex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FDMO4",
"name":"FMNH2-dependent monooxygenase (butanesulfonate)",
"metabolites":{
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"btal_c":1.0,
"butso3_c":-1.0,
"fmnh2_c":-1.0,
"h2o_c":1.0,
"h_c":1.0,
"o2_c":-1.0,
"so3_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00956",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FDMO4",
"sbo":"SBO:0000176"
}
},
{
"id":"CYSabc2pp",
"name":"L-cysteine export via ABC system (cytoplasm to periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"cys__L_c":-1.0,
"cys__L_p":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00907 and HFPHFOGF_00906",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CYSabc2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"BUTSO3abcpp",
"name":"butanesulfonate transport via ABC system (periplasm)",
"metabolites":{
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"atp_c":-1.0,
"butso3_c":1.0,
"butso3_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00955 and HFPHFOGF_00954 and HFPHFOGF_00957) or (HFPHFOGF_00396 and HFPHFOGF_00395 and HFPHFOGF_00397)",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"BUTSO3abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ETHSO3abcpp",
"name":"ethanesulfonate transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"eths_c":1.0,
"eths_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00955 and HFPHFOGF_00954 and HFPHFOGF_00957",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ETHSO3abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"MELIBtex",
"name":"melibiose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"melib_e":-1.0,
"melib_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"MELIBtex",
"sbo":"SBO:0000655"
}
},
{
"id":"DMSOtex",
"name":"Dimethyl sulfoxide transport via diffusion (extracellular to periplasm)",
"metabolites":{
"dmso_e":-1.0,
"dmso_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DMSOtex",
"sbo":"SBO:0000655"
}
},
{
"id":"DURItex",
"name":"deoxyuridine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"duri_e":-1.0,
"duri_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00441",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"DURItex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_mal__D_e",
"name":"Exchange of (R)-malate(2-).",
"metabolites":{
"mal__D_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_mal__D_e",
"sbo":"SBO:0000627"
}
},
{
"id":"FRUtex",
"name":"D-fructose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"fru_e":-1.0,
"fru_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"FRUtex",
"sbo":"SBO:0000655"
}
},
{
"id":"FUCtex",
"name":"L-fucose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"fuc__L_e":-1.0,
"fuc__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"FUCtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_sel_e",
"name":"Exchange of selenate.",
"metabolites":{
"sel_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_sel_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_hg2_e",
"name":"Exchange of mercury(2+).",
"metabolites":{
"hg2_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_hg2_e",
"sbo":"SBO:0000627"
}
},
{
"id":"FUMtex",
"name":"Fumarate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"fum_e":-1.0,
"fum_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"FUMtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ACACT5r",
"name":"acetyl-CoA C-acyltransferase (decanoyl-CoA) (r)",
"metabolites":{
"3oddcoa_c":1.0,
"accoa_c":-1.0,
"coa_c":1.0,
"dcacoa_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03971 or HFPHFOGF_02427",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"ACACT5r",
"rhea":"RHEA:31183",
"sbo":"SBO:0000176"
}
},
{
"id":"PRASCSi",
"name":"phosphoribosylaminoimidazolesuccinocarboxamide synthase",
"metabolites":{
"25aics_c":1.0,
"5aizc_c":-1.0,
"adp_c":1.0,
"asp__L_c":-1.0,
"atp_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02554",
"subsystem":"Purine and Pyrimidine Biosynthesis",
"annotation":{
"biggr":"PRASCSi:2",
"rhea":"RHEA:22628",
"sbo":"SBO:0000176"
}
},
{
"id":"MALTATr",
"name":"maltose O-acetyltransferase",
"metabolites":{
"accoa_c":-1.0,
"acmalt_c":1.0,
"coa_c":1.0,
"malt_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00488",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"MALTATr",
"rhea":"RHEA:10456",
"sbo":"SBO:0000176"
}
},
{
"id":"DHBSH",
"name":"2,3-dihydroxybenzoylserine hydrolase",
"metabolites":{
"23dhb_c":1.0,
"23dhbzs_c":-1.0,
"h2o_c":-1.0,
"ser__L_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"DHBSH",
"sbo":"SBO:0000176"
}
},
{
"id":"MALDDH",
"name":"malate decarboxylating oxidoreductase (decarboxylating)",
"metabolites":{
"co2_c":1.0,
"mal__D_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01859",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"MALDDH",
"rhea":"RHEA:18365",
"sbo":"SBO:0000176"
}
},
{
"id":"FE2tex",
"name":"iron (II) transport via diffusion (extracellular to periplasm)",
"metabolites":{
"fe2_e":-1.0,
"fe2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"FE2tex",
"sbo":"SBO:0000655"
}
},
{
"id":"NMNtex",
"name":"NMN transport via diffusion (extracellular to periplasm)",
"metabolites":{
"nmn_e":-1.0,
"nmn_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"NMNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ENTERES",
"name":"Enterochelin Esterase",
"metabolites":{
"23dhbzs_c":3.0,
"enter_c":-1.0,
"h2o_c":-3.0,
"h_c":3.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00602",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"ENTERES:2",
"rhea":"RHEA:28018",
"sbo":"SBO:0000176"
}
},
{
"id":"NO2tex",
"name":"nitrite transport via diffusion (extracellular to periplasm)",
"metabolites":{
"no2_e":-1.0,
"no2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"NO2tex:2",
"sbo":"SBO:0000655"
}
},
{
"id":"HOXPRx",
"name":"tartronate semialdehyde reductase",
"metabolites":{
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"glyc__R_c":1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00537 or HFPHFOGF_03228",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"HOXPRx",
"rhea":"RHEA:18845",
"sbo":"SBO:0000176"
}
},
{
"id":"DHPS2_1",
"name":"dihydropteroate synthase",
"metabolites":{
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"4abz_c":-1.0,
"dhpt_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03278",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"DHPS2_1",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FEOXAMUtex",
"name":"Ferroxamine (minus Fe3) secretion (to extracellular)",
"metabolites":{
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"__Ecoli_panGEMs__feoxam_un_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FEOXAMUtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ARBTNtpp",
"name":"aerobactin secretion (to periplasm)",
"metabolites":{
"arbtn_c":-1.0,
"arbtn_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"ARBTNtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"MTHFC_1",
"name":"methenyltetrahydrofolate cyclohydrolase",
"metabolites":{
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"h2o_c":-1.0,
"h_c":1.0,
"methf_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00556",
"subsystem":"Folate Metabolism",
"annotation":{
"biggr":"MTHFC_1",
"rhea":"RHEA:23700",
"sbo":"SBO:0000176"
}
},
{
"id":"ARBTNtex",
"name":"aerobactin secretion (to extracellular)",
"metabolites":{
"arbtn_e":1.0,
"arbtn_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"ARBTNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"MTHFD",
"name":"methylenetetrahydrofolate dehydrogenase (NADP)",
"metabolites":{
"methf_c":1.0,
"mlthf_c":-1.0,
"nadp_c":-1.0,
"nadph_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00556",
"subsystem":"Folate Metabolism",
"annotation":{
"biggr":"MTHFD",
"rhea":"RHEA:22812",
"sbo":"SBO:0000176"
}
},
{
"id":"LYXI",
"name":"Lyxose isomerase",
"metabolites":{
"lyx__L_c":-1.0,
"xylu__L_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04032",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"LYXI",
"rhea":"RHEA:28058",
"sbo":"SBO:0000176"
}
},
{
"id":"BUTt2rpp",
"name":"Butyrate transport via proton symport, reversible (periplasm)",
"metabolites":{
"but_c":1.0,
"but_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02309",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"BUTt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"CADVtpp",
"name":"Lysine/Cadaverine antiporter (periplasm)",
"metabolites":{
"15dap_c":-1.0,
"15dap_p":1.0,
"h_c":1.0,
"h_p":-1.0,
"lys__L_c":1.0,
"lys__L_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04271",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CADVtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"QULNS_1",
"name":"quinolinate synthase",
"metabolites":{
"dhap_c":-1.0,
"h2o_c":2.0,
"iasp_c":-1.0,
"pi_c":1.0,
"quln_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00770",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"QULNS_1:2",
"rhea":"RHEA:25888",
"sbo":"SBO:0000176"
}
},
{
"id":"23CAMPtex",
"name":"23cAMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"23camp_e":-1.0,
"23camp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"23CAMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"23CCMPtex",
"name":"23cCMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"23ccmp_e":-1.0,
"23ccmp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"23CCMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"23CUMPtex",
"name":"23cUMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"23cump_e":-1.0,
"23cump_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"23CUMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"23CGMPtex",
"name":"23cGMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"23cgmp_e":-1.0,
"23cgmp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"23CGMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"3AMPtex",
"name":"3AMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"3amp_e":-1.0,
"3amp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"3AMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"3CMPtex",
"name":"3CMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"3cmp_e":-1.0,
"3cmp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"3CMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__LADGMDH",
"name":"L-alanyl-gamma-D-glutamyl-meso-diaminopimelate hydrolase",
"metabolites":{
"26dap__M_c":1.0,
"LalaDglu_c":1.0,
"__Ecoli_panGEMs__LalaDgluMdap_c":-1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01441",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__LADGMDH",
"sbo":"SBO:0000176"
}
},
{
"id":"ALKP",
"name":"alkaline phosphatase",
"metabolites":{
"dha_c":1.0,
"dhap_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02781",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"ALKP",
"rhea":"RHEA:51728",
"sbo":"SBO:0000176"
}
},
{
"id":"GDPtex",
"name":"GDP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"gdp_e":-1.0,
"gdp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GDPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_cobalt2_e",
"name":"Exchange of cobalt(2+).",
"metabolites":{
"cobalt2_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cobalt2_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ALAGLUE",
"name":"L-alanyl-gamma-glutamate epimerase",
"metabolites":{
"LalaDglu_c":-1.0,
"LalaLglu_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01440",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"ALAGLUE",
"rhea":"RHEA:28394",
"sbo":"SBO:0000176"
}
},
{
"id":"FEENTERtpp",
"name":"enterochelin transport (secretion)",
"metabolites":{
"enter_c":-1.0,
"enter_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00609",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"FEENTERtpp:2",
"sbo":"SBO:0000655"
}
},
{
"id":"TMAtex",
"name":"Trimethylamine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"tmam_e":-1.0,
"tmam_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"TMAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_pheme_e",
"name":"Exchange of ferroheme b(2-).",
"metabolites":{
"pheme_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_pheme_e",
"sbo":"SBO:0000627"
}
},
{
"id":"TMAOtex",
"name":"Trimethylamine N-oxide transport via diffusion (extracellular to periplasm)",
"metabolites":{
"tmao_e":-1.0,
"tmao_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"TMAOtex",
"sbo":"SBO:0000655"
}
},
{
"id":"TREtex",
"name":"trehalose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"tre_e":-1.0,
"tre_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"TREtex",
"sbo":"SBO:0000655"
}
},
{
"id":"L_LACD3",
"name":"L-Lactate dehydrogenase (menaquinone)",
"metabolites":{
"lac__L_c":-1.0,
"mql8_c":1.0,
"mqn8_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00341 and HFPHFOGF_00343 and HFPHFOGF_00342) or HFPHFOGF_03716",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"L_LACD3",
"sbo":"SBO:0000176"
}
},
{
"id":"FEENTERtex",
"name":"enterochelin transport (secretion periplasm)",
"metabolites":{
"enter_e":1.0,
"enter_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03147",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"FEENTERtex:2",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FE3HOXUtpp",
"name":"Fe(III)hydroxamate unloaded secretion (extracellular)",
"metabolites":{
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"__Ecoli_panGEMs__fe3hox_un_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FE3HOXUtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FEOXAMUtpp",
"name":"Ferroxamine (minus Fe3) secretion (to periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__feoxam_un_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FEOXAMUtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FECRMUtpp",
"name":"Ferrichrome (minus Fe) secretion (to periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__fecrm_un_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FECRMUtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FE3HOXR2",
"name":"Fe(III)hydroxamate reductase",
"metabolites":{
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"__Ecoli_panGEMs__fe3hox_un_c":2.0,
"__Ecoli_panGEMs__fmn_c":1.0,
"fe2_c":2.0,
"fmnh2_c":-1.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FE3HOXR2",
"sbo":"SBO:0000176"
}
},
{
"id":"L_LACD2",
"name":"L-Lactate dehydrogenase (ubiquinone)",
"metabolites":{
"lac__L_c":-1.0,
"pyr_c":1.0,
"q8_c":-1.0,
"q8h2_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00343 and HFPHFOGF_00341 and HFPHFOGF_00342) or HFPHFOGF_03716",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"L_LACD2",
"sbo":"SBO:0000176"
}
},
{
"id":"ACACT9",
"name":"acetyl-CoA C-acyltransferase (dodecanoyl-CoA) (r)",
"metabolites":{
"3otdcoa_c":1.0,
"accoa_c":-1.0,
"coa_c":1.0,
"ddcacoa_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02427 or HFPHFOGF_03971",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"ACACT9",
"rhea":"RHEA:31091",
"sbo":"SBO:0000176"
}
},
{
"id":"TRPtex",
"name":"L-tryptophan transport via diffusion (extracellular to periplasm)",
"metabolites":{
"trp__L_e":-1.0,
"trp__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"TRPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"PTRCt2pp",
"name":"putrescine transport in via proton symport",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"ptrc_c":1.0,
"ptrc_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00706 or HFPHFOGF_01410 or HFPHFOGF_02116",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PTRCt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GGGABAH",
"name":"gamma-glutamyl-gamma-aminobutyric acid hydrolase",
"metabolites":{
"4abut_c":1.0,
"gg4abut_c":-1.0,
"glu__L_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01412",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"GGGABAH",
"rhea":"RHEA:19737",
"sbo":"SBO:0000176"
}
},
{
"id":"PNTOtex",
"name":"Pantothenate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"pnto__R_e":-1.0,
"pnto__R_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"PNTOtex",
"sbo":"SBO:0000655"
}
},
{
"id":"FRULYSK",
"name":"Fructoselysine Kinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"frulys_c":-1.0,
"frulysp_c":1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03478",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"FRULYSK",
"rhea":"RHEA:28378",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FDMO6",
"name":"FMNH2-dependent monooxygenase (sulfoacetate)",
"metabolites":{
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"fmnh2_c":-1.0,
"glx_c":1.0,
"h2o_c":1.0,
"h_c":1.0,
"o2_c":-1.0,
"so3_c":1.0,
"sulfac_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00956",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FDMO6",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__TSULtex",
"name":"Thiosulfate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"__Ecoli_panGEMs__tsul_e":-1.0,
"__Ecoli_panGEMs__tsul_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"__Ecoli_panGEMs__TSULtex",
"sbo":"SBO:0000655"
}
},
{
"id":"TYRtex",
"name":"L-tyrosine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"tyr__L_e":-1.0,
"tyr__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"TYRtex",
"sbo":"SBO:0000655"
}
},
{
"id":"URAtex",
"name":"uracil transport via diffusion (extracellular to periplasm)",
"metabolites":{
"ura_e":-1.0,
"ura_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"URAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"UREAtex",
"name":"Urea transport via diffusion (extracellular to periplasm)",
"metabolites":{
"urea_e":-1.0,
"urea_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"UREAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"URItex",
"name":"uridine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"uri_e":-1.0,
"uri_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00441",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"URItex",
"sbo":"SBO:0000655"
}
},
{
"id":"SULFACabcpp",
"name":"sulfoacetate transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"sulfac_c":1.0,
"sulfac_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00955 and HFPHFOGF_00954 and HFPHFOGF_00957",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"SULFACabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ETHSO3tex",
"name":"ethanesulfonate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"eths_e":-1.0,
"eths_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ETHSO3tex",
"sbo":"SBO:0000655"
}
},
{
"id":"BUTSO3tex",
"name":"butanesulfonate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"butso3_e":-1.0,
"butso3_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"BUTSO3tex",
"sbo":"SBO:0000655"
}
},
{
"id":"LIPOtex",
"name":"lipoate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"lipoate_e":-1.0,
"lipoate_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00950 or HFPHFOGF_00262",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"LIPOtex:2",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__CYANSTpp",
"name":"Cyanide sulfurtransferase (periplasmic)",
"metabolites":{
"__Ecoli_panGEMs__tsul_p":-1.0,
"cyan_p":-1.0,
"h_p":1.0,
"so3_p":1.0,
"tcynt_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01422",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CYANSTpp",
"sbo":"SBO:0000176"
}
},
{
"id":"VALtex",
"name":"L-valine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"val__L_e":-1.0,
"val__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"VALtex",
"sbo":"SBO:0000655"
}
},
{
"id":"XANtex",
"name":"xanthine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"xan_e":-1.0,
"xan_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"XANtex",
"sbo":"SBO:0000655"
}
},
{
"id":"MCPST",
"name":"3-mercaptopyruvate sulfurtransferase",
"metabolites":{
"cyan_c":-1.0,
"h_c":1.0,
"mercppyr_c":-1.0,
"pyr_c":1.0,
"tcynt_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02604",
"subsystem":"Cysteine Metabolism",
"annotation":{
"biggr":"MCPST",
"sbo":"SBO:0000176"
}
},
{
"id":"XYLtex",
"name":"D-xylose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"xyl__D_e":-1.0,
"xyl__D_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"XYLtex",
"sbo":"SBO:0000655"
}
},
{
"id":"PPPNtex",
"name":"3-phenylpropionate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"pppn_e":-1.0,
"pppn_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"PPPNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ABUTtex",
"name":"4-aminobutyrate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"4abut_e":-1.0,
"4abut_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ABUTtex",
"sbo":"SBO:0000655"
}
},
{
"id":"FORtppi",
"name":"formate transport via diffusion (cytoplasm to periplasm)",
"metabolites":{
"for_c":-1.0,
"for_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00924 or HFPHFOGF_02571",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"FORtppi",
"sbo":"SBO:0000655"
}
},
{
"id":"PHEMEabcpp",
"name":"protoheme transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pheme_c":-1.0,
"pheme_p":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02282 and HFPHFOGF_02283 and HFPHFOGF_02281 and HFPHFOGF_02284 and HFPHFOGF_02285",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PHEMEabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"METSOX1abcpp",
"name":"L-methionine S-oxide transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"metsox_S__L_c":1.0,
"metsox_S__L_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"METSOX1abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"PPTtex",
"name":"Phosphonate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"ppt_e":-1.0,
"ppt_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"PPTtex:2",
"sbo":"SBO:0000655"
}
},
{
"id":"GALBDtex",
"name":"beta D-galactose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"gal_bD_e":-1.0,
"gal_bD_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GALBDtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__LIPAHT2ex",
"name":"Core oligosaccharide lipid A:hexadecanoate transferase (n-C16:0) (extracellular membrane)",
"metabolites":{
"__Ecoli_panGEMs__colipa_e":-1.0,
"__Ecoli_panGEMs__hacolipa_e":1.0,
"h2o_e":1.0,
"h_e":-1.0,
"hdca_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00641",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__LIPAHT2ex",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__GLCTR1",
"name":"Glucosyltransferase I (LPS core synthesis)",
"metabolites":{
"__Ecoli_panGEMs__gicolipa_c":1.0,
"__Ecoli_panGEMs__icolipa_c":-1.0,
"h_c":1.0,
"udp_c":1.0,
"udpg_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03741",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__GLCTR1",
"sbo":"SBO:0000176"
}
},
{
"id":"LIPAabcpp",
"name":"lipid A transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"lipa_c":-1.0,
"lipa_p":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"LIPAabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__LIPAHTex",
"name":"Lipid A:hexadecanoate transferase (n-C16:0) (extracellular membrane)",
"metabolites":{
"__Ecoli_panGEMs__halipa_e":1.0,
"h2o_e":1.0,
"h_e":-1.0,
"hdca_e":-1.0,
"lipa_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00641",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__LIPAHTex",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LIPACabcpp",
"name":"Lipid (cold) A transport via ABC system (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__lipa_cold_c":-1.0,
"__Ecoli_panGEMs__lipa_cold_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__LIPACabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__ECAP1pp",
"name":"Enterobacterial common antigen polymerase (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__eca2und_p":1.0,
"h_p":1.0,
"udcpdp_p":1.0,
"unagamuf_p":-2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03913 and HFPHFOGF_03922",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__ECAP1pp",
"sbo":"SBO:0000176"
}
},
{
"id":"PTRCtex",
"name":"putrescine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"ptrc_e":-1.0,
"ptrc_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"PTRCtex",
"sbo":"SBO:0000655"
}
},
{
"id":"UDCPDPpp",
"name":"undecaprenyl-diphosphatase (periplasm)",
"metabolites":{
"h2o_p":-1.0,
"h_p":1.0,
"pi_p":1.0,
"udcpdp_p":-1.0,
"udcpp_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01391 or HFPHFOGF_03167 or HFPHFOGF_00861",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"UDCPDPpp",
"rhea":"RHEA:28094",
"sbo":"SBO:0000176"
}
},
{
"id":"GGGABADr",
"name":"gamma-glutamyl-gamma aminobutyric acid dehydrogenase",
"metabolites":{
"gg4abut_c":1.0,
"ggbutal_c":-1.0,
"h2o_c":-1.0,
"h_c":2.0,
"nadp_c":-1.0,
"nadph_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01414",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"GGGABADr",
"rhea":"RHEA:28410",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_mso3_e",
"name":"Exchange of methanesulfonate.",
"metabolites":{
"mso3_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_mso3_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_23camp_e",
"name":"Exchange of 2',3'-cyclic AMP(1-).",
"metabolites":{
"23camp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_23camp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_23cgmp_e",
"name":"Exchange of 2',3'-cyclic GMP(1-).",
"metabolites":{
"23cgmp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_23cgmp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_23cump_e",
"name":"Exchange of 2',3'-cyclic UMP(1-).",
"metabolites":{
"23cump_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_23cump_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__ECAP2pp",
"name":"Enterobacterial common antigen polymerase (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__eca2und_p":-1.0,
"__Ecoli_panGEMs__eca3und_p":1.0,
"h_p":1.0,
"udcpdp_p":1.0,
"unagamuf_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03913 and HFPHFOGF_03922",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__ECAP2pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FE3Ri",
"name":"Fe(III) reduction",
"metabolites":{
"__Ecoli_panGEMs__fad_c":1.0,
"fadh2_c":-1.0,
"fe2_c":2.0,
"fe3_c":-2.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03970",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__FE3Ri",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FE3HOXR3",
"name":"Fe(III)hydroxamate reductase",
"metabolites":{
"__Ecoli_panGEMs__fe3hox_c":-2.0,
"__Ecoli_panGEMs__fe3hox_un_c":2.0,
"fe2_c":2.0,
"h_c":2.0,
"rbflvrd_c":-1.0,
"ribflv_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FE3HOXR3",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FEENTERR1",
"name":"Fe-enterobactin reduction (Fe(III)-unloading)",
"metabolites":{
"__Ecoli_panGEMs__fad_c":1.0,
"__Ecoli_panGEMs__feenter_c":-2.0,
"enter_c":2.0,
"fadh2_c":-1.0,
"fe2_c":2.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FEENTERR1",
"sbo":"SBO:0000176"
}
},
{
"id":"NODOy",
"name":"nitric oxide dioxygenase",
"metabolites":{
"h_c":1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"no3_c":2.0,
"no_c":-2.0,
"o2_c":-2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02635",
"subsystem":"Nitrogen Metabolism",
"annotation":{
"biggr":"NODOy",
"rhea":"RHEA:19465",
"sbo":"SBO:0000176"
}
},
{
"id":"PYRtex",
"name":"pyruvate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"pyr_e":-1.0,
"pyr_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"PYRtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GALM2pp",
"name":"aldose-1-epimerase",
"metabolites":{
"gal_bD_p":-1.0,
"gal_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00776",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"GALM2pp",
"rhea":"RHEA:28675",
"sbo":"SBO:0000176"
}
},
{
"id":"CU1abcpp",
"name":"Copper (Cu +1) ABC transporter (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"cu_c":-1.0,
"cu_p":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00513",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"CU1abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"HG2abcpp",
"name":"Mercury (Hg+2) ABC transporter (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"hg2_c":-1.0,
"hg2_p":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03571",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"HG2abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FEENTERR3",
"name":"Fe-enterobactin reduction (Fe(III)-unloading)",
"metabolites":{
"__Ecoli_panGEMs__feenter_c":-2.0,
"enter_c":2.0,
"fe2_c":2.0,
"h_c":2.0,
"rbflvrd_c":-1.0,
"ribflv_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FEENTERR3",
"sbo":"SBO:0000176"
}
},
{
"id":"SULFACtex",
"name":"sulfoaceate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"sulfac_e":-1.0,
"sulfac_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"SULFACtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_sulfac_e",
"name":"Exchange of sulfonatoacetate.",
"metabolites":{
"sulfac_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_sulfac_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_butso3_e",
"name":"Exchange of butane-1-sulfonate.",
"metabolites":{
"butso3_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_butso3_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__GLCTR3",
"name":"Glucosyltransferase III (LPS core synthesis)",
"metabolites":{
"__Ecoli_panGEMs__ggagicolipa_c":-1.0,
"__Ecoli_panGEMs__gggagicolipa_c":1.0,
"h_c":1.0,
"udp_c":1.0,
"udpg_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03736",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__GLCTR3",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_eths_e",
"name":"Exchange of ethanesulfonate.",
"metabolites":{
"eths_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_eths_e",
"sbo":"SBO:0000627"
}
},
{
"id":"DSERtex",
"name":"D-serine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"ser__D_e":-1.0,
"ser__D_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DSERtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__LA4NTpp",
"name":"4-amino-4-deoxy-L-arabinotransferase (LPS lipid A modification, periplasmic face of membrane))",
"metabolites":{
"__Ecoli_panGEMs__acolipa_p":1.0,
"__Ecoli_panGEMs__colipa_p":-1.0,
"__Ecoli_panGEMs__uLa4n_p":-1.0,
"udcpp_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02344",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__LA4NTpp",
"sbo":"SBO:0000176"
}
},
{
"id":"NODOx",
"name":"nitric oxide dioxygenase",
"metabolites":{
"h_c":1.0,
"nad_c":1.0,
"nadh_c":-1.0,
"no3_c":2.0,
"no_c":-2.0,
"o2_c":-2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02635",
"subsystem":"Nitrogen Metabolism",
"annotation":{
"biggr":"NODOx",
"rhea":"RHEA:19469",
"sbo":"SBO:0000176"
}
},
{
"id":"SERtex",
"name":"L-serine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"ser__L_e":-1.0,
"ser__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"SERtex",
"sbo":"SBO:0000655"
}
},
{
"id":"NOtex",
"name":"nitric oxide transport via diffusion (extracellular to periplasm)",
"metabolites":{
"no_e":-1.0,
"no_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"NOtex",
"sbo":"SBO:0000655"
}
},
{
"id":"NHFRBO",
"name":"NADH:flavorubredoxin oxidoreductase",
"metabolites":{
"h2o_c":1.0,
"h_c":-1.0,
"n2o_c":1.0,
"nad_c":1.0,
"nadh_c":-1.0,
"no_c":-2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02803 and HFPHFOGF_02802",
"subsystem":"Nitrogen Metabolism",
"annotation":{
"biggr":"NHFRBO",
"rhea":"RHEA:29607",
"sbo":"SBO:0000176"
}
},
{
"id":"N2Otex",
"name":"nitrious oxide transport via diffusion (extracellular to periplasm)",
"metabolites":{
"n2o_e":-1.0,
"n2o_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"N2Otex",
"sbo":"SBO:0000655"
}
},
{
"id":"CRNt8pp",
"name":"L-carnitine/D-carnitine antiporter (periplasm)",
"metabolites":{
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"crn__D_p":1.0,
"crn_c":1.0,
"crn_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00041",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CRNt8pp",
"sbo":"SBO:0000655"
}
},
{
"id":"CRNt2rpp",
"name":"L-carnitine outward transport (H+ antiport)",
"metabolites":{
"crn_c":1.0,
"crn_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04248",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CRNt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"CRNDt2rpp",
"name":"D-carnitine outward transport (H+ antiport)",
"metabolites":{
"crn__D_c":1.0,
"crn__D_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04248",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CRNDt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"CTBTt2rpp",
"name":"cronobetaine outward transport (H+ antiport)",
"metabolites":{
"ctbt_c":1.0,
"ctbt_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04248",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CTBTt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"42A12BOOXpp",
"name":"4-(2-Aminoethyl)-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)",
"metabolites":{
"34dhpac_p":1.0,
"dopa_p":-1.0,
"h2o2_p":1.0,
"h2o_p":-1.0,
"nh4_p":1.0,
"o2_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01472",
"subsystem":"Nitrogen Metabolism",
"annotation":{
"biggr":"42A12BOOXpp",
"rhea":"RHEA:27946",
"sbo":"SBO:0000176"
}
},
{
"id":"TYROXDApp",
"name":"Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (periplasm)",
"metabolites":{
"4hoxpacd_p":1.0,
"h2o2_p":1.0,
"h2o_p":-1.0,
"nh4_p":1.0,
"o2_p":-1.0,
"tym_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01472",
"subsystem":"Nitrogen Metabolism",
"annotation":{
"biggr":"TYROXDApp",
"rhea":"RHEA:30591",
"sbo":"SBO:0000176"
}
},
{
"id":"PACALDt2rpp",
"name":"phenylacetaldehyde reversible transport via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"pacald_c":1.0,
"pacald_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PACALDt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"PEAMNtex",
"name":"phenethylamine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"peamn_e":-1.0,
"peamn_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"PEAMNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"PACALDtex",
"name":"phenethylacetaldehyde transport via diffusion (extracellular to periplasm)",
"metabolites":{
"pacald_e":-1.0,
"pacald_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"PACALDtex",
"sbo":"SBO:0000655"
}
},
{
"id":"LIPOt2pp",
"name":"Lipoate transport via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"lipoate_c":1.0,
"lipoate_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"LIPOt2pp:2",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__AGM4PA",
"name":"N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide amidase",
"metabolites":{
"__Ecoli_panGEMs__LalaDgluMdapDala_c":1.0,
"__Ecoli_panGEMs__anhgm4p_c":-1.0,
"__Ecoli_panGEMs__anhgm_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00107",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGM4PA",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__RNDR3b",
"name":"Ribonucleoside-diphosphate reductase (CDP) (glutaredoxin)",
"metabolites":{
"__Ecoli_panGEMs__grxox_c":1.0,
"__Ecoli_panGEMs__grxrd_c":-1.0,
"cdp_c":-1.0,
"dcdp_c":1.0,
"h2o_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00869 and (HFPHFOGF_02767 and HFPHFOGF_02768)) or ((HFPHFOGF_02767 and HFPHFOGF_02768) and HFPHFOGF_03721) or ((HFPHFOGF_02767 and HFPHFOGF_02768) and HFPHFOGF_01081) or ((HFPHFOGF_02767 and HFPHFOGF_02768) and HFPHFOGF_01710)",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"__Ecoli_panGEMs__RNDR3b",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__RNDR4b",
"name":"Ribonucleoside-diphosphate reductase (UDP) (glutaredoxin)",
"metabolites":{
"__Ecoli_panGEMs__grxox_c":1.0,
"__Ecoli_panGEMs__grxrd_c":-1.0,
"dudp_c":1.0,
"h2o_c":1.0,
"udp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00869 and (HFPHFOGF_02767 and HFPHFOGF_02768)) or ((HFPHFOGF_02767 and HFPHFOGF_02768) and HFPHFOGF_03721) or ((HFPHFOGF_02767 and HFPHFOGF_02768) and HFPHFOGF_01710) or ((HFPHFOGF_02767 and HFPHFOGF_02768) and HFPHFOGF_01081)",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"__Ecoli_panGEMs__RNDR4b",
"sbo":"SBO:0000176"
}
},
{
"id":"ACGAL1Ptex",
"name":"N-acetyl-D-galactosamine 1-phosphate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"acgal1p_e":-1.0,
"acgal1p_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ACGAL1Ptex",
"sbo":"SBO:0000655"
}
},
{
"id":"ACGALtex",
"name":"N-acetyl-D-galactosamine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"acgal_e":-1.0,
"acgal_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ACGALtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GLCUR1Ptex",
"name":"D-glucuronate 1-phosphate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"glcur1p_e":-1.0,
"glcur1p_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GLCUR1Ptex",
"sbo":"SBO:0000655"
}
},
{
"id":"UDPGLCURtex",
"name":"UDP-D-glucuronate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"udpglcur_e":-1.0,
"udpglcur_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"UDPGLCURtex",
"sbo":"SBO:0000655"
}
},
{
"id":"UDPGALPpp",
"name":"UDPgalactose pyrophosphohydrolase",
"metabolites":{
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"h2o_p":-1.0,
"h_p":2.0,
"udpgal_p":-1.0,
"ump_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00509",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"UDPGALPpp",
"sbo":"SBO:0000176"
}
},
{
"id":"UACGAMPpp",
"name":"UDP-N-acetyl-D-glucosamine pyrophosphohydrolase (periplasm)",
"metabolites":{
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"h2o_p":-1.0,
"h_p":2.0,
"uacgam_p":-1.0,
"ump_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00509",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"UACGAMPpp",
"rhea":"RHEA:29547",
"sbo":"SBO:0000176"
}
},
{
"id":"UACGALPpp",
"name":"UDP-N-acetyl-D-galactosamine pyrophosphohydrolase (periplasm)",
"metabolites":{
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"h2o_p":-1.0,
"h_p":2.0,
"udpacgal_p":-1.0,
"ump_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00509",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"UACGALPpp",
"rhea":"RHEA:29851",
"sbo":"SBO:0000176"
}
},
{
"id":"UGLCURPpp",
"name":"UDP-D-glucuronate pyrophosphohydrolase (periplasm)",
"metabolites":{
"glcur1p_p":1.0,
"h2o_p":-1.0,
"h_p":2.0,
"udpglcur_p":-1.0,
"ump_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00509",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"UGLCURPpp",
"rhea":"RHEA:29559",
"sbo":"SBO:0000176"
}
},
{
"id":"FEROpp",
"name":"ferroxidase",
"metabolites":{
"fe2_p":-4.0,
"fe3_p":4.0,
"h2o_p":2.0,
"h_p":-4.0,
"o2_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00120 or HFPHFOGF_03440",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"FEROpp",
"rhea":"RHEA:11148",
"sbo":"SBO:0000176"
}
},
{
"id":"ISETACabcpp",
"name":"isethionate transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"isetac_c":1.0,
"isetac_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00395 and HFPHFOGF_00396 and HFPHFOGF_00397) or (HFPHFOGF_00954 and HFPHFOGF_00955 and HFPHFOGF_00957)",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ISETACabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ISETACtex",
"name":"isethionate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"isetac_e":-1.0,
"isetac_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ISETACtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GUR1PPpp",
"name":"Glucuronate 1-phosphate phosphatase (periplasm)",
"metabolites":{
"glcur1p_p":-1.0,
"glcur_p":1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"GUR1PPpp",
"sbo":"SBO:0000176"
}
},
{
"id":"UDPGtex",
"name":"UDPglucose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"udpg_e":-1.0,
"udpg_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"UDPGtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ACGAL1PPpp",
"name":"N-acetyl-D-galactosamine 1-phosphatase (periplasm)",
"metabolites":{
"acgal1p_p":-1.0,
"acgal_p":1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"ACGAL1PPpp",
"sbo":"SBO:0000176"
}
},
{
"id":"UDPGALtex",
"name":"UDPgalactose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"udpgal_e":-1.0,
"udpgal_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"UDPGALtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ACGAM1Ptex",
"name":"N-acetyl-D-glucosamine 1-phosphate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"acgam1p_e":-1.0,
"acgam1p_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ACGAM1Ptex",
"sbo":"SBO:0000655"
}
},
{
"id":"UACGAMtex",
"name":"UDP-N-acetyl-D-glucosamine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"uacgam_e":-1.0,
"uacgam_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"UACGAMtex",
"sbo":"SBO:0000655"
}
},
{
"id":"UDPACGALtex",
"name":"UDP-N-acetyl-D-galactosamine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"udpacgal_e":-1.0,
"udpacgal_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"UDPACGALtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__AM4PCP",
"name":"Anhydrous-N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase",
"metabolites":{
"__Ecoli_panGEMs__anhm3p_c":1.0,
"__Ecoli_panGEMs__anhm4p_c":-1.0,
"ala__D_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01295",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__AM4PCP",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AM3PA",
"name":"Anhydrous-N-Acetylmuramyl-tripeptide amidase",
"metabolites":{
"__Ecoli_panGEMs__LalaDgluMdap_c":1.0,
"__Ecoli_panGEMs__anhm3p_c":-1.0,
"anhm_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00107",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__AM3PA",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__UM4PCP",
"name":"UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate-D-alanine L,D-carboxypeptidase",
"metabolites":{
"__Ecoli_panGEMs__um4p_c":-1.0,
"ala__D_c":1.0,
"h2o_c":-1.0,
"ugmd_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01295",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__UM4PCP",
"sbo":"SBO:0000176"
}
},
{
"id":"CBLAT",
"name":"cob(I)alamin adenosyltransferase",
"metabolites":{
"adocbl_c":1.0,
"atp_c":-1.0,
"cbl1_c":-1.0,
"h_c":-1.0,
"pppi_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01378",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"CBLAT:2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__NTRIR4pp",
"name":"Nitrite Reductase (Menaquinole-8, periplasm)",
"metabolites":{
"h2o_p":2.0,
"h_p":-2.0,
"mql8_c":-3.0,
"mqn8_c":3.0,
"nh4_p":1.0,
"no2_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04205 and HFPHFOGF_04206 and HFPHFOGF_04207 and HFPHFOGF_04208",
"subsystem":"Nitrogen Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__NTRIR4pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__NTRIR3pp",
"name":"Nitrite Reductase (Ubiquinole-8, periplasm)",
"metabolites":{
"h2o_p":2.0,
"h_p":-2.0,
"nh4_p":1.0,
"no2_p":-1.0,
"q8_c":3.0,
"q8h2_c":-3.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04205 and HFPHFOGF_04206 and HFPHFOGF_04207 and HFPHFOGF_04208",
"subsystem":"Nitrogen Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__NTRIR3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"INOSTt4pp",
"name":"Na+/myo-inositol symporter (periplasm)",
"metabolites":{
"inost_c":1.0,
"inost_p":-1.0,
"na1_c":1.0,
"na1_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03807",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"INOSTt4pp",
"sbo":"SBO:0000655"
}
},
{
"id":"PHEMEtiex",
"name":"protoheme transport irreversible out via diffusion (periplasm to extracellular)",
"metabolites":{
"pheme_e":1.0,
"pheme_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"PHEMEtiex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__AGM3PA",
"name":"N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide amidase",
"metabolites":{
"__Ecoli_panGEMs__LalaDgluMdap_c":1.0,
"__Ecoli_panGEMs__anhgm3p_c":-1.0,
"__Ecoli_panGEMs__anhgm_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00107",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGM3PA",
"sbo":"SBO:0000176"
}
},
{
"id":"CYANtex",
"name":"Cyanide transport via diffusion (extracellular to periplasm)",
"metabolites":{
"cyan_e":-1.0,
"cyan_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CYANtex",
"sbo":"SBO:0000655"
}
},
{
"id":"SO3tex",
"name":"sulfite transport via diffusion (extracellular to periplasm)",
"metabolites":{
"so3_e":-1.0,
"so3_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"SO3tex:2",
"sbo":"SBO:0000655"
}
},
{
"id":"TCYNTtex",
"name":"Thiocyanate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"tcynt_e":-1.0,
"tcynt_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"TCYNTtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ACANTHAT",
"name":"acetyl-CoA:anthranilate acetyltransferase",
"metabolites":{
"acanth_c":1.0,
"accoa_c":-1.0,
"anth_c":-1.0,
"coa_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01550",
"subsystem":"Tyrosine, Tryptophan, and Phenylalanine Metabolism",
"annotation":{
"biggr":"ACANTHAT",
"rhea":"RHEA:28550",
"sbo":"SBO:0000176"
}
},
{
"id":"METSOX2abcpp",
"name":"L-methionine R-oxide transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"metsox_R__L_c":1.0,
"metsox_R__L_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"METSOX2abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"METSOX1tex",
"name":"L-methionine S-oxide diffusion (extracellular)",
"metabolites":{
"metsox_S__L_e":-1.0,
"metsox_S__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"METSOX1tex",
"sbo":"SBO:0000655"
}
},
{
"id":"METSOX2tex",
"name":"L-methionine R-oxide diffusion (extracellular)",
"metabolites":{
"metsox_R__L_e":-1.0,
"metsox_R__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"METSOX2tex",
"sbo":"SBO:0000655"
}
},
{
"id":"3UMPtex",
"name":"3UMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"3ump_e":-1.0,
"3ump_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"3UMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"MSO3abcpp",
"name":"methanesulfonate transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"mso3_c":1.0,
"mso3_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00954 and HFPHFOGF_00957 and HFPHFOGF_00955",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"MSO3abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"MSO3tex",
"name":"methanesulfonate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"mso3_e":-1.0,
"mso3_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"MSO3tex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FECRMR1",
"name":"Ferrichrome reductase",
"metabolites":{
"__Ecoli_panGEMs__fad_c":1.0,
"__Ecoli_panGEMs__fecrm_c":-2.0,
"__Ecoli_panGEMs__fecrm_un_c":2.0,
"fadh2_c":-1.0,
"fe2_c":2.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FECRMR1",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FECRMR2",
"name":"Ferrichrome reductase",
"metabolites":{
"__Ecoli_panGEMs__fecrm_c":-2.0,
"__Ecoli_panGEMs__fecrm_un_c":2.0,
"__Ecoli_panGEMs__fmn_c":1.0,
"fe2_c":2.0,
"fmnh2_c":-1.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FECRMR2",
"sbo":"SBO:0000176"
}
},
{
"id":"TDP",
"name":"thiamin pyrophosphatase",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"thmmp_c":1.0,
"thmpp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01208",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"TDP",
"rhea":"RHEA:27998",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3PEPTabcpp",
"name":"Tripeptide (LalaDgluMdap) transport via ABC system (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__LalaDgluMdap_c":1.0,
"__Ecoli_panGEMs__LalaDgluMdap_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_01353 and HFPHFOGF_01355 and HFPHFOGF_01352 and HFPHFOGF_01445 and HFPHFOGF_01354) or (HFPHFOGF_02263 and HFPHFOGF_02266 and HFPHFOGF_02264 and HFPHFOGF_02265) or (HFPHFOGF_01353 and HFPHFOGF_01355 and HFPHFOGF_01354 and HFPHFOGF_01352 and HFPHFOGF_01351)",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__3PEPTabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__4PEPTabcpp",
"name":"Tetrapeptide (LalaDgluMdapDala) transport via ABC system (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__LalaDgluMdapDala_c":1.0,
"__Ecoli_panGEMs__LalaDgluMdapDala_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_01351 and HFPHFOGF_01355 and HFPHFOGF_01352 and HFPHFOGF_01353 and HFPHFOGF_01354) or (HFPHFOGF_02263 and HFPHFOGF_02266 and HFPHFOGF_02264 and HFPHFOGF_02265)",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__4PEPTabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"3GMPtex",
"name":"3GMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"3gmp_e":-1.0,
"3gmp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"3GMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_tym_e",
"name":"Exchange of tyraminium.",
"metabolites":{
"tym_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_tym_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__AGM3Pt2pp",
"name":"GlcNAc-anhMurNAc tripeptide transport in via proton symport (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__anhgm3p_c":1.0,
"__Ecoli_panGEMs__anhgm3p_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00463",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGM3Pt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"SO4tex",
"name":"sulfate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"so4_e":-1.0,
"so4_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"SO4tex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__AGM4Pt2pp",
"name":"GlcNAc-anhMurNAc tetrapeptide transport in via proton symport (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__anhgm4p_c":1.0,
"__Ecoli_panGEMs__anhgm4p_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00463",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGM4Pt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__AGMt2pp",
"name":"GlcNAc-anhMurNAc transport in via proton symport (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__anhgm_c":1.0,
"__Ecoli_panGEMs__anhgm_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00463",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGMt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__ARBTNR1",
"name":"Aerobactin reductase",
"metabolites":{
"__Ecoli_panGEMs__arbtn_fe3_c":-2.0,
"__Ecoli_panGEMs__fad_c":1.0,
"arbtn_c":2.0,
"fadh2_c":-1.0,
"fe2_c":2.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__ARBTNR1",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ARBTNR2",
"name":"Aerobactin reductase",
"metabolites":{
"__Ecoli_panGEMs__arbtn_fe3_c":-2.0,
"__Ecoli_panGEMs__fmn_c":1.0,
"arbtn_c":2.0,
"fe2_c":2.0,
"fmnh2_c":-1.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__ARBTNR2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__METSOXR1",
"name":"L-methionine-S-oxide reductase",
"metabolites":{
"__Ecoli_panGEMs__trdox_c":1.0,
"__Ecoli_panGEMs__trdrd_c":-1.0,
"h2o_c":1.0,
"met__L_c":1.0,
"metsox_S__L_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_02665 and HFPHFOGF_04370) or (HFPHFOGF_03909 and HFPHFOGF_04370) or (HFPHFOGF_03658 and HFPHFOGF_02665) or (HFPHFOGF_03658 and HFPHFOGF_03909)",
"subsystem":"Methionine Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__METSOXR1",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__METSOXR2",
"name":"L-methionine-R-sulfoxide reductase",
"metabolites":{
"__Ecoli_panGEMs__trdox_c":1.0,
"__Ecoli_panGEMs__trdrd_c":-1.0,
"h2o_c":1.0,
"met__L_c":1.0,
"metsox_R__L_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_02665 and HFPHFOGF_01837) or (HFPHFOGF_03909 and HFPHFOGF_01837) or (HFPHFOGF_01891 and HFPHFOGF_03909) or (HFPHFOGF_01891 and HFPHFOGF_02665)",
"subsystem":"Methionine Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__METSOXR2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__DAPAL",
"name":"2,3-diaminopropionate amonnia lyase",
"metabolites":{
"__Ecoli_panGEMs__23dappa_c":-1.0,
"h2o_c":-1.0,
"nh4_c":2.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03004",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__DAPAL",
"sbo":"SBO:0000176"
}
},
{
"id":"AMPTASECG",
"name":"alanyl aminopeptidase (cys-gly)",
"metabolites":{
"cgly_c":-1.0,
"cys__L_c":1.0,
"gly_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00953 or HFPHFOGF_04407 or HFPHFOGF_02606 or HFPHFOGF_00258",
"subsystem":"Cysteine Metabolism",
"annotation":{
"biggr":"AMPTASECG",
"rhea":"RHEA:28783",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_imp_e",
"name":"Exchange of IMP(2-).",
"metabolites":{
"imp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_imp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"DOPAtex",
"name":"dopamine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"dopa_e":-1.0,
"dopa_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DOPAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"4HOXPACDtex",
"name":"4-hydroxyphenylacetaldehyde transport via diffusion (extracellular to periplasm)",
"metabolites":{
"4hoxpacd_e":-1.0,
"4hoxpacd_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"4HOXPACDtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__ARBTNR3",
"name":"Aerobactin reductase",
"metabolites":{
"__Ecoli_panGEMs__arbtn_fe3_c":-2.0,
"arbtn_c":2.0,
"fe2_c":2.0,
"h_c":2.0,
"rbflvrd_c":-1.0,
"ribflv_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__ARBTNR3",
"sbo":"SBO:0000176"
}
},
{
"id":"LACZpp",
"name":"b-galactosidase",
"metabolites":{
"gal_p":1.0,
"glc__D_p":1.0,
"h2o_p":-1.0,
"lcts_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02218",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"LACZpp",
"sbo":"SBO:0000176"
}
},
{
"id":"SPMDtex",
"name":"spermidine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"spmd_e":-1.0,
"spmd_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"SPMDtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GPDDA1pp",
"name":"Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)",
"metabolites":{
"chol_p":1.0,
"g3pc_p":-1.0,
"glyc3p_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02325",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"GPDDA1pp",
"rhea":"RHEA:16061",
"sbo":"SBO:0000176"
}
},
{
"id":"GPDDA5pp",
"name":"Glycerophosphodiester phosphodiesterase (Glycerophosphoinositol)",
"metabolites":{
"g3pi_p":-1.0,
"glyc3p_p":1.0,
"h2o_p":-1.0,
"h_p":1.0,
"inost_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02325",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"GPDDA5pp",
"rhea":"RHEA:16501",
"sbo":"SBO:0000176"
}
},
{
"id":"ETHAtex",
"name":"ethanolamine transport via diffusion (extracellular)",
"metabolites":{
"etha_e":-1.0,
"etha_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ETHAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"G3PStex",
"name":"glycerophosphserine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"g3ps_e":-1.0,
"g3ps_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"G3PStex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FEOXAMR1",
"name":"Ferroxamine reductase",
"metabolites":{
"__Ecoli_panGEMs__fad_c":1.0,
"__Ecoli_panGEMs__feoxam_c":-2.0,
"__Ecoli_panGEMs__feoxam_un_c":2.0,
"fadh2_c":-1.0,
"fe2_c":2.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04504",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FEOXAMR1",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FEOXAMR2",
"name":"Ferroxamine reductase",
"metabolites":{
"__Ecoli_panGEMs__feoxam_c":-2.0,
"__Ecoli_panGEMs__feoxam_un_c":2.0,
"__Ecoli_panGEMs__fmn_c":1.0,
"fe2_c":2.0,
"fmnh2_c":-1.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04504",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FEOXAMR2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FEOXAMR3",
"name":"Ferroxamine reductase",
"metabolites":{
"__Ecoli_panGEMs__feoxam_c":-2.0,
"__Ecoli_panGEMs__feoxam_un_c":2.0,
"fe2_c":2.0,
"h_c":2.0,
"rbflvrd_c":-1.0,
"ribflv_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04504",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FEOXAMR3",
"sbo":"SBO:0000176"
}
},
{
"id":"PTHRpp",
"name":"phospho-L-threonine phosphatase (periplasmic)",
"metabolites":{
"h2o_p":-1.0,
"pi_p":1.0,
"thr__L_p":1.0,
"thrp_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04190 or HFPHFOGF_00414",
"subsystem":"Threonine and Lysine Metabolism",
"annotation":{
"biggr":"PTHRpp",
"rhea":"RHEA:30579",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FEENTERR2",
"name":"Fe-enterobactin reduction (Fe(III)-unloading)",
"metabolites":{
"__Ecoli_panGEMs__feenter_c":-2.0,
"__Ecoli_panGEMs__fmn_c":1.0,
"enter_c":2.0,
"fe2_c":2.0,
"fmnh2_c":-1.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FEENTERR2",
"sbo":"SBO:0000176"
}
},
{
"id":"FLVR",
"name":"flavin reductase",
"metabolites":{
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"rbflvrd_c":1.0,
"ribflv_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03970 or (HFPHFOGF_02867 and HFPHFOGF_02866)",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"FLVR:2",
"rhea":"RHEA:19377",
"sbo":"SBO:0000176"
}
},
{
"id":"SUCCtex",
"name":"succinate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"succ_e":-1.0,
"succ_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"SUCCtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FE3HOXR1",
"name":"Fe(III)hydroxamate reductase",
"metabolites":{
"__Ecoli_panGEMs__fad_c":1.0,
"__Ecoli_panGEMs__fe3hox_c":-2.0,
"__Ecoli_panGEMs__fe3hox_un_c":2.0,
"fadh2_c":-1.0,
"fe2_c":2.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FE3HOXR1",
"sbo":"SBO:0000176"
}
},
{
"id":"SUCRtex",
"name":"sucrose transport transport via diffusion (extracellular to periplasm)",
"metabolites":{
"sucr_e":-1.0,
"sucr_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"SUCRtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FECRMR3",
"name":"Ferrichrome reductase",
"metabolites":{
"__Ecoli_panGEMs__fecrm_c":-2.0,
"__Ecoli_panGEMs__fecrm_un_c":2.0,
"fe2_c":2.0,
"h_c":2.0,
"rbflvrd_c":-1.0,
"ribflv_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FECRMR3",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FDMO2",
"name":"FMNH2-dependent monooxygenase (methanesulfonate)",
"metabolites":{
"__Ecoli_panGEMs__fmn_c":1.0,
"fald_c":1.0,
"fmnh2_c":-1.0,
"h2o_c":1.0,
"h_c":1.0,
"mso3_c":-1.0,
"o2_c":-1.0,
"so3_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00956",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FDMO2",
"sbo":"SBO:0000176"
}
},
{
"id":"LALGP",
"name":"L-alanyl-gamma-L-glutamate peptidase",
"metabolites":{
"LalaLglu_c":-1.0,
"ala__L_c":1.0,
"glu__L_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00258",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"LALGP",
"rhea":"RHEA:29335",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AGM4PApp",
"name":"N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide amidase (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__LalaDgluMdapDala_p":1.0,
"__Ecoli_panGEMs__anhgm4p_p":-1.0,
"__Ecoli_panGEMs__anhgm_p":1.0,
"h2o_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02933 or HFPHFOGF_04310 or HFPHFOGF_02521 or HFPHFOGF_00887",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGM4PApp",
"sbo":"SBO:0000176"
}
},
{
"id":"ARABDI",
"name":"L-fucose isomerase",
"metabolites":{
"arab__D_c":-1.0,
"rbl__D_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02911",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"ARABDI",
"rhea":"RHEA:13849",
"sbo":"SBO:0000176"
}
},
{
"id":"AGt3",
"name":"silver transport out via proton antiport",
"metabolites":{
"ag_c":-1.0,
"ag_e":1.0,
"h_c":1.0,
"h_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00570 and HFPHFOGF_00572 and HFPHFOGF_00571 and HFPHFOGF_00573",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"AGt3",
"sbo":"SBO:0000655"
}
},
{
"id":"CD2t3pp",
"name":"cadmium (Cd+2) transport out via proton antiport (periplasm)",
"metabolites":{
"cd2_c":-1.0,
"cd2_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04043 or HFPHFOGF_00772",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"CD2t3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"ZNabcpp",
"name":"zinc (Zn+2) transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"zn2_c":1.0,
"zn2_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01920 and HFPHFOGF_01919 and HFPHFOGF_01918",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"ZNabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"SKMt2pp",
"name":"shikimate transport in via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"skm_c":1.0,
"skm_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02062",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"SKMt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"FE2t2pp",
"name":"iron (II) transport in via proton symport (periplasm)",
"metabolites":{
"fe2_c":1.0,
"fe2_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02478",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"FE2t2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYC2Ptex",
"name":"Glycerol-2-phosphate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"glyc2p_e":-1.0,
"glyc2p_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GLYC2Ptex",
"sbo":"SBO:0000655"
}
},
{
"id":"PSERtex",
"name":"phospho-L-serine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"pser_e":-1.0,
"pser_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"PSERtex",
"sbo":"SBO:0000655"
}
},
{
"id":"TARTRtex",
"name":"Tartrate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"tartr__L_e":-1.0,
"tartr__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"TARTRtex",
"sbo":"SBO:0000655"
}
},
{
"id":"R5Ptex",
"name":"Ribose 5-phosphate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"r5p_e":-1.0,
"r5p_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"R5Ptex",
"sbo":"SBO:0000655"
}
},
{
"id":"THRPtex",
"name":"phospho-L-threonine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"thrp_e":-1.0,
"thrp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"THRPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"TYRPtex",
"name":"phopho-L-tyrosine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"tyrp_e":-1.0,
"tyrp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"TYRPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"R5PPpp",
"name":"ribose 5-phosphate phosphatase",
"metabolites":{
"h2o_p":-1.0,
"pi_p":1.0,
"r5p_p":-1.0,
"rib__D_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04190 or HFPHFOGF_00414",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"R5PPpp",
"rhea":"RHEA:29471",
"sbo":"SBO:0000176"
}
},
{
"id":"PSP_Lpp",
"name":"phospho-L-serine phosphatase (periplasmic)",
"metabolites":{
"h2o_p":-1.0,
"pi_p":1.0,
"pser_p":-1.0,
"ser__L_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04190 or HFPHFOGF_00414",
"subsystem":"Glycine and Serine Metabolism",
"annotation":{
"biggr":"PSP_Lpp",
"rhea":"RHEA:21208",
"sbo":"SBO:0000176"
}
},
{
"id":"TYRPpp",
"name":"phospho-L-tyrosine phosphatase (periplasmic)",
"metabolites":{
"h2o_p":-1.0,
"pi_p":1.0,
"tyr__L_p":1.0,
"tyrp_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04190",
"subsystem":"Tyrosine, Tryptophan, and Phenylalanine Metabolism",
"annotation":{
"biggr":"TYRPpp",
"sbo":"SBO:0000176"
}
},
{
"id":"R1PK",
"name":"ribose 1-phosphokinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"r15bp_c":1.0,
"r1p_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"R1PK",
"rhea":"RHEA:29775",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PAPSR2",
"name":"Phosphoadenylyl-sulfate reductase (glutaredoxin)",
"metabolites":{
"__Ecoli_panGEMs__grxox_c":1.0,
"__Ecoli_panGEMs__grxrd_c":-1.0,
"h_c":2.0,
"pap_c":1.0,
"paps_c":-1.0,
"so3_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_03721 and HFPHFOGF_02865) or (HFPHFOGF_00869 and HFPHFOGF_02865) or (HFPHFOGF_01081 and HFPHFOGF_02865) or (HFPHFOGF_01710 and HFPHFOGF_02865)",
"subsystem":"Cysteine Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PAPSR2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__GRXR",
"name":"Glutaredoxin reductase",
"metabolites":{
"__Ecoli_panGEMs__grxox_c":-1.0,
"__Ecoli_panGEMs__grxrd_c":1.0,
"gthox_c":1.0,
"gthrd_c":-2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01081 or HFPHFOGF_03721 or HFPHFOGF_01710 or HFPHFOGF_00869",
"subsystem":"Unassigned",
"annotation":{
"biggr":"__Ecoli_panGEMs__GRXR",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__RNDR1b",
"name":"Ribonucleoside-diphosphate reductase (ADP) (glutaredoxin)",
"metabolites":{
"__Ecoli_panGEMs__grxox_c":1.0,
"__Ecoli_panGEMs__grxrd_c":-1.0,
"adp_c":-1.0,
"dadp_c":1.0,
"h2o_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"((HFPHFOGF_02767 and HFPHFOGF_02768) and HFPHFOGF_01081) or ((HFPHFOGF_02767 and HFPHFOGF_02768) and HFPHFOGF_03721) or (HFPHFOGF_00869 and (HFPHFOGF_02767 and HFPHFOGF_02768)) or ((HFPHFOGF_02767 and HFPHFOGF_02768) and HFPHFOGF_01710)",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"__Ecoli_panGEMs__RNDR1b",
"sbo":"SBO:0000176"
}
},
{
"id":"R15BPK",
"name":"ribose-1,5-bisphosphokinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"prpp_c":1.0,
"r15bp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04231",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"R15BPK",
"rhea":"RHEA:20109",
"sbo":"SBO:0000176"
}
},
{
"id":"Kabcpp",
"name":"Potassium ABC transporter (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"k_c":1.0,
"k_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00715 and HFPHFOGF_00714 and HFPHFOGF_00713",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"Kabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__RNDR2b",
"name":"Ribonucleoside-diphosphate reductase (GDP) (glutaredoxin)",
"metabolites":{
"__Ecoli_panGEMs__grxox_c":1.0,
"__Ecoli_panGEMs__grxrd_c":-1.0,
"dgdp_c":1.0,
"gdp_c":-1.0,
"h2o_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00869 and (HFPHFOGF_02767 and HFPHFOGF_02768)) or ((HFPHFOGF_02767 and HFPHFOGF_02768) and HFPHFOGF_01081) or ((HFPHFOGF_02767 and HFPHFOGF_02768) and HFPHFOGF_01710) or ((HFPHFOGF_02767 and HFPHFOGF_02768) and HFPHFOGF_03721)",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"__Ecoli_panGEMs__RNDR2b",
"sbo":"SBO:0000176"
}
},
{
"id":"TAURtex",
"name":"taurine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"taur_e":-1.0,
"taur_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"TAURtex",
"sbo":"SBO:0000655"
}
},
{
"id":"FACOAE181",
"name":"fatty-acid-CoA thioesterase (octadecenoate)",
"metabolites":{
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ocdcea_c":1.0,
"octdececoa_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00482",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAE181",
"rhea":"RHEA:40139",
"sbo":"SBO:0000176"
}
},
{
"id":"FACOAE160",
"name":"fatty-acid-CoA thioesterase (hexadecanoate)",
"metabolites":{
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"hdca_c":1.0,
"pmtcoa_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00482",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAE160",
"rhea":"RHEA:16645",
"sbo":"SBO:0000176"
}
},
{
"id":"FACOAE140",
"name":"fatty-acid-CoA thioesterase (tetradecanoate)",
"metabolites":{
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"tdcoa_c":-1.0,
"ttdca_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00482",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAE140",
"rhea":"RHEA:40119",
"sbo":"SBO:0000176"
}
},
{
"id":"LEUabcpp",
"name":"L-leucine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"leu__L_c":1.0,
"leu__L_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_03557 and HFPHFOGF_03562 and HFPHFOGF_03559 and HFPHFOGF_03556 and HFPHFOGF_03558) or (HFPHFOGF_03560 and HFPHFOGF_03558 and HFPHFOGF_03557 and HFPHFOGF_03559 and HFPHFOGF_03556)",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"LEUabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"L_LACt2rpp",
"name":"L-lactate reversible transport via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"lac__L_c":1.0,
"lac__L_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03714",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"L_LACt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"MALt2_2pp",
"name":"Malate transport via proton symport (2 H) (periplasm)",
"metabolites":{
"h_c":2.0,
"h_p":-2.0,
"mal__L_c":1.0,
"mal__L_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03633",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"MALt2_2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__CPGNR1",
"name":"Coprogen(Fe(III)) reductase",
"metabolites":{
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"__Ecoli_panGEMs__cpgn_un_c":2.0,
"__Ecoli_panGEMs__fad_c":1.0,
"fadh2_c":-1.0,
"fe2_c":2.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CPGNR1",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CPGNR2",
"name":"Coprogen(Fe(III)) reductase",
"metabolites":{
"__Ecoli_panGEMs__cpgn_c":-2.0,
"__Ecoli_panGEMs__cpgn_un_c":2.0,
"__Ecoli_panGEMs__fmn_c":1.0,
"fe2_c":2.0,
"fmnh2_c":-1.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CPGNR2",
"sbo":"SBO:0000176"
}
},
{
"id":"THRtex",
"name":"L-threonine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"thr__L_e":-1.0,
"thr__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"THRtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__CPGNR3",
"name":"Coprogen(Fe(III)) reductase",
"metabolites":{
"__Ecoli_panGEMs__cpgn_c":-2.0,
"__Ecoli_panGEMs__cpgn_un_c":2.0,
"fe2_c":2.0,
"h_c":2.0,
"rbflvrd_c":-1.0,
"ribflv_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CPGNR3",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CPGNUtpp",
"name":"Coprogen unloaded secretion",
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"__Ecoli_panGEMs__cpgn_un_c":-1.0,
"__Ecoli_panGEMs__cpgn_un_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CPGNUtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__CPGNUtex",
"name":"Coprogen unloaded secretion (extracellular)",
"metabolites":{
"__Ecoli_panGEMs__cpgn_un_e":1.0,
"__Ecoli_panGEMs__cpgn_un_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CPGNUtex",
"sbo":"SBO:0000655"
}
},
{
"id":"MALt2_3pp",
"name":"Malate transport via proton symport (3 H) (periplasm)",
"metabolites":{
"h_c":3.0,
"h_p":-3.0,
"mal__L_c":1.0,
"mal__L_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04261 or HFPHFOGF_04277",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"MALt2_3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"MALTabcpp",
"name":"maltose transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"malt_c":1.0,
"malt_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04164 and HFPHFOGF_04167 and HFPHFOGF_04163 and HFPHFOGF_04165",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"MALTabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__MALTHXabcpp",
"name":"Maltohexaose transport via ABC system (periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__malthx_p":-1.0,
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"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
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"gene_reaction_rule":"HFPHFOGF_04165 and HFPHFOGF_04163 and HFPHFOGF_04164 and HFPHFOGF_04167",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__MALTHXabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__MALTPTabcpp",
"name":"Maltopentaose transport via ABC system (periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__maltpt_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_04167 and HFPHFOGF_04163 and HFPHFOGF_04164 and HFPHFOGF_04165",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__MALTPTabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__AAMYL",
"name":"Alpha-amylase",
"metabolites":{
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"__Ecoli_panGEMs__malthx_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02002",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__AAMYL",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AAMYLpp",
"name":"Alpha-amylase (periplasm)",
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"__Ecoli_panGEMs__malthx_p":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03680",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__AAMYLpp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MALTTRabcpp",
"name":"Maltotriose transport via ABC system (periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__malttr_p":-1.0,
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"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__MALTTRabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"THMDtex",
"name":"thymidine transport via diffusion (extracellular to periplasm)",
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"thymd_p":1.0
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"lower_bound":-1000.0,
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"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
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"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__MALTTTRabcpp",
"name":"Maltotetraose transport via ABC system (periplasm)",
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"atp_c":-1.0,
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"h_c":1.0,
"pi_c":1.0
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"gene_reaction_rule":"HFPHFOGF_04164 and HFPHFOGF_04163 and HFPHFOGF_04165 and HFPHFOGF_04167",
"subsystem":"Transport, Inner Membrane",
"annotation":{
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"sbo":"SBO:0000655"
}
},
{
"id":"MAN6Pt6_2pp",
"name":"Mannose-6-phosphate transport via phosphate antiport (periplasm)",
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"man6p_p":-1.0,
"pi_c":-2.0,
"pi_p":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03793",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"MAN6Pt6_2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"FACOAL80t2pp",
"name":"fatty-acid-CoA ligase (octanoate transport via vectoral Co-A coupling)",
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"atp_c":-1.0,
"coa_c":-1.0,
"h_c":1.0,
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"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01864 or HFPHFOGF_01758",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAL80t2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"PPGPPDP",
"name":"guanosine-3',5'-bis(diphosphate) 3'-diphosphatase",
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"h2o_c":-1.0,
"ppgpp_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03764",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"PPGPPDP:2",
"rhea":"RHEA:14253",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CPGNabcpp",
"name":"Coprogen transport via ABC system (periplasm)",
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"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00148 and HFPHFOGF_00150 and HFPHFOGF_00149",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__CPGNabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"MANGLYCptspp",
"name":"2-O-alpha-mannosyl-D-glycerate transport via PEP:Pyr PTS (periplasm)",
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"man6pglyc_c":1.0,
"manglyc_p":-1.0,
"pep_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02501 and HFPHFOGF_00750 and HFPHFOGF_02502",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"MANGLYCptspp",
"sbo":"SBO:0000655"
}
},
{
"id":"MELIBt2pp",
"name":"melibiose transport in via symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"melib_c":1.0,
"melib_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04258 or HFPHFOGF_00377",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"MELIBt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"CBIuabcpp",
"name":"Cobinamide transport via ABC system (uptake, periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"cbi_c":1.0,
"cbi_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01768 and HFPHFOGF_00155 and HFPHFOGF_01766",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CBIuabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"METabcpp",
"name":"L-methionine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"met__L_c":1.0,
"met__L_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00196 and HFPHFOGF_00195 and HFPHFOGF_00197",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"METabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"CITtex",
"name":"citrate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"cit_e":-1.0,
"cit_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CITtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ACGAtex",
"name":"N-Acetyl-D-glucosamine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"acgam_e":-1.0,
"acgam_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ACGAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"DDCAtexi",
"name":"Fatty acid (dodecanoate) transport via facilitated irreversible diffusion (extracellular to periplasm)",
"metabolites":{
"ddca_e":-1.0,
"ddca_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02429",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"DDCAtexi",
"sbo":"SBO:0000655"
}
},
{
"id":"TTDCAtexi",
"name":"Tetradecanoate transport via facilitated irreversible diffusion (extracellular to periplasm)",
"metabolites":{
"ttdca_e":-1.0,
"ttdca_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02429",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"TTDCAtexi",
"sbo":"SBO:0000655"
}
},
{
"id":"HDCAtexi",
"name":"Hexadecanoate transport via facilitated irreversible diffusion (extracellular to periplasm)",
"metabolites":{
"hdca_e":-1.0,
"hdca_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02429",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"HDCAtexi",
"sbo":"SBO:0000655"
}
},
{
"id":"GUAC",
"name":"guanylate cyclase",
"metabolites":{
"35cgmp_c":1.0,
"gtp_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"GUAC",
"rhea":"RHEA:13665",
"sbo":"SBO:0000176"
}
},
{
"id":"EX___Ecoli_panGEMs__fe3hox_un_e",
"name":"Fe(III)hydoxamate, unloaded exchange",
"metabolites":{
"__Ecoli_panGEMs__fe3hox_un_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__fe3hox_un_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GGPTRCS",
"name":"gamma glutamyl putrescine synthase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"ggptrc_c":1.0,
"glu__L_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"ptrc_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01411",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"GGPTRCS",
"rhea":"RHEA:13633",
"sbo":"SBO:0000176"
}
},
{
"id":"EX___Ecoli_panGEMs__23dappa_e",
"name":"2,3-diaminopropionate exchange",
"metabolites":{
"__Ecoli_panGEMs__23dappa_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__23dappa_e",
"sbo":"SBO:0000627"
}
},
{
"id":"RMNtpp",
"name":"L-rhamnose transport via proton symport (periplasm)",
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"h_p":-1.0,
"rmn_c":1.0,
"rmn_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04036",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"RMNtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"23PDE2pp",
"name":"2',3'-cyclic-nucleotide phosphodiesterase (UMP) (periplasm)",
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"3ump_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04364",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"23PDE2pp",
"rhea":"RHEA:27878",
"sbo":"SBO:0000176"
}
},
{
"id":"23PDE4pp",
"name":"2',3'-cyclic-nucleotide phosphodiesterase (CMP) (periplasm)",
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"3cmp_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
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"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"23PDE4pp",
"rhea":"RHEA:27882",
"sbo":"SBO:0000176"
}
},
{
"id":"23PDE9pp",
"name":"2',3'-cyclic-nucleotide phosphodiesterase (GMP) (periplasm)",
"metabolites":{
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"3gmp_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04364",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"23PDE9pp",
"rhea":"RHEA:27858",
"sbo":"SBO:0000176"
}
},
{
"id":"SERt4pp",
"name":"L-serine via sodium symport (periplasm)",
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"na1_p":-1.0,
"ser__L_c":1.0,
"ser__L_p":-1.0
},
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"gene_reaction_rule":"HFPHFOGF_03197",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"SERt4pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__METDtex",
"name":"D-methionine transport via diffusion (extracellular to periplasm)",
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"__Ecoli_panGEMs__met__D_p":1.0
},
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"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"__Ecoli_panGEMs__METDtex",
"sbo":"SBO:0000655"
}
},
{
"id":"SUCCt2_3pp",
"name":"Succintate transport via proton symport (3 H) (periplasm)",
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"h_c":3.0,
"h_p":-3.0,
"succ_c":1.0,
"succ_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
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"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"SUCCt2_3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"MNLptspp",
"name":"mannitol transport via PEP:Pyr PTS (periplasm)",
"metabolites":{
"mnl1p_c":1.0,
"mnl_p":-1.0,
"pep_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"(HFPHFOGF_02501 and HFPHFOGF_03709 and HFPHFOGF_02502) or (HFPHFOGF_02501 and HFPHFOGF_03064 and HFPHFOGF_03063 and HFPHFOGF_02502) or (HFPHFOGF_02501 and HFPHFOGF_02796 and HFPHFOGF_02794 and HFPHFOGF_02795 and HFPHFOGF_02502)",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"MNLptspp",
"sbo":"SBO:0000655"
}
},
{
"id":"NAt3_1p5pp",
"name":"sodium proton antiporter (H:NA is 1.5) (periplasm)",
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"h_c":3.0,
"h_p":-3.0,
"na1_c":-2.0,
"na1_p":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01288",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"NAt3_1p5pp",
"sbo":"SBO:0000655"
}
},
{
"id":"SARCOX",
"name":"sarcosine oxidase",
"metabolites":{
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"gly_c":1.0,
"h2o2_c":1.0,
"h2o_c":-1.0,
"o2_c":-1.0,
"sarcs_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01076",
"subsystem":"Glycine and Serine Metabolism",
"annotation":{
"biggr":"SARCOX",
"rhea":"RHEA:13313",
"sbo":"SBO:0000176"
}
},
{
"id":"MN6PP",
"name":"mannose 6-phosphate phosphatase",
"metabolites":{
"h2o_c":-1.0,
"man6p_c":-1.0,
"man_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00842 or HFPHFOGF_01784 or HFPHFOGF_03825 or HFPHFOGF_03954",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"MN6PP",
"sbo":"SBO:0000176"
}
},
{
"id":"NAt3_2pp",
"name":"sodium proton antiporter (H:NA is 2) (periplasm)",
"metabolites":{
"h_c":2.0,
"h_p":-2.0,
"na1_c":-1.0,
"na1_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00019",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"NAt3_2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"NH4tpp",
"name":"ammonia reversible transport (periplasm)",
"metabolites":{
"nh4_c":1.0,
"nh4_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00481",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"NH4tpp",
"sbo":"SBO:0000655"
}
},
{
"id":"3KGK",
"name":"3-keto-L-gulonate kinase",
"metabolites":{
"3dhguln_c":-1.0,
"3dhgulnp_c":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03689",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"3KGK",
"rhea":"RHEA:28222",
"sbo":"SBO:0000176"
}
},
{
"id":"METtex",
"name":"L-methionine transport via diffusion (extracellular to periplasm)",
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"met__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
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"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"METtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_cd2_e",
"name":"Exchange of cadmium(2+).",
"metabolites":{
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cd2_e",
"sbo":"SBO:0000627"
}
},
{
"id":"F6PP",
"name":"D-fructose 6-phosphate phosphatase",
"metabolites":{
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"fru_c":1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00842 or HFPHFOGF_03825 or HFPHFOGF_02781 or HFPHFOGF_02379 or HFPHFOGF_03954",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"F6PP",
"sbo":"SBO:0000176"
}
},
{
"id":"NMNPtpp",
"name":"NMN permease (periplasm)",
"metabolites":{
"nmn_c":1.0,
"nmn_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00771",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"NMNPtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"NO2t2rpp",
"name":"nitrite transport in via proton symport, reversible (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"no2_c":1.0,
"no2_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
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"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"NO2t2rpp:2",
"sbo":"SBO:0000655"
}
},
{
"id":"NO3t7pp",
"name":"nitrate transport in via nitrite antiport (periplasm)",
"metabolites":{
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"no2_p":1.0,
"no3_c":1.0,
"no3_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01331 or HFPHFOGF_01557",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"NO3t7pp:2",
"sbo":"SBO:0000655"
}
},
{
"id":"ORNabcpp",
"name":"ornithine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"orn__L_c":1.0,
"orn__L_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02393 and HFPHFOGF_02394 and HFPHFOGF_02392 and HFPHFOGF_02396",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ORNabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"PIuabcpp",
"name":"phosphate transport via ABC system (uptake, periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":2.0,
"pi_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03856 and HFPHFOGF_03858 and HFPHFOGF_03859 and HFPHFOGF_03857",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"PIuabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"PNTOt4pp",
"name":"Pantothenate sodium symporter (periplasm)",
"metabolites":{
"na1_c":1.0,
"na1_p":-1.0,
"pnto__R_c":1.0,
"pnto__R_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03359",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PNTOt4pp",
"sbo":"SBO:0000655"
}
},
{
"id":"FRULYSDG",
"name":"Fructoselysine phosphate deglycase",
"metabolites":{
"frulysp_c":-1.0,
"g6p_c":1.0,
"h2o_c":-1.0,
"lys__L_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03476",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"FRULYSDG",
"rhea":"RHEA:28382",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__METDabcpp",
"name":"D-methionine transport via ABC system (periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__met__D_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00196 and HFPHFOGF_00197 and HFPHFOGF_00195",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__METDabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"FACOAL60t2pp",
"name":"fatty-acid-CoA ligase (hexanoate transport via vectoral Co-A coupling)",
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"atp_c":-1.0,
"coa_c":-1.0,
"h_c":1.0,
"h_p":-1.0,
"hxa_p":-1.0,
"hxcoa_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01864 or HFPHFOGF_01758",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAL60t2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"ILEabcpp",
"name":"L-isoleucine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ile__L_c":1.0,
"ile__L_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03558 and HFPHFOGF_03557 and HFPHFOGF_03562 and HFPHFOGF_03559 and HFPHFOGF_03556",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ILEabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"INDOLEt2pp",
"name":"Indole transport via proton symport, irreversible (periplasm)",
"metabolites":{
"h_c":-1.0,
"h_p":1.0,
"indole_c":-1.0,
"indole_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_03369 and HFPHFOGF_03368) and HFPHFOGF_03147",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"INDOLEt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"INSt2pp",
"name":"inosine transport in via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"ins_c":1.0,
"ins_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03092 or HFPHFOGF_02491 or HFPHFOGF_02479",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"INSt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"PROabcpp",
"name":"L-proline transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"pro__L_c":1.0,
"pro__L_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02769 and HFPHFOGF_02770 and HFPHFOGF_02771",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PROabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"PROt2rpp",
"name":"L-proline reversible transport via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"pro__L_c":1.0,
"pro__L_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04248 or HFPHFOGF_00432",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PROt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"MNLtex",
"name":"mannitol transport via diffusion (extracellular to periplasm)",
"metabolites":{
"mnl_e":-1.0,
"mnl_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"MNLtex",
"sbo":"SBO:0000655"
}
},
{
"id":"PROt4pp",
"name":"Na+/Proline-L symporter (periplasm)",
"metabolites":{
"na1_c":1.0,
"na1_p":-1.0,
"pro__L_c":1.0,
"pro__L_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01036",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PROt4pp",
"sbo":"SBO:0000655"
}
},
{
"id":"PTRCabcpp",
"name":"putrescine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"ptrc_c":1.0,
"ptrc_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00874 and HFPHFOGF_00875 and HFPHFOGF_00877 and HFPHFOGF_00876) or (HFPHFOGF_01526 and HFPHFOGF_01528 and HFPHFOGF_01527 and HFPHFOGF_01529) or (HFPHFOGF_01199 and HFPHFOGF_01200 and HFPHFOGF_01142 and HFPHFOGF_01141)",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PTRCabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"LYXt2pp",
"name":"L-Lyxose transport via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"lyx__L_c":1.0,
"lyx__L_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04036",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"LYXt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GDPDPK",
"name":"GDP diphosphokinase",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"gdp_c":-1.0,
"h_c":1.0,
"ppgpp_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02889 or HFPHFOGF_03764",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"GDPDPK:2",
"rhea":"RHEA:28098",
"sbo":"SBO:0000176"
}
},
{
"id":"OCDCAtexi",
"name":"Octadecanoate transport via facilitated irreversible diffusion (extracellular to periplasm)",
"metabolites":{
"ocdca_e":-1.0,
"ocdca_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02429",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"OCDCAtexi",
"sbo":"SBO:0000655"
}
},
{
"id":"OCDCEAtexi",
"name":"Octadecenoate (n-C18:1) transport via facilitated irreversible diffusion (extracellular to periplasm)",
"metabolites":{
"ocdcea_e":-1.0,
"ocdcea_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02429",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"OCDCEAtexi",
"sbo":"SBO:0000655"
}
},
{
"id":"ASNNpp",
"name":"L-asparaginase",
"metabolites":{
"asn__L_p":-1.0,
"asp__L_p":1.0,
"h2o_p":-1.0,
"nh4_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03085",
"subsystem":"Alanine and Aspartate Metabolism",
"annotation":{
"biggr":"ASNNpp",
"rhea":"RHEA:21016",
"sbo":"SBO:0000176"
}
},
{
"id":"GLUNpp",
"name":"glutaminase",
"metabolites":{
"gln__L_p":-1.0,
"glu__L_p":1.0,
"h2o_p":-1.0,
"nh4_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03085",
"subsystem":"Glutamate Metabolism",
"annotation":{
"biggr":"GLUNpp",
"rhea":"RHEA:15889",
"sbo":"SBO:0000176"
}
},
{
"id":"G6Ptex",
"name":"glucose 6-phosphate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"g6p_e":-1.0,
"g6p_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"G6Ptex",
"sbo":"SBO:0000655"
}
},
{
"id":"NTD12",
"name":"5'-nucleotidase (dIMP)",
"metabolites":{
"dimp_c":-1.0,
"din_c":1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02844 or HFPHFOGF_02377 or HFPHFOGF_03503",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD12",
"rhea":"RHEA:29383",
"sbo":"SBO:0000176"
}
},
{
"id":"TUNGSabcpp",
"name":"tungstate transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"tungs_c":1.0,
"tungs_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00784 and HFPHFOGF_00785 and HFPHFOGF_00783",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"TUNGSabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"NAtex",
"name":"sodium transport via diffusion (extracellular to periplasm)",
"metabolites":{
"na1_e":-1.0,
"na1_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"NAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"MOBDabcpp",
"name":"molybdate transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"mobd_c":1.0,
"mobd_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"(HFPHFOGF_00784 and HFPHFOGF_00785 and HFPHFOGF_00783) or (HFPHFOGF_02507 and HFPHFOGF_02508 and HFPHFOGF_02509 and HFPHFOGF_04046) or (HFPHFOGF_02510 and HFPHFOGF_02507 and HFPHFOGF_02508 and HFPHFOGF_02509)",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"MOBDabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"MOBDtex",
"name":"molybdate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"mobd_e":-1.0,
"mobd_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"MOBDtex",
"sbo":"SBO:0000655"
}
},
{
"id":"NI2uabcpp",
"name":"nickel transport via ABC system (uptake, periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ni2_c":1.0,
"ni2_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_03582 and HFPHFOGF_03578 and HFPHFOGF_03581 and HFPHFOGF_03579 and HFPHFOGF_03580) or HFPHFOGF_04391",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"NI2uabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FECRMtonex",
"name":"Ferrichrome transport via ton system (extracellular)",
"metabolites":{
"__Ecoli_panGEMs__fecrm_e":-1.0,
"__Ecoli_panGEMs__fecrm_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_01361 and HFPHFOGF_03120 and HFPHFOGF_03121) and HFPHFOGF_00147",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__FECRMtonex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__ARBTNtonex",
"name":"Aerobactin transport via ton system (extracellular)",
"metabolites":{
"__Ecoli_panGEMs__arbtn_fe3_e":-1.0,
"__Ecoli_panGEMs__arbtn_fe3_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__ARBTNtonex",
"sbo":"SBO:0000655"
}
},
{
"id":"ADOCBLabcpp",
"name":"Adenosylcobalamin transport via ABC system (periplasm)",
"metabolites":{
"adocbl_c":1.0,
"adocbl_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01766 and HFPHFOGF_00155 and HFPHFOGF_01768",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ADOCBLabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_enter_e",
"name":"Enterochelin exchange",
"metabolites":{
"enter_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_enter_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX___Ecoli_panGEMs__fecrm_un_e",
"name":"Ferrichrome minus Fe(III) exchange",
"metabolites":{
"__Ecoli_panGEMs__fecrm_un_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__fecrm_un_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_cgly_e",
"name":"Exchange of L-cysteinylglycine zwitterion.",
"metabolites":{
"cgly_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cgly_e",
"sbo":"SBO:0000627"
}
},
{
"id":"NI2tex",
"name":"nickel transport via diffusion (extracellular to periplasm)",
"metabolites":{
"ni2_e":-1.0,
"ni2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"NI2tex",
"sbo":"SBO:0000655"
}
},
{
"id":"NTD10pp",
"name":"5'-nucleotidase (XMP)",
"metabolites":{
"h2o_p":-1.0,
"pi_p":1.0,
"xmp_p":-1.0,
"xtsn_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04190 or HFPHFOGF_00509",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD10pp",
"rhea":"RHEA:28530",
"sbo":"SBO:0000176"
}
},
{
"id":"NTD1pp",
"name":"5'-nucleotidase (dUMP)",
"metabolites":{
"dump_p":-1.0,
"duri_p":1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00509 or HFPHFOGF_04190",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD1pp",
"rhea":"RHEA:29355",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_chtbs_e",
"name":"Exchange of N,N'-diacetylchitobiose.",
"metabolites":{
"chtbs_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_chtbs_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_gmp_e",
"name":"Exchange of guanosine 5'-monophosphate(2-).",
"metabolites":{
"gmp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_gmp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"NTD2pp",
"name":"5'-nucleotidase (UMP)",
"metabolites":{
"h2o_p":-1.0,
"pi_p":1.0,
"ump_p":-1.0,
"uri_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04190 or HFPHFOGF_00509 or HFPHFOGF_00414",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD2pp",
"rhea":"RHEA:29359",
"sbo":"SBO:0000176"
}
},
{
"id":"NACtex",
"name":"Nicotinic acid transport via diffusion (extracellular to periplasm)",
"metabolites":{
"nac_e":-1.0,
"nac_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"NACtex",
"sbo":"SBO:0000655"
}
},
{
"id":"NTD3pp",
"name":"5'-nucleotidase (dCMP)",
"metabolites":{
"dcmp_p":-1.0,
"dcyt_p":1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00509 or HFPHFOGF_04190",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD3pp",
"rhea":"RHEA:29363",
"sbo":"SBO:0000176"
}
},
{
"id":"NTD4pp",
"name":"5'-nucleotidase (CMP)",
"metabolites":{
"cmp_p":-1.0,
"cytd_p":1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00509 or HFPHFOGF_04190 or HFPHFOGF_00414",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD4pp",
"rhea":"RHEA:29367",
"sbo":"SBO:0000176"
}
},
{
"id":"NTD5pp",
"name":"5'-nucleotidase (dTMP)",
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"dtmp_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0,
"thymd_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04190 or HFPHFOGF_00509",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD5pp",
"rhea":"RHEA:11080",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_h2o2_e",
"name":"Exchange of hydrogen peroxide.",
"metabolites":{
"h2o2_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_h2o2_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_ump_e",
"name":"Exchange of uridine 5'-monophosphate(2-).",
"metabolites":{
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ump_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_pydam_e",
"name":"Exchange of pyridoxaminium(1+).",
"metabolites":{
"pydam_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_pydam_e",
"sbo":"SBO:0000627"
}
},
{
"id":"CRNabcpp",
"name":"L-carnitine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"crn_c":1.0,
"crn_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02771 and HFPHFOGF_02769 and HFPHFOGF_02770",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CRNabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"CRNDabcpp",
"name":"D-carnitine transport via ABC system (periplasm)",
"metabolites":{
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"atp_c":-1.0,
"crn__D_c":1.0,
"crn__D_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02771 and HFPHFOGF_02769 and HFPHFOGF_02770",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CRNDabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"DNTPPA",
"name":"Dihydroneopterin triphosphate pyrophosphatase",
"metabolites":{
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"dhpmp_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
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"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_01926 or HFPHFOGF_00098",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"DNTPPA",
"rhea":"RHEA:25302",
"sbo":"SBO:0000176"
}
},
{
"id":"NTD6pp",
"name":"5'-nucleotidase (dAMP)",
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"damp_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00509 or HFPHFOGF_04190",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD6pp",
"rhea":"RHEA:29371",
"sbo":"SBO:0000176"
}
},
{
"id":"NTD7pp",
"name":"5'-nucleotidase (AMP)",
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"amp_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00509 or HFPHFOGF_04190 or HFPHFOGF_00414",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD7pp",
"rhea":"RHEA:29375",
"sbo":"SBO:0000176"
}
},
{
"id":"CTBTabcpp",
"name":"crotonobetaine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"ctbt_c":1.0,
"ctbt_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02770 and HFPHFOGF_02769 and HFPHFOGF_02771",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CTBTabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"NTD9pp",
"name":"5'-nucleotidase (GMP)",
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"gmp_p":-1.0,
"gsn_p":1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00509 or HFPHFOGF_04190 or HFPHFOGF_00414",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD9pp",
"rhea":"RHEA:27714",
"sbo":"SBO:0000176"
}
},
{
"id":"NH4tex",
"name":"ammonia transport via diffusion (extracellular to periplasm)",
"metabolites":{
"nh4_e":-1.0,
"nh4_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"NH4tex",
"sbo":"SBO:0000655"
}
},
{
"id":"PEAMNOpp",
"name":"Phenethylamine oxidase",
"metabolites":{
"h2o2_p":1.0,
"h2o_p":-1.0,
"nh4_p":1.0,
"o2_p":-1.0,
"pacald_p":1.0,
"peamn_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01472",
"subsystem":"Nitrogen Metabolism",
"annotation":{
"biggr":"PEAMNOpp",
"rhea":"RHEA:25265",
"sbo":"SBO:0000176"
}
},
{
"id":"GAL1PPpp",
"name":"D-galactose 1-phosphatase",
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"gal_p":1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01022",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"GAL1PPpp",
"sbo":"SBO:0000176"
}
},
{
"id":"NTPP9_1",
"name":"Nucleoside triphosphate pyrophosphorylase (itp)",
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"h2o_c":-1.0,
"h_c":1.0,
"imp_c":1.0,
"itp_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03082",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTPP9_1",
"rhea":"RHEA:29399",
"sbo":"SBO:0000176"
}
},
{
"id":"NTPP10",
"name":"Nucleoside triphosphate pyrophosphorylase (ditp)",
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"ditp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03082",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTPP10",
"rhea":"RHEA:28342",
"sbo":"SBO:0000176"
}
},
{
"id":"NTPP11_1",
"name":"Nucleoside triphosphate pyrophosphorylase (xtp)",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0,
"xmp_c":1.0,
"xtp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03082",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTPP11_1",
"rhea":"RHEA:28610",
"sbo":"SBO:0000176"
}
},
{
"id":"H2O2tex",
"name":"hydrogen peroxide transport via diffusion (external)",
"metabolites":{
"h2o2_e":-1.0,
"h2o2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"H2O2tex",
"sbo":"SBO:0000655"
}
},
{
"id":"ARGDCpp",
"name":"arginine decarboxylase",
"metabolites":{
"agm_p":1.0,
"arg__L_p":-1.0,
"co2_p":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03068",
"subsystem":"Arginine and Proline Metabolism",
"annotation":{
"biggr":"ARGDCpp",
"rhea":"RHEA:17641",
"sbo":"SBO:0000176"
}
},
{
"id":"URIH",
"name":"Uridine hydrolase",
"metabolites":{
"h2o_c":-1.0,
"rib__D_c":1.0,
"ura_c":1.0,
"uri_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02247 or HFPHFOGF_00670 or HFPHFOGF_00030",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"URIH",
"rhea":"RHEA:15577",
"sbo":"SBO:0000176"
}
},
{
"id":"ALLPI",
"name":"Allose 6-phosphate isomerase",
"metabolites":{
"all6p_c":-1.0,
"allul6p_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04227",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"ALLPI",
"rhea":"RHEA:28430",
"sbo":"SBO:0000176"
}
},
{
"id":"ALLK",
"name":"Allose kinase",
"metabolites":{
"adp_c":1.0,
"all6p_c":1.0,
"all__D_c":-1.0,
"atp_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04221",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"ALLK",
"rhea":"RHEA:14805",
"sbo":"SBO:0000176"
}
},
{
"id":"ALLULPE",
"name":"Allulose 6-phosphate epimerase",
"metabolites":{
"allul6p_c":-1.0,
"f6p_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04222",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"ALLULPE",
"sbo":"SBO:0000176"
}
},
{
"id":"ADEtex",
"name":"adenine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"ade_e":-1.0,
"ade_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ADEtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ADNtex",
"name":"adenosine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"adn_e":-1.0,
"adn_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00441",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"ADNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"NADPHQR2",
"name":"NADPH Quinone Reductase (Ubiquinone-8)",
"metabolites":{
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"q8_c":-1.0,
"q8h2_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03140",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"NADPHQR2",
"rhea":"RHEA:29111",
"sbo":"SBO:0000176"
}
},
{
"id":"NADPHQR3",
"name":"NADPH Quinone Reductase (Menaquinone-8)",
"metabolites":{
"h_c":-1.0,
"mql8_c":1.0,
"mqn8_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03140",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"NADPHQR3",
"rhea":"RHEA:29115",
"sbo":"SBO:0000176"
}
},
{
"id":"NADPHQR4",
"name":"NADPH Quinone Reductase (2-Demethylmenaquinone-8)",
"metabolites":{
"2dmmq8_c":-1.0,
"2dmmql8_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03140",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"NADPHQR4",
"rhea":"RHEA:30511",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__GLBRAN2",
"name":"1,4-alpha-glucan branching enzyme (glycogen -> bglycogen)",
"metabolites":{
"__Ecoli_panGEMs__bglycogen_c":1.0,
"__Ecoli_panGEMs__glycogen_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03535",
"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__GLBRAN2",
"sbo":"SBO:0000176"
}
},
{
"id":"ASR",
"name":"arsenate reductase",
"metabolites":{
"arsna_c":-1.0,
"aso3_c":1.0,
"gthox_c":1.0,
"gthrd_c":-2.0,
"h2o_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02574",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"ASR:2",
"sbo":"SBO:0000176"
}
},
{
"id":"ASO3tex",
"name":"arsenite transport via diffusion (extracellular to periplasm)",
"metabolites":{
"aso3_e":-1.0,
"aso3_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ASO3tex:2",
"sbo":"SBO:0000655"
}
},
{
"id":"AGMtex",
"name":"agmatine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"agm_e":-1.0,
"agm_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"AGMtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ALAtex",
"name":"L-alanine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"ala__L_e":-1.0,
"ala__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ALAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"BALAtex",
"name":"beta-alanine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"ala_B_e":-1.0,
"ala_B_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"BALAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"DALAtex",
"name":"D-Alanine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"ala__D_e":-1.0,
"ala__D_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DALAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"MANGLYCtex",
"name":"2-O-alpha-mannosyl-D-glycerate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"manglyc_e":-1.0,
"manglyc_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"MANGLYCtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_frulys_e",
"name":"Exchange of fructosyllysine(1+).",
"metabolites":{
"frulys_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_frulys_e",
"sbo":"SBO:0000627"
}
},
{
"id":"AMPtex",
"name":"AMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"amp_e":-1.0,
"amp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"AMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"XTSNH",
"name":"Xanthosine hydrolase",
"metabolites":{
"h2o_c":-1.0,
"rib__D_c":1.0,
"xan_c":1.0,
"xtsn_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00030",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"XTSNH",
"sbo":"SBO:0000176"
}
},
{
"id":"FRUURt2rpp",
"name":"D-fructuronate transport via proton symport, reversible (periplasm)",
"metabolites":{
"fruur_c":1.0,
"fruur_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04467",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"FRUURt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"FRUURtex",
"name":"D-fructuronate transport via diffusion (extracellular)",
"metabolites":{
"fruur_e":-1.0,
"fruur_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"FRUURtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ARBtex",
"name":"L-arabinose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"arab__L_e":-1.0,
"arab__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ARBtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ARGtex",
"name":"L-arginine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"arg__L_e":-1.0,
"arg__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ARGtex",
"sbo":"SBO:0000655"
}
},
{
"id":"INSH",
"name":"Inosine hydrolase",
"metabolites":{
"h2o_c":-1.0,
"hxan_c":1.0,
"ins_c":-1.0,
"rib__D_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00030",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"INSH",
"rhea":"RHEA:16657",
"sbo":"SBO:0000176"
}
},
{
"id":"ASCBtex",
"name":"L-ascorbate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"ascb__L_e":-1.0,
"ascb__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ASCBtex:2",
"sbo":"SBO:0000655"
}
},
{
"id":"FACOAL100t2pp",
"name":"fatty-acid-CoA ligase (decanoate transport via vectoral Co-A coupling)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"dca_p":-1.0,
"dcacoa_c":1.0,
"h_c":1.0,
"h_p":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01864 or HFPHFOGF_01758",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAL100t2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"RIBabcpp",
"name":"D-ribose transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"rib__D_c":1.0,
"rib__D_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_04379 and HFPHFOGF_04377 and HFPHFOGF_04378 and HFPHFOGF_04380) or (HFPHFOGF_03881 and HFPHFOGF_03882 and HFPHFOGF_03880 and HFPHFOGF_03879) or (HFPHFOGF_04225 and HFPHFOGF_04223 and HFPHFOGF_04224)",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"RIBabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ECAtpp",
"name":"enterobacterial common antigen transferase (flippase, cytoplasm to periplasm)",
"metabolites":{
"unagamuf_c":-1.0,
"unagamuf_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03920",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"ECAtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__O16GLCT2",
"name":"Glucosyltransferase II (LPS O16 antigen biosynthesis)",
"metabolites":{
"__Ecoli_panGEMs__gfgaragund_c":-1.0,
"__Ecoli_panGEMs__o16aund_c":1.0,
"h_c":1.0,
"udp_c":1.0,
"udpg_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__O16GLCT2",
"sbo":"SBO:0000176"
}
},
{
"id":"GPDDA3pp",
"name":"Glycerophosphodiester phosphodiesterase (Glycerophosphoserine)",
"metabolites":{
"g3ps_p":-1.0,
"glyc3p_p":1.0,
"h2o_p":-1.0,
"h_p":1.0,
"ser__L_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02325",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"GPDDA3pp",
"rhea":"RHEA:29875",
"sbo":"SBO:0000176"
}
},
{
"id":"GPDDA4pp",
"name":"Glycerophosphodiester phosphodiesterase (Glycerophosphoglycerol)",
"metabolites":{
"g3pg_p":-1.0,
"glyc3p_p":1.0,
"glyc_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02325",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"GPDDA4pp",
"rhea":"RHEA:29907",
"sbo":"SBO:0000176"
}
},
{
"id":"GPDDA2pp",
"name":"Glycerophosphodiester phosphodiesterase (Glycerophosphoethanolamine)",
"metabolites":{
"etha_p":1.0,
"g3pe_p":-1.0,
"glyc3p_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02325",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"GPDDA2pp",
"sbo":"SBO:0000176"
}
},
{
"id":"FACOAL120t2pp",
"name":"fatty-acid-CoA ligase (dodecanoate transport via vectoral Co-A coupling)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"ddca_p":-1.0,
"ddcacoa_c":1.0,
"h_c":1.0,
"h_p":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01758 or HFPHFOGF_01864",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAL120t2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYCAt2rpp",
"name":"D-glycerate transport via proton symport, reversible (periplasm)",
"metabolites":{
"glyc__R_c":1.0,
"glyc__R_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03230 or HFPHFOGF_02894",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLYCAt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYCAtex",
"name":"D-glycerate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"glyc__R_e":-1.0,
"glyc__R_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GLYCAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"FACOAL140t2pp",
"name":"fatty-acid-CoA ligase (tetradecanoate transport via vectoral Co-A coupling)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"h_c":1.0,
"h_p":-1.0,
"ppi_c":1.0,
"tdcoa_c":1.0,
"ttdca_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01758 or HFPHFOGF_01864",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAL140t2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX___Ecoli_panGEMs__enlipa_e",
"name":"Phosphoethanolamine KDO(2)-lipid (A) exchange",
"metabolites":{
"__Ecoli_panGEMs__enlipa_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__enlipa_e",
"sbo":"SBO:0000627"
}
},
{
"id":"BUTtex",
"name":"Butyrate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"but_e":-1.0,
"but_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"BUTtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX___Ecoli_panGEMs__hacolipa_e",
"name":"Hepta-acylated core oligosaccharide lipid A (E. coli) exchange",
"metabolites":{
"__Ecoli_panGEMs__hacolipa_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__hacolipa_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__AGM4PCP",
"name":"N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase",
"metabolites":{
"__Ecoli_panGEMs__anhgm3p_c":1.0,
"__Ecoli_panGEMs__anhgm4p_c":-1.0,
"ala__D_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01295",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGM4PCP",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__4PCP",
"name":"Tetrapeptide L,D-carboxypeptidase",
"metabolites":{
"__Ecoli_panGEMs__LalaDgluMdapDala_c":-1.0,
"__Ecoli_panGEMs__LalaDgluMdap_c":1.0,
"ala__D_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01295",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__4PCP",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FE3HOXtonex",
"name":"Fe(III)hydroxamine transport via ton system (extracellular)",
"metabolites":{
"__Ecoli_panGEMs__fe3hox_e":-1.0,
"__Ecoli_panGEMs__fe3hox_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_01361 and HFPHFOGF_03120 and HFPHFOGF_03121) and HFPHFOGF_00147",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__FE3HOXtonex",
"sbo":"SBO:0000655"
}
},
{
"id":"CU2abcpp",
"name":"Copper (Cu+2) ABC transporter (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"cu2_c":-1.0,
"cu2_p":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03571",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"CU2abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"COBALT2abcpp",
"name":"Cobalt (Co+2) ABC transporter (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"cobalt2_c":-1.0,
"cobalt2_p":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03571",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"COBALT2abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"NI2abcpp",
"name":"Nickle (Ni+2) ABC transporter (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ni2_c":-1.0,
"ni2_p":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03571",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"NI2abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"MG2uabcpp",
"name":"Magnesium (Mg+2) ABC transporter (ubtake, periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"mg2_c":1.0,
"mg2_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04391",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"MG2uabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__4PCPpp",
"name":"Tetrapeptide L,D-carboxypeptidase (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__LalaDgluMdapDala_p":-1.0,
"__Ecoli_panGEMs__LalaDgluMdap_p":1.0,
"ala__D_p":1.0,
"h2o_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02261",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__4PCPpp",
"sbo":"SBO:0000176"
}
},
{
"id":"HCYSMT2",
"name":"Homocysteine Methyltransferase",
"metabolites":{
"h_c":1.0,
"hcys__L_c":-1.0,
"met__L_c":2.0,
"mmet_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04732",
"subsystem":"Methionine Metabolism",
"annotation":{
"biggr":"HCYSMT2",
"rhea":"RHEA:26337",
"sbo":"SBO:0000176"
}
},
{
"id":"FALDH2",
"name":"formaldehyde dehydrogenase",
"metabolites":{
"Sfglutth_c":1.0,
"h_c":1.0,
"hmgth_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00390",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"FALDH2",
"rhea":"RHEA:19985",
"sbo":"SBO:0000176"
}
},
{
"id":"CHLtex",
"name":"choline transport via diffusion (extracellular to periplasm)",
"metabolites":{
"chol_e":-1.0,
"chol_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CHLtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYBabcpp",
"name":"Glycine betaine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"glyb_c":1.0,
"glyb_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_02217 and HFPHFOGF_02215 and HFPHFOGF_02216 and HFPHFOGF_02214) or (HFPHFOGF_02769 and HFPHFOGF_02771 and HFPHFOGF_02770)",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLYBabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYC3Pt6pp",
"name":"Glycerol-3-phosphate : phosphate antiporter (periplasm)",
"metabolites":{
"glyc3p_c":1.0,
"glyc3p_p":-1.0,
"pi_c":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02326",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLYC3Pt6pp",
"sbo":"SBO:0000655"
}
},
{
"id":"MMETtex",
"name":"S-methyl-L-methionine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"mmet_e":-1.0,
"mmet_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"MMETtex",
"sbo":"SBO:0000655"
}
},
{
"id":"FE3tex",
"name":"iron (III) transport via diffusion (extracellular to periplasm)",
"metabolites":{
"fe3_e":-1.0,
"fe3_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"FE3tex",
"sbo":"SBO:0000655"
}
},
{
"id":"MG2tex",
"name":"magnesium (Mg+2) transport via diffusion (extracellular to periplasm)",
"metabolites":{
"mg2_e":-1.0,
"mg2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"MG2tex",
"sbo":"SBO:0000655"
}
},
{
"id":"Zn2tex",
"name":"zinc (Zn+2) transport via diffusion (extracellular to periplasm)",
"metabolites":{
"zn2_e":-1.0,
"zn2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"Zn2tex",
"sbo":"SBO:0000655"
}
},
{
"id":"MMETt2pp",
"name":"S-methylmethionine permease (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"mmet_c":1.0,
"mmet_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04733",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"MMETt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"CD2tex",
"name":"cadmium (Cd+2) transport via diffusion (extracellular to periplasm)",
"metabolites":{
"cd2_e":-1.0,
"cd2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CD2tex",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYCLTt4pp",
"name":"glycolate transport via sodium symport (periplasm)",
"metabolites":{
"glyclt_c":1.0,
"glyclt_p":-1.0,
"na1_c":1.0,
"na1_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04202",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLYCLTt4pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYCtpp",
"name":"glycerol transport via channel (periplasm)",
"metabolites":{
"glyc_c":-1.0,
"glyc_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04056",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLYCtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"H2Otpp",
"name":"H2O transport via diffusion (periplasm)",
"metabolites":{
"h2o_c":1.0,
"h2o_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00895",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"H2Otpp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLNabcpp",
"name":"L-glutamine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"gln__L_c":1.0,
"gln__L_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00831 and HFPHFOGF_00829 and HFPHFOGF_00830",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLNabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"CO2tex",
"name":"CO2 transport via diffusion (extracellular to periplasm)",
"metabolites":{
"co2_e":-1.0,
"co2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CO2tex",
"sbo":"SBO:0000655"
}
},
{
"id":"GLUabcpp",
"name":"L-glutamate transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"glu__L_c":1.0,
"glu__L_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00672 and HFPHFOGF_00674 and HFPHFOGF_00673 and HFPHFOGF_00671",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLUabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLUABUTt7pp",
"name":"4-aminobutyrate/glutamate antiport (periplasm)",
"metabolites":{
"4abut_c":-1.0,
"4abut_p":1.0,
"glu__L_c":1.0,
"glu__L_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01582",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLUABUTt7pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLUt2rpp",
"name":"L-glutamate transport via proton symport, reversible (periplasm)",
"metabolites":{
"glu__L_c":1.0,
"glu__L_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04212",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLUt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"HCINNMt2rpp",
"name":"3-hydroxycinnamic acid transport via proton symport, reversible (periplasm)",
"metabolites":{
"3hcinnm_c":1.0,
"3hcinnm_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00387",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"HCINNMt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"HISabcpp",
"name":"L-histidine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"his__L_c":1.0,
"his__L_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02393 and HFPHFOGF_02392 and HFPHFOGF_02394 and HFPHFOGF_02395",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"HISabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"HISt2rpp",
"name":"L-histidine reversible transport via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"his__L_c":1.0,
"his__L_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00109",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"HISt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"CBIAT",
"name":"Cobinamide adenyltransferase",
"metabolites":{
"adocbi_c":1.0,
"atp_c":-1.0,
"cbi_c":-1.0,
"h_c":-1.0,
"pppi_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01378",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"CBIAT:2",
"sbo":"SBO:0000176"
}
},
{
"id":"GLUt4pp",
"name":"Na+/glutamate symport (periplasm)",
"metabolites":{
"glu__L_c":1.0,
"glu__L_p":-1.0,
"na1_c":1.0,
"na1_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03767",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLUt4pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYALDtpp",
"name":"Glyceraldehyde facilitated diffusion (periplasm)",
"metabolites":{
"glyald_c":1.0,
"glyald_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04056",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLYALDtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"CRNtex",
"name":"L-carnitine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"crn_e":-1.0,
"crn_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CRNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_etha_e",
"name":"Exchange of ethanolaminium(1+).",
"metabolites":{
"etha_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_etha_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ACGK",
"name":"acetylglutamate kinase",
"metabolites":{
"acg5p_c":1.0,
"acglu_c":-1.0,
"adp_c":1.0,
"atp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04087",
"subsystem":"Arginine and Proline Metabolism",
"annotation":{
"biggr":"ACGK",
"rhea":"RHEA:14629",
"sbo":"SBO:0000176"
}
},
{
"id":"LYSabcpp",
"name":"L-lysine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"lys__L_c":1.0,
"lys__L_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02394 and HFPHFOGF_02392 and HFPHFOGF_02396 and HFPHFOGF_02393",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"LYSabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"COBALT2tex",
"name":"cobalt (Co+2) transport via diffusion (extracellular to periplasm)",
"metabolites":{
"cobalt2_e":-1.0,
"cobalt2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"COBALT2tex",
"sbo":"SBO:0000655"
}
},
{
"id":"LCTSt3ipp",
"name":"Lactose transport via proton aniport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"lcts_c":-1.0,
"lcts_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01617 or HFPHFOGF_02255 or HFPHFOGF_00071",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"LCTSt3ipp",
"sbo":"SBO:0000655"
}
},
{
"id":"PPK2",
"name":"polyphosphate kinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"ppi_c":-1.0,
"pppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02580",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"PPK2:2",
"rhea":"RHEA:29423",
"sbo":"SBO:0000176"
}
},
{
"id":"ARBt3ipp",
"name":"L-arabinose transport via proton antiport (periplasm)",
"metabolites":{
"arab__L_c":-1.0,
"arab__L_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01617",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ARBt3ipp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__14GLUCANabcpp",
"name":"1,4-alpha-D-glucan transport via ABC system (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__14glucan_c":1.0,
"__Ecoli_panGEMs__14glucan_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04163 and HFPHFOGF_04165 and HFPHFOGF_04167 and HFPHFOGF_04164",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__14GLUCANabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__14GLUCANtexi",
"name":"1,4-alpha-D-glucan transport via diffusion (extracellular to periplasm) irreversible",
"metabolites":{
"__Ecoli_panGEMs__14glucan_e":-1.0,
"__Ecoli_panGEMs__14glucan_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04168",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__14GLUCANtexi",
"sbo":"SBO:0000655"
}
},
{
"id":"DINStex",
"name":"deoxyinosine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"din_e":-1.0,
"din_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DINStex",
"sbo":"SBO:0000655"
}
},
{
"id":"DHPTPE",
"name":"dihydroneopterin triphosphate 2'-epimerase",
"metabolites":{
"ahdt_c":-1.0,
"dhmptp_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02389",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"DHPTPE",
"rhea":"RHEA:28346",
"sbo":"SBO:0000176"
}
},
{
"id":"PPDOy",
"name":"Propane-1,2-diol:NADP+ 1-oxidoreductase",
"metabolites":{
"12ppd__R_c":1.0,
"h_c":-1.0,
"lald__D_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00359",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"PPDOy",
"sbo":"SBO:0000176"
}
},
{
"id":"NTD12pp",
"name":"5'-nucleotidase (dIMP) (periplasm)",
"metabolites":{
"dimp_p":-1.0,
"din_p":1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00509 or HFPHFOGF_04190",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD12pp",
"rhea":"RHEA:29383",
"sbo":"SBO:0000176"
}
},
{
"id":"PPA2",
"name":"inorganic triphosphatase",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"ppi_c":1.0,
"pppi_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02581 or HFPHFOGF_02844 or HFPHFOGF_03164",
"subsystem":"Anaplerotic Reactions",
"annotation":{
"biggr":"PPA2:2",
"rhea":"RHEA:14157",
"sbo":"SBO:0000176"
}
},
{
"id":"DIMPtex",
"name":"dIMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"dimp_e":-1.0,
"dimp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DIMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_hdca_e",
"name":"Exchange of hexadecanoate.",
"metabolites":{
"hdca_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_hdca_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_glcr_e",
"name":"Exchange of D-glucarate(2-).",
"metabolites":{
"glcr_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_glcr_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GNKr",
"name":"gluconokinase",
"metabolites":{
"6pgc_c":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"glcn_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03539",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"GNKr",
"rhea":"RHEA:19433",
"sbo":"SBO:0000176"
}
},
{
"id":"HMBS",
"name":"hydroxymethylbilane synthase",
"metabolites":{
"h2o_c":-1.0,
"hmbil_c":1.0,
"nh4_c":4.0,
"ppbng_c":-4.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03934",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"HMBS",
"rhea":"RHEA:13185",
"sbo":"SBO:0000176"
}
},
{
"id":"3NTD7pp",
"name":"3'-nucleotidase (AMP) (periplasm)",
"metabolites":{
"3amp_p":-1.0,
"adn_p":1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04364 or HFPHFOGF_00414",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"3NTD7pp",
"rhea":"RHEA:27898",
"sbo":"SBO:0000176"
}
},
{
"id":"DMStex",
"name":"Dimethyl sulfide transport via diffusion (extracellular to periplasm)",
"metabolites":{
"dms_e":-1.0,
"dms_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DMStex",
"sbo":"SBO:0000655"
}
},
{
"id":"3NTD4pp",
"name":"3'-nucleotidase (CMP) (periplasm)",
"metabolites":{
"3cmp_p":-1.0,
"cytd_p":1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04364 or HFPHFOGF_00414 or HFPHFOGF_00414",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"3NTD4pp",
"rhea":"RHEA:27894",
"sbo":"SBO:0000176"
}
},
{
"id":"3NTD2pp",
"name":"3'-nucleotidase (UMP) (periplasm)",
"metabolites":{
"3ump_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0,
"uri_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04364 or HFPHFOGF_00414",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"3NTD2pp",
"rhea":"RHEA:27890",
"sbo":"SBO:0000176"
}
},
{
"id":"3NTD9pp",
"name":"3'-nucleotidase (GMP) (periplasm)",
"metabolites":{
"3gmp_p":-1.0,
"gsn_p":1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04364 or HFPHFOGF_00414",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"3NTD9pp",
"rhea":"RHEA:27862",
"sbo":"SBO:0000176"
}
},
{
"id":"RMK",
"name":"rhamnulokinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"rml1p_c":1.0,
"rml_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04033",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"RMK",
"rhea":"RHEA:20117",
"sbo":"SBO:0000176"
}
},
{
"id":"FHL",
"name":"Formate-hydrogen lyase",
"metabolites":{
"co2_c":1.0,
"for_c":-1.0,
"h2_c":1.0,
"h_c":-1.0
},
"lower_bound":0.0,
"upper_bound":0.0,
"gene_reaction_rule":"(HFPHFOGF_04215 and (HFPHFOGF_02568 and HFPHFOGF_02566 and HFPHFOGF_02564 and HFPHFOGF_02561 and HFPHFOGF_02562 and HFPHFOGF_02565 and HFPHFOGF_02569 and HFPHFOGF_02567 and HFPHFOGF_02563 and HFPHFOGF_02560)) or (HFPHFOGF_04215 and (HFPHFOGF_02816 and HFPHFOGF_02817 and HFPHFOGF_02818 and HFPHFOGF_02814 and HFPHFOGF_02815 and HFPHFOGF_02813))",
"subsystem":"Pyruvate Metabolism",
"annotation":{
"biggr":"FHL",
"rhea":"RHEA:27610",
"sbo":"SBO:0000176"
}
},
{
"id":"HYPOE",
"name":"hypothetical enyme",
"metabolites":{
"h2o_c":-1.0,
"pi_c":1.0,
"pyam5p_c":-1.0,
"pydam_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"HYPOE",
"rhea":"RHEA:25135",
"sbo":"SBO:0000176"
}
},
{
"id":"MEPCT",
"name":"2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase",
"metabolites":{
"2me4p_c":-1.0,
"4c2me_c":1.0,
"ctp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02847",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"MEPCT",
"rhea":"RHEA:13429",
"sbo":"SBO:0000176"
}
},
{
"id":"GLUDy_1",
"name":"glutamate dehydrogenase (NADP)",
"metabolites":{
"akg_c":1.0,
"glu__L_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"nadp_c":-1.0,
"nadph_c":1.0,
"nh4_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01820 or (HFPHFOGF_03314 and HFPHFOGF_03313)",
"subsystem":"Glutamate Metabolism",
"annotation":{
"biggr":"GLUDy_1",
"rhea":"RHEA:11612",
"sbo":"SBO:0000176"
}
},
{
"id":"23PDE7pp",
"name":"2',3'-cyclic-nucleotide phosphodiesterase (AMP) (periplasm)",
"metabolites":{
"23camp_p":-1.0,
"3amp_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04364",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"23PDE7pp",
"rhea":"RHEA:27886",
"sbo":"SBO:0000176"
}
},
{
"id":"GALURt2rpp",
"name":"D-galacturonate transport via proton symport, reversible (periplasm)",
"metabolites":{
"galur_c":1.0,
"galur_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03201",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GALURt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ZN2abcpp",
"name":"Zinc (Zn+2) ABC transporter, efflux (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"zn2_c":-1.0,
"zn2_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03571",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"ZN2abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"CSNtex",
"name":"cytosine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"csn_e":-1.0,
"csn_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CSNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYCLTDy",
"name":"Glycolate dehydrogenase (NADP)",
"metabolites":{
"glx_c":-1.0,
"glyclt_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01051 or HFPHFOGF_03660",
"subsystem":"Glyoxylate Metabolism",
"annotation":{
"biggr":"GLYCLTDy",
"rhea":"RHEA:10992",
"sbo":"SBO:0000176"
}
},
{
"id":"LYSDC",
"name":"lysine decarboxylase",
"metabolites":{
"15dap_c":1.0,
"co2_c":1.0,
"h_c":-1.0,
"lys__L_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00183 or HFPHFOGF_04270",
"subsystem":"Threonine and Lysine Metabolism",
"annotation":{
"biggr":"LYSDC",
"rhea":"RHEA:22352",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__DAAD",
"name":"D-Amino acid dehydrogenase",
"metabolites":{
"__Ecoli_panGEMs__fad_c":-1.0,
"ala__D_c":-1.0,
"fadh2_c":1.0,
"h2o_c":-1.0,
"nh4_c":1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01291",
"subsystem":"Alanine and Aspartate Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__DAAD",
"sbo":"SBO:0000176"
}
},
{
"id":"GLCNt2rpp",
"name":"D-gluconate transport via proton symport, reversible (periplasm)",
"metabolites":{
"glcn_c":1.0,
"glcn_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04467 or HFPHFOGF_03538 or HFPHFOGF_03519",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLCNt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLCptspp",
"name":"D-glucose transport via PEP:Pyr PTS (periplasm)",
"metabolites":{
"g6p_c":1.0,
"glc__D_p":-1.0,
"pep_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_01676 and HFPHFOGF_02501 and HFPHFOGF_02503 and HFPHFOGF_02502) or (HFPHFOGF_01119 and HFPHFOGF_02502 and HFPHFOGF_02501 and HFPHFOGF_02503) or (HFPHFOGF_01879 and HFPHFOGF_02501 and HFPHFOGF_01878 and HFPHFOGF_01877 and HFPHFOGF_02502)",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLCptspp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLCRt2rpp",
"name":"D-glucarate transport via proton symport, reversible (periplasm)",
"metabolites":{
"glcr_c":1.0,
"glcr_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03230 or HFPHFOGF_02894",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLCRt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLCt2pp",
"name":"D-glucose transport in via proton symport (periplasm)",
"metabolites":{
"glc__D_c":1.0,
"glc__D_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03071",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLCt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"UREAtpp",
"name":"Urea transport via facilitate diffusion (periplasm)",
"metabolites":{
"urea_c":1.0,
"urea_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04056",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"UREAtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"XANt2pp",
"name":"xanthine transport in via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"xan_c":1.0,
"xan_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03015 or HFPHFOGF_03768 or HFPHFOGF_03020",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"XANt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYC3Pabcpp",
"name":"sn-Glycerol 3-phosphate transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"glyc3p_c":1.0,
"glyc3p_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03554 and HFPHFOGF_03553 and HFPHFOGF_03555 and HFPHFOGF_03552",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLYC3Pabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"PPPNt2rpp",
"name":"3-phenylpropionate transport via proton symport, reversible (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"pppn_c":1.0,
"pppn_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02619",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PPPNt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"PTRCORNt7pp",
"name":"putrescine/ornithine antiporter (periplasm)",
"metabolites":{
"orn__L_c":-1.0,
"orn__L_p":1.0,
"ptrc_c":1.0,
"ptrc_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00706",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PTRCORNt7pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLCURt2rpp",
"name":"D-glucuronate transport via proton symport, reversible (periplasm)",
"metabolites":{
"glcur_c":1.0,
"glcur_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04038 or HFPHFOGF_03201",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLCURt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__ACMUMptspp",
"name":"N-acetylmuramate transport via PEP:Pyr PTS (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__acmum_p":-1.0,
"acmum6p_c":1.0,
"pep_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02503 and HFPHFOGF_02502 and HFPHFOGF_02501 and HFPHFOGF_02514",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__ACMUMptspp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_h2o_e",
"name":"Exchange of water.",
"metabolites":{
"h2o_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_h2o_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_ala__D_e",
"name":"Exchange of D-alanine zwitterion.",
"metabolites":{
"ala__D_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ala__D_e",
"sbo":"SBO:0000627"
}
},
{
"id":"HSTPT",
"name":"histidinol-phosphate transaminase",
"metabolites":{
"akg_c":1.0,
"glu__L_c":-1.0,
"hisp_c":1.0,
"imacp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02123",
"subsystem":"Histidine Metabolism",
"annotation":{
"biggr":"HSTPT",
"rhea":"RHEA:23744",
"sbo":"SBO:0000176"
}
},
{
"id":"SPMDabcpp",
"name":"spermidine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"spmd_c":1.0,
"spmd_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_01141 and HFPHFOGF_01199 and HFPHFOGF_01142 and HFPHFOGF_01200) or (HFPHFOGF_01529 and HFPHFOGF_01528 and HFPHFOGF_01527 and HFPHFOGF_01526)",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"SPMDabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"CYNTtex",
"name":"Cyanate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"cynt_e":-1.0,
"cynt_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CYNTtex:2",
"sbo":"SBO:0000655"
}
},
{
"id":"HG2tex",
"name":"mercury (Hg+2) transport via diffusion (extracellular to periplasm)",
"metabolites":{
"hg2_e":-1.0,
"hg2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"HG2tex",
"sbo":"SBO:0000655"
}
},
{
"id":"NTPP5",
"name":"Nucleoside triphosphate pyrophosphorylase (datp)",
"metabolites":{
"damp_c":1.0,
"datp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01926 or HFPHFOGF_02886",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTPP5",
"rhea":"RHEA:28334",
"sbo":"SBO:0000176"
}
},
{
"id":"THDPS",
"name":"tetrahydrodipicolinate succinylase",
"metabolites":{
"coa_c":1.0,
"h2o_c":-1.0,
"sl2a6o_c":1.0,
"succoa_c":-1.0,
"thdp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00162",
"subsystem":"Threonine and Lysine Metabolism",
"annotation":{
"biggr":"THDPS",
"rhea":"RHEA:17325",
"sbo":"SBO:0000176"
}
},
{
"id":"ACONMT",
"name":"Trans-aconitate methyltransferase",
"metabolites":{
"acon_T_c":-1.0,
"aconm_c":1.0,
"ahcys_c":1.0,
"amet_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01608",
"subsystem":"Unassigned",
"annotation":{
"biggr":"ACONMT",
"sbo":"SBO:0000176"
}
},
{
"id":"XTSNtex",
"name":"xanthosine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"xtsn_e":-1.0,
"xtsn_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"XTSNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ATPM",
"name":"ATP maintenance requirement",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":6.86,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Biomass and maintenance functions",
"annotation":{
"biggr":"ATPM",
"rhea":"RHEA:13065",
"sbo":"SBO:0000176"
}
},
{
"id":"CYStex",
"name":"L-cysteine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"cys__L_e":-1.0,
"cys__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CYStex",
"sbo":"SBO:0000655"
}
},
{
"id":"NADPPPS",
"name":"NADP phosphatase",
"metabolites":{
"h2o_c":-1.0,
"nad_c":1.0,
"nadp_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"NADPPPS",
"rhea":"RHEA:28050",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_mnl_e",
"name":"Exchange of D-mannitol.",
"metabolites":{
"mnl_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_mnl_e",
"sbo":"SBO:0000627"
}
},
{
"id":"THRD_L",
"name":"L-threonine deaminase",
"metabolites":{
"2obut_c":1.0,
"nh4_c":1.0,
"thr__L_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03901 or HFPHFOGF_03223",
"subsystem":"Valine, Leucine, and Isoleucine Metabolism",
"annotation":{
"biggr":"THRD_L",
"rhea":"RHEA:22108",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_malt_e",
"name":"Exchange of maltose.",
"metabolites":{
"malt_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_malt_e",
"sbo":"SBO:0000627"
}
},
{
"id":"NTD3",
"name":"5'-nucleotidase (dCMP)",
"metabolites":{
"dcmp_c":-1.0,
"dcyt_c":1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02844 or HFPHFOGF_02377",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD3",
"rhea":"RHEA:29363",
"sbo":"SBO:0000176"
}
},
{
"id":"CYTDtex",
"name":"cytidine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"cytd_e":-1.0,
"cytd_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CYTDtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYOX",
"name":"hydroxyacylglutathione hydrolase",
"metabolites":{
"gthrd_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"lac__D_c":1.0,
"lgt__S_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00210",
"subsystem":"Methylglyoxal Metabolism",
"annotation":{
"biggr":"GLYOX",
"rhea":"RHEA:25245",
"sbo":"SBO:0000176"
}
},
{
"id":"DADNtex",
"name":"deoxyadenosine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"dad_2_e":-1.0,
"dad_2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00441",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"DADNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__4PEPTtex",
"name":"LalaDgluMdapDala (pentapeptide) transport via diffusion (extracellular to periplasm)",
"metabolites":{
"__Ecoli_panGEMs__LalaDgluMdapDala_e":-1.0,
"__Ecoli_panGEMs__LalaDgluMdapDala_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"__Ecoli_panGEMs__4PEPTtex",
"sbo":"SBO:0000655"
}
},
{
"id":"NAMNPP",
"name":"nicotinic acid mononucleotide pyrophosphorylase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"nac_c":-1.0,
"nicrnt_c":1.0,
"pi_c":1.0,
"ppi_c":1.0,
"prpp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00952",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"NAMNPP",
"rhea":"RHEA:36163",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_pnto__R_e",
"name":"Exchange of (R)-pantothenate.",
"metabolites":{
"pnto__R_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_pnto__R_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__SELNPS",
"name":"Selenophosphate synthase",
"metabolites":{
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"amp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0,
"seln_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01823",
"subsystem":"Unassigned",
"annotation":{
"biggr":"__Ecoli_panGEMs__SELNPS",
"sbo":"SBO:0000176"
}
},
{
"id":"DHAtex",
"name":"Dihydroxyacetone transport via diffusion (extracellular to periplasm)",
"metabolites":{
"dha_e":-1.0,
"dha_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DHAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ETOHtex",
"name":"ethanol transport via diffusion (extracellular to periplasm)",
"metabolites":{
"etoh_e":-1.0,
"etoh_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ETOHtex",
"sbo":"SBO:0000655"
}
},
{
"id":"MTRPOX",
"name":"N-methyltryptophan oxidase",
"metabolites":{
"Nmtrp_c":-1.0,
"fald_c":1.0,
"h2o2_c":1.0,
"h2o_c":-1.0,
"o2_c":-1.0,
"trp__L_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01076",
"subsystem":"Glycine and Serine Metabolism",
"annotation":{
"biggr":"MTRPOX",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AGM4PCPpp",
"name":"N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase (periplasmic)",
"metabolites":{
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"__Ecoli_panGEMs__anhgm4p_p":-1.0,
"ala__D_p":1.0,
"h2o_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02261",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGM4PCPpp",
"sbo":"SBO:0000176"
}
},
{
"id":"GDTP",
"name":"guanosine-5'-triphosphate,3'-diphosphate diphosphatase",
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"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"ppgpp_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03907",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"GDTP:2",
"rhea":"RHEA:13073",
"sbo":"SBO:0000176"
}
},
{
"id":"CRNCAR",
"name":"carnitine-CoA racemase",
"metabolites":{
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"crncoa_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00037",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"CRNCAR",
"rhea":"RHEA:30539",
"sbo":"SBO:0000176"
}
},
{
"id":"GALabcpp",
"name":"D-galactose transport via ABC system (periplasm)",
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"atp_c":-1.0,
"gal_c":1.0,
"gal_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_02233 and HFPHFOGF_02234 and HFPHFOGF_02235) or (HFPHFOGF_04377 and HFPHFOGF_04379 and HFPHFOGF_04378 and HFPHFOGF_04380)",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GALabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYCLTt2rpp",
"name":"glycolate transport via proton symport, reversible (periplasm)",
"metabolites":{
"glyclt_c":1.0,
"glyclt_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03714",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLYCLTt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"GUAt2pp",
"name":"guanine transport in via proton symport (periplasm)",
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"gua_c":1.0,
"gua_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03768",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GUAt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"HPPPNt2rpp",
"name":"3-(3-hydroxyphenyl)propionate transport via proton symport, reversible (periplasm)",
"metabolites":{
"3hpppn_c":1.0,
"3hpppn_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00387",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"HPPPNt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__RNDR2",
"name":"Ribonucleoside-diphosphate reductase (GDP)",
"metabolites":{
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"__Ecoli_panGEMs__trdrd_c":-1.0,
"dgdp_c":1.0,
"gdp_c":-1.0,
"h2o_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_03909 and (HFPHFOGF_02319 and HFPHFOGF_02320)) or (HFPHFOGF_02665 and (HFPHFOGF_02319 and HFPHFOGF_02320))",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"__Ecoli_panGEMs__RNDR2",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_asn__L_e",
"name":"Exchange of L-asparagine zwitterion.",
"metabolites":{
"asn__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_asn__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ANHMK",
"name":"1,6-anhydrous-N-Acetylmuramate kinase",
"metabolites":{
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"adp_c":1.0,
"anhm_c":-1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01696",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"ANHMK",
"sbo":"SBO:0000176"
}
},
{
"id":"DCAtex",
"name":"Decanoate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"dca_e":-1.0,
"dca_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DCAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"DHFR",
"name":"dihydrofolate reductase",
"metabolites":{
"dhf_c":-1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"thf_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01660 or HFPHFOGF_00049",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"DHFR",
"rhea":"RHEA:15009",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_cit_e",
"name":"Exchange of citrate(3-).",
"metabolites":{
"cit_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cit_e",
"sbo":"SBO:0000627"
}
},
{
"id":"PRAIi",
"name":"phosphoribosylanthranilate isomerase (irreversible)",
"metabolites":{
"2cpr5p_c":1.0,
"pran_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01371",
"subsystem":"Tyrosine, Tryptophan, and Phenylalanine Metabolism",
"annotation":{
"biggr":"PRAIi",
"rhea":"RHEA:21540",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_mal__L_e",
"name":"Exchange of (S)-malate(2-).",
"metabolites":{
"mal__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_mal__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"NMNN",
"name":"NMN nucleosidase",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"ncam_c":1.0,
"nmn_c":-1.0,
"r5p_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"NMNN",
"rhea":"RHEA:23140",
"sbo":"SBO:0000176"
}
},
{
"id":"XAND",
"name":"xanthine dehydrogenase",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"urate_c":1.0,
"xan_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02999 and HFPHFOGF_03000 and HFPHFOGF_03001",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"XAND",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_no2_e",
"name":"Nitrite exchange",
"metabolites":{
"no2_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_no2_e",
"sbo":"SBO:0000627"
}
},
{
"id":"HACD3",
"name":"3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA)",
"metabolites":{
"3hocoa_c":1.0,
"3oocoa_c":-1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03972 or HFPHFOGF_02426",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"HACD3",
"rhea":"RHEA:31195",
"sbo":"SBO:0000176"
}
},
{
"id":"TYRTA",
"name":"tyrosine transaminase",
"metabolites":{
"34hpp_c":1.0,
"akg_c":-1.0,
"glu__L_c":1.0,
"tyr__L_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04188 or HFPHFOGF_00949 or HFPHFOGF_03899",
"subsystem":"Tyrosine, Tryptophan, and Phenylalanine Metabolism",
"annotation":{
"biggr":"TYRTA",
"rhea":"RHEA:15093",
"sbo":"SBO:0000176"
}
},
{
"id":"SHKK",
"name":"shikimate kinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"skm5p_c":1.0,
"skm_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03494 or HFPHFOGF_00419",
"subsystem":"Tyrosine, Tryptophan, and Phenylalanine Metabolism",
"annotation":{
"biggr":"SHKK",
"rhea":"RHEA:13121",
"sbo":"SBO:0000176"
}
},
{
"id":"DCYTtex",
"name":"deoxycytidine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"dcyt_e":-1.0,
"dcyt_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00441",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"DCYTtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_gam_e",
"name":"Exchange of 2-ammonio-2-deoxy-D-glucopyranose.",
"metabolites":{
"gam_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_gam_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ACACtex",
"name":"acetoacetate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"acac_e":-1.0,
"acac_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ACACtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ACNAMtex",
"name":"N-acetylneuraminate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"acnam_e":-1.0,
"acnam_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04463 or HFPHFOGF_00950 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"ACNAMtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__ARBTNabcpp",
"name":"Aerobactin transport via ABC system (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__arbtn_fe3_c":1.0,
"__Ecoli_panGEMs__arbtn_fe3_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
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"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__ARBTNabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_inost_e",
"name":"Exchange of myo-inositol.",
"metabolites":{
"inost_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_inost_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_mobd_e",
"name":"Exchange of molybdate.",
"metabolites":{
"mobd_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_mobd_e",
"sbo":"SBO:0000627"
}
},
{
"id":"NNDMBRT",
"name":"Nicotinate-nucleotide dimethylbenzimidazole phosphoribosyltransferase",
"metabolites":{
"5prdmbz_c":1.0,
"dmbzid_c":-1.0,
"h_c":1.0,
"nac_c":1.0,
"nicrnt_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02074",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"NNDMBRT",
"rhea":"RHEA:11196",
"sbo":"SBO:0000176"
}
},
{
"id":"DGSNtex",
"name":"deoxyguanosine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"dgsn_e":-1.0,
"dgsn_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DGSNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"THRA2",
"name":"L-allo-Threonine Aldolase",
"metabolites":{
"acald_c":1.0,
"athr__L_c":-1.0,
"gly_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02634 or HFPHFOGF_00890",
"subsystem":"Threonine and Lysine Metabolism",
"annotation":{
"biggr":"THRA2",
"rhea":"RHEA:26209",
"sbo":"SBO:0000176"
}
},
{
"id":"ASO3t8pp",
"name":"arsenite efflux via ATP hydrolysis (periplasm)",
"metabolites":{
"adp_c":1.0,
"aso3_c":-1.0,
"aso3_p":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03605",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ASO3t8pp:2",
"sbo":"SBO:0000655"
}
},
{
"id":"H2Stex",
"name":"h2s transport via diffusion (extracellular to periplasm)",
"metabolites":{
"h2s_e":-1.0,
"h2s_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"H2Stex:2",
"sbo":"SBO:0000655"
}
},
{
"id":"PPK",
"name":"polyphosphate kinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"pi_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02580",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"PPK",
"rhea":"RHEA:29431",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_so4_e",
"name":"Exchange of sulfate.",
"metabolites":{
"so4_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_so4_e",
"sbo":"SBO:0000627"
}
},
{
"id":"SADH",
"name":"Succinylarginine dihydrolase",
"metabolites":{
"co2_c":1.0,
"h2o_c":-2.0,
"h_c":-2.0,
"nh4_c":2.0,
"sucarg_c":-1.0,
"sucorn_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01804",
"subsystem":"Arginine and Proline Metabolism",
"annotation":{
"biggr":"SADH",
"rhea":"RHEA:19533",
"sbo":"SBO:0000176"
}
},
{
"id":"GLUSy",
"name":"glutamate synthase (NADPH)",
"metabolites":{
"akg_c":-1.0,
"gln__L_c":-1.0,
"glu__L_c":2.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03314 and HFPHFOGF_03313",
"subsystem":"Glutamate Metabolism",
"annotation":{
"biggr":"GLUSy",
"rhea":"RHEA:15501",
"sbo":"SBO:0000176"
}
},
{
"id":"GUAPRT",
"name":"guanine phosphoribosyltransferase",
"metabolites":{
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"gua_c":-1.0,
"ppi_c":1.0,
"prpp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00122 or HFPHFOGF_00259",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"GUAPRT",
"rhea":"RHEA:25424",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_phe__L_e",
"name":"Exchange of L-phenylalanine zwitterion.",
"metabolites":{
"phe__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_phe__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_thr__L_e",
"name":"Exchange of L-threonine zwitterion.",
"metabolites":{
"thr__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_thr__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_uri_e",
"name":"Exchange of uridine.",
"metabolites":{
"uri_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_uri_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ABUTD",
"name":"Aminobutyraldehyde dehydrogenase",
"metabolites":{
"4abut_c":1.0,
"4abutn_c":-1.0,
"h2o_c":-1.0,
"h_c":2.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01530",
"subsystem":"Arginine and Proline Metabolism",
"annotation":{
"biggr":"ABUTD",
"rhea":"RHEA:19105",
"sbo":"SBO:0000176"
}
},
{
"id":"E4PD",
"name":"Erythrose 4-phosphate dehydrogenase",
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"e4p_c":-1.0,
"h2o_c":-1.0,
"h_c":2.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03058 or HFPHFOGF_01838 or HFPHFOGF_01502",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"E4PD",
"rhea":"RHEA:12056",
"sbo":"SBO:0000176"
}
},
{
"id":"IG3PS",
"name":"Imidazole-glycerol-3-phosphate synthase",
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"eig3p_c":1.0,
"gln__L_c":-1.0,
"glu__L_c":1.0,
"h_c":1.0,
"prlp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02125 and HFPHFOGF_02127",
"subsystem":"Histidine Metabolism",
"annotation":{
"biggr":"IG3PS",
"rhea":"RHEA:24793",
"sbo":"SBO:0000176"
}
},
{
"id":"PDH",
"name":"pyruvate dehydrogenase",
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"co2_c":1.0,
"coa_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"pyr_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00112 and HFPHFOGF_00113 and HFPHFOGF_00111",
"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
"biggr":"PDH",
"rhea":"RHEA:28042",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MTHFR2",
"name":"5,10-methylenetetrahydrofolate reductase (NADH)",
"metabolites":{
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"h_c":-2.0,
"mlthf_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04070",
"subsystem":"Folate Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__MTHFR2",
"sbo":"SBO:0000176"
}
},
{
"id":"DMSOR2pp",
"name":"Dimethyl sulfoxide reductase (Demethylmenaquinol 8) (periplasm)",
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"2dmmql8_c":-1.0,
"dms_p":1.0,
"dmso_p":-1.0,
"h2o_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01933 and HFPHFOGF_01934",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"DMSOR2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_nh4_e",
"name":"Exchange of ammonium.",
"metabolites":{
"nh4_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_nh4_e",
"sbo":"SBO:0000627"
}
},
{
"id":"DADK",
"name":"deoxyadenylate kinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"dadp_c":1.0,
"damp_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00503",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"DADK",
"rhea":"RHEA:23100",
"sbo":"SBO:0000176"
}
},
{
"id":"DUTPDP",
"name":"dUTP diphosphatase",
"metabolites":{
"dump_c":1.0,
"dutp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03750 or HFPHFOGF_02338",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"DUTPDP",
"rhea":"RHEA:10248",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_ddca_e",
"name":"Exchange of dodecanoate.",
"metabolites":{
"ddca_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ddca_e",
"sbo":"SBO:0000627"
}
},
{
"id":"HYD3pp",
"name":"Hydrogenase (Demethylmenaquinone-8: 2 protons) (periplasm)",
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"2dmmql8_c":1.0,
"h2_c":-1.0,
"h_c":-2.0,
"h_p":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00994 and HFPHFOGF_00995 and HFPHFOGF_00993) or (HFPHFOGF_03109 and HFPHFOGF_03112 and HFPHFOGF_03111 and HFPHFOGF_03110)",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"HYD3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__NO3R1pp",
"name":"Nitrate reductase (Ubiquinol-8) (periplasm)",
"metabolites":{
"h2o_c":1.0,
"h_c":-2.0,
"h_p":2.0,
"no2_c":1.0,
"no3_c":-1.0,
"q8_c":1.0,
"q8h2_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_01554 and HFPHFOGF_01556 and HFPHFOGF_01553 and HFPHFOGF_01552) or (HFPHFOGF_01332 and HFPHFOGF_01335 and HFPHFOGF_01334 and HFPHFOGF_01333)",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"__Ecoli_panGEMs__NO3R1pp",
"sbo":"SBO:0000655"
}
},
{
"id":"NTP5",
"name":"nucleoside-triphosphatase (CTP)",
"metabolites":{
"cdp_c":1.0,
"ctp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04302",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTP5",
"rhea":"RHEA:29387",
"sbo":"SBO:0000176"
}
},
{
"id":"CELBpts",
"name":"cellobiose transport via PEP:Pyr PTS",
"metabolites":{
"6pgg_c":1.0,
"cellb_e":-1.0,
"pep_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_02807 and HFPHFOGF_02502 and HFPHFOGF_02501) or (HFPHFOGF_02502 and (HFPHFOGF_01795 and HFPHFOGF_01794 and HFPHFOGF_01793) and HFPHFOGF_02501)",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CELBpts",
"sbo":"SBO:0000655"
}
},
{
"id":"FORt2pp",
"name":"formate transport via proton symport (uptake only, periplasm)",
"metabolites":{
"for_c":1.0,
"for_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00924 or HFPHFOGF_02571",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"FORt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_r5p_e",
"name":"Exchange of D-ribofuranose 5-phosphate(2-).",
"metabolites":{
"r5p_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_r5p_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_glyc2p_e",
"name":"Exchange of glycerol 2-phosphate(2-).",
"metabolites":{
"glyc2p_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_glyc2p_e",
"sbo":"SBO:0000627"
}
},
{
"id":"MTAN",
"name":"methylthioadenosine nucleosidase",
"metabolites":{
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"5mtr_c":1.0,
"ade_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00156",
"subsystem":"Arginine and Proline Metabolism",
"annotation":{
"biggr":"MTAN",
"rhea":"RHEA:13617",
"sbo":"SBO:0000176"
}
},
{
"id":"DPR",
"name":"2-dehydropantoate 2-reductase",
"metabolites":{
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"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"pant__R_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00455 or HFPHFOGF_03903",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"DPR",
"rhea":"RHEA:16233",
"sbo":"SBO:0000176"
}
},
{
"id":"EX___Ecoli_panGEMs__halipa_e",
"name":"Hepta-acylated KDO(2)-lipid (A) exchange",
"metabolites":{
"__Ecoli_panGEMs__halipa_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__halipa_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__AACPS5",
"name":"Acyl-[acyl-carrier-protein] synthetase  (n-C18:1)",
"metabolites":{
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"__Ecoli_panGEMs__octeACP_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"ocdcea_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01112 and HFPHFOGF_02953",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__AACPS5",
"sbo":"SBO:0000176"
}
},
{
"id":"MANptspp",
"name":"D-mannose transport via PEP:Pyr PTS (periplasm)",
"metabolites":{
"man6p_c":1.0,
"man_p":-1.0,
"pep_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01879 and HFPHFOGF_01878 and HFPHFOGF_01877 and HFPHFOGF_02502 and HFPHFOGF_02501",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"MANptspp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_cmp_e",
"name":"Exchange of cytidine 5'-monophosphate(2-).",
"metabolites":{
"cmp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cmp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"NTD8",
"name":"5'-nucleotidase (dGMP)",
"metabolites":{
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"dgsn_c":1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02844 or HFPHFOGF_02377 or HFPHFOGF_03503",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD8",
"rhea":"RHEA:29379",
"sbo":"SBO:0000176"
}
},
{
"id":"GALCTD",
"name":"galactarate dehydratase",
"metabolites":{
"5dh4dglc_c":1.0,
"galct__D_c":-1.0,
"h2o_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03231",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"GALCTD",
"rhea":"RHEA:16005",
"sbo":"SBO:0000176"
}
},
{
"id":"EX___Ecoli_panGEMs__malthx_e",
"name":"Maltohexaose exchange",
"metabolites":{
"__Ecoli_panGEMs__malthx_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__malthx_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__MLTG4",
"name":"Maltodextrin glucosidase (maltohexaose)",
"metabolites":{
"__Ecoli_panGEMs__malthx_c":-1.0,
"__Ecoli_panGEMs__maltpt_c":1.0,
"glc__D_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00433",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__MLTG4",
"sbo":"SBO:0000176"
}
},
{
"id":"UDPGDC",
"name":"UDP-glucuronate C-4'' decarboxylase",
"metabolites":{
"co2_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"udpLa4o_c":1.0,
"udpglcur_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02342",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"UDPGDC",
"rhea":"RHEA:24702",
"sbo":"SBO:0000176"
}
},
{
"id":"PUNP4",
"name":"purine-nucleoside phosphorylase (Deoxyguanosine)",
"metabolites":{
"2dr1p_c":1.0,
"dgsn_c":-1.0,
"gua_c":1.0,
"pi_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02492 or HFPHFOGF_04523",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"PUNP4",
"rhea":"RHEA:27738",
"sbo":"SBO:0000176"
}
},
{
"id":"AMAOTr",
"name":"adenosylmethionine-8-amino-7-oxononanoate transaminase",
"metabolites":{
"8aonn_c":-1.0,
"amet_c":-1.0,
"amob_c":1.0,
"dann_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00794",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"AMAOTr",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_csn_e",
"name":"Exchange of cytosine.",
"metabolites":{
"csn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_csn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_etoh_e",
"name":"Exchange of ethanol.",
"metabolites":{
"etoh_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_etoh_e",
"sbo":"SBO:0000627"
}
},
{
"id":"G6PP",
"name":"glucose-6-phosphate phosphatase",
"metabolites":{
"g6p_c":-1.0,
"glc__D_c":1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00842 or HFPHFOGF_03954 or HFPHFOGF_02379",
"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
"biggr":"G6PP",
"rhea":"RHEA:16689",
"sbo":"SBO:0000176"
}
},
{
"id":"MMCD",
"name":"Methylmalonyl-CoA decarboxylase",
"metabolites":{
"co2_c":1.0,
"h_c":-1.0,
"mmcoa__S_c":-1.0,
"ppcoa_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03050",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"MMCD",
"rhea":"RHEA:61340",
"sbo":"SBO:0000176"
}
},
{
"id":"GLNS",
"name":"glutamine synthetase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"gln__L_c":1.0,
"glu__L_c":-1.0,
"h_c":1.0,
"nh4_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03996",
"subsystem":"Glutamate Metabolism",
"annotation":{
"biggr":"GLNS",
"rhea":"RHEA:16169",
"sbo":"SBO:0000176"
}
},
{
"id":"TYMtex",
"name":"tyramine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"tym_e":-1.0,
"tym_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"TYMtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GTHS",
"name":"glutathione synthetase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"glucys_c":-1.0,
"gly_c":-1.0,
"gthrd_c":1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03075",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"GTHS",
"rhea":"RHEA:13557",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_g3pe_e",
"name":"sn-Glycero-3-phosphoethanolamine exchange",
"metabolites":{
"g3pe_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_g3pe_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_pacald_e",
"name":"Exchange of phenylacetaldehyde.",
"metabolites":{
"pacald_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_pacald_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_his__L_e",
"name":"Exchange of L-histidine zwitterion.",
"metabolites":{
"his__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_his__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_k_e",
"name":"Exchange of potassium(1+).",
"metabolites":{
"k_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_k_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_na1_e",
"name":"Exchange of sodium(1+).",
"metabolites":{
"na1_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_na1_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ACACT1r",
"name":"acetyl-CoA C-acetyltransferase",
"metabolites":{
"aacoa_c":1.0,
"accoa_c":-2.0,
"coa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02310 or HFPHFOGF_02427 or HFPHFOGF_03971",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"ACACT1r",
"rhea":"RHEA:21036",
"sbo":"SBO:0000176"
}
},
{
"id":"ARGORNt7pp",
"name":"arginine/ornithine antiporter (periplasm)",
"metabolites":{
"arg__L_c":1.0,
"arg__L_p":-1.0,
"orn__L_c":-1.0,
"orn__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01659",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ARGORNt7pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_dmso_e",
"name":"Exchange of dimethyl sulfoxide.",
"metabolites":{
"dmso_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_dmso_e",
"sbo":"SBO:0000627"
}
},
{
"id":"CMPtex",
"name":"CMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"cmp_e":-1.0,
"cmp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"DUMPtex",
"name":"dUMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"dump_e":-1.0,
"dump_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DUMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"XMPtex",
"name":"XMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"xmp_e":-1.0,
"xmp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"XMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__3PEPTtex",
"name":"LalaDgluMdap (tripeptide) transport via diffusion (extracellular to periplasm)",
"metabolites":{
"__Ecoli_panGEMs__LalaDgluMdap_e":-1.0,
"__Ecoli_panGEMs__LalaDgluMdap_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"__Ecoli_panGEMs__3PEPTtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_12ppd__S_e",
"name":"Exchange of (S)-propane-1,2-diol.",
"metabolites":{
"12ppd__S_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_12ppd__S_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_pppn_e",
"name":"Exchange of 3-phenylpropionate.",
"metabolites":{
"pppn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_pppn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__ANHGMtex",
"name":"GlcNAc-anhMurNAc transport via diffusion (extracellular to periplasm)",
"metabolites":{
"__Ecoli_panGEMs__anhgm_e":-1.0,
"__Ecoli_panGEMs__anhgm_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"__Ecoli_panGEMs__ANHGMtex",
"sbo":"SBO:0000655"
}
},
{
"id":"MALTptspp",
"name":"maltose transport via PEP:Pyr PTS (periplasm)",
"metabolites":{
"malt6p_c":1.0,
"malt_p":-1.0,
"pep_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01676 and HFPHFOGF_02503 and HFPHFOGF_02501 and HFPHFOGF_02502",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"MALTptspp",
"sbo":"SBO:0000655"
}
},
{
"id":"UDPKAAT",
"name":"UDP-4''-ketopentose:UDP-4-amino-4-deoxy-L-arabinose aminotransferase",
"metabolites":{
"akg_c":1.0,
"glu__L_c":-1.0,
"udpLa4n_c":1.0,
"udpLa4o_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02340",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"UDPKAAT",
"rhea":"RHEA:24710",
"sbo":"SBO:0000176"
}
},
{
"id":"ULA4NFT",
"name":"UDP-L-Ara4N formyltransferase",
"metabolites":{
"10fthf_c":-1.0,
"h_c":1.0,
"thf_c":1.0,
"udpLa4fn_c":1.0,
"udpLa4n_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02342",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"ULA4NFT",
"rhea":"RHEA:24706",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_acgam1p_e",
"name":"Exchange of N-acetyl-alpha-D-glucosamine 1-phosphate(2-).",
"metabolites":{
"acgam1p_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_acgam1p_e",
"sbo":"SBO:0000627"
}
},
{
"id":"NTD11pp",
"name":"5'-nucleotidase (IMP)",
"metabolites":{
"h2o_p":-1.0,
"imp_p":-1.0,
"ins_p":1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00509 or HFPHFOGF_04190",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD11pp",
"rhea":"RHEA:27718",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_galt_e",
"name":"Exchange of galactitol.",
"metabolites":{
"galt_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_galt_e",
"sbo":"SBO:0000627"
}
},
{
"id":"DKGLCNR2x",
"name":"2,5-diketo-D-gluconate reductase (NADH)",
"metabolites":{
"25dkglcn_c":-1.0,
"5dglcn_c":1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03660",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"DKGLCNR2x",
"rhea":"RHEA:30103",
"sbo":"SBO:0000176"
}
},
{
"id":"ACGS",
"name":"N-acetylglutamate synthase",
"metabolites":{
"accoa_c":-1.0,
"acglu_c":1.0,
"coa_c":1.0,
"glu__L_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02934",
"subsystem":"Arginine and Proline Metabolism",
"annotation":{
"biggr":"ACGS",
"rhea":"RHEA:24292",
"sbo":"SBO:0000176"
}
},
{
"id":"PDE1",
"name":"3',5'-cyclic-nucleotide phosphodiesterase",
"metabolites":{
"amp_c":1.0,
"camp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01579 or HFPHFOGF_03144",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"PDE1",
"rhea":"RHEA:25277",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__UPLA4FNT",
"name":"Undecaprenyl phosphate-L-Ara4FN transferase",
"metabolites":{
"__Ecoli_panGEMs__uLa4fn_c":1.0,
"udcpp_c":-1.0,
"udpLa4fn_c":-1.0,
"udp_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02341",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__UPLA4FNT",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__UPLA4FNF",
"name":"Undecaprenyl phosphate-L-Ara4FN formylase",
"metabolites":{
"__Ecoli_panGEMs__uLa4fn_c":-1.0,
"__Ecoli_panGEMs__uLa4n_c":1.0,
"for_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02343",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__UPLA4FNF",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ULA4Ntppi",
"name":"Transport (cytoplasm to periplasm)",
"metabolites":{
"__Ecoli_panGEMs__uLa4n_c":-1.0,
"__Ecoli_panGEMs__uLa4n_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02346 and HFPHFOGF_02345",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__ULA4Ntppi",
"sbo":"SBO:0000655"
}
},
{
"id":"HEPT1",
"name":"heptosyltransferase I (LPS core synthesis)",
"metabolites":{
"adp_c":1.0,
"adphep_LD_c":-1.0,
"h_c":1.0,
"hlipa_c":1.0,
"lipa_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03731",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"HEPT1",
"rhea":"RHEA:28402",
"sbo":"SBO:0000176"
}
},
{
"id":"FALDtex",
"name":"formaldehyde transport via diffusion (extracellular to periplasm)",
"metabolites":{
"fald_e":-1.0,
"fald_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"FALDtex",
"sbo":"SBO:0000655"
}
},
{
"id":"MCITD",
"name":"2-methylcitrate dehydratase",
"metabolites":{
"2mcacn_c":1.0,
"2mcit_c":-1.0,
"h2o_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00368",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"MCITD",
"rhea":"RHEA:57496",
"sbo":"SBO:0000176"
}
},
{
"id":"CU2tex",
"name":"copper (Cu+2) transport via diffusion (extracellular to periplasm)",
"metabolites":{
"cu2_e":-1.0,
"cu2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CU2tex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_glcur1p_e",
"name":"Exchange of 1-phosphonato-alpha-D-glucuronate(3-).",
"metabolites":{
"glcur1p_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_glcur1p_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GLCATr",
"name":"D-glucose O-acetyltransferase",
"metabolites":{
"accoa_c":-1.0,
"acglc__D_c":1.0,
"coa_c":1.0,
"glc__D_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00488",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"GLCATr",
"sbo":"SBO:0000176"
}
},
{
"id":"ALR2",
"name":"aldose reductase (methylglyoxal)",
"metabolites":{
"acetol_c":1.0,
"h_c":-1.0,
"mthgxl_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03126 or HFPHFOGF_00205 or HFPHFOGF_01840 or HFPHFOGF_03117",
"subsystem":"Methylglyoxal Metabolism",
"annotation":{
"biggr":"ALR2",
"rhea":"RHEA:27986",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AMALT2",
"name":"Amylomaltase (maltotetraose)",
"metabolites":{
"__Ecoli_panGEMs__maltpt_c":1.0,
"__Ecoli_panGEMs__maltttr_c":-1.0,
"glc__D_c":1.0,
"malt_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03520",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__AMALT2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MLTP1",
"name":"Maltodextrin phosphorylase (maltopentaose)",
"metabolites":{
"__Ecoli_panGEMs__maltpt_c":-1.0,
"__Ecoli_panGEMs__maltttr_c":1.0,
"g1p_c":1.0,
"pi_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03521",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__MLTP1",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__HEPT2",
"name":"Heptosyltransferase II (LPS core synthesis)",
"metabolites":{
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"adp_c":1.0,
"adphep_LD_c":-1.0,
"h_c":1.0,
"hlipa_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03730",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__HEPT2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FECRMUtex",
"name":"Ferrichrome (minus Fe) secretion (to extracellular)",
"metabolites":{
"__Ecoli_panGEMs__fecrm_un_e":1.0,
"__Ecoli_panGEMs__fecrm_un_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FECRMUtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ALAALAr",
"name":"D-alanine-D-alanine ligase (reversible)",
"metabolites":{
"adp_c":1.0,
"ala__D_c":-2.0,
"alaala_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00412 or HFPHFOGF_00091",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"ALAALAr",
"rhea":"RHEA:11224",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_thrp_e",
"name":"Exchange of O-phosphonato-L-threonine(2-).",
"metabolites":{
"thrp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_thrp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"CLtex",
"name":"chloride (Cl-1) transport via diffusion (extracellular to periplasm)",
"metabolites":{
"cl_e":-1.0,
"cl_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CLtex:2",
"sbo":"SBO:0000655"
}
},
{
"id":"CYSDtex",
"name":"D-cysteine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"cys__D_e":-1.0,
"cys__D_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CYSDtex",
"sbo":"SBO:0000655"
}
},
{
"id":"CYSDabcpp",
"name":"D-cysteine uptake via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"cys__D_c":1.0,
"cys__D_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CYSDabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"HXAND",
"name":"hypoxanthine dehydrogenase",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"hxan_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"xan_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02999 and HFPHFOGF_03000 and HFPHFOGF_03001",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"HXAND",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_fald_e",
"name":"Exchange of formaldehyde.",
"metabolites":{
"fald_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_fald_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_pydxn_e",
"name":"Exchange of pyridoxine.",
"metabolites":{
"pydxn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_pydxn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_acgal_e",
"name":"Exchange of N-acetyl-alpha-D-galactosamine.",
"metabolites":{
"acgal_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_acgal_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_so2_e",
"name":"sulfur dioxide exchange",
"metabolites":{
"so2_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_so2_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_dms_e",
"name":"Exchange of dimethyl sulfide.",
"metabolites":{
"dms_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_dms_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GMPtex",
"name":"GMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"gmp_e":-1.0,
"gmp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"IMPtex",
"name":"IMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"imp_e":-1.0,
"imp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"IMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"G3PItex",
"name":"glycero-3-phospho-1-inositol transport via diffusion (extracellular to periplasm)",
"metabolites":{
"g3pi_e":-1.0,
"g3pi_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"G3PItex",
"sbo":"SBO:0000655"
}
},
{
"id":"CD2abcpp",
"name":"Cadmium (Cd+2) ABC transporter (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"cd2_c":-1.0,
"cd2_p":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03571",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"CD2abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"G3PGtex",
"name":"glycerophoglycerol transport via diffusion (extracellular to periplasm)",
"metabolites":{
"g3pg_e":-1.0,
"g3pg_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"G3PGtex",
"sbo":"SBO:0000655"
}
},
{
"id":"G3PEtex",
"name":"glycero-3-phosphoethanolamine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"g3pe_e":-1.0,
"g3pe_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"G3PEtex",
"sbo":"SBO:0000655"
}
},
{
"id":"G3PCtex",
"name":"glycero-3-phosphocholine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"g3pc_e":-1.0,
"g3pc_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"G3PCtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__MOAT3C",
"name":"3-deoxy-D-manno-octulosonic acid transferase III (LPS core biosynthesis)",
"metabolites":{
"__Ecoli_panGEMs__kphphhlipa_c":1.0,
"__Ecoli_panGEMs__phphhlipa_c":-1.0,
"ckdo_c":-1.0,
"cmp_c":1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03734",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__MOAT3C",
"sbo":"SBO:0000176"
}
},
{
"id":"UMPtex",
"name":"UMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"ump_e":-1.0,
"ump_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"UMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"G1Ptex",
"name":"D-glucose 1-phosphate transport via diffusion",
"metabolites":{
"g1p_e":-1.0,
"g1p_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"G1Ptex",
"sbo":"SBO:0000655"
}
},
{
"id":"ADNK1",
"name":"adenosine kinase",
"metabolites":{
"adn_c":-1.0,
"adp_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00503",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"ADNK1",
"rhea":"RHEA:20824",
"sbo":"SBO:0000176"
}
},
{
"id":"CUt3",
"name":"copper transport out via proton antiport",
"metabolites":{
"cu_c":-1.0,
"cu_e":1.0,
"h_c":1.0,
"h_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00570 and HFPHFOGF_00572 and HFPHFOGF_00571 and HFPHFOGF_00573",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"CUt3",
"sbo":"SBO:0000655"
}
},
{
"id":"ZN2t3pp",
"name":"zinc (Zn+2) transport out via proton antiport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"zn2_c":-1.0,
"zn2_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04043 or HFPHFOGF_00772",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"ZN2t3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"SKMtex",
"name":"shikimate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"skm_e":-1.0,
"skm_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"SKMtex",
"sbo":"SBO:0000655"
}
},
{
"id":"MNt2pp",
"name":"manganese (Mn+2) transport in via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"mn2_c":1.0,
"mn2_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02478",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"MNt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLCabcpp",
"name":"D-glucose transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"glc__D_c":1.0,
"glc__D_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02234 and HFPHFOGF_02233 and HFPHFOGF_02235",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLCabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__GALT1",
"name":"Galactosyltransferase I (LPS core synthesis)",
"metabolites":{
"__Ecoli_panGEMs__gagicolipa_c":1.0,
"__Ecoli_panGEMs__gicolipa_c":-1.0,
"h_c":1.0,
"udp_c":1.0,
"udpg_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03738",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__GALT1",
"sbo":"SBO:0000176"
}
},
{
"id":"MNtex",
"name":"Manganese (Mn+2) transport via diffusion (extracellular to periplasm)",
"metabolites":{
"mn2_e":-1.0,
"mn2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"MNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GAL1Ptex",
"name":"D-galactose 1-phosphate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"gal1p_e":-1.0,
"gal1p_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GAL1Ptex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__GLCTR2",
"name":"Glucosyltransferase II (LPS core synthesis)",
"metabolites":{
"__Ecoli_panGEMs__gagicolipa_c":-1.0,
"__Ecoli_panGEMs__ggagicolipa_c":1.0,
"h_c":1.0,
"udp_c":1.0,
"udpg_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03737",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__GLCTR2",
"sbo":"SBO:0000176"
}
},
{
"id":"G2PPpp",
"name":"glycerol 2-phosphate phosphatase (periplasmic)",
"metabolites":{
"glyc2p_p":-1.0,
"glyc_p":1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04190 or HFPHFOGF_00414",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"G2PPpp",
"rhea":"RHEA:13105",
"sbo":"SBO:0000176"
}
},
{
"id":"UDPGPpp",
"name":"UDPglucose pyrophosphohydrolase",
"metabolites":{
"g1p_p":1.0,
"h2o_p":-1.0,
"h_p":2.0,
"udpg_p":-1.0,
"ump_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00509",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"UDPGPpp",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_acgal1p_e",
"name":"Exchange of N-acetyl-alpha-D-galactosamine 1-phosphate(2-).",
"metabolites":{
"acgal1p_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_acgal1p_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_cyan_e",
"name":"Exchange of hydrogen cyanide.",
"metabolites":{
"cyan_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cyan_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_tyrp_e",
"name":"Phosphotyrosine exchange",
"metabolites":{
"tyrp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_tyrp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"O2Stex",
"name":"superoxide anion transport via diffusion (extracellular to periplasm)",
"metabolites":{
"o2s_e":-1.0,
"o2s_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"O2Stex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__HEPK1",
"name":"LPS heptose kinase I (LPS core synthesis)",
"metabolites":{
"__Ecoli_panGEMs__hhlipa_c":-1.0,
"__Ecoli_panGEMs__phhlipa_c":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03740",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__HEPK1",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__HEPT3",
"name":"Heptosyltransferase III (LPS core synthesis)",
"metabolites":{
"__Ecoli_panGEMs__hphhlipa_c":1.0,
"__Ecoli_panGEMs__phhlipa_c":-1.0,
"adp_c":1.0,
"adphep_LD_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03742",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__HEPT3",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__HEPK2",
"name":"LPS heptose kinase II (LPS core synthesis)",
"metabolites":{
"__Ecoli_panGEMs__hphhlipa_c":-1.0,
"__Ecoli_panGEMs__phphhlipa_c":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03735",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__HEPK2",
"sbo":"SBO:0000176"
}
},
{
"id":"ALDD3y",
"name":"aldehyde dehydrogenase (propanal, NADP)",
"metabolites":{
"h2o_c":-1.0,
"h_c":2.0,
"nadp_c":-1.0,
"nadph_c":1.0,
"ppal_c":-1.0,
"prpnte_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03698 or HFPHFOGF_04411 or HFPHFOGF_03125",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"ALDD3y",
"rhea":"RHEA:27918",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_uacgam_e",
"name":"Exchange of UDP-N-acetyl-alpha-D-glucosamine(2-).",
"metabolites":{
"uacgam_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_uacgam_e",
"sbo":"SBO:0000627"
}
},
{
"id":"Kt3pp",
"name":"potassium transport out via proton antiport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"k_c":-1.0,
"k_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03455 or HFPHFOGF_00048 or HFPHFOGF_01323 or HFPHFOGF_00862",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"Kt3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_udpacgal_e",
"name":"Exchange of UDP-N-acetyl-alpha-D-galactosamine(2-).",
"metabolites":{
"udpacgal_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_udpacgal_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_udpg_e",
"name":"Exchange of UDP-alpha-D-glucose(2-).",
"metabolites":{
"udpg_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_udpg_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_udpgal_e",
"name":"Exchange of UDP-alpha-D-galactose(2-).",
"metabolites":{
"udpgal_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_udpgal_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_udpglcur_e",
"name":"Exchange of UDP-alpha-D-glucuronate(3-).",
"metabolites":{
"udpglcur_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_udpglcur_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX___Ecoli_panGEMs__14glucan_e",
"name":"1,4-alpha-D-glucan exchange",
"metabolites":{
"__Ecoli_panGEMs__14glucan_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__14glucan_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_pser_e",
"name":"Exchange of O-phosphonato-L-serine(2-).",
"metabolites":{
"pser_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_pser_e",
"sbo":"SBO:0000627"
}
},
{
"id":"R5PP",
"name":"ribose 5-phosphate phosphatase",
"metabolites":{
"h2o_c":-1.0,
"pi_c":1.0,
"r5p_c":-1.0,
"rib__D_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00842 or HFPHFOGF_02781 or HFPHFOGF_00689 or HFPHFOGF_02379 or HFPHFOGF_03825",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"R5PP",
"rhea":"RHEA:29471",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_xmp_e",
"name":"Exchange of 5'-xanthylate(2-).",
"metabolites":{
"xmp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_xmp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_damp_e",
"name":"Exchange of 2'-deoxyadenosine 5'-monophosphate(2-).",
"metabolites":{
"damp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_damp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"CYSSADS",
"name":"L-cysteine sulfinic acid desulfurase",
"metabolites":{
"3sala_c":-1.0,
"ala__L_c":1.0,
"h_c":-2.0,
"so2_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02919 or HFPHFOGF_01737",
"subsystem":"Cysteine Metabolism",
"annotation":{
"biggr":"CYSSADS:2",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_dimp_e",
"name":"Exchange of 2'-deoxyinosine 5'-phosphate(2-).",
"metabolites":{
"dimp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_dimp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"CPPPGO2",
"name":"Oxygen Independent coproporphyrinogen-III oxidase",
"metabolites":{
"amet_c":-2.0,
"co2_c":2.0,
"cpppg3_c":-1.0,
"dad_5_c":2.0,
"met__L_c":2.0,
"pppg9_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03992",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"CPPPGO2",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_isetac_e",
"name":"Exchange of isethionate.",
"metabolites":{
"isetac_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_isetac_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__AGM3PH",
"name":"N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide beta -1,4-N-acetylglucosaminidase",
"metabolites":{
"__Ecoli_panGEMs__anhgm3p_c":-1.0,
"__Ecoli_panGEMs__anhm3p_c":1.0,
"acgam_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01125",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGM3PH",
"sbo":"SBO:0000176"
}
},
{
"id":"HOMt2pp",
"name":"L-homoserineserine efflux via proton symport",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"hom__L_c":-1.0,
"hom__L_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00833 or HFPHFOGF_03952",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"HOMt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_aso3_e",
"name":"arsenite exchange",
"metabolites":{
"aso3_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_aso3_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_tcynt_e",
"name":"Exchange of thiocyanate.",
"metabolites":{
"tcynt_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_tcynt_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX___Ecoli_panGEMs__fe3dhbzs_e",
"name":"Ferric 2,3-dihydroxybenzoylserine exchange",
"metabolites":{
"__Ecoli_panGEMs__fe3dhbzs_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__fe3dhbzs_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__AGM3PApp",
"name":"N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide amidase (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__LalaDgluMdap_p":1.0,
"__Ecoli_panGEMs__anhgm3p_p":-1.0,
"__Ecoli_panGEMs__anhgm_p":1.0,
"h2o_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04310 or HFPHFOGF_02521 or HFPHFOGF_02933 or HFPHFOGF_00887",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGM3PApp",
"sbo":"SBO:0000176"
}
},
{
"id":"PPPGO",
"name":"protoporphyrinogen oxidase (aerobic)",
"metabolites":{
"h2o_c":3.0,
"o2_c":-1.5,
"ppp9_c":1.0,
"pppg9_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03976",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"PPPGO",
"sbo":"SBO:0000176"
}
},
{
"id":"EX___Ecoli_panGEMs__feoxam_un_e",
"name":"Ferroxamine minus Fe(3) exchange",
"metabolites":{
"__Ecoli_panGEMs__feoxam_un_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__feoxam_un_e",
"sbo":"SBO:0000627"
}
},
{
"id":"HOMtex",
"name":"L-homoserine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"hom__L_e":-1.0,
"hom__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"HOMtex",
"sbo":"SBO:0000655"
}
},
{
"id":"SO2tex",
"name":"SO2 transport via diffusion (extracellular to periplasm)",
"metabolites":{
"so2_e":-1.0,
"so2_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"SO2tex",
"sbo":"SBO:0000655"
}
},
{
"id":"LDH_D2",
"name":"D-lactate dehydrogenase",
"metabolites":{
"lac__D_c":-1.0,
"pyr_c":1.0,
"q8_c":-1.0,
"q8h2_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02219",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"LDH_D2",
"rhea":"RHEA:29079",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_g3pc_e",
"name":"Exchange of choline alfoscerate.",
"metabolites":{
"g3pc_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_g3pc_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_g3pg_e",
"name":"Exchange of sn-glycero-3-phosphoglycerol(1-).",
"metabolites":{
"g3pg_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_g3pg_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_g3pi_e",
"name":"Exchange of 1-(sn-glycero-3-O-phosphonato)-1D-myo-inositol.",
"metabolites":{
"g3pi_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_g3pi_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__SHCHF",
"name":"Sirohydrochlorin ferrochelatase",
"metabolites":{
"__Ecoli_panGEMs__scl_c":-1.0,
"fe2_c":-1.0,
"h_c":3.0,
"sheme_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03473",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__SHCHF",
"sbo":"SBO:0000176"
}
},
{
"id":"SUCOAS",
"name":"succinyl-CoA synthetase (ADP-forming)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"pi_c":1.0,
"succ_c":-1.0,
"succoa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00748 and HFPHFOGF_00747",
"subsystem":"Citric Acid Cycle",
"annotation":{
"biggr":"SUCOAS",
"rhea":"RHEA:17661",
"sbo":"SBO:0000176"
}
},
{
"id":"SUCBZL",
"name":"o-succinylbenzoate-CoA ligase",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"ppi_c":1.0,
"sbzcoa_c":1.0,
"sucbz_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02348",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"SUCBZL",
"rhea":"RHEA:17009",
"sbo":"SBO:0000176"
}
},
{
"id":"CYSDDS",
"name":"D-cysteine desulfhydrase",
"metabolites":{
"cys__D_c":-1.0,
"h2o_c":-1.0,
"h2s_c":1.0,
"nh4_c":1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01994",
"subsystem":"Cysteine Metabolism",
"annotation":{
"biggr":"CYSDDS:2",
"rhea":"RHEA:11268",
"sbo":"SBO:0000176"
}
},
{
"id":"CYStpp",
"name":"L-cysteine export via facilitated transport",
"metabolites":{
"cys__L_c":-1.0,
"cys__L_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02661 or HFPHFOGF_01622",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CYStpp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_g3ps_e",
"name":"Exchange of sn-glycero-3-phosphoserine(1-).",
"metabolites":{
"g3ps_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_g3ps_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_peamn_e",
"name":"Exchange of 2-phenylethanaminium.",
"metabolites":{
"peamn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_peamn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_34dhpac_e",
"name":"Exchange of 3,4-dihydroxyphenylacetaldehyde.",
"metabolites":{
"34dhpac_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_34dhpac_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ATPM:2",
"name":"ATP maintenance requirement",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00669 or HFPHFOGF_04302",
"subsystem":"Biomass and maintenance functions",
"annotation":{
"biggr":"ATPM",
"rhea":"RHEA:13065",
"sbo":"SBO:0000176"
}
},
{
"id":"DAMPtex",
"name":"dAMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"damp_e":-1.0,
"damp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DAMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"DCMPtex",
"name":"dCMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"dcmp_e":-1.0,
"dcmp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DCMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"DGMPtex",
"name":"dGMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"dgmp_e":-1.0,
"dgmp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DGMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"DTMPtex",
"name":"dTMP transport via diffusion (extracellular to periplasm)",
"metabolites":{
"dtmp_e":-1.0,
"dtmp_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"DTMPtex",
"sbo":"SBO:0000655"
}
},
{
"id":"ACSERtpp",
"name":"O-Acetyl-L-serine export via facilitated transport",
"metabolites":{
"acser_c":-1.0,
"acser_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02661 or HFPHFOGF_01622",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ACSERtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ACSERtex",
"name":"O-Acetyl-L-serine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"acser_e":-1.0,
"acser_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ACSERtex",
"sbo":"SBO:0000655"
}
},
{
"id":"LALDO3",
"name":"L-Lactaldehyde:NADP+ 1-oxidoreductase",
"metabolites":{
"h_c":-1.0,
"lald__L_c":1.0,
"mthgxl_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Methylglyoxal Metabolism",
"annotation":{
"biggr":"LALDO3",
"rhea":"RHEA:21748",
"sbo":"SBO:0000176"
}
},
{
"id":"NTP10",
"name":"nucleoside-triphosphatase (ITP)",
"metabolites":{
"h2o_c":-1.0,
"h_c":1.0,
"idp_c":1.0,
"itp_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04302 or HFPHFOGF_04534",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTP10",
"rhea":"RHEA:28330",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PRAIS",
"name":"Phosphoribosylaminoimidazole synthase",
"metabolites":{
"__Ecoli_panGEMs__air_c":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"fpram_c":-1.0,
"h_c":2.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02578",
"subsystem":"Purine and Pyrimidine Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__PRAIS",
"sbo":"SBO:0000176"
}
},
{
"id":"GPDDA4",
"name":"Glycerophosphodiester phosphodiesterase (Glycerophosphoglycerol)",
"metabolites":{
"g3pg_c":-1.0,
"glyc3p_c":1.0,
"glyc_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03551",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"GPDDA4",
"rhea":"RHEA:29907",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2ATG120",
"name":"Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C12:0)",
"metabolites":{
"__Ecoli_panGEMs__2agpg120_c":-1.0,
"__Ecoli_panGEMs__apg120_c":1.0,
"__Ecoli_panGEMs__pg120_c":-1.0,
"g3pg_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2ATG120",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1E140pp",
"name":"Phospholipase A1 (phosphatidylethanolamine, n-C14:0) (periplasm)",
"metabolites":{
"2agpe140_p":1.0,
"__Ecoli_panGEMs__pe140_p":-1.0,
"h2o_p":-1.0,
"h_p":1.0,
"ttdca_p":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA1E140pp",
"sbo":"SBO:0000176"
}
},
{
"id":"LPLIPAL2E140",
"name":"Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C14:0)",
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"g3pe_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ttdca_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"LPLIPAL2E140",
"sbo":"SBO:0000176"
}
},
{
"id":"PLIPA1E160pp",
"name":"Phospholipase A1 (phosphatidylethanolamine, n-C16:0) (periplasm)",
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"h2o_p":-1.0,
"h_p":1.0,
"hdca_p":1.0,
"pe160_p":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"PLIPA1E160pp",
"sbo":"SBO:0000176"
}
},
{
"id":"GALKr",
"name":"galactokinase",
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"adp_c":1.0,
"atp_c":-1.0,
"gal1p_c":1.0,
"gal_c":-1.0,
"h_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00777",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"GALKr",
"rhea":"RHEA:13553",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1E161pp",
"name":"Phospholipase A1 (phosphatidylethanolamine, n-C16:1) (periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__pe161_p":-1.0,
"h2o_p":-1.0,
"h_p":1.0,
"hdcea_p":1.0
},
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"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA1E161pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AACPS8",
"name":"Acyl-[acyl-carrier-protein] synthetase  (n-C10:0)",
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"__Ecoli_panGEMs__dcaACP_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"dca_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_01112 and HFPHFOGF_02953",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__AACPS8",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AACPS9",
"name":"Acyl-[acyl-carrier-protein] synthetase  (n-C8:0)",
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"__Ecoli_panGEMs__ocACP_c":1.0,
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"octa_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
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"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__AACPS9",
"sbo":"SBO:0000176"
}
},
{
"id":"LPLIPAL2E180",
"name":"Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C18:0)",
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"h2o_c":-1.0,
"h_c":1.0,
"ocdca_c":1.0
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"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"LPLIPAL2E180",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2G161",
"name":"Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C16:1)",
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"h_c":1.0,
"hdcea_c":1.0
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"lower_bound":0.0,
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2G161",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2G181",
"name":"Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C18:1)",
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"h_c":1.0,
"ocdcea_c":1.0
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"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2G181",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__2AGPE120tipp",
"name":"2-Acyl-sn-glycero-3-phosphoethanolamine (n-C12:0) transporter via facilitated diffusion (periplasm)",
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"__Ecoli_panGEMs__2agpe120_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02952",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__2AGPE120tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"HXCT",
"name":"Acetyl-CoA:hexanoate-CoA transferase",
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"accoa_c":-1.0,
"hxa_c":-1.0,
"hxcoa_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02308 and HFPHFOGF_02307",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AACPS6",
"name":"Acyl-[acyl-carrier-protein] synthetase  (n-C18:0)",
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"__Ecoli_panGEMs__ocdcaACP_c":1.0,
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"ppi_c":1.0
},
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"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__AACPS6",
"sbo":"SBO:0000176"
}
},
{
"id":"2AGPEAT160",
"name":"2-acyl-glycerophospho-ethanolamine acyltransferase (n-C16:0)",
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"atp_c":-1.0,
"hdca_c":-1.0,
"pe160_c":1.0,
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"subsystem":"Glycerophospholipid Metabolism",
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"biggr":"2AGPEAT160",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AACPS7",
"name":"Acyl-[acyl-carrier-protein] synthetase  (n-C12:0)",
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"__Ecoli_panGEMs__ddcaACP_c":1.0,
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"atp_c":-1.0,
"ddca_c":-1.0,
"ppi_c":1.0
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"lower_bound":0.0,
"upper_bound":1000.0,
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"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__AACPS7",
"sbo":"SBO:0000176"
}
},
{
"id":"PANTS",
"name":"pantothenate synthase",
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"amp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"pant__R_c":-1.0,
"pnto__R_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00130",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"PANTS",
"rhea":"RHEA:10912",
"sbo":"SBO:0000176"
}
},
{
"id":"G3PGabcpp",
"name":"sn-glycerol-3-phosphoglycerol transport via ABC system (periplasm)",
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"atp_c":-1.0,
"g3pg_c":1.0,
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"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"G3PGabcpp",
"sbo":"SBO:0000655"
}
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{
"id":"G3PIabcpp",
"name":"sn-glycerol-3-phosphoethanolamine transport via ABC system (periplasm)",
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"atp_c":-1.0,
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"subsystem":"Transport, Inner Membrane",
"annotation":{
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"sbo":"SBO:0000655"
}
},
{
"id":"DURADx",
"name":"dihydrouracil dehydrogenase (NAD)",
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"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"ura_c":1.0
},
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"gene_reaction_rule":"HFPHFOGF_02232 and HFPHFOGF_02231",
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"rhea":"RHEA:20189",
"sbo":"SBO:0000176"
}
},
{
"id":"ECOAH7",
"name":"3-hydroxyacyl-CoA dehydratase (3-hydroxyhexadecanoyl-CoA)",
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"h2o_c":1.0,
"hdd2coa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02426 or HFPHFOGF_03972",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"ECOAH7",
"rhea":"RHEA:31163",
"sbo":"SBO:0000176"
}
},
{
"id":"G1PPpp",
"name":"Glucose-1-phosphatase",
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"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_01022 or HFPHFOGF_00414",
"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
"biggr":"G1PPpp",
"sbo":"SBO:0000176"
}
},
{
"id":"GALCTND",
"name":"galactonate dehydratase",
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"h2o_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03820",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"GALCTND",
"rhea":"RHEA:18649",
"sbo":"SBO:0000176"
}
},
{
"id":"GCALDD",
"name":"Glycolaldehyde dehydrogenase",
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"glyclt_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"nad_c":-1.0,
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_01500",
"subsystem":"Folate Metabolism",
"annotation":{
"biggr":"GCALDD",
"sbo":"SBO:0000176"
}
},
{
"id":"HISTP_1",
"name":"histidinol-phosphatase",
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"histd_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02124",
"subsystem":"Histidine Metabolism",
"annotation":{
"biggr":"HISTP_1",
"rhea":"RHEA:14465",
"sbo":"SBO:0000176"
}
},
{
"id":"G3PSabcpp",
"name":"sn-glycerol-3-phosphoserine transport via ABC system (periplasm)",
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"atp_c":-1.0,
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"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"G3PSabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"QMO2",
"name":"quinol monooxygenase (Ubiquinol-8)",
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"o2_c":-2.0,
"o2s_c":2.0,
"q8_c":1.0,
"q8h2_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03141",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"QMO2",
"rhea":"RHEA:29175",
"sbo":"SBO:0000176"
}
},
{
"id":"QMO3",
"name":"quinol monooxygenase (menaquinol 8)",
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"mql8_c":-1.0,
"mqn8_c":1.0,
"o2_c":-2.0,
"o2s_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03141",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"QMO3",
"rhea":"RHEA:29183",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2E141",
"name":"Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C14:1)",
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"h2o_c":-1.0,
"h_c":1.0,
"ttdcea_c":1.0
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"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2E141",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2E161",
"name":"Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C16:1)",
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"h_c":1.0,
"hdcea_c":1.0
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"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2E161",
"sbo":"SBO:0000176"
}
},
{
"id":"LDH_D",
"name":"D-lactate dehydrogenase",
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"lac__D_c":-1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"pyr_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01466",
"subsystem":"Pyruvate Metabolism",
"annotation":{
"biggr":"LDH_D",
"rhea":"RHEA:16369",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AMALT4",
"name":"Amylomaltase (maltohexaose)",
"metabolites":{
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"__Ecoli_panGEMs__malthx_c":-1.0,
"glc__D_c":1.0,
"malt_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03520",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__AMALT4",
"sbo":"SBO:0000176"
}
},
{
"id":"NTD11",
"name":"5'-nucleotidase (IMP)",
"metabolites":{
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"imp_c":-1.0,
"ins_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02844 or HFPHFOGF_03503",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTD11",
"rhea":"RHEA:27718",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2E181",
"name":"Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C18:1)",
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"h2o_c":-1.0,
"h_c":1.0,
"ocdcea_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2E181",
"sbo":"SBO:0000176"
}
},
{
"id":"YUMPS",
"name":"yUMP synthetase",
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"psd5p_c":1.0,
"r5p_c":-1.0,
"ura_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02250",
"subsystem":"Purine and Pyrimidine Biosynthesis",
"annotation":{
"biggr":"YUMPS",
"rhea":"RHEA:18337",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2G180",
"name":"Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C18:0)",
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"h_c":1.0,
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"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2G180",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2G141",
"name":"Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C14:1)",
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"h2o_c":-1.0,
"h_c":1.0,
"ttdcea_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2G141",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__2AGPA120tipp",
"name":"2-Acyl-sn-glycero-3-phosphatidate (n-C12:0) transporter via facilitated diffusion (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2ddecg3p_c":1.0,
"__Ecoli_panGEMs__2ddecg3p_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02952",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__2AGPA120tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__2AGPG180tipp",
"name":"2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0) transporter via facilitated diffusion (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpg180_c":1.0,
"__Ecoli_panGEMs__2agpg180_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02952",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__2AGPG180tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"IPDDI",
"name":"isopentenyl-diphosphate D-isomerase",
"metabolites":{
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"ipdp_c":-1.0
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"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
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"biggr":"IPDDI",
"rhea":"RHEA:23284",
"sbo":"SBO:0000176"
}
},
{
"id":"ORNDC",
"name":"Ornithine Decarboxylase",
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"h_c":-1.0,
"orn__L_c":-1.0,
"ptrc_c":1.0
},
"lower_bound":0.0,
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"biggr":"ORNDC",
"rhea":"RHEA:22964",
"sbo":"SBO:0000176"
}
},
{
"id":"UPP3MT",
"name":"uroporphyrinogen methyltransferase",
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"h_c":1.0,
"pre2_c":1.0,
"uppg3_c":-1.0
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__KAS15",
"name":"Beta-ketoacyl-ACP synthase (2)",
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"biggr":"__Ecoli_panGEMs__KAS15",
"sbo":"SBO:0000176"
}
},
{
"id":"ALAALAtex",
"name":"D-alanyl-D-alanine (DalaDala) transport via diffusion (extracellular to periplasm)",
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"alaala_p":1.0
},
"lower_bound":-1000.0,
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"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
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"biggr":"ALAALAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"FACOAL181t2pp",
"name":"fatty-acid-CoA ligase (octadecenoate transport via vectoral Co-A coupling)",
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"atp_c":-1.0,
"coa_c":-1.0,
"h_c":1.0,
"h_p":-1.0,
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"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__T2DECAI",
"name":"Trans-2-decenoyl-ACP isomerase",
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"__Ecoli_panGEMs__tdec2eACP_c":-1.0
},
"lower_bound":-1000.0,
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"biggr":"__Ecoli_panGEMs__T2DECAI",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__2AGPGAT180",
"name":"2-acyl-glycerophospho-glycerol acyltransferase (n-C18:0)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__2AGPGAT181",
"name":"2-acyl-glycerophospho-glycerol acyltransferase (n-C18:1)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAS161",
"name":"3-oxoacyl-[acyl-carrier-protein] synthase (n-C16:1)",
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"h_c":-1.0
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"sbo":"SBO:0000176"
}
},
{
"id":"DHQS",
"name":"3-dehydroquinate synthase",
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"3dhq_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03493",
"subsystem":"Tyrosine, Tryptophan, and Phenylalanine Metabolism",
"annotation":{
"biggr":"DHQS",
"rhea":"RHEA:21968",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR141y",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C14:1)",
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"__Ecoli_panGEMs__tdeACP_c":1.0,
"h_c":-1.0,
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"nadph_c":-1.0
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"biggr":"__Ecoli_panGEMs__EAR141y",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR161x",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C16:1)",
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"h_c":-1.0,
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__2AGPG141tipp",
"name":"2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1) transporter via facilitated diffusion (periplasm)",
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},
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}
},
{
"id":"__Ecoli_panGEMs__2AGPG161tipp",
"name":"2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1) transporter via facilitated diffusion (periplasm)",
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{
"id":"__Ecoli_panGEMs__2AGPG181tipp",
"name":"2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1) transporter via facilitated diffusion (periplasm)",
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}
},
{
"id":"__Ecoli_panGEMs__2AGPEAT140",
"name":"2-acyl-glycerophospho-ethanolamine acyltransferase (n-C14:0)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__2AGPEAT120",
"name":"2-acyl-glycerophospho-ethanolamine acyltransferase (n-C12:0)",
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"sbo":"SBO:0000176"
}
},
{
"id":"DASYN160",
"name":"CDP-diacylglycerol synthetase (n-C16:0)",
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{
"id":"__Ecoli_panGEMs__DASYN161",
"name":"CDP-diacylglycerol synthetase (n-C16:1)",
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{
"id":"__Ecoli_panGEMs__DASYN181",
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{
"id":"__Ecoli_panGEMs__CDAPPA161",
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{
"id":"__Ecoli_panGEMs__2AGPEAT161",
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{
"id":"__Ecoli_panGEMs__2AGPEAT141",
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{
"id":"__Ecoli_panGEMs__2AGPGAT160",
"name":"2-acyl-glycerophospho-glycerol acyltransferase (n-C16:0)",
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},
{
"id":"__Ecoli_panGEMs__PGSA180",
"name":"Phosphatidylglycerol synthase (n-C18:0)",
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{
"id":"PGCD",
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}
},
{
"id":"__Ecoli_panGEMs__PSSA140",
"name":"Phosphatidylserine syntase (n-C14:0)",
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}
},
{
"id":"__Ecoli_panGEMs__2AGPGAT141",
"name":"2-acyl-glycerophospho-glycerol acyltransferase (n-C14:1)",
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"sbo":"SBO:0000176"
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{
"id":"FACOAE180",
"name":"fatty-acid-CoA thioesterase (octadecanoate)",
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"rhea":"RHEA:30139",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2ATG140",
"name":"Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C14:0)",
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"sbo":"SBO:0000176"
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},
{
"id":"__Ecoli_panGEMs__LPLIPAL2ATG141",
"name":"Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C14:1)",
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2ATG160",
"name":"Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C16:0)",
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2ATG180",
"name":"Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C18:0)",
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"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2ATG161",
"name":"Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C16:1)",
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"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2ATG181",
"name":"Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C18:1)",
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"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"FACOAE100",
"name":"fatty-acid-CoA thioesterase (decanoate)",
"metabolites":{
"coa_c":1.0,
"dca_c":1.0,
"dcacoa_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00482",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAE100",
"rhea":"RHEA:40059",
"sbo":"SBO:0000176"
}
},
{
"id":"FACOAE80",
"name":"fatty-acid-CoA thioesterase (octanoate)",
"metabolites":{
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"octa_c":1.0,
"octcoa_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00482",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAE80",
"rhea":"RHEA:30143",
"sbo":"SBO:0000176"
}
},
{
"id":"FACOAE60",
"name":"fatty-acid-CoA thioesterase (hexanoate)",
"metabolites":{
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"hxa_c":1.0,
"hxcoa_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00482",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAE60",
"rhea":"RHEA:40115",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CLPNS180pp",
"name":"Cardiolipin synthase (periplasmic, n-C18:0)",
"metabolites":{
"__Ecoli_panGEMs__clpn180_p":1.0,
"__Ecoli_panGEMs__pg180_p":-2.0,
"glyc_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01357 or HFPHFOGF_00809",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CLPNS180pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1E120pp",
"name":"Phospholipase A1 (phosphatidylethanolamine, n-C12:0) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpe120_p":1.0,
"__Ecoli_panGEMs__pe120_p":-1.0,
"ddca_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA1E120pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CLPNS181pp",
"name":"Cardiolipin synthase (periplasmic, n-C18:1)",
"metabolites":{
"__Ecoli_panGEMs__clpn181_p":1.0,
"__Ecoli_panGEMs__pg181_p":-2.0,
"glyc_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01357 or HFPHFOGF_00809",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CLPNS181pp",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_cys__L_e",
"name":"Exchange of L-cysteine zwitterion.",
"metabolites":{
"cys__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cys__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__PG161abcpp",
"name":"Phosphatidylglycerol transport via ABC system (n-C16:1, periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__pg161_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PG161abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PGP120abcpp",
"name":"Phosphatidylglycerophosphate transport via ABC system (n-C12:0, periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__pgp120_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGP120abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"MALtex",
"name":"Malate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"mal__L_e":-1.0,
"mal__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"MALtex",
"sbo":"SBO:0000655"
}
},
{
"id":"NO3tex",
"name":"nitrate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"no3_e":-1.0,
"no3_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"NO3tex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__3OAS141",
"name":"3-oxoacyl-[acyl-carrier-protein] synthase (n-C14:1)",
"metabolites":{
"__Ecoli_panGEMs__3ocmrs7eACP_c":1.0,
"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__cddec5eACP_c":-1.0,
"__Ecoli_panGEMs__malACP_c":-1.0,
"co2_c":1.0,
"h_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02409",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__3OAS141",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAR121",
"name":"3-oxoacyl-[acyl-carrier-protein] reductase (n-C12:1)",
"metabolites":{
"__Ecoli_panGEMs__3hcddec5eACP_c":1.0,
"__Ecoli_panGEMs__3ocddec5eACP_c":-1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01111",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__3OAR121",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CFAS160G",
"name":"Cyclopropane fatty acid synthase (Phosphatidylglycerol, n-C16:0)",
"metabolites":{
"__Ecoli_panGEMs__cpg160_c":1.0,
"__Ecoli_panGEMs__pg161_c":-1.0,
"ahcys_c":2.0,
"amet_c":-2.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01718",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CFAS160G",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PGP161abcpp",
"name":"Phosphatidylglycerophosphate transport via ABC system (n-C16:1, periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__pgp161_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGP161abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PGP181abcpp",
"name":"Phosphatidylglycerophosphate transport via ABC system (n-C18:1, periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__pgp181_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGP181abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PA120abcpp",
"name":"Phosphatidate transport via ABC system (n-C12:0, periplasm)",
"metabolites":{
"__Ecoli_panGEMs__pa120_c":-1.0,
"__Ecoli_panGEMs__pa120_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PA120abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1G120pp",
"name":"Phospholipase A1 (phosphatidylglycerol, n-C12:0) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpg120_p":1.0,
"__Ecoli_panGEMs__pg120_p":-1.0,
"ddca_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA1G120pp",
"sbo":"SBO:0000176"
}
},
{
"id":"URAt2pp",
"name":"uracil transport in via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"ura_c":1.0,
"ura_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02576 or HFPHFOGF_01026",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"URAt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"FACOAE141",
"name":"fatty-acid-CoA thioesterase (tetradecenoate)",
"metabolites":{
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"tdecoa_c":-1.0,
"ttdcea_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00482",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAE141",
"rhea":"RHEA:40135",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CLPNS120pp",
"name":"Cardiolipin synthase (periplasmic, n-C12:0)",
"metabolites":{
"__Ecoli_panGEMs__clpn120_p":1.0,
"__Ecoli_panGEMs__pg120_p":-2.0,
"glyc_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00809 or HFPHFOGF_01357",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CLPNS120pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ALPATE160pp",
"name":"Apolipoprotein N-acyltransferase (phosphatidylethanolamine, periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__alpp_p":-1.0,
"__Ecoli_panGEMs__lpp_p":1.0,
"pe160_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01734 and HFPHFOGF_00675",
"subsystem":"Unassigned",
"annotation":{
"biggr":"__Ecoli_panGEMs__ALPATE160pp",
"sbo":"SBO:0000176"
}
},
{
"id":"FACOAE161",
"name":"fatty-acid-CoA thioesterase (hexadecenoate)",
"metabolites":{
"coa_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"hdcea_c":1.0,
"hdcoa_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00482",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAE161",
"rhea":"RHEA:40131",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_gsn_e",
"name":"Exchange of guanosine.",
"metabolites":{
"gsn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_gsn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"TTDCEAtexi",
"name":"Tetradecenoate transport via facilitated irreversible diffusion (extracellular to periplasm)",
"metabolites":{
"ttdcea_e":-1.0,
"ttdcea_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02429",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"TTDCEAtexi",
"sbo":"SBO:0000655"
}
},
{
"id":"HDCEAtexi",
"name":"Hexadecenoate transport via facilitated irreversible diffusion (extracellular to periplasm)",
"metabolites":{
"hdcea_e":-1.0,
"hdcea_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02429",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"HDCEAtexi",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__ALPATG160pp",
"name":"Apolipoprotein N-acyltransferase (phosphatidylglycerol, periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpg160_p":1.0,
"__Ecoli_panGEMs__alpp_p":-1.0,
"__Ecoli_panGEMs__lpp_p":1.0,
"__Ecoli_panGEMs__pg160_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01734 and HFPHFOGF_00675",
"subsystem":"Unassigned",
"annotation":{
"biggr":"__Ecoli_panGEMs__ALPATG160pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__2AGPGAT120",
"name":"2-acyl-glycerophospho-glycerol acyltransferase (n-C12:0)",
"metabolites":{
"__Ecoli_panGEMs__2agpg120_c":-1.0,
"__Ecoli_panGEMs__pg120_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"ddca_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__2AGPGAT120",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2ATE120",
"name":"Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C12:0)",
"metabolites":{
"__Ecoli_panGEMs__2agpe120_c":-1.0,
"__Ecoli_panGEMs__apg120_c":1.0,
"__Ecoli_panGEMs__pg120_c":-1.0,
"g3pe_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2ATE120",
"sbo":"SBO:0000176"
}
},
{
"id":"ALAALAD",
"name":"D-alanine-D-alanine dipeptidase",
"metabolites":{
"ala__D_c":2.0,
"alaala_c":-1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01578",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"ALAALAD",
"rhea":"RHEA:20661",
"sbo":"SBO:0000176"
}
},
{
"id":"2AGPEAT180",
"name":"2-acyl-glycerophospho-ethanolamine acyltransferase (n-C18:0)",
"metabolites":{
"2agpe180_c":-1.0,
"amp_c":1.0,
"atp_c":-1.0,
"ocdca_c":-1.0,
"pe180_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"2AGPEAT180",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2ATE140",
"name":"Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C14:0)",
"metabolites":{
"2agpe140_c":-1.0,
"__Ecoli_panGEMs__apg140_c":1.0,
"__Ecoli_panGEMs__pg140_c":-1.0,
"g3pe_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2ATE140",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_orot_e",
"name":"Exchange of orotate.",
"metabolites":{
"orot_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_orot_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2ATE160",
"name":"Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C16:0)",
"metabolites":{
"2agpe160_c":-1.0,
"__Ecoli_panGEMs__apg160_c":1.0,
"__Ecoli_panGEMs__pg160_c":-1.0,
"g3pe_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2ATE160",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2ATE180",
"name":"Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C18:0)",
"metabolites":{
"2agpe180_c":-1.0,
"__Ecoli_panGEMs__apg180_c":1.0,
"__Ecoli_panGEMs__pg180_c":-1.0,
"g3pe_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2ATE180",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2ATE141",
"name":"Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C14:1)",
"metabolites":{
"__Ecoli_panGEMs__2agpe141_c":-1.0,
"__Ecoli_panGEMs__apg141_c":1.0,
"__Ecoli_panGEMs__pg141_c":-1.0,
"g3pe_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2ATE141",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__2AGPEAT181",
"name":"2-acyl-glycerophospho-ethanolamine acyltransferase (n-C18:1)",
"metabolites":{
"__Ecoli_panGEMs__2agpe181_c":-1.0,
"__Ecoli_panGEMs__pe181_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"ocdcea_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__2AGPEAT181",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__2AGPGAT140",
"name":"2-acyl-glycerophospho-glycerol acyltransferase (n-C14:0)",
"metabolites":{
"__Ecoli_panGEMs__2agpg140_c":-1.0,
"__Ecoli_panGEMs__pg140_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"ppi_c":1.0,
"ttdca_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__2AGPGAT140",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1E181pp",
"name":"Phospholipase A1 (phosphatidylethanolamine, n-C18:1) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpe181_p":1.0,
"__Ecoli_panGEMs__pe181_p":-1.0,
"h2o_p":-1.0,
"h_p":1.0,
"ocdcea_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA1E181pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1G180pp",
"name":"Phospholipase A1 (phosphatidylglycerol, n-C18:0) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpg180_p":1.0,
"__Ecoli_panGEMs__pg180_p":-1.0,
"h2o_p":-1.0,
"h_p":1.0,
"ocdca_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA1G180pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2ATE161",
"name":"Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C16:1)",
"metabolites":{
"__Ecoli_panGEMs__2agpe161_c":-1.0,
"__Ecoli_panGEMs__apg161_c":1.0,
"__Ecoli_panGEMs__pg161_c":-1.0,
"g3pe_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2ATE161",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2ATE181",
"name":"Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C18:1)",
"metabolites":{
"__Ecoli_panGEMs__2agpe181_c":-1.0,
"__Ecoli_panGEMs__apg181_c":1.0,
"__Ecoli_panGEMs__pg181_c":-1.0,
"g3pe_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2ATE181",
"sbo":"SBO:0000176"
}
},
{
"id":"FACOAL141t2pp",
"name":"fatty-acid-CoA ligase (tetradecenoate transport via vectoral Co-A coupling)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"h_c":1.0,
"h_p":-1.0,
"ppi_c":1.0,
"tdecoa_c":1.0,
"ttdcea_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01758 or HFPHFOGF_01864",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAL141t2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"FACOAL161t2pp",
"name":"fatty-acid-CoA ligase (hexadecenoate transport via vectoral Co-A coupling)",
"metabolites":{
"amp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"h_c":1.0,
"h_p":-1.0,
"hdcea_p":-1.0,
"hdcoa_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01864 or HFPHFOGF_01758",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"FACOAL161t2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"PA160abcpp",
"name":"phosphatidate transport via ABC system (n-C16:0, periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pa160_c":-1.0,
"pa160_p":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PA160abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1G181pp",
"name":"Phospholipase A1 (phosphatidylglycerol, n-C18:1) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpg181_p":1.0,
"__Ecoli_panGEMs__pg181_p":-1.0,
"h2o_p":-1.0,
"h_p":1.0,
"ocdcea_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA1G181pp",
"sbo":"SBO:0000176"
}
},
{
"id":"ALAALAabcpp",
"name":"D-alanyl-D-alanine (DalaDala) transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"alaala_c":1.0,
"alaala_p":-1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_03651 and HFPHFOGF_03649 and HFPHFOGF_03650 and HFPHFOGF_03647 and HFPHFOGF_03648) or (HFPHFOGF_01577 and HFPHFOGF_01576 and HFPHFOGF_01573 and HFPHFOGF_01575 and HFPHFOGF_01574)",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ALAALAabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"HEXt2rpp",
"name":"hexanoate transport via proton symport, reversible (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"hxa_c":1.0,
"hxa_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02309",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"HEXt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"G3PEabcpp",
"name":"sn-glycerol-3-phosphoethanolamine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"g3pe_c":1.0,
"g3pe_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03552 and HFPHFOGF_03553 and HFPHFOGF_03555 and HFPHFOGF_03554",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"G3PEabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"G3PCabcpp",
"name":"sn-glycerol-3-phosphocholine transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"g3pc_c":1.0,
"g3pc_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03552 and HFPHFOGF_03553 and HFPHFOGF_03555 and HFPHFOGF_03554",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"G3PCabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__2AGPGAT161",
"name":"2-acyl-glycerophospho-glycerol acyltransferase (n-C16:1)",
"metabolites":{
"__Ecoli_panGEMs__2agpg161_c":-1.0,
"__Ecoli_panGEMs__pg161_c":1.0,
"amp_c":1.0,
"atp_c":-1.0,
"hdcea_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__2AGPGAT161",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PA181abcpp",
"name":"Phosphatidate transport via ABC system (n-C18:1, periplasm)",
"metabolites":{
"__Ecoli_panGEMs__pa181_c":-1.0,
"__Ecoli_panGEMs__pa181_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PA181abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"12DGR141tipp",
"name":"1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C14:1)",
"metabolites":{
"12dgr141_c":1.0,
"12dgr141_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"12DGR141tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"AMPTASEPG",
"name":"aminopeptidase (pro-gly)",
"metabolites":{
"gly_c":1.0,
"h2o_c":-1.0,
"pro__L_c":1.0,
"progly_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02606 or HFPHFOGF_00953 or HFPHFOGF_04407 or HFPHFOGF_00258",
"subsystem":"Arginine and Proline Metabolism",
"annotation":{
"biggr":"AMPTASEPG",
"rhea":"RHEA:28799",
"sbo":"SBO:0000176"
}
},
{
"id":"ADSL1r",
"name":"adenylsuccinate lyase",
"metabolites":{
"amp_c":1.0,
"dcamp_c":-1.0,
"fum_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01205",
"subsystem":"Purine and Pyrimidine Biosynthesis",
"annotation":{
"biggr":"ADSL1r",
"rhea":"RHEA:16853",
"sbo":"SBO:0000176"
}
},
{
"id":"PROGLYabcpp",
"name":"L-Prolinylglycine (Pro-Gly) transport via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"progly_c":1.0,
"progly_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03651 and HFPHFOGF_03649 and HFPHFOGF_03647 and HFPHFOGF_03648 and HFPHFOGF_03650",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PROGLYabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"GTHRDabcpp",
"name":"Reduced glutathione via ABC system (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"gthrd_c":1.0,
"gthrd_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00851 and HFPHFOGF_00850 and HFPHFOGF_00849 and HFPHFOGF_00852",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GTHRDabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PGPP140pp",
"name":"Phosphatidylglycerol phosphate phosphatase (periplasm, n-C14:0)",
"metabolites":{
"__Ecoli_panGEMs__pg140_p":1.0,
"__Ecoli_panGEMs__pgp140_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00448 or HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGPP140pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PGPP141pp",
"name":"Phosphatidylglycerol phosphate phosphatase (periplasm, n-C14:1)",
"metabolites":{
"__Ecoli_panGEMs__pg141_p":1.0,
"__Ecoli_panGEMs__pgp141_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00448 or HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGPP141pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PGPP160pp",
"name":"Phosphatidylglycerol phosphate phosphatase (periplasm, n-C16:0)",
"metabolites":{
"__Ecoli_panGEMs__pg160_p":1.0,
"__Ecoli_panGEMs__pgp160_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00448 or HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGPP160pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__2AGPG140tipp",
"name":"2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:0) transporter via facilitated diffusion (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpg140_c":1.0,
"__Ecoli_panGEMs__2agpg140_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02952",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__2AGPG140tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PGPP180pp",
"name":"Phosphatidylglycerol phosphate phosphatase (periplasm, n-C18:0)",
"metabolites":{
"__Ecoli_panGEMs__pg180_p":1.0,
"__Ecoli_panGEMs__pgp180_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00448 or HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGPP180pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__2AGPG160tipp",
"name":"2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0) transporter via facilitated diffusion (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpg160_c":1.0,
"__Ecoli_panGEMs__2agpg160_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02952",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__2AGPG160tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"SERD_D",
"name":"D-serine deaminase",
"metabolites":{
"nh4_c":1.0,
"pyr_c":1.0,
"ser__D_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02453",
"subsystem":"Glycine and Serine Metabolism",
"annotation":{
"biggr":"SERD_D",
"rhea":"RHEA:13977",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CLPNH141pp",
"name":"Cardiolipin hydrolase (periplasm, n-C14:1)",
"metabolites":{
"__Ecoli_panGEMs__clpn141_p":-1.0,
"__Ecoli_panGEMs__pa141_p":1.0,
"__Ecoli_panGEMs__pg141_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CLPNH141pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CLPNH160pp",
"name":"Cardiolipin hydrolase (periplasm, n-C16:0)",
"metabolites":{
"__Ecoli_panGEMs__clpn160_p":-1.0,
"__Ecoli_panGEMs__pg160_p":1.0,
"h2o_p":-1.0,
"h_p":1.0,
"pa160_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CLPNH160pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CLPNH161pp",
"name":"Cardiolipin hydrolase (periplasm, n-C16:1)",
"metabolites":{
"__Ecoli_panGEMs__clpn161_p":-1.0,
"__Ecoli_panGEMs__pa161_p":1.0,
"__Ecoli_panGEMs__pg161_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CLPNH161pp",
"sbo":"SBO:0000176"
}
},
{
"id":"AICART",
"name":"phosphoribosylaminoimidazolecarboxamide formyltransferase",
"metabolites":{
"10fthf_c":-1.0,
"aicar_c":-1.0,
"fprica_c":1.0,
"thf_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04134",
"subsystem":"Purine and Pyrimidine Biosynthesis",
"annotation":{
"biggr":"AICART",
"rhea":"RHEA:22192",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CLPNH181pp",
"name":"Cardiolipin hydrolase (periplasm, n-C18:1)",
"metabolites":{
"__Ecoli_panGEMs__clpn181_p":-1.0,
"__Ecoli_panGEMs__pa181_p":1.0,
"__Ecoli_panGEMs__pg181_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CLPNH181pp",
"sbo":"SBO:0000176"
}
},
{
"id":"D_LACt2pp",
"name":"D-lactate transport via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"lac__D_c":1.0,
"lac__D_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03714",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"D_LACt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"PLIPA1E180pp",
"name":"Phospholipase A1 (phosphatidylethanolamine, n-C18:0) (periplasm)",
"metabolites":{
"2agpe180_p":1.0,
"h2o_p":-1.0,
"h_p":1.0,
"ocdca_p":1.0,
"pe180_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"PLIPA1E180pp",
"sbo":"SBO:0000176"
}
},
{
"id":"RIBtex",
"name":"ribose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"rib__D_e":-1.0,
"rib__D_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"RIBtex",
"sbo":"SBO:0000655"
}
},
{
"id":"FLVRx",
"name":"flavin reductase (NAD)",
"metabolites":{
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0,
"rbflvrd_c":1.0,
"ribflv_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03970",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"FLVRx:2",
"rhea":"RHEA:31455",
"sbo":"SBO:0000176"
}
},
{
"id":"THMtex",
"name":"Thiamine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"thm_e":-1.0,
"thm_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"THMtex",
"sbo":"SBO:0000655"
}
},
{
"id":"XYLUtex",
"name":"L-xylulose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"xylu__L_e":-1.0,
"xylu__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"XYLUtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1G140pp",
"name":"Phospholipase A1 (phosphatidylglycerol, n-C14:0) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpg140_p":1.0,
"__Ecoli_panGEMs__pg140_p":-1.0,
"h2o_p":-1.0,
"h_p":1.0,
"ttdca_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA1G140pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1G161pp",
"name":"Phospholipase A1 (phosphatidylglycerol, n-C16:1) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpg161_p":1.0,
"__Ecoli_panGEMs__pg161_p":-1.0,
"h2o_p":-1.0,
"h_p":1.0,
"hdcea_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA1G161pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CLPNS160pp",
"name":"Cardiolipin synthase (periplasmic, n-C16:0)",
"metabolites":{
"__Ecoli_panGEMs__clpn160_p":1.0,
"__Ecoli_panGEMs__pg160_p":-2.0,
"glyc_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00809 or HFPHFOGF_01357",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CLPNS160pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CLPNS161pp",
"name":"Cardiolipin synthase (periplasmic, n-C16:1)",
"metabolites":{
"__Ecoli_panGEMs__clpn161_p":1.0,
"__Ecoli_panGEMs__pg161_p":-2.0,
"glyc_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01357 or HFPHFOGF_00809",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CLPNS161pp",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_manglyc_e",
"name":"Exchange of 2-(alpha-D-mannosyl)-D-glycerate.",
"metabolites":{
"manglyc_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_manglyc_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ALLtex",
"name":"Allose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"all__D_e":-1.0,
"all__D_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00950 or HFPHFOGF_00262 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ALLtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PG160abcpp",
"name":"Phosphatidylglycerol transport via ABC system (n-C16:0, periplasm)",
"metabolites":{
"__Ecoli_panGEMs__pg160_c":-1.0,
"__Ecoli_panGEMs__pg160_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PG160abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"FRUpts2pp",
"name":"Fructose transport via PEP:Pyr PTS (f6p generating) (periplasm)",
"metabolites":{
"f6p_c":1.0,
"fru_p":-1.0,
"pep_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01878 and HFPHFOGF_01877 and HFPHFOGF_02502 and HFPHFOGF_01879 and HFPHFOGF_02501",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"FRUpts2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PGP140abcpp",
"name":"Phosphatidylglycerophosphate transport via ABC system (n-C14:0, periplasm)",
"metabolites":{
"__Ecoli_panGEMs__pgp140_c":-1.0,
"__Ecoli_panGEMs__pgp140_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGP140abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PAPA120pp",
"name":"Phosphatidate phosphatase (periplasmic, n-C12:0)",
"metabolites":{
"12dgr120_p":1.0,
"__Ecoli_panGEMs__pa120_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PAPA120pp",
"sbo":"SBO:0000176"
}
},
{
"id":"PAPA140pp",
"name":"Phosphatidate phosphatase (periplasmic, n-C14:0)",
"metabolites":{
"12dgr140_p":1.0,
"h2o_p":-1.0,
"pa140_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"PAPA140pp",
"sbo":"SBO:0000176"
}
},
{
"id":"GGPTRCO",
"name":"gamma glutamyl putrescine oxidase",
"metabolites":{
"ggbutal_c":1.0,
"ggptrc_c":-1.0,
"h2o2_c":1.0,
"h2o_c":-1.0,
"nh4_c":1.0,
"o2_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01415",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"GGPTRCO",
"rhea":"RHEA:28414",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_metsox_R__L_e",
"name":"Exchange of L-methionine (R)-S-oxide zwitterion.",
"metabolites":{
"metsox_R__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_metsox_R__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__PAPA141pp",
"name":"Phosphatidate phosphatase (periplasmic, n-C14:1)",
"metabolites":{
"12dgr141_p":1.0,
"__Ecoli_panGEMs__pa141_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PAPA141pp",
"sbo":"SBO:0000176"
}
},
{
"id":"34dhpactex",
"name":"dihydroxyphenylacetaldehyde transport via diffusion (extracellular to periplasm)",
"metabolites":{
"34dhpac_e":-1.0,
"34dhpac_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"34dhpactex",
"sbo":"SBO:0000655"
}
},
{
"id":"PAPA160pp",
"name":"Phosphatidate phosphatase (periplasmic, n-C16:0)",
"metabolites":{
"12dgr160_p":1.0,
"h2o_p":-1.0,
"pa160_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"PAPA160pp",
"rhea":"RHEA:43236",
"sbo":"SBO:0000176"
}
},
{
"id":"G6Pt6_2pp",
"name":"Glucose-6-phosphate transport via phosphate antiport (periplasm)",
"metabolites":{
"g6p_c":1.0,
"g6p_p":-1.0,
"pi_c":-2.0,
"pi_p":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03793",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"G6Pt6_2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PAPA161pp",
"name":"Phosphatidate phosphatase (periplasmic, n-C16:1)",
"metabolites":{
"12dgr161_p":1.0,
"__Ecoli_panGEMs__pa161_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PAPA161pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MALTHXtexi",
"name":"Maltohexaose transport via diffusion (extracellular to periplasm) irreversible",
"metabolites":{
"__Ecoli_panGEMs__malthx_e":-1.0,
"__Ecoli_panGEMs__malthx_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04168",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__MALTHXtexi",
"sbo":"SBO:0000655"
}
},
{
"id":"12PPDStpp",
"name":"(S)-Propane-1,2-diol facilitated transport (periplasm)",
"metabolites":{
"12ppd__S_c":1.0,
"12ppd__S_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"12PPDStpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PAPA180pp",
"name":"Phosphatidate phosphatase (periplasmic, n-C18:0)",
"metabolites":{
"12dgr180_p":1.0,
"__Ecoli_panGEMs__pa180_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PAPA180pp",
"sbo":"SBO:0000176"
}
},
{
"id":"PROtex",
"name":"L-proline transport via diffusion (extracellular to periplasm)",
"metabolites":{
"pro__L_e":-1.0,
"pro__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"PROtex",
"sbo":"SBO:0000655"
}
},
{
"id":"HPYRI",
"name":"hydroxypyruvate isomerase",
"metabolites":{
"2h3opp_c":1.0,
"hpyr_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00536",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"HPYRI",
"rhea":"RHEA:11952",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FE3HOXUtex",
"name":"Fe(III)hydroxamate unloaded secretion",
"metabolites":{
"__Ecoli_panGEMs__fe3hox_un_c":-1.0,
"__Ecoli_panGEMs__fe3hox_un_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FE3HOXUtex",
"sbo":"SBO:0000655"
}
},
{
"id":"HYD1pp",
"name":"hydrogenase (ubiquinone-8: 2 protons) (periplasm)",
"metabolites":{
"h2_c":-1.0,
"h_c":-2.0,
"h_p":2.0,
"q8_c":-1.0,
"q8h2_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00994 and HFPHFOGF_00995 and HFPHFOGF_00993) or (HFPHFOGF_03109 and HFPHFOGF_03112 and HFPHFOGF_03111 and HFPHFOGF_03110) or (HFPHFOGF_02816 and HFPHFOGF_02817 and HFPHFOGF_02818 and HFPHFOGF_02814 and HFPHFOGF_02815 and HFPHFOGF_02813)",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"HYD1pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_cl_e",
"name":"Chloride exchange",
"metabolites":{
"cl_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cl_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__FE3DHBZStonex",
"name":"Ferric 2,3-dihydroxybenzoylserine transport via ton system (extracellular)",
"metabolites":{
"__Ecoli_panGEMs__fe3dhbzs_e":-1.0,
"__Ecoli_panGEMs__fe3dhbzs_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"((HFPHFOGF_01361 and HFPHFOGF_03120 and HFPHFOGF_03121) and HFPHFOGF_00825) or ((HFPHFOGF_01361 and HFPHFOGF_03120 and HFPHFOGF_03121) and HFPHFOGF_02240)",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__FE3DHBZStonex",
"sbo":"SBO:0000655"
}
},
{
"id":"AACTOOR",
"name":"Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)",
"metabolites":{
"aact_c":-1.0,
"h2o2_c":1.0,
"h2o_c":-1.0,
"mthgxl_c":1.0,
"nh4_c":1.0,
"o2_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Methylglyoxal Metabolism",
"annotation":{
"biggr":"AACTOOR",
"rhea":"RHEA:28186",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__23DAPPAtex",
"name":"2,3-diaminopropionate transport via diffusion",
"metabolites":{
"__Ecoli_panGEMs__23dappa_e":-1.0,
"__Ecoli_panGEMs__23dappa_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"__Ecoli_panGEMs__23DAPPAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__ECAP3pp",
"name":"Enterobacterial common antigen polymerase (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__eca3und_p":-1.0,
"__Ecoli_panGEMs__eca4und_p":1.0,
"h_p":1.0,
"udcpdp_p":1.0,
"unagamuf_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03913 and HFPHFOGF_03922",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__ECAP3pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FEOXAMtonex",
"name":"Ferroxamine transport via ton system (extracellular)",
"metabolites":{
"__Ecoli_panGEMs__feoxam_e":-1.0,
"__Ecoli_panGEMs__feoxam_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00147 and (HFPHFOGF_01361 and HFPHFOGF_03120 and HFPHFOGF_03121)",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__FEOXAMtonex",
"sbo":"SBO:0000655"
}
},
{
"id":"TPRDCOAS",
"name":"triphosphoribosyl-dephospho-CoA synthase",
"metabolites":{
"2tpr3dpcoa_c":1.0,
"ade_c":1.0,
"atp_c":-1.0,
"dpcoa_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00632",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"TPRDCOAS",
"rhea":"RHEA:15117",
"sbo":"SBO:0000176"
}
},
{
"id":"ACGAM1PPpp",
"name":"N-acetyl-D-glucosamine 1-phosphatase (periplasm)",
"metabolites":{
"acgam1p_p":-1.0,
"acgam_p":1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"ACGAM1PPpp",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_dgmp_e",
"name":"Exchange of 2'-deoxyguanosine 5'-monophosphate(2-).",
"metabolites":{
"dgmp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_dgmp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GAMptspp",
"name":"D-glucosamine transport via PEP:Pyr PTS (periplasm)",
"metabolites":{
"gam6p_c":1.0,
"gam_p":-1.0,
"pep_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02501 and HFPHFOGF_02502 and HFPHFOGF_01879 and HFPHFOGF_01877 and HFPHFOGF_01878",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GAMptspp",
"sbo":"SBO:0000655"
}
},
{
"id":"GSNt2pp",
"name":"guanosine transport in via proton symport (periplasm)",
"metabolites":{
"gsn_c":1.0,
"gsn_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03092",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GSNt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_4hoxpacd_e",
"name":"Exchange of (4-hydroxyphenyl)acetaldehyde.",
"metabolites":{
"4hoxpacd_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_4hoxpacd_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__FMNRx",
"name":"FMN reductase",
"metabolites":{
"__Ecoli_panGEMs__fmn_c":-1.0,
"fmnh2_c":1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00958 or HFPHFOGF_03970",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__FMNRx",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_3hpppn_e",
"name":"Exchange of 3-(3-hydroxyphenyl)propanoate.",
"metabolites":{
"3hpppn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_3hpppn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_man6p_e",
"name":"Exchange of alpha-D-mannose 6-phosphate(2-).",
"metabolites":{
"man6p_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_man6p_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GSNtex",
"name":"guanosine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"gsn_e":-1.0,
"gsn_p":1.0
},
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}
},
{
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"name":"D-sorbitol transport via diffusion (extracellular to periplasm)",
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"sbt__D_p":1.0
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}
},
{
"id":"FORtex",
"name":"formate transport via diffusion (extracellular to periplasm)",
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"for_p":1.0
},
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}
},
{
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"sbo":"SBO:0000627"
}
},
{
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}
},
{
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"sbo":"SBO:0000176"
}
},
{
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"sbo":"SBO:0000176"
}
},
{
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}
},
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"sbo":"SBO:0000176"
}
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{
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},
{
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}
},
{
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"sbo":"SBO:0000176"
}
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{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1A181pp",
"name":"Phospholipase A1 (phosphatidate, n-C18:1) (periplasm)",
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"sbo":"SBO:0000176"
}
},
{
"id":"PGM",
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"3pg_c":1.0
},
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"rhea":"RHEA:15901",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2A141",
"name":"Lysophospholipase L2 (2-acylglycerophosphotidate, n-C14:1)",
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"sbo":"SBO:0000176"
}
},
{
"id":"HG2t3pp",
"name":"mercury (Hg+2) transport out via proton antiport (periplasm)",
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"h_p":-1.0,
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"hg2_p":1.0
},
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"sbo":"SBO:0000655"
}
},
{
"id":"CYTBO3_4pp",
"name":"cytochrome oxidase bo3 (ubiquinol-8: 4 protons) (periplasm)",
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"h_p":4.0,
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},
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"sbo":"SBO:0000655"
}
},
{
"id":"EX___Ecoli_panGEMs__maltttr_e",
"name":"Maltotetraose exchange",
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"sbo":"SBO:0000627"
}
},
{
"id":"GLYCK",
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"h_c":1.0
},
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"subsystem":"Glyoxylate Metabolism",
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"rhea":"RHEA:23516",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MLTG5",
"name":"Maltodextrin glucosidase (maltoheptaose)",
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"sbo":"SBO:0000176"
}
},
{
"id":"GPDDA3",
"name":"Glycerophosphodiester phosphodiesterase (Glycerophosphoserine)",
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"h_c":1.0,
"ser__L_c":1.0
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"subsystem":"Glycerophospholipid Metabolism",
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"rhea":"RHEA:29875",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR141x",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C14:1)",
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"__Ecoli_panGEMs__tdeACP_c":1.0,
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR181x",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C18:1)",
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"sbo":"SBO:0000176"
}
},
{
"id":"TPI",
"name":"triose-phosphate isomerase",
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"g3p_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
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"subsystem":"Glycolysis/Gluconeogenesis",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR181y",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C18:1)",
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},
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"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__G3PAT141",
"name":"Glycerol-3-phosphate acyltransferase (C14:1)",
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__G3PAT141",
"sbo":"SBO:0000176"
}
},
{
"id":"2DOXG6PP",
"name":"2-deoxyglucose-6-phosphatase",
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"2doxg6p_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03954 or HFPHFOGF_01784 or HFPHFOGF_02379 or HFPHFOGF_00476",
"subsystem":"Alternate Carbon Metabolism",
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"biggr":"2DOXG6PP",
"rhea":"RHEA:22236",
"sbo":"SBO:0000176"
}
},
{
"id":"OXAMTC",
"name":"oxamate transcarbamoylase",
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"oxam_c":1.0,
"oxur_c":-1.0,
"pi_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Nitrogen Metabolism",
"annotation":{
"biggr":"OXAMTC",
"rhea":"RHEA:22984",
"sbo":"SBO:0000176"
}
},
{
"id":"UDCPPtppi",
"name":"undecaprenyl phosphate transport (cytoplasm to periplasm)",
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"udcpp_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"UDCPPtppi",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__AGMH",
"name":"N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl beta -1,4-N-acetylglucosaminidase",
"metabolites":{
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"acgam_c":1.0,
"anhm_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01125",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGMH",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__G3PAT181",
"name":"Glycerol-3-phosphate acyltransferase (C18:1)",
"metabolites":{
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"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__octeACP_c":-1.0,
"glyc3p_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01112 and HFPHFOGF_04175",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__G3PAT181",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__DASYN140",
"name":"CDP-diacylglycerol synthetase (n-C14:0)",
"metabolites":{
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"ctp_c":-1.0,
"h_c":-1.0,
"pa140_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00172",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__DASYN140",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MPTG",
"name":"Murein polymerizing transglycosylase",
"metabolites":{
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"h_c":2.0,
"uaagmda_c":-2.0,
"udcpdp_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_01086 and HFPHFOGF_00088 and HFPHFOGF_03309) or (HFPHFOGF_03500 and HFPHFOGF_01086 and HFPHFOGF_00088) or (HFPHFOGF_02602 and HFPHFOGF_01086 and HFPHFOGF_00088) or (HFPHFOGF_00146 and HFPHFOGF_01086 and HFPHFOGF_00088)",
"subsystem":"Murein Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__MPTG",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__DASYN180",
"name":"CDP-diacylglycerol synthetase (n-C18:0)",
"metabolites":{
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"__Ecoli_panGEMs__pa180_c":-1.0,
"ctp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00172",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__DASYN180",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MPTG2",
"name":"Murein polymerizing transglycosylase 2 (three linked units)",
"metabolites":{
"__Ecoli_panGEMs__murein5p5p5p_p":1.0,
"__Ecoli_panGEMs__murein5p5p_p":-1.0,
"h_c":1.0,
"uaagmda_c":-1.0,
"udcpdp_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00146 and HFPHFOGF_01086 and HFPHFOGF_00088) or (HFPHFOGF_01086 and HFPHFOGF_00088 and HFPHFOGF_03309) or (HFPHFOGF_03500 and HFPHFOGF_01086 and HFPHFOGF_00088) or (HFPHFOGF_02602 and HFPHFOGF_01086 and HFPHFOGF_00088)",
"subsystem":"Murein Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__MPTG2",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__DASYN141",
"name":"CDP-diacylglycerol synthetase (n-C14:1)",
"metabolites":{
"__Ecoli_panGEMs__cdpdtdec7eg_c":1.0,
"__Ecoli_panGEMs__pa141_c":-1.0,
"ctp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00172",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__DASYN141",
"sbo":"SBO:0000176"
}
},
{
"id":"RPI",
"name":"ribose-5-phosphate isomerase",
"metabolites":{
"r5p_c":-1.0,
"ru5p__D_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03045 or HFPHFOGF_04227",
"subsystem":"Pentose Phosphate Pathway",
"annotation":{
"biggr":"RPI",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MCTP1App",
"name":"Murein crosslinking transpeptidase 1A:(A2pm->D-ala) (periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__murein5px4p_p":1.0,
"ala__D_p":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"(HFPHFOGF_00654 and HFPHFOGF_00083 and HFPHFOGF_03500) or (HFPHFOGF_00654 and HFPHFOGF_00083 and HFPHFOGF_00146)",
"subsystem":"Murein Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__MCTP1App",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MCTP2App",
"name":"Murein crosslinking transpeptidase 1A:(A2pm->D-ala) (periplasm)",
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"ala__D_p":2.0
},
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"gene_reaction_rule":"(HFPHFOGF_00654 and HFPHFOGF_00083 and HFPHFOGF_03500) or (HFPHFOGF_00654 and HFPHFOGF_00083 and HFPHFOGF_00146)",
"subsystem":"Murein Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__MCTP2App",
"sbo":"SBO:0000176"
}
},
{
"id":"CDAPPA160",
"name":"CDP-Diacylglycerol pyrophostatase (n-C16:0)",
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"cmp_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"pa160_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04047",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"CDAPPA160",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CDAPPA141",
"name":"CDP-Diacylglycerol pyrophostatase (n-C14:1)",
"metabolites":{
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"__Ecoli_panGEMs__pa141_c":1.0,
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"h2o_c":-1.0,
"h_c":2.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_04047",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CDAPPA141",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MCTP1Bpp",
"name":"Murein crosslinking transpeptidase 1B:(A2pm->A2pm) (periplasm)",
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"__Ecoli_panGEMs__murein5px3p_p":1.0,
"alaala_p":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_01735 or HFPHFOGF_00946",
"subsystem":"Murein Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__MCTP1Bpp",
"sbo":"SBO:0000176"
}
},
{
"id":"PERD",
"name":"Erythronate 4-phosphate (4per) dehydrogenase",
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"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"ohpb_c":1.0
},
"lower_bound":-1000.0,
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"gene_reaction_rule":"HFPHFOGF_02406",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"PERD",
"rhea":"RHEA:18829",
"sbo":"SBO:0000176"
}
},
{
"id":"MELIBt3ipp",
"name":"melibiose transport in via antiport (periplasm)",
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"h_c":1.0,
"h_p":-1.0,
"melib_c":-1.0,
"melib_p":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_01617",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"MELIBt3ipp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PGSA141",
"name":"Phosphatidylglycerol synthase (n-C14:1)",
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"__Ecoli_panGEMs__pgp141_c":1.0,
"cmp_c":1.0,
"glyc3p_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01987",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGSA141",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_alaala_e",
"name":"Exchange of D-alanyl-D-alanine zwitterion.",
"metabolites":{
"alaala_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_alaala_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_dtmp_e",
"name":"Exchange of dTMP(2-).",
"metabolites":{
"dtmp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_dtmp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"5DOAN",
"name":"5'-deoxyadenosine nuclosidase",
"metabolites":{
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"ade_c":1.0,
"dad_5_c":-1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00156",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"5DOAN",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_5drib_c",
"name":"Sink needed to allow 5'-deoxyribose to leave system",
"metabolites":{
"5drib_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Intracellular demand",
"annotation":{
"biggr":"EX_5drib_c",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_lipoate_e",
"name":"Lipoate exchange",
"metabolites":{
"lipoate_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_lipoate_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_pydx_e",
"name":"Exchange of pyridoxal.",
"metabolites":{
"pydx_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_pydx_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_g1p_e",
"name":"Exchange of D-glucopyranose 1-phosphate(2-).",
"metabolites":{
"g1p_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_g1p_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GLCtex:2",
"name":"glucose transport via diffusion (extracellular to periplasm)",
"metabolites":{
"glc__D_e":-1.0,
"glc__D_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GLCtex",
"sbo":"SBO:0000655"
}
},
{
"id":"NAt3pp",
"name":"sodium transport out via proton antiport (cytoplasm to periplasm)",
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"h_c":1.0,
"h_p":-1.0,
"na1_c":-1.0,
"na1_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00862 or HFPHFOGF_01323",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"NAt3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"MINOHPtexi",
"name":"myo-inositol phosphate transport via diffusion (extracellular to periplasm)",
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"minohp_e":-1.0,
"minohp_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"MINOHPtexi",
"sbo":"SBO:0000655"
}
},
{
"id":"12PPDRtpp",
"name":"(R)-Propane-1,2-diol facilitated transport (periplasm)",
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"12ppd__R_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"12PPDRtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"SFGTHi",
"name":"S-Formylglutathione hydralase",
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"for_c":1.0,
"gthrd_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02239 or HFPHFOGF_00389",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
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"rhea":"RHEA:14961",
"sbo":"SBO:0000176"
}
},
{
"id":"ATPX5P",
"name":"pyridoxamine kinase",
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"h_c":1.0,
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"pydam_c":-1.0
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"rhea":"RHEA:25104",
"sbo":"SBO:0000176"
}
},
{
"id":"DHORDfum",
"name":"Fumarate dependent DHORD",
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"fum_c":-1.0,
"orot_c":1.0,
"succ_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"",
"subsystem":"Purine and Pyrimidine Biosynthesis",
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"rhea":"RHEA:30059",
"sbo":"SBO:0000176"
}
},
{
"id":"K2L4Aabcpp",
"name":"KDO(2)-lipid IV A transport via ABC system (periplasm)",
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"atp_c":-1.0,
"h2o_c":-1.0,
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"subsystem":"Transport, Inner Membrane",
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"sbo":"SBO:0000655"
}
},
{
"id":"FACOAE120",
"name":"fatty-acid-CoA thioesterase (dodecanoate)",
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"ddca_c":1.0,
"ddcacoa_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0
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"lower_bound":0.0,
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAR120",
"name":"3-oxoacyl-[acyl-carrier-protein] reductase (n-C12:0)",
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}
},
{
"id":"__Ecoli_panGEMs__3HAD80",
"name":"3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C8:0)",
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}
},
{
"id":"__Ecoli_panGEMs__3HAD120",
"name":"3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C12:0)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__DSBCGT",
"name":"DsbC:glutathione thiotransferase",
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"__Ecoli_panGEMs__dsbcrd_p":1.0,
"gthox_p":1.0,
"gthrd_p":-2.0
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"lower_bound":0.0,
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"subsystem":"Unassigned",
"annotation":{
"biggr":"__Ecoli_panGEMs__DSBCGT",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__DSBGGT",
"name":"DsbG:glutathione thiotransferase",
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"__Ecoli_panGEMs__dsbgrd_p":1.0,
"gthox_p":1.0,
"gthrd_p":-2.0
},
"lower_bound":0.0,
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"annotation":{
"biggr":"__Ecoli_panGEMs__DSBGGT",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR180x",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C18:0)",
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"nadh_c":-1.0
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"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_01402",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__EAR180x",
"sbo":"SBO:0000176"
}
},
{
"id":"AKGtex",
"name":"alpha-ketoglutarate transport via diffusion (extracellular to periplasm)",
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"akg_p":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"AKGtex",
"sbo":"SBO:0000655"
}
},
{
"id":"SO4t2pp",
"name":"sulfate transport in via proton symport (periplasm to cytoplasm)",
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"h_p":-1.0,
"so4_c":1.0,
"so4_p":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02499",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"SO4t2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__EAR180y",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C18:0)",
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"__Ecoli_panGEMs__toctd2eACP_c":-1.0,
"h_c":-1.0,
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"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01402",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__EAR180y",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AGPAT120",
"name":"1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C12:0)",
"metabolites":{
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"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__ddcaACP_c":-1.0,
"__Ecoli_panGEMs__pa120_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03131",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGPAT120",
"sbo":"SBO:0000176"
}
},
{
"id":"DHNAOT4",
"name":"1,4-dihydroxy-2-naphthoate octaprenyltransferase",
"metabolites":{
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"co2_c":1.0,
"dhna_c":-1.0,
"h_c":-1.0,
"octdp_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04059",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
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"rhea":"RHEA:30099",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AMPMS2",
"name":"4-amino-2-methyl-5-phosphomethylpyrimidine synthetase",
"metabolites":{
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"__Ecoli_panGEMs__air_c":-1.0,
"for_c":2.0,
"h2o_c":-1.0,
"h_c":3.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":0.0,
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"annotation":{
"biggr":"__Ecoli_panGEMs__AMPMS2",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_oxam_c",
"name":"Exchange of oxamate.",
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Intracellular demand",
"annotation":{
"biggr":"EX_oxam_c",
"sbo":"SBO:0000627"
}
},
{
"id":"ALR4x",
"name":"aldose reductase (acetol)",
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"acetol_c":-1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04074",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"ALR4x",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PGPP120",
"name":"Phosphatidylglycerol phosphate phosphatase (n-C14:0)",
"metabolites":{
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"__Ecoli_panGEMs__pgp120_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00448 or HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGPP120",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__DAGK120",
"name":"Diacylglycerol kinase (n-C12:0)",
"metabolites":{
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"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04176",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"ALLTNtex",
"name":"allantoin transport via diffusion (extracellular to periplasm)",
"metabolites":{
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"alltn_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"ALLTNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PSSA180",
"name":"Phosphatidylserine syntase (n-C18:0)",
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"cmp_c":1.0,
"h_c":1.0,
"ser__L_c":-1.0
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"lower_bound":0.0,
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"sbo":"SBO:0000176"
}
},
{
"id":"ASNtex",
"name":"L-asparagine transport via diffusion (extracellular to periplasm)",
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"asn__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
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"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PSSA161",
"name":"Phosphatidylserine syntase (n-C16:1)",
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"h_c":1.0,
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PSSA141",
"name":"Phosphatidylserine syntase (n-C14:1)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PSD160",
"name":"Phosphatidylserine decarboxylase (n-C16:0)",
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},
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PSD160",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PSD161",
"name":"Phosphatidylserine decarboxylase (n-C16:1)",
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"subsystem":"Glycerophospholipid Metabolism",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PSD180",
"name":"Phosphatidylserine decarboxylase (n-C18:0)",
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PSD180",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__COLIPAabcpp",
"name":"Core oligosaccharide lipid A transport via ABC system (periplasm)",
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"__Ecoli_panGEMs__colipa_p":1.0,
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"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
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"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL1G141pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C14:1) (periplasm)",
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"sbo":"SBO:0000176"
}
},
{
"id":"LPLIPAL1G180pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C18:0) (periplasm)",
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}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL1G181pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C18:1) (periplasm)",
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"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL1G181pp",
"sbo":"SBO:0000176"
}
},
{
"id":"ACONTb",
"name":"aconitase (half-reaction B, Isocitrate hydro-lyase)",
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"icit_c":1.0
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"subsystem":"Citric Acid Cycle",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__GLCP2",
"name":"Glycogen phosphorylase",
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"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"F6Pt6_2pp",
"name":"Fructose-6-phosphate transport via phosphate antiport (periplasm)",
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"sbo":"SBO:0000655"
}
},
{
"id":"PPALtpp",
"name":"propanal transport via channel (periplasm)",
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"subsystem":"Transport, Inner Membrane",
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"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA2A140pp",
"name":"Phospholipase A2 (phosphatidate, n-C14:0) (periplasm)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA2A141pp",
"name":"Phospholipase A2 (phosphatidate, n-C14:1) (periplasm)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA2A180pp",
"name":"Phospholipase A2 (phosphatidate, n-C18:0) (periplasm)",
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"sbo":"SBO:0000176"
}
},
{
"id":"GAM6Pt6_2pp",
"name":"D-Glucosamine 6-phosphate transport via phosphate antiport (periplasm)",
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}
},
{
"id":"__Ecoli_panGEMs__PLIPA2E141pp",
"name":"Phospholipase A2 (phosphatidylethanolamine, n-C14:1) (periplasm)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FE3HOXabcpp",
"name":"Ferric-dicitrate transport via ABC system (periplasm)",
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"sbo":"SBO:0000655"
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},
{
"id":"__Ecoli_panGEMs__PLIPA2E181pp",
"name":"Phospholipase A2 (phosphatidylethanolamine, n-C18:1) (periplasm)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA2G140pp",
"name":"Phospholipase A2 (phosphatidylglycerol, n-C14:0) (periplasm)",
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},
{
"id":"PPALtex",
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},
{
"id":"CA2tex",
"name":"calcium (Ca+2) transport via diffusion (extracellular to periplasm)",
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"ca2_p":1.0
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"lower_bound":-1000.0,
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},
{
"id":"CUtex",
"name":"copper (Cu+1) transport via diffusion (extracellular to periplasm)",
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"lower_bound":-1000.0,
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"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__3HAD161",
"name":"3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C16:1)",
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00975 or HFPHFOGF_00177",
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"annotation":{
"biggr":"__Ecoli_panGEMs__3HAD161",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA2G160pp",
"name":"Phospholipase A2 (phosphatidylglycerol, n-C16:0) (periplasm)",
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"CU1Opp",
"name":"Cuprous Oxidase (Cu+1)",
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"cu_p":-4.0,
"h2o_p":2.0,
"h_p":-4.0,
"o2_p":-1.0
},
"lower_bound":0.0,
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"rhea":"RHEA:30083",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA2G181pp",
"name":"Phospholipase A2 (phosphatidylglycerol, n-C18:1) (periplasm)",
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},
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"SUCDi",
"name":"succinate dehydrogenase (irreversible)",
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"q8_c":-1.0,
"q8h2_c":1.0,
"succ_c":-1.0
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"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00741 and HFPHFOGF_00742 and HFPHFOGF_00743 and HFPHFOGF_00744",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"SUCDi",
"rhea":"RHEA:29187",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FADRx2",
"name":"FAD reductase",
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"h_c":-1.0,
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"nadph_c":-1.0
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"gene_reaction_rule":"HFPHFOGF_02867 and HFPHFOGF_02866",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL1E141pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C14:1) (periplasm)",
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"h_p":1.0,
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"gene_reaction_rule":"HFPHFOGF_00523",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"LALDO2x",
"name":"D-Lactaldehyde:NAD+ 1-oxidoreductase",
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"mthgxl_c":-1.0,
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_04074",
"subsystem":"Methylglyoxal Metabolism",
"annotation":{
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"rhea":"RHEA:24528",
"sbo":"SBO:0000176"
}
},
{
"id":"12PPDRtex",
"name":"(R)-Propane-1,2-diol transport via diffusion (extracellular to periplasm)",
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"12ppd__R_p":1.0
},
"lower_bound":-1000.0,
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"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"12PPDRtex",
"sbo":"SBO:0000655"
}
},
{
"id":"LPLIPAL1E160pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C16:0) (periplasm)",
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"h2o_p":-1.0,
"h_p":1.0,
"hdca_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00523",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"LPLIPAL1E160pp",
"sbo":"SBO:0000176"
}
},
{
"id":"LPLIPAL1E180pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C18:0) (periplasm)",
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"g3pe_p":1.0,
"h2o_p":-1.0,
"h_p":1.0,
"ocdca_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00523",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"LPLIPAL1E180pp",
"sbo":"SBO:0000176"
}
},
{
"id":"ASNS1",
"name":"asparagine synthase (glutamine-hydrolysing)",
"metabolites":{
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"asn__L_c":1.0,
"asp__L_c":-1.0,
"atp_c":-1.0,
"gln__L_c":-1.0,
"glu__L_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00688",
"subsystem":"Alanine and Aspartate Metabolism",
"annotation":{
"biggr":"ASNS1",
"rhea":"RHEA:12228",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR80y",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C8:0)",
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},
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"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__EAR80y",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR120y",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C12:0)",
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},
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"annotation":{
"biggr":"__Ecoli_panGEMs__EAR120y",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAR181",
"name":"3-oxoacyl-[acyl-carrier-protein] reductase (n-C18:1)",
"metabolites":{
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"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__3OAR181",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3HAD121",
"name":"3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C12:1)",
"metabolites":{
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"__Ecoli_panGEMs__t3c5ddeceACP_c":1.0,
"h2o_c":1.0
},
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"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR121y",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C12:1)",
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"subsystem":"Cell Envelope Biosynthesis",
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"biggr":"__Ecoli_panGEMs__EAR121y",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL1E181pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C18:1) (periplasm)",
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"h2o_p":-1.0,
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},
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL1E181pp",
"sbo":"SBO:0000176"
}
},
{
"id":"LPLIPAL1G160pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C16:0) (periplasm)",
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"g3pg_p":1.0,
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"gene_reaction_rule":"HFPHFOGF_00523",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL1G161pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C16:1) (periplasm)",
"metabolites":{
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"g3pg_p":1.0,
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"GTHRDHpp",
"name":"glutathione hydralase (periplasmic)",
"metabolites":{
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"glu__L_p":1.0,
"gthrd_p":-1.0,
"h2o_p":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03548",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"GTHRDHpp",
"rhea":"RHEA:28807",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_o2_e",
"name":"Exchange of dioxygen.",
"metabolites":{
"o2_e":-1.0
},
"lower_bound":-20.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_o2_e",
"sbo":"SBO:0000627"
}
},
{
"id":"PROGLYtex",
"name":"L-Prolinylglycine transport via diffusion (extracellular to periplasm)",
"metabolites":{
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"progly_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"PROGLYtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_progly_e",
"name":"Exchange of L-prolinylglycine zwitterion.",
"metabolites":{
"progly_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_progly_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__MDDCP2pp",
"name":"Murein D,D-carboxypeptidase (murein5px4px4p) (periplasm)",
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"__Ecoli_panGEMs__murein5px4px4p_p":-1.0,
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},
"lower_bound":0.0,
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"subsystem":"Murein Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__MDDCP2pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL1G120pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C12:0) (periplasm)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA2E140pp",
"name":"Phospholipase A2 (phosphatidylethanolamine, n-C14:0) (periplasm)",
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"h_p":1.0,
"ttdca_p":1.0
},
"lower_bound":0.0,
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA2E140pp",
"sbo":"SBO:0000176"
}
},
{
"id":"PLIPA2E160pp",
"name":"Phospholipase A2 (phosphatidylethanolamine, n-C16:0) (periplasm)",
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"rhea":"RHEA:62100",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA2A161pp",
"name":"Phospholipase A2 (phosphatidate, n-C16:1) (periplasm)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA2A181pp",
"name":"Phospholipase A2 (phosphatidate, n-C18:1) (periplasm)",
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"F6Ptex",
"name":"fructose 6-phosphate transport via diffusion (extracellular to periplasm)",
"metabolites":{
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"f6p_p":1.0
},
"lower_bound":-1000.0,
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"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
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"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__MDDCP3pp",
"name":"Murein D,D-carboxypeptidase (murein5p5p) (periplasm)",
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"lower_bound":0.0,
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"subsystem":"Murein Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__MDDCP3pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR140x",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C14:0)",
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"lower_bound":0.0,
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"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR40y",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C4:0)",
"metabolites":{
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"lower_bound":0.0,
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"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"GAMAN6Ptex",
"name":"D-glucosamine 6-phosphate transport via diffusion (extracellular to periplasm)",
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"gam6p_p":1.0
},
"lower_bound":-1000.0,
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"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
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"sbo":"SBO:0000655"
}
},
{
"id":"EX_gal_bD_e",
"name":"Exchange of beta-D-galactose.",
"metabolites":{
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_gal_bD_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__3OAS181",
"name":"3-oxoacyl-[acyl-carrier-protein] synthase (n-C18:1)",
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"co2_c":1.0,
"h_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01113",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__3OAS181",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR161y",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C16:1)",
"metabolites":{
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"__Ecoli_panGEMs__t3c9palmeACP_c":-1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01402",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__EAR161y",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__G3PAT140",
"name":"Glycerol-3-phosphate acyltransferase (C14:0)",
"metabolites":{
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"__Ecoli_panGEMs__ACP_c":1.0,
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"glyc3p_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01112 and HFPHFOGF_04175",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__G3PAT140",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__G3PAT160",
"name":"Glycerol-3-phosphate acyltransferase (C16:0)",
"metabolites":{
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"glyc3p_c":-1.0
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"lower_bound":0.0,
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__G3PAT161",
"name":"Glycerol-3-phosphate acyltransferase (C16:1)",
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"lower_bound":0.0,
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AGPAT160",
"name":"1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0)",
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},
"lower_bound":0.0,
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AGPAT140",
"name":"1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:0)",
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"lower_bound":0.0,
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PGSA160",
"name":"Phosphatidylglycerol synthase (n-C16:0)",
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"glyc3p_c":-1.0,
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_01987",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MLDCP2Bpp",
"name":"Murein L,D-carboxypeptidase (murein4p3p) (periplasm)",
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"h2o_p":-1.0
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"gene_reaction_rule":"HFPHFOGF_01131 or HFPHFOGF_00839 or HFPHFOGF_02073 or HFPHFOGF_01735 or HFPHFOGF_00946",
"subsystem":"Murein Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__MLDCP2Bpp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAS140",
"name":"3-oxoacyl-[acyl-carrier-protein] synthase (n-C14:0)",
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"co2_c":1.0,
"h_c":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02409 or HFPHFOGF_01113",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAR140",
"name":"3-oxoacyl-[acyl-carrier-protein] reductase (n-C14:0)",
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"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":-1000.0,
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"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CDAPPA140",
"name":"CDP-Diacylglycerol pyrophostatase (n-C14:0)",
"metabolites":{
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_04047",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MLDCP1App",
"name":"Murein L,D-carboxypeptidase (murein5px4p) (periplasm)",
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{
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{
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"id":"__Ecoli_panGEMs__PG140abcpp",
"name":"Phosphatidylglycerol transport via ABC system (n-C14:0, periplasm)",
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},
{
"id":"ACONTa_1",
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},
{
"id":"__Ecoli_panGEMs__MLDCP2App",
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},
{
"id":"12DGR140tipp",
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"name":"Phosphatidylglycerol transport via ABC system (n-C18:0, periplasm)",
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"adp_c":1.0,
"atp_c":-1.0,
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"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PG180abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"12DGR160tipp",
"name":"1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C16:0)",
"metabolites":{
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"12dgr160_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"12DGR160tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PG181abcpp",
"name":"Phosphatidylglycerol transport via ABC system (n-C18:1, periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__pg181_p":1.0,
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"h2o_c":-1.0,
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PG181abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__AM4PA",
"name":"Anhydrous-N-Acetylmuramyl-tetrapeptide amidase",
"metabolites":{
"__Ecoli_panGEMs__LalaDgluMdapDala_c":1.0,
"__Ecoli_panGEMs__anhm4p_c":-1.0,
"anhm_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00107",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__AM4PA",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PGP141abcpp",
"name":"Phosphatidylglycerophosphate transport via ABC system (n-C14:1, periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__pgp141_p":1.0,
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGP141abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PGP160abcpp",
"name":"Phosphatidylglycerophosphate transport via ABC system (n-C16:0, periplasm)",
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGP160abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"12DGR180tipp",
"name":"1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C18:0)",
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"12dgr180_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"12DGR180tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PGPP120pp",
"name":"Phosphatidylglycerol phosphate phosphatase (periplasm, n-C14:0)",
"metabolites":{
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"__Ecoli_panGEMs__pgp120_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00448 or HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGPP120pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PGPP181pp",
"name":"Phosphatidylglycerol phosphate phosphatase (periplasm, n-C18:1)",
"metabolites":{
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"__Ecoli_panGEMs__pgp181_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00448 or HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGPP181pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CLPNH120pp",
"name":"Cardiolipin hydrolase (periplasm, n-C12:0)",
"metabolites":{
"__Ecoli_panGEMs__clpn120_p":-1.0,
"__Ecoli_panGEMs__pa120_p":1.0,
"__Ecoli_panGEMs__pg120_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CLPNH120pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PGP180abcpp",
"name":"Phosphatidylglycerophosphate transport via ABC system (n-C18:0, periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__pgp180_p":1.0,
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"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGP180abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_dump_e",
"name":"Exchange of dUMP(2-).",
"metabolites":{
"dump_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_dump_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__PAPA181pp",
"name":"Phosphatidate phosphatase (periplasmic, n-C18:1)",
"metabolites":{
"12dgr181_p":1.0,
"__Ecoli_panGEMs__pa181_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PAPA181pp",
"sbo":"SBO:0000176"
}
},
{
"id":"PA140abcpp",
"name":"phosphatidate transport via ABC system (n-C14:0, periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pa140_c":-1.0,
"pa140_p":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PA140abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__CLPNH140pp",
"name":"Cardiolipin hydrolase (periplasm, n-C14:0)",
"metabolites":{
"__Ecoli_panGEMs__clpn140_p":-1.0,
"__Ecoli_panGEMs__pg140_p":1.0,
"h2o_p":-1.0,
"h_p":1.0,
"pa140_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CLPNH140pp",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_12ppd__R_e",
"name":"Exchange of (R)-propane-1,2-diol.",
"metabolites":{
"12ppd__R_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_12ppd__R_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__PGSA181",
"name":"Phosphatidylglycerol synthase (n-C18:1)",
"metabolites":{
"__Ecoli_panGEMs__cdpdodec11eg_c":-1.0,
"__Ecoli_panGEMs__pgp181_c":1.0,
"cmp_c":1.0,
"glyc3p_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01987",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGSA181",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PGPP140",
"name":"Phosphatidylglycerol phosphate phosphatase (n-C14:0)",
"metabolites":{
"__Ecoli_panGEMs__pg140_c":1.0,
"__Ecoli_panGEMs__pgp140_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00448 or HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGPP140",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PGPP141",
"name":"Phosphatidylglycerol phosphate phosphatase (n-C14:1)",
"metabolites":{
"__Ecoli_panGEMs__pg141_c":1.0,
"__Ecoli_panGEMs__pgp141_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00448 or HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGPP141",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MDDCP5pp",
"name":"Murein D,D-carboxypeptidase (murein5p3p) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__murein4p3p_p":1.0,
"__Ecoli_panGEMs__murein5p3p_p":-1.0,
"ala__D_p":1.0,
"h2o_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00651 or HFPHFOGF_03283 or HFPHFOGF_00859 or HFPHFOGF_02112 or HFPHFOGF_02515 or HFPHFOGF_00406",
"subsystem":"Murein Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__MDDCP5pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MLTGY3pp",
"name":"Murein lytic transglycosylase (murein3p3p) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__anhgm3p_p":2.0,
"__Ecoli_panGEMs__murein3p3p_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04532 or HFPHFOGF_02922 or HFPHFOGF_02793 or HFPHFOGF_01296 or HFPHFOGF_03091 or HFPHFOGF_02641 or HFPHFOGF_00209 or HFPHFOGF_01115",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__MLTGY3pp",
"sbo":"SBO:0000176"
}
},
{
"id":"12DGR120tipp",
"name":"1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C12:0)",
"metabolites":{
"12dgr120_c":1.0,
"12dgr120_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"12DGR120tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__MDDCP4pp",
"name":"Murein D,D-carboxypeptidase (murein5p4p) (periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__murein5p4p_p":-1.0,
"ala__D_p":1.0,
"h2o_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00651 or HFPHFOGF_03283 or HFPHFOGF_00859 or HFPHFOGF_02112 or HFPHFOGF_02515 or HFPHFOGF_00406",
"subsystem":"Murein Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__MDDCP4pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CLPNS140pp",
"name":"Cardiolipin synthase (periplasmic, n-C14:0)",
"metabolites":{
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"__Ecoli_panGEMs__pg140_p":-2.0,
"glyc_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01357 or HFPHFOGF_00809",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CLPNS140pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CLPNS141pp",
"name":"Cardiolipin synthase (periplasmic, n-C14:1)",
"metabolites":{
"__Ecoli_panGEMs__clpn141_p":1.0,
"__Ecoli_panGEMs__pg141_p":-2.0,
"glyc_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01357 or HFPHFOGF_00809",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CLPNS141pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__G3PAT180",
"name":"Glycerol-3-phosphate acyltransferase (C18:0)",
"metabolites":{
"1odecg3p_c":1.0,
"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__ocdcaACP_c":-1.0,
"glyc3p_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01112 and HFPHFOGF_04175",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__G3PAT180",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_o2s_e",
"name":"Exchange of superoxide.",
"metabolites":{
"o2s_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_o2s_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1G160pp",
"name":"Phospholipase A1 (phosphatidylglycerol, n-C16:0) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpg160_p":1.0,
"__Ecoli_panGEMs__pg160_p":-1.0,
"h2o_p":-1.0,
"h_p":1.0,
"hdca_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA1G160pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PG120abcpp",
"name":"Phosphatidylglycerol transport via ABC system (n-C12:0, periplasm)",
"metabolites":{
"__Ecoli_panGEMs__pg120_c":-1.0,
"__Ecoli_panGEMs__pg120_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PG120abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_gal1p_e",
"name":"Exchange of alpha-D-galactose 1-phosphate(2-).",
"metabolites":{
"gal1p_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_gal1p_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__PE140abcpp",
"name":"Phosphatidylethanolamine transport via ABC system (n-C14:0, periplasm)",
"metabolites":{
"__Ecoli_panGEMs__pe140_c":-1.0,
"__Ecoli_panGEMs__pe140_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PE140abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__CFAS160E",
"name":"Cyclopropane fatty acid synthase (Phosphatidylethanolamine, n-C16:0)",
"metabolites":{
"__Ecoli_panGEMs__cpe160_c":1.0,
"__Ecoli_panGEMs__pe161_c":-1.0,
"ahcys_c":2.0,
"amet_c":-2.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01718",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CFAS160E",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1G141pp",
"name":"Phospholipase A1 (phosphatidylglycerol, n-C14:1) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpg141_p":1.0,
"__Ecoli_panGEMs__pg141_p":-1.0,
"h2o_p":-1.0,
"h_p":1.0,
"ttdcea_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA1G141pp",
"sbo":"SBO:0000176"
}
},
{
"id":"LPLIPAL2E160",
"name":"Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C16:0)",
"metabolites":{
"2agpe160_c":-1.0,
"g3pe_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"hdca_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"LPLIPAL2E160",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2G140",
"name":"Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C14:0)",
"metabolites":{
"__Ecoli_panGEMs__2agpg140_c":-1.0,
"g3pg_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ttdca_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2G140",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2G160",
"name":"Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C16:0)",
"metabolites":{
"__Ecoli_panGEMs__2agpg160_c":-1.0,
"g3pg_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"hdca_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2G160",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CFAS180E",
"name":"Cyclopropane fatty acid synthase (Phosphatidylethanolamine, n-C18:0)",
"metabolites":{
"__Ecoli_panGEMs__cpe180_c":1.0,
"__Ecoli_panGEMs__pe181_c":-1.0,
"ahcys_c":2.0,
"amet_c":-2.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01718",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CFAS180E",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_dcmp_e",
"name":"Exchange of 2'-deoxycytosine 5'-monophosphate(2-).",
"metabolites":{
"dcmp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_dcmp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__CFAS180G",
"name":"Cyclopropane fatty acid synthase (Phosphatidylglycerol, n-C18:0)",
"metabolites":{
"__Ecoli_panGEMs__cpg180_c":1.0,
"__Ecoli_panGEMs__pg181_c":-1.0,
"ahcys_c":2.0,
"amet_c":-2.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01718",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CFAS180G",
"sbo":"SBO:0000176"
}
},
{
"id":"PAPA160",
"name":"Phosphatidate phosphatase (n-C16:0)",
"metabolites":{
"12dgr160_c":1.0,
"h2o_c":-1.0,
"pa160_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"PAPA160",
"rhea":"RHEA:43236",
"sbo":"SBO:0000176"
}
},
{
"id":"2AGPE140tipp",
"name":"2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:0) transporter via facilitated diffusion (periplasm)",
"metabolites":{
"2agpe140_c":1.0,
"2agpe140_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02952",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"2AGPE140tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"2AGPE160tipp",
"name":"2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:0) transporter via facilitated diffusion (periplasm)",
"metabolites":{
"2agpe160_c":1.0,
"2agpe160_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02952",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"2AGPE160tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"2AGPE180tipp",
"name":"2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:0) transporter via facilitated diffusion (periplasm)",
"metabolites":{
"2agpe180_c":1.0,
"2agpe180_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02952",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"2AGPE180tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PAPA180",
"name":"Phosphatidate phosphatase (n-C18:0)",
"metabolites":{
"12dgr180_c":1.0,
"__Ecoli_panGEMs__pa180_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PAPA180",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PAPA181",
"name":"Phosphatidate phosphatase (n-C18:1)",
"metabolites":{
"12dgr181_c":1.0,
"__Ecoli_panGEMs__pa181_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PAPA181",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__2AGPE141tipp",
"name":"2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:1) transporter via facilitated diffusion (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpe141_c":1.0,
"__Ecoli_panGEMs__2agpe141_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02952",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__2AGPE141tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__2AGPE161tipp",
"name":"2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:1) transporter via facilitated diffusion (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpe161_c":1.0,
"__Ecoli_panGEMs__2agpe161_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02952",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__2AGPE161tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_23ccmp_e",
"name":"Exchange of 2',3'-cyclic CMP(1-).",
"metabolites":{
"23ccmp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_23ccmp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__2AGPA161tipp",
"name":"2-Acyl-sn-glycero-3-phosphatidate (n-C16:1) transporter via facilitated diffusion (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2hdec9eg3p_c":1.0,
"__Ecoli_panGEMs__2hdec9eg3p_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02952",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__2AGPA161tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__2AGPA181tipp",
"name":"2-Acyl-sn-glycero-3-phosphatidate (n-C18:1) transporter via facilitated diffusion (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2odec11eg3p_c":1.0,
"__Ecoli_panGEMs__2odec11eg3p_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02952",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__2AGPA181tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__2AGPG120tipp",
"name":"2-Acyl-sn-glycero-3-phosphoglycerol (n-C12:0) transporter via facilitated diffusion (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpg120_c":1.0,
"__Ecoli_panGEMs__2agpg120_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02952",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__2AGPG120tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2G120",
"name":"Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C12:0)",
"metabolites":{
"__Ecoli_panGEMs__2agpg120_c":-1.0,
"ddca_c":1.0,
"g3pg_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2G120",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PA141abcpp",
"name":"Phosphatidate transport via ABC system (n-C14:1, periplasm)",
"metabolites":{
"__Ecoli_panGEMs__pa141_c":-1.0,
"__Ecoli_panGEMs__pa141_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PA141abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PETNT161pp",
"name":"Phosphoethanolamine transferase (c-C16:1)",
"metabolites":{
"12dgr161_p":1.0,
"__Ecoli_panGEMs__enlipa_p":1.0,
"__Ecoli_panGEMs__pe161_p":-1.0,
"lipa_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03653",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__PETNT161pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PSSA160",
"name":"Phosphatidylserine syntase (n-C16:0)",
"metabolites":{
"__Ecoli_panGEMs__ps160_c":1.0,
"cdpdhdecg_c":-1.0,
"cmp_c":1.0,
"h_c":1.0,
"ser__L_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02668",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PSSA160",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PSSA181",
"name":"Phosphatidylserine syntase (n-C18:1)",
"metabolites":{
"__Ecoli_panGEMs__cdpdodec11eg_c":-1.0,
"__Ecoli_panGEMs__ps181_c":1.0,
"cmp_c":1.0,
"h_c":1.0,
"ser__L_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02668",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PSSA181",
"sbo":"SBO:0000176"
}
},
{
"id":"DAGK140",
"name":"diacylglycerol kinase (n-C14:0)",
"metabolites":{
"12dgr140_c":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"pa140_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04176",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"DAGK140",
"sbo":"SBO:0000176"
}
},
{
"id":"DAGK160",
"name":"diacylglycerol kinase (n-C16:0)",
"metabolites":{
"12dgr160_c":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"pa160_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04176",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"DAGK160",
"rhea":"RHEA:63324",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__DAGK141",
"name":"Diacylglycerol kinase (n-C14:1)",
"metabolites":{
"12dgr141_c":-1.0,
"__Ecoli_panGEMs__pa141_c":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04176",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__DAGK141",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__DAGK161",
"name":"Diacylglycerol kinase (n-C16:1)",
"metabolites":{
"12dgr161_c":-1.0,
"__Ecoli_panGEMs__pa161_c":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04176",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__DAGK161",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AGPAT181",
"name":"1-octadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:1)",
"metabolites":{
"__Ecoli_panGEMs__1odec11eg3p_c":-1.0,
"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__octeACP_c":-1.0,
"__Ecoli_panGEMs__pa181_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03131",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGPAT181",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PA161abcpp",
"name":"Phosphatidate transport via ABC system (n-C16:1, periplasm)",
"metabolites":{
"__Ecoli_panGEMs__pa161_c":-1.0,
"__Ecoli_panGEMs__pa161_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PA161abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PA180abcpp",
"name":"Phosphatidate transport via ABC system (n-C18:0, periplasm)",
"metabolites":{
"__Ecoli_panGEMs__pa180_c":-1.0,
"__Ecoli_panGEMs__pa180_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PA180abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PGPP161pp",
"name":"Phosphatidylglycerol phosphate phosphatase (periplasm, n-C16:1)",
"metabolites":{
"__Ecoli_panGEMs__pg161_p":1.0,
"__Ecoli_panGEMs__pgp161_p":-1.0,
"h2o_p":-1.0,
"pi_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00448 or HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGPP161pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PE120abcpp",
"name":"Phosphatidylethanolamine transport via ABC system (n-C12:0, periplasm)",
"metabolites":{
"__Ecoli_panGEMs__pe120_c":-1.0,
"__Ecoli_panGEMs__pe120_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PE120abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__MDDEP3pp",
"name":"Murein D,D-endopeptidase (murein5px4p) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__murein5p4p_p":1.0,
"__Ecoli_panGEMs__murein5px4p_p":-1.0,
"h2o_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03283 or HFPHFOGF_02414 or HFPHFOGF_02220 or HFPHFOGF_02261 or HFPHFOGF_00406 or HFPHFOGF_01711 or HFPHFOGF_01917",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__MDDEP3pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MDDEP4pp",
"name":"Murein D,D-endopeptidase (murein4px4px4p) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__murein4px4p4p_p":1.0,
"__Ecoli_panGEMs__murein4px4px4p_p":-1.0,
"h2o_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03283 or HFPHFOGF_02414 or HFPHFOGF_02220 or HFPHFOGF_00406 or HFPHFOGF_02261 or HFPHFOGF_01711 or HFPHFOGF_01917",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__MDDEP4pp",
"sbo":"SBO:0000176"
}
},
{
"id":"PE180abcpp",
"name":"phosphatidylethanolamine transport via ABC system (n-C18:0, periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pe180_c":-1.0,
"pe180_p":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PE180abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"PAPA140",
"name":"Phosphatidate phosphatase (n-C14:0)",
"metabolites":{
"12dgr140_c":1.0,
"h2o_c":-1.0,
"pa140_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"PAPA140",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MLTGY1pp",
"name":"Murein lytic transglycosylase (murein4p4p) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__anhgm4p_p":2.0,
"__Ecoli_panGEMs__murein4p4p_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03091 or HFPHFOGF_04532 or HFPHFOGF_02922 or HFPHFOGF_02793 or HFPHFOGF_01296 or HFPHFOGF_02641 or HFPHFOGF_00209 or HFPHFOGF_01115",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__MLTGY1pp",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_3cmp_e",
"name":"Exchange of 3'-CMP(2-).",
"metabolites":{
"3cmp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_3cmp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"CGLYtex",
"name":"L-Cysteinylglycine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"cgly_e":-1.0,
"cgly_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CGLYtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__3HAD40",
"name":"3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C4:0)",
"metabolites":{
"__Ecoli_panGEMs__3haACP_c":-1.0,
"__Ecoli_panGEMs__but2eACP_c":1.0,
"h2o_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00975 or HFPHFOGF_00177",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__3HAD40",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1E141pp",
"name":"Phospholipase A1 (phosphatidylethanolamine, n-C14:1) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__2agpe141_p":1.0,
"__Ecoli_panGEMs__pe141_p":-1.0,
"h2o_p":-1.0,
"h_p":1.0,
"ttdcea_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA1E141pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAS60",
"name":"3-oxoacyl-[acyl-carrier-protein] synthase (n-C6:0)",
"metabolites":{
"__Ecoli_panGEMs__3ohexACP_c":1.0,
"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__butACP_c":-1.0,
"__Ecoli_panGEMs__malACP_c":-1.0,
"co2_c":1.0,
"h_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01113 or HFPHFOGF_02409",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__3OAS60",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAS160",
"name":"3-oxoacyl-[acyl-carrier-protein] synthase (n-C16:0)",
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"h_c":-1.0
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"biggr":"__Ecoli_panGEMs__3OAS160",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PAPA141",
"name":"Phosphatidate phosphatase (n-C14:1)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PAPA161",
"name":"Phosphatidate phosphatase (n-C16:1)",
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"subsystem":"Glycerophospholipid Metabolism",
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"sbo":"SBO:0000176"
}
},
{
"id":"GTHOXtex",
"name":"glutathione (ox) transport via diffusion (extracellular to periplasm)",
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"gthox_p":1.0
},
"lower_bound":-1000.0,
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"biggr":"GTHOXtex",
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}
},
{
"id":"__Ecoli_panGEMs__DSBAO1",
"name":"DsbA protein reoxidation reaction (aerobic)",
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"q8h2_c":1.0
},
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"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__DSBAO2",
"name":"DsbA protein reoxidation reaction (anaerobic)",
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"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__DSBDR",
"name":"DsbD reductase",
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"biggr":"__Ecoli_panGEMs__DSBDR",
"sbo":"SBO:0000176"
}
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{
"id":"__Ecoli_panGEMs__TDSR1",
"name":"Thiol:disulfide reductase (DsbC)",
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"biggr":"__Ecoli_panGEMs__TDSR1",
"sbo":"SBO:0000655"
}
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{
"id":"CGLYabcpp",
"name":"L-Cysteinylglycine (Cys-Gly) transport via ABC system (periplasm)",
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}
},
{
"id":"__Ecoli_panGEMs__PLIPA2A120pp",
"name":"Phospholipase A2 (phosphatidate, n-C12:0) (periplasm)",
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"sbo":"SBO:0000176"
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},
{
"id":"PLIPA2A160pp",
"name":"Phospholipase A2 (phosphatidate, n-C16:0) (periplasm)",
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"rhea":"RHEA:63304",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CLPNH180pp",
"name":"Cardiolipin hydrolase (periplasm, n-C18:0)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAR60",
"name":"3-oxoacyl-[acyl-carrier-protein] reductase (n-C6:0)",
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}
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{
"id":"__Ecoli_panGEMs__3OAR80",
"name":"3-oxoacyl-[acyl-carrier-protein] reductase (n-C8:0)",
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}
},
{
"id":"__Ecoli_panGEMs__MLDCP3App",
"name":"Murein L,D-carboxypeptidase (murein5px3p) (periplasm)",
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},
{
"id":"__Ecoli_panGEMs__MLDCP1Bpp",
"name":"Murein L,D-carboxypeptidase (murein4p4p) (periplasm)",
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{
"id":"__Ecoli_panGEMs__2AGPE181tipp",
"name":"2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:1) transporter via facilitated diffusion (periplasm)",
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{
"id":"__Ecoli_panGEMs__2AGPA140tipp",
"name":"2-Acyl-sn-glycero-3-phosphatidate (n-C14:0) transporter via facilitated diffusion (periplasm)",
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},
{
"id":"__Ecoli_panGEMs__LPLIPAL2E120",
"name":"Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C12:0)",
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},
{
"id":"__Ecoli_panGEMs__EAR100x",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C10:0)",
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},
{
"id":"__Ecoli_panGEMs__EAR120x",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C12:0)",
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}
},
{
"id":"__Ecoli_panGEMs__EAR160x",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C16:0)",
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},
{
"id":"__Ecoli_panGEMs__2AGPA160tipp",
"name":"2-Acyl-sn-glycero-3-phosphatidate (n-C16:0) transporter via facilitated diffusion (periplasm)",
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},
{
"id":"ATHRDHr",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__2AGPA180tipp",
"name":"2-Acyl-sn-glycero-3-phosphatidate (n-C18:0) transporter via facilitated diffusion (periplasm)",
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"subsystem":"Transport, Inner Membrane",
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}
},
{
"id":"__Ecoli_panGEMs__2AGPA141tipp",
"name":"2-Acyl-sn-glycero-3-phosphatidate (n-C14:1) transporter via facilitated diffusion (periplasm)",
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"subsystem":"Transport, Inner Membrane",
"annotation":{
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"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__EAR140y",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C14:0)",
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"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
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}
},
{
"id":"__Ecoli_panGEMs__3OAS121",
"name":"3-oxoacyl-[acyl-carrier-protein] synthase (n-C12:1)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAS80",
"name":"3-oxoacyl-[acyl-carrier-protein] synthase (n-C8:0)",
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"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAS100",
"name":"3-oxoacyl-[acyl-carrier-protein] synthase (n-C10:0)",
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"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAS120",
"name":"3-oxoacyl-[acyl-carrier-protein] synthase (n-C12:0)",
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},
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"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__3OAS120",
"sbo":"SBO:0000176"
}
},
{
"id":"LSERDHr",
"name":"L-serine dehydrogenase",
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"h_c":1.0,
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"nadph_c":1.0,
"ser__L_c":-1.0
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"lower_bound":-1000.0,
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"subsystem":"Glycine and Serine Metabolism",
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"rhea":"RHEA:21596",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAR40",
"name":"3-oxoacyl-[acyl-carrier-protein] reductase (n-C4:0)",
"metabolites":{
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"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAR100",
"name":"3-oxoacyl-[acyl-carrier-protein] reductase (n-C10:0)",
"metabolites":{
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"nadph_c":-1.0
},
"lower_bound":-1000.0,
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"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__3OAR100",
"sbo":"SBO:0000176"
}
},
{
"id":"DSERDHr",
"name":"D-serine dehydrogenase",
"metabolites":{
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"h_c":1.0,
"nadp_c":-1.0,
"nadph_c":1.0,
"ser__D_c":-1.0
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"lower_bound":-1000.0,
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"gene_reaction_rule":"HFPHFOGF_01629",
"subsystem":"Glycine and Serine Metabolism",
"annotation":{
"biggr":"DSERDHr",
"rhea":"RHEA:30107",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3HAD60",
"name":"3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C6:0)",
"metabolites":{
"__Ecoli_panGEMs__3hhexACP_c":-1.0,
"__Ecoli_panGEMs__thex2eACP_c":1.0,
"h2o_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00975 or HFPHFOGF_00177",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__3HAD60",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3HAD100",
"name":"3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C10:0)",
"metabolites":{
"__Ecoli_panGEMs__3hdecACP_c":-1.0,
"__Ecoli_panGEMs__tdec2eACP_c":1.0,
"h2o_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00975 or HFPHFOGF_00177",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__3HAD100",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3HAD140",
"name":"3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C14:0)",
"metabolites":{
"__Ecoli_panGEMs__3hmrsACP_c":-1.0,
"__Ecoli_panGEMs__tmrs2eACP_c":1.0,
"h2o_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00975 or HFPHFOGF_00177",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__3HAD140",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3HAD160",
"name":"3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C16:0)",
"metabolites":{
"__Ecoli_panGEMs__3hpalmACP_c":-1.0,
"__Ecoli_panGEMs__tpalm2eACP_c":1.0,
"h2o_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00975 or HFPHFOGF_00177",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__3HAD160",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_urate_e",
"name":"Exchange of 7,9-dihydro-1H-purine-2,6,8(3H)-trione.",
"metabolites":{
"urate_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_urate_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__PSD120",
"name":"Phosphatidylserine decarboxylase (n-C12:0)",
"metabolites":{
"__Ecoli_panGEMs__pe120_c":1.0,
"__Ecoli_panGEMs__ps120_c":-1.0,
"co2_c":1.0,
"h_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04301",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PSD120",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AGPAT180",
"name":"1-octadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:0)",
"metabolites":{
"1odecg3p_c":-1.0,
"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__ocdcaACP_c":-1.0,
"__Ecoli_panGEMs__pa180_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03131",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGPAT180",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AGPAT141",
"name":"1-tetradec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:1)",
"metabolites":{
"__Ecoli_panGEMs__1tdec7eg3p_c":-1.0,
"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__pa141_c":1.0,
"__Ecoli_panGEMs__tdeACP_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03131",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGPAT141",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PAPA120",
"name":"Phosphatidate phosphatase (n-C12:0)",
"metabolites":{
"12dgr120_c":1.0,
"__Ecoli_panGEMs__pa120_c":-1.0,
"h2o_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01391",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PAPA120",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_skm_e",
"name":"Exchange of shikimate.",
"metabolites":{
"skm_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_skm_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX___Ecoli_panGEMs__cpgn_un_e",
"name":"Coprogen unloaded (no Fe(III)) exchange",
"metabolites":{
"__Ecoli_panGEMs__cpgn_un_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__cpgn_un_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__MDDEP1pp",
"name":"Murein D,D-endopeptidase (murein4px4p) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__murein4p4p_p":1.0,
"__Ecoli_panGEMs__murein4px4p_p":-1.0,
"h2o_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03283 or HFPHFOGF_02414 or HFPHFOGF_02220 or HFPHFOGF_01711 or HFPHFOGF_01917 or HFPHFOGF_02261 or HFPHFOGF_00406",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__MDDEP1pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MDDEP2pp",
"name":"Murein D,D-endopeptidase (murein3px4p) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__murein3px4p_p":-1.0,
"__Ecoli_panGEMs__murein4p3p_p":1.0,
"h2o_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03283 or HFPHFOGF_02414 or HFPHFOGF_02220 or HFPHFOGF_01711 or HFPHFOGF_01917 or HFPHFOGF_02261 or HFPHFOGF_00406",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__MDDEP2pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__AGPAT161",
"name":"1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1)",
"metabolites":{
"__Ecoli_panGEMs__1hdec9eg3p_c":-1.0,
"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__hdeACP_c":-1.0,
"__Ecoli_panGEMs__pa161_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03131",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__AGPAT161",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__DASYN120",
"name":"CDP-diacylglycerol synthetase (n-C12:0)",
"metabolites":{
"__Ecoli_panGEMs__cdpdddecg_c":1.0,
"__Ecoli_panGEMs__pa120_c":-1.0,
"ctp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01494",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__DASYN120",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR40x",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C4:0)",
"metabolites":{
"__Ecoli_panGEMs__but2eACP_c":-1.0,
"__Ecoli_panGEMs__butACP_c":1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01402",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__EAR40x",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR60y",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C6:0)",
"metabolites":{
"__Ecoli_panGEMs__hexACP_c":1.0,
"__Ecoli_panGEMs__thex2eACP_c":-1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01402",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__EAR60y",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MLDEP1pp",
"name":"Murein L,D-endopeptidase (murein3px3p) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__murein3p3p_p":1.0,
"__Ecoli_panGEMs__murein3px3p_p":-1.0,
"h2o_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02414",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__MLDEP1pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PSD181",
"name":"Phosphatidylserine decarboxylase (n-C18:1)",
"metabolites":{
"__Ecoli_panGEMs__pe181_c":1.0,
"__Ecoli_panGEMs__ps181_c":-1.0,
"co2_c":1.0,
"h_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04301",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PSD181",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__DAGK180",
"name":"Diacylglycerol kinase (n-C18:0)",
"metabolites":{
"12dgr180_c":-1.0,
"__Ecoli_panGEMs__pa180_c":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04176",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__DAGK180",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__DAGK181",
"name":"Diacylglycerol kinase (n-C18:1)",
"metabolites":{
"12dgr181_c":-1.0,
"__Ecoli_panGEMs__pa181_c":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04176",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__DAGK181",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MLDEP2pp",
"name":"Murein L,D-endopeptidase (murein5px3p) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__murein5p3p_p":1.0,
"__Ecoli_panGEMs__murein5px3p_p":-1.0,
"h2o_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02414",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__MLDEP2pp",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_ag_e",
"name":"Exchange of silver(1+).",
"metabolites":{
"ag_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ag_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__MLTGY2pp",
"name":"Murein lytic transglycosylase (murein4p3p) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__anhgm3p_p":1.0,
"__Ecoli_panGEMs__anhgm4p_p":1.0,
"__Ecoli_panGEMs__murein4p3p_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03091 or HFPHFOGF_04532 or HFPHFOGF_02922 or HFPHFOGF_02793 or HFPHFOGF_01296 or HFPHFOGF_02641 or HFPHFOGF_00209 or HFPHFOGF_01115",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__MLTGY2pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA2E120pp",
"name":"Phospholipase A2 (phosphatidylethanolamine, n-C12:0) (periplasm)",
"metabolites":{
"1agpe120_p":1.0,
"__Ecoli_panGEMs__pe120_p":-1.0,
"ddca_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA2E120pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA2G141pp",
"name":"Phospholipase A2 (phosphatidylglycerol, n-C14:1) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__1agpg141_p":1.0,
"__Ecoli_panGEMs__pg141_p":-1.0,
"h2o_p":-1.0,
"h_p":1.0,
"ttdcea_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA2G141pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MLTGY4pp",
"name":"Murein lytic transglycosylase (murein4px4p4p) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__anhgm4p_p":1.0,
"__Ecoli_panGEMs__murein4px4p4p_p":-1.0,
"__Ecoli_panGEMs__murein4px4p_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04532 or HFPHFOGF_02922 or HFPHFOGF_02793 or HFPHFOGF_01296 or HFPHFOGF_03091 or HFPHFOGF_02641 or HFPHFOGF_00209 or HFPHFOGF_01115",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__MLTGY4pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR60x",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C6:0)",
"metabolites":{
"__Ecoli_panGEMs__hexACP_c":1.0,
"__Ecoli_panGEMs__thex2eACP_c":-1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01402",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__EAR60x",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA2G161pp",
"name":"Phospholipase A2 (phosphatidylglycerol, n-C16:1) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__1agpg161_p":1.0,
"__Ecoli_panGEMs__pg161_p":-1.0,
"h2o_p":-1.0,
"h_p":1.0,
"hdcea_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA2G161pp",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_cys__D_e",
"name":"Exchange of D-cysteine zwitterion.",
"metabolites":{
"cys__D_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cys__D_e",
"sbo":"SBO:0000627"
}
},
{
"id":"LPLIPAL1A120pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphotidate, n-C12:0) (periplasm)",
"metabolites":{
"1ddecg3p_p":-1.0,
"ddca_p":1.0,
"glyc3p_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00523",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"LPLIPAL1A120pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL1A140pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphotidate, n-C14:0) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__1tdecg3p_p":-1.0,
"glyc3p_p":1.0,
"h2o_p":-1.0,
"h_p":1.0,
"ttdca_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00523",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL1A140pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__EAR80x",
"name":"Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C8:0)",
"metabolites":{
"__Ecoli_panGEMs__ocACP_c":1.0,
"__Ecoli_panGEMs__toct2eACP_c":-1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01402",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__EAR80x",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PE181abcpp",
"name":"Phosphatidylethanolamine transport via ABC system (n-C18:1, periplasm)",
"metabolites":{
"__Ecoli_panGEMs__pe181_c":-1.0,
"__Ecoli_panGEMs__pe181_p":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00935",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__PE181abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"12DGR161tipp",
"name":"1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C16:1)",
"metabolites":{
"12dgr161_c":1.0,
"12dgr161_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"12DGR161tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"12DGR181tipp",
"name":"1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C18:1)",
"metabolites":{
"12dgr181_c":1.0,
"12dgr181_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"12DGR181tipp",
"sbo":"SBO:0000655"
}
},
{
"id":"NTP11",
"name":"nucleoside-triphosphatase (dITP)",
"metabolites":{
"didp_c":1.0,
"ditp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04534",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"NTP11",
"rhea":"RHEA:30859",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL1A181pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphotidate, n-C18:1) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__1odec11eg3p_p":-1.0,
"glyc3p_p":1.0,
"h2o_p":-1.0,
"h_p":1.0,
"ocdcea_p":1.0
},
"lower_bound":0.0,
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"subsystem":"Glycerophospholipid Metabolism",
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"biggr":"__Ecoli_panGEMs__LPLIPAL1A181pp",
"sbo":"SBO:0000176"
}
},
{
"id":"LPLIPAL1E120pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C12:0) (periplasm)",
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"ddca_p":1.0,
"g3pe_p":1.0,
"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00523",
"subsystem":"Glycerophospholipid Metabolism",
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"biggr":"LPLIPAL1E120pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAR180",
"name":"3-oxoacyl-[acyl-carrier-protein] reductase (n-C18:0)",
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"__Ecoli_panGEMs__3ooctdACP_c":-1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01111",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__3OAR180",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__G3PAT120",
"name":"Glycerol-3-phosphate acyltransferase (C12:0)",
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"1ddecg3p_c":1.0,
"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__ddcaACP_c":-1.0,
"glyc3p_c":-1.0
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"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01112 and HFPHFOGF_04175",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__G3PAT120",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PGSA120",
"name":"Phosphatidylglycerol synthase (n-C12:0)",
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"__Ecoli_panGEMs__pgp120_c":1.0,
"cmp_c":1.0,
"glyc3p_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01987",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PGSA120",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3OAS180",
"name":"3-oxoacyl-[acyl-carrier-protein] synthase (n-C18:0)",
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"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__malACP_c":-1.0,
"__Ecoli_panGEMs__palmACP_c":-1.0,
"co2_c":1.0,
"h_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01113 or HFPHFOGF_02409",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__3OAS180",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__3HAD180",
"name":"3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C18:0)",
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"__Ecoli_panGEMs__toctd2eACP_c":1.0,
"h2o_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00975 or HFPHFOGF_00177",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__3HAD180",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CDAPPA120",
"name":"CDP-Diacylglycerol pyrophostatase (n-C12:0)",
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"__Ecoli_panGEMs__pa120_c":1.0,
"cmp_c":1.0,
"h2o_c":-1.0,
"h_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04047",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__CDAPPA120",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__TDSR2",
"name":"Thiol:disulfide reductase (DsbG)",
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"__Ecoli_panGEMs__dsbdox_c":1.0,
"__Ecoli_panGEMs__dsbdrd_c":-1.0,
"__Ecoli_panGEMs__dsbgox_p":-1.0,
"__Ecoli_panGEMs__dsbgrd_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00623 and HFPHFOGF_04275",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__TDSR2",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_acser_e",
"name":"Exchange of O-acetyl-L-serine zwitterion.",
"metabolites":{
"acser_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_acser_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GTHRDtex",
"name":"glutathione transport via diffusion (extracellular to periplasm)",
"metabolites":{
"gthrd_e":-1.0,
"gthrd_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GTHRDtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GTHRDabc2pp",
"name":"glutathione export via ABC system (cytoplasm to periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"gthrd_c":-1.0,
"gthrd_p":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00906 and HFPHFOGF_00907",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GTHRDabc2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"OMMBLHX3",
"name":"2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase (anaerobic)",
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"2omhmbl_c":1.0,
"2ommbl_c":-1.0,
"adp_c":2.0,
"atp_c":-2.0,
"h2o_c":-3.0,
"h_c":3.0,
"nad_c":-1.0,
"nadh_c":1.0,
"pi_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"OMMBLHX3",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PSSA120",
"name":"Phosphatidylserine syntase (n-C12:0)",
"metabolites":{
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"__Ecoli_panGEMs__ps120_c":1.0,
"cmp_c":1.0,
"h_c":1.0,
"ser__L_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02668",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PSSA120",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__UM4PL",
"name":"UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate-D-alanine ligase",
"metabolites":{
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"__Ecoli_panGEMs__um4p_c":1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"uamr_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04382",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__UM4PL",
"sbo":"SBO:0000176"
}
},
{
"id":"2MAHMP",
"name":"2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphatase",
"metabolites":{
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"4ampm_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
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"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00476 or HFPHFOGF_01208",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"2MAHMP",
"rhea":"RHEA:27914",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_cu_e",
"name":"Exchange of copper(1+).",
"metabolites":{
"cu_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_cu_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ZN2tpp",
"name":"zinc transport in via permease (no H+)",
"metabolites":{
"zn2_c":1.0,
"zn2_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03151",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"ZN2tpp",
"sbo":"SBO:0000655"
}
},
{
"id":"NI2tpp",
"name":"nickel (+2) transport in via permease (no H+)",
"metabolites":{
"ni2_c":1.0,
"ni2_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03944",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"NI2tpp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_arbtn_e",
"name":"Exchange of aerobactinate(3-).",
"metabolites":{
"arbtn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_arbtn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"COBALT2t3pp",
"name":"cobalt (Co+2) transport out via proton antiport (periplasm)",
"metabolites":{
"cobalt2_c":-1.0,
"cobalt2_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00772 or HFPHFOGF_04043",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"COBALT2t3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__23DAPPAt2pp",
"name":"2,3-diaminopropionate transport in via proton symport",
"metabolites":{
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"__Ecoli_panGEMs__23dappa_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"__Ecoli_panGEMs__23DAPPAt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"NADHPO",
"name":"NADH peroxidase",
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"h2o_c":2.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00625 and HFPHFOGF_00624",
"subsystem":"Unassigned",
"annotation":{
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"rhea":"RHEA:18509",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ACOAD7f",
"name":"Acyl-CoA dehydrogenase (hexadecanoyl-CoA)",
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"fadh2_c":1.0,
"hdd2coa_c":1.0,
"pmtcoa_c":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00241",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ACOAD8f",
"name":"Acyl-CoA dehydrogenase (octadecanoyl-CoA)",
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"fadh2_c":1.0,
"od2coa_c":1.0,
"stcoa_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00241",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1A120pp",
"name":"Phospholipase A1 (phosphatidate, n-C12:0) (periplasm)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ACOAD5f",
"name":"Acyl-CoA dehydrogenase (dodecanoyl-CoA)",
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"dd2coa_c":1.0,
"ddcacoa_c":-1.0,
"fadh2_c":1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00241",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1A140pp",
"name":"Phospholipase A1 (phosphatidate, n-C14:0) (periplasm)",
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"pa140_p":-1.0,
"ttdca_p":1.0
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"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"EX_dopa_e",
"name":"Exchange of dopaminium(1+).",
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"dopa_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_dopa_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1A141pp",
"name":"Phospholipase A1 (phosphatidate, n-C14:1) (periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__pa141_p":-1.0,
"h2o_p":-1.0,
"ttdcea_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA1A141pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1A160pp",
"name":"Phospholipase A1 (phosphatidate, n-C16:0) (periplasm)",
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"h2o_p":-1.0,
"hdca_p":1.0,
"pa160_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1A161pp",
"name":"Phospholipase A1 (phosphatidate, n-C16:1) (periplasm)",
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"h2o_p":-1.0,
"hdcea_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA1A180pp",
"name":"Phospholipase A1 (phosphatidate, n-C18:0) (periplasm)",
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"ocdca_p":1.0
},
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"subsystem":"Glycerophospholipid Metabolism",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2A120",
"name":"Lysophospholipase L2 (2-acylglycerophosphotidate, n-C12:0)",
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"h2o_c":-1.0,
"h_c":2.0
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"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"CAt6pp",
"name":"calcium / sodium antiporter (1:1)",
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"ca2_p":1.0,
"na1_c":1.0,
"na1_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03297",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"CAt6pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__ACOAD3f",
"name":"Acyl-CoA dehydrogenase (octanoyl-CoA)",
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"fadh2_c":1.0,
"oc2coa_c":1.0,
"octcoa_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00241",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ACOAD2f",
"name":"Acyl-CoA dehydrogenase (hexanoyl-CoA)",
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"fadh2_c":1.0,
"hx2coa_c":1.0,
"hxcoa_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00241",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ACOAD4f",
"name":"Acyl-CoA dehydrogenase (decanoyl-CoA)",
"metabolites":{
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"dc2coa_c":1.0,
"dcacoa_c":-1.0,
"fadh2_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00241",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ACOAD6f",
"name":"Acyl-CoA dehydrogenase (tetradecanoyl-CoA)",
"metabolites":{
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"fadh2_c":1.0,
"td2coa_c":1.0,
"tdcoa_c":-1.0
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"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00241",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"NADH16pp",
"name":"NADH dehydrogenase (ubiquinone-8 & 3 protons) (periplasm)",
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"h_p":3.0,
"nad_c":1.0,
"nadh_c":-1.0,
"q8_c":-1.0,
"q8h2_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03011",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"NADH16pp",
"sbo":"SBO:0000655"
}
},
{
"id":"NADH18pp",
"name":"NADH dehydrogenase (demethylmenaquinone-8 & 3 protons) (periplasm)",
"metabolites":{
"2dmmq8_c":-1.0,
"2dmmql8_c":1.0,
"h_c":-4.0,
"h_p":3.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02364 and HFPHFOGF_02362 and HFPHFOGF_02369 and HFPHFOGF_02367 and HFPHFOGF_02363 and HFPHFOGF_02373 and HFPHFOGF_02361 and HFPHFOGF_02372 and HFPHFOGF_02368 and HFPHFOGF_02366 and HFPHFOGF_02371 and HFPHFOGF_02365 and HFPHFOGF_02370",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"NADH18pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_tartr__D_e",
"name":"Exchange of D-tartrate(2-).",
"metabolites":{
"tartr__D_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_tartr__D_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GLYBt2pp",
"name":"Glycine betaine transport via proton symport (periplasm)",
"metabolites":{
"glyb_c":1.0,
"glyb_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01860 or HFPHFOGF_04248",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLYBt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GALCTNt2pp",
"name":"D-galactonate transport via proton symport (periplasm)",
"metabolites":{
"galctn__D_c":1.0,
"galctn__D_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03819",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GALCTNt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GALCTNLtex",
"name":"L-galactonate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"galctn__L_e":-1.0,
"galctn__L_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02300 or HFPHFOGF_01462 or HFPHFOGF_00950 or HFPHFOGF_00262",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"GALCTNLtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_galctn__L_e",
"name":"Exchange of L-galactonate.",
"metabolites":{
"galctn__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_galctn__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"DSERt2pp",
"name":"D-serine transport in via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"ser__D_c":1.0,
"ser__D_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04359",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"DSERt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_hom__L_e",
"name":"Exchange of L-homoserine zwitterion.",
"metabolites":{
"hom__L_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_hom__L_e",
"sbo":"SBO:0000627"
}
},
{
"id":"ALAt4pp",
"name":"L-alanine transport in via sodium symport (periplasm)",
"metabolites":{
"ala__L_c":1.0,
"ala__L_p":-1.0,
"na1_c":1.0,
"na1_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00006",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ALAt4pp",
"sbo":"SBO:0000655"
}
},
{
"id":"LYSt3pp",
"name":"L-lysine transport out via proton antiport (cytoplasm to periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"lys__L_c":-1.0,
"lys__L_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03054 or HFPHFOGF_00894",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"LYSt3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"KDUI",
"name":"5-keto-4-deoxyuronate isomerase",
"metabolites":{
"dkdglcn_c":1.0,
"dt5hsu_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02960",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"KDUI",
"rhea":"RHEA:23896",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_tungs_e",
"name":"Exchange of tungstate.",
"metabolites":{
"tungs_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_tungs_e",
"sbo":"SBO:0000627"
}
},
{
"id":"CA2t3pp",
"name":"calcium (Ca+2) transport out via proton antiport (periplasm)",
"metabolites":{
"ca2_c":-1.0,
"ca2_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01323",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"CA2t3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"CTBTCAL2",
"name":"Crotonobetaine-CoA Ligase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"ctbt_c":-1.0,
"ctbtcoa_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00038",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"CTBTCAL2",
"sbo":"SBO:0000176"
}
},
{
"id":"OBTFL",
"name":"2-Oxobutanoate formate lyase",
"metabolites":{
"2obut_c":-1.0,
"coa_c":-1.0,
"for_c":1.0,
"ppcoa_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"((HFPHFOGF_00922 and HFPHFOGF_00923) and HFPHFOGF_02662) or (HFPHFOGF_00922 and HFPHFOGF_00923) or (HFPHFOGF_00922 and HFPHFOGF_03220)",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"OBTFL",
"rhea":"RHEA:28054",
"sbo":"SBO:0000176"
}
},
{
"id":"NADH17pp",
"name":"NADH dehydrogenase (menaquinone-8 & 3 protons) (periplasm)",
"metabolites":{
"h_c":-4.0,
"h_p":3.0,
"mql8_c":1.0,
"mqn8_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02364 and HFPHFOGF_02362 and HFPHFOGF_02369 and HFPHFOGF_02367 and HFPHFOGF_02363 and HFPHFOGF_02373 and HFPHFOGF_02361 and HFPHFOGF_02372 and HFPHFOGF_02368 and HFPHFOGF_02366 and HFPHFOGF_02371 and HFPHFOGF_02365 and HFPHFOGF_02370",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"NADH17pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FA161ACPHi",
"name":"Fatty-acyl-ACP hydrolase",
"metabolites":{
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"__Ecoli_panGEMs__hdeACP_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"hdcea_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00434",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__FA161ACPHi",
"sbo":"SBO:0000176"
}
},
{
"id":"BGLA1",
"name":"6-phospho-beta-glucosidase",
"metabolites":{
"6pgg_c":-1.0,
"g6p_c":1.0,
"glc__D_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01791 or HFPHFOGF_02808 or HFPHFOGF_03852",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"BGLA1",
"rhea":"RHEA:10772",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FA141ACPHi",
"name":"Fatty-acyl-ACP hydrolase",
"metabolites":{
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"__Ecoli_panGEMs__tdeACP_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ttdcea_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00434",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__FA141ACPHi",
"sbo":"SBO:0000176"
}
},
{
"id":"THRt2pp",
"name":"L-threonine efflux transport via proton antiport (periplasm)",
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"h_c":1.0,
"h_p":-1.0,
"thr__L_c":-1.0,
"thr__L_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00833 or HFPHFOGF_03951",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"THRt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"ARGt3pp",
"name":"L-arginine transport out via proton antiport (cytoplasm to periplasm)",
"metabolites":{
"arg__L_c":-1.0,
"arg__L_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03054",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ARGt3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FA160ACPHi",
"name":"Fatty-acyl-ACP hydrolase",
"metabolites":{
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"__Ecoli_panGEMs__palmACP_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"hdca_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00434",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__FA160ACPHi",
"sbo":"SBO:0000176"
}
},
{
"id":"MALDtex",
"name":"D-Malate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"mal__D_e":-1.0,
"mal__D_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"MALDtex",
"sbo":"SBO:0000655"
}
},
{
"id":"OROTtex",
"name":"Orotate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"orot_e":-1.0,
"orot_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_00950 or HFPHFOGF_02300 or HFPHFOGF_00262",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"OROTtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_crn__D_e",
"name":"Exchange of (S)-carnitine.",
"metabolites":{
"crn__D_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_crn__D_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GDPMNP",
"name":"GDP-mannose phyrophosphatase",
"metabolites":{
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"gmp_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"man1p_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02544",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"GDPMNP",
"rhea":"RHEA:27978",
"sbo":"SBO:0000176"
}
},
{
"id":"OPHHX3",
"name":"2-Octaprenylphenol hydroxylase (anaerobic)",
"metabolites":{
"2ohph_c":1.0,
"2oph_c":-1.0,
"adp_c":2.0,
"atp_c":-2.0,
"h2o_c":-3.0,
"h_c":3.0,
"nad_c":-1.0,
"nadh_c":1.0,
"pi_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"OPHHX3",
"sbo":"SBO:0000176"
}
},
{
"id":"AMMQLT8",
"name":"S-adenosylmethione:2-demthylmenaquinole methyltransferase (menaquinone 8)",
"metabolites":{
"2dmmql8_c":-1.0,
"ahcys_c":1.0,
"amet_c":-1.0,
"h_c":1.0,
"mql8_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03961",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"AMMQLT8",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FA120ACPHi",
"name":"Fatty-acyl-ACP hydrolase",
"metabolites":{
"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__ddcaACP_c":-1.0,
"ddca_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00434",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__FA120ACPHi",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FA80ACPHi",
"name":"Fatty-acyl-ACP hydrolase",
"metabolites":{
"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__ocACP_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"octa_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00434",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__FA80ACPHi",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FA140ACPHi",
"name":"Fatty-acyl-ACP hydrolase",
"metabolites":{
"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__myrsACP_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"ttdca_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00434",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__FA140ACPHi",
"sbo":"SBO:0000176"
}
},
{
"id":"PPAt4pp",
"name":"Na+/Propionate symporter (periplasm)",
"metabolites":{
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"na1_p":-1.0,
"prpnte_c":1.0,
"prpnte_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01036",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PPAt4pp",
"sbo":"SBO:0000655"
}
},
{
"id":"OROTt2_2pp",
"name":"Orotate transport via proton symport (2 H) (periplasm)",
"metabolites":{
"h_c":2.0,
"h_p":-2.0,
"orot_c":1.0,
"orot_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03633",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"OROTt2_2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"MALDt2_2pp",
"name":"D-Malate transport via proton symport (2 H) (periplasm)",
"metabolites":{
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"h_p":-2.0,
"mal__D_c":1.0,
"mal__D_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03633",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"MALDt2_2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FA100ACPHi",
"name":"Fatty-acyl-ACP hydrolase",
"metabolites":{
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"__Ecoli_panGEMs__dcaACP_c":-1.0,
"dca_c":1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00434",
"subsystem":"Cell Envelope Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__FA100ACPHi",
"sbo":"SBO:0000176"
}
},
{
"id":"CRNDCAL2",
"name":"D-Carnitine-CoA Ligase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"crnDcoa_c":1.0,
"crn__D_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00038",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"CRNDCAL2",
"rhea":"RHEA:30543",
"sbo":"SBO:0000176"
}
},
{
"id":"5DGLCNtex",
"name":"5-Dehydro-D-gluconate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"5dglcn_e":-1.0,
"5dglcn_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"5DGLCNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX___Ecoli_panGEMs__LalaDgluMdapDala_e",
"name":"L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine exchange",
"metabolites":{
"__Ecoli_panGEMs__LalaDgluMdapDala_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__LalaDgluMdapDala_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_5dglcn_e",
"name":"Exchange of 5-dehydro-D-gluconate.",
"metabolites":{
"5dglcn_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_5dglcn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"DTARTD",
"name":"D(-)-tartrate dehydratase",
"metabolites":{
"h2o_c":1.0,
"oaa_c":1.0,
"tartr__D_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04260",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"DTARTD",
"rhea":"RHEA:18289",
"sbo":"SBO:0000176"
}
},
{
"id":"CRNCAL2",
"name":"Carnitine-CoA Ligase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"coa_c":-1.0,
"crn_c":-1.0,
"crncoa_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00040",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"CRNCAL2",
"sbo":"SBO:0000176"
}
},
{
"id":"CHLt2pp",
"name":"choline transport via proton symport (periplasm)",
"metabolites":{
"chol_c":1.0,
"chol_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00348 or HFPHFOGF_01860",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"CHLt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GLYt4pp",
"name":"glycine transport in via sodium symport (periplasm)",
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"gly_c":1.0,
"gly_p":-1.0,
"na1_c":1.0,
"na1_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00006",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLYt4pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA2E161pp",
"name":"Phospholipase A2 (phosphatidylethanolamine, n-C16:1) (periplasm)",
"metabolites":{
"__Ecoli_panGEMs__1agpe161_p":1.0,
"__Ecoli_panGEMs__pe161_p":-1.0,
"h2o_p":-1.0,
"h_p":1.0,
"hdcea_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA2E161pp",
"sbo":"SBO:0000176"
}
},
{
"id":"PLIPA2E180pp",
"name":"Phospholipase A2 (phosphatidylethanolamine, n-C18:0) (periplasm)",
"metabolites":{
"1agpe180_p":1.0,
"h2o_p":-1.0,
"h_p":1.0,
"ocdca_p":1.0,
"pe180_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"PLIPA2E180pp",
"sbo":"SBO:0000176"
}
},
{
"id":"FRULYSE",
"name":"fructoselysine 3-epimerase",
"metabolites":{
"frulys_c":1.0,
"psclys_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03477",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"FRULYSE",
"rhea":"RHEA:28390",
"sbo":"SBO:0000176"
}
},
{
"id":"FRULYSt2pp",
"name":"Fructoselysine transport via proton symport (periplasm)",
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"frulys_c":1.0,
"frulys_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03475",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"FRULYSt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX___Ecoli_panGEMs__LalaDgluMdap_e",
"name":"L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate exchange",
"metabolites":{
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__LalaDgluMdap_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_psclys_e",
"name":"Exchange of psicosyllysine(1+).",
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_psclys_e",
"sbo":"SBO:0000627"
}
},
{
"id":"TUNGStex",
"name":"tungstate transport via diffusion (extracellular to periplasm)",
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"tungs_e":-1.0,
"tungs_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00950 or HFPHFOGF_02300 or HFPHFOGF_01462 or HFPHFOGF_00262",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"TUNGStex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA2G120pp",
"name":"Phospholipase A2 (phosphatidylglycerol, n-C12:0) (periplasm)",
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"__Ecoli_panGEMs__pg120_p":-1.0,
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"h2o_p":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03949",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA2G120pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__PLIPA2G180pp",
"name":"Phospholipase A2 (phosphatidylglycerol, n-C18:0) (periplasm)",
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"__Ecoli_panGEMs__pg180_p":-1.0,
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"h_p":1.0,
"ocdca_p":1.0
},
"lower_bound":0.0,
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__PLIPA2G180pp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL1A161pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphotidate, n-C16:1) (periplasm)",
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"h_p":1.0,
"hdcea_p":1.0
},
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"gene_reaction_rule":"HFPHFOGF_00523",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL1A161pp",
"sbo":"SBO:0000176"
}
},
{
"id":"LPLIPAL1A160pp",
"name":"Lysophospholipase L1 (2-acylglycerophosphotidate, n-C16:0) (periplasm)",
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"glyc3p_p":1.0,
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},
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"gene_reaction_rule":"HFPHFOGF_00523",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"LPLIPAL1A160pp",
"rhea":"RHEA:49092",
"sbo":"SBO:0000176"
}
},
{
"id":"PSCLYSt2pp",
"name":"psicoselysine transport via proton symport (periplasm)",
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"h_p":-1.0,
"psclys_c":1.0,
"psclys_p":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03475",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"PSCLYSt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"LYSt2pp",
"name":"L-lysine transport in via proton symport (periplasm)",
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"h_p":-1.0,
"lys__L_c":1.0,
"lys__L_p":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02241",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"LYSt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"COBALT2tpp",
"name":"cobalt transport in via permease (no H+)",
"metabolites":{
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"cobalt2_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03151 or HFPHFOGF_03944",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"COBALT2tpp",
"sbo":"SBO:0000655"
}
},
{
"id":"OXCDC",
"name":"Oxalyl-CoA decarboxylase",
"metabolites":{
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"forcoa_c":1.0,
"h_c":-1.0,
"oxalcoa_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02460",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"OXCDC",
"rhea":"RHEA:19333",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2A140",
"name":"Lysophospholipase L2 (2-acylglycerophosphotidate, n-C14:0)",
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"glyc3p_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"ttdca_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2A140",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2A160",
"name":"Lysophospholipase L2 (2-acylglycerophosphotidate, n-C16:0)",
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"glyc3p_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"hdca_c":1.0
},
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"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2A160",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2A161",
"name":"Lysophospholipase L2 (2-acylglycerophosphotidate, n-C16:1)",
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"glyc3p_c":1.0,
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"h_c":2.0,
"hdcea_c":1.0
},
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"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2A161",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2A180",
"name":"Lysophospholipase L2 (2-acylglycerophosphotidate, n-C18:0)",
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"h_c":2.0,
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"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2A180",
"sbo":"SBO:0000176"
}
},
{
"id":"GLYt2pp",
"name":"glycine transport in via proton symport (periplasm)",
"metabolites":{
"gly_c":1.0,
"gly_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_01860 or HFPHFOGF_04359",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GLYt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"ALAt2pp",
"name":"L-alanine transport in via proton symport (periplasm)",
"metabolites":{
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"ala__L_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04359 or HFPHFOGF_04269",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ALAt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX___Ecoli_panGEMs__anhgm_e",
"name":"N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramic acid exchange",
"metabolites":{
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__anhgm_e",
"sbo":"SBO:0000627"
}
},
{
"id":"BALAt2pp",
"name":"beta-alanine transport in via proton symport (periplasm)",
"metabolites":{
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"ala_B_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04359",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"BALAt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"DALAt2pp",
"name":"D-alanine transport in via proton symport (periplasm)",
"metabolites":{
"ala__D_c":1.0,
"ala__D_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04359",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"DALAt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"FE2tpp",
"name":"iron (+2) transport in via permease (no H+)",
"metabolites":{
"fe2_c":1.0,
"fe2_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03151",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"FE2tpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__LPLIPAL2A181",
"name":"Lysophospholipase L2 (2-acylglycerophosphotidate, n-C18:1)",
"metabolites":{
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"glyc3p_c":1.0,
"h2o_c":-1.0,
"h_c":2.0,
"ocdcea_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03953",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__LPLIPAL2A181",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_aacald_c",
"name":"Exchange of ammonioacetaldehyde.",
"metabolites":{
"aacald_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Intracellular demand",
"annotation":{
"biggr":"EX_aacald_c",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__UM3PL",
"name":"UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase",
"metabolites":{
"__Ecoli_panGEMs__LalaDgluMdap_c":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"uamr_c":-1.0,
"ugmd_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04382",
"subsystem":"Murein Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__UM3PL",
"sbo":"SBO:0000176"
}
},
{
"id":"MN2tpp",
"name":"manganese transport in via permease (no H+)",
"metabolites":{
"mn2_c":1.0,
"mn2_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03151",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"MN2tpp",
"sbo":"SBO:0000655"
}
},
{
"id":"MG2tpp",
"name":"magnesium (+2) transport in via diffusion",
"metabolites":{
"mg2_c":1.0,
"mg2_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03944",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"MG2tpp",
"sbo":"SBO:0000655"
}
},
{
"id":"5MTRtex",
"name":"5-Methylthio-D-ribose transport via proton diffusion (extracellular to periplasm)",
"metabolites":{
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"5mtr_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_00950 or HFPHFOGF_02300 or HFPHFOGF_00262",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"5MTRtex",
"sbo":"SBO:0000655"
}
},
{
"id":"NI2t3pp",
"name":"nickle (Ni+2) transport out via proton antiport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"ni2_c":-1.0,
"ni2_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04043 or HFPHFOGF_00772",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"NI2t3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"PPAtex",
"name":"propionate transport via diffusion",
"metabolites":{
"prpnte_e":-1.0,
"prpnte_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_01462 or HFPHFOGF_00950 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"PPAtex",
"sbo":"SBO:0000655"
}
},
{
"id":"GALCTNLt2pp",
"name":"L-galactonate transport via proton symport (periplasm)",
"metabolites":{
"galctn__L_c":1.0,
"galctn__L_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04493",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"GALCTNLt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"GALCTLO",
"name":"L-galactonate oxidoreductase",
"metabolites":{
"galctn__L_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"tagur_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04495",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"GALCTLO",
"rhea":"RHEA:30183",
"sbo":"SBO:0000176"
}
},
{
"id":"THYMt3pp",
"name":"thymine transport out via proton antiport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"thym_c":-1.0,
"thym_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"THYMt3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"CLt3_2pp",
"name":"chloride transport out via proton antiport (2:1) (periplasm)",
"metabolites":{
"cl_c":2.0,
"cl_p":-2.0,
"h_c":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00152",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"CLt3_2pp:2",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_ppal_e",
"name":"Exchange of propanal.",
"metabolites":{
"ppal_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ppal_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__POR5",
"name":"Pyruvate synthase",
"metabolites":{
"__Ecoli_panGEMs__flxr_c":2.0,
"__Ecoli_panGEMs__flxso_c":-2.0,
"accoa_c":1.0,
"co2_c":1.0,
"coa_c":-1.0,
"h_c":1.0,
"pyr_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_01463 and HFPHFOGF_00699) or (HFPHFOGF_01463 and HFPHFOGF_03028)",
"subsystem":"Pyruvate Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__POR5",
"sbo":"SBO:0000176"
}
},
{
"id":"HACD8",
"name":"3-hydroxyacyl-CoA dehydrogenase (3-oxooctadecanoyl-CoA), peroxisomal",
"metabolites":{
"3hodcoa_c":1.0,
"3ohodcoa_c":-1.0,
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03972 or HFPHFOGF_02426",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"HACD8",
"rhea":"RHEA:78739",
"sbo":"SBO:0000176"
}
},
{
"id":"CTECOAI8",
"name":"3-cis-2-trans-enoyl-CoA isomerase",
"metabolites":{
"octdececoa_c":-1.0,
"od2coa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03972",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"CTECOAI8",
"sbo":"SBO:0000176"
}
},
{
"id":"CTECOAI6",
"name":"3-cis-2-trans-enoyl-CoA isomerase",
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"tdecoa_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03972",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"CTECOAI6",
"sbo":"SBO:0000176"
}
},
{
"id":"SELGTHR",
"name":"selenate glutathione reductase",
"metabolites":{
"dgslnt_c":1.0,
"gthox_c":1.0,
"gthrd_c":-4.0,
"h2o_c":3.0,
"h_c":-2.0,
"slnt_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"SELGTHR",
"rhea":"RHEA:34903",
"sbo":"SBO:0000176"
}
},
{
"id":"SELGTHR3",
"name":"selenate glutathione reductase III",
"metabolites":{
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"gthrd_c":1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"seln_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"SELGTHR3",
"rhea":"RHEA:34931",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_slnt_e",
"name":"Exchange of selenite(2-).",
"metabolites":{
"slnt_e":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_slnt_e",
"sbo":"SBO:0000627"
}
},
{
"id":"MALCOAMT",
"name":"Malonyl-CoA methyltransferase",
"metabolites":{
"ahcys_c":1.0,
"amet_c":-1.0,
"malcoa_c":-1.0,
"malcoame_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00797",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"MALCOAMT",
"sbo":"SBO:0000176"
}
},
{
"id":"PSCLYStex",
"name":"psicoselysine transporter via diffusion (extracellular)",
"metabolites":{
"psclys_e":-1.0,
"psclys_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00950 or HFPHFOGF_02300 or HFPHFOGF_01462 or HFPHFOGF_00262",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"PSCLYStex",
"sbo":"SBO:0000655"
}
},
{
"id":"THYMtex",
"name":"thymine transport via diffusion (extracellular to periplasm)",
"metabolites":{
"thym_e":-1.0,
"thym_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00262 or HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"THYMtex",
"sbo":"SBO:0000655"
}
},
{
"id":"CU2tpp",
"name":"copper transport in via permease (no H+)",
"metabolites":{
"cu2_c":1.0,
"cu2_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03151",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"CU2tpp",
"sbo":"SBO:0000655"
}
},
{
"id":"FE2t3pp",
"name":"iron (Fe+2) transport out via proton antiport (periplasm)",
"metabolites":{
"fe2_c":-1.0,
"fe2_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_04043",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"FE2t3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"MN2t3pp",
"name":"manganese (Mn+2) transport out via proton antiport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"mn2_c":-1.0,
"mn2_p":1.0
},
"lower_bound":0.0,
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"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"MN2t3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"MG2t3_2pp",
"name":"magnesium (Mg+2) transport in/out via proton antiport (periplasm)",
"metabolites":{
"h_c":-2.0,
"h_p":2.0,
"mg2_c":1.0,
"mg2_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"MG2t3_2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"CD2tpp",
"name":"cadmium (+2) transport in via permease (no H+)",
"metabolites":{
"cd2_c":1.0,
"cd2_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03151",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"CD2tpp",
"sbo":"SBO:0000655"
}
},
{
"id":"ETHAt2pp",
"name":"ethanolamine transport in via proton symport",
"metabolites":{
"etha_c":1.0,
"etha_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ETHAt2pp",
"sbo":"SBO:0000655"
}
},
{
"id":"FE3abcpp",
"name":"iron (III) transport via ABC system (periplasm to cytoplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"fe3_c":1.0,
"fe3_p":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"FE3abcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"THRA",
"name":"Threonine aldolase",
"metabolites":{
"acald_c":1.0,
"gly_c":1.0,
"thr__L_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02634 or HFPHFOGF_00890",
"subsystem":"Threonine and Lysine Metabolism",
"annotation":{
"biggr":"THRA",
"rhea":"RHEA:19625",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__OGMEACPS",
"name":"3-Oxo-glutaryl-[ACP] methyl ester synthase",
"metabolites":{
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"__Ecoli_panGEMs__ogmeACP_c":1.0,
"co2_c":1.0,
"coa_c":1.0,
"h_c":-1.0,
"malcoame_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01109",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__OGMEACPS",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__OGMEACPR",
"name":"3-Oxo-glutaryl-[ACP] methyl ester reductase",
"metabolites":{
"__Ecoli_panGEMs__hgmeACP_c":1.0,
"__Ecoli_panGEMs__ogmeACP_c":-1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01111",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__OGMEACPR",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__OPMEACPS",
"name":"3-Oxo-pimeloyl-[ACP] methyl ester synthase",
"metabolites":{
"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__gmeACP_c":-1.0,
"__Ecoli_panGEMs__malACP_c":-1.0,
"__Ecoli_panGEMs__opmeACP_c":1.0,
"co2_c":1.0,
"h_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02409",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__OPMEACPS",
"sbo":"SBO:0000176"
}
},
{
"id":"LIPAabctex",
"name":"lipid A transport via ABC system (periplasm to extracellular)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"lipa_e":1.0,
"lipa_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04409 and HFPHFOGF_04408 and HFPHFOGF_03300 and HFPHFOGF_03302 and HFPHFOGF_03301 and HFPHFOGF_00055 and HFPHFOGF_00660",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"LIPAabctex",
"sbo":"SBO:0000655"
}
},
{
"id":"DGUNC",
"name":"diguanylate cyclase",
"metabolites":{
"cdigmp_c":1.0,
"gtp_c":-2.0,
"ppi_c":2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01456 or HFPHFOGF_01853 or HFPHFOGF_01625 or HFPHFOGF_01045 or HFPHFOGF_01580 or (((HFPHFOGF_02159 and HFPHFOGF_02160) and HFPHFOGF_00416) and HFPHFOGF_02027)",
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"annotation":{
"biggr":"DGUNC",
"rhea":"RHEA:24898",
"sbo":"SBO:0000176"
}
},
{
"id":"XYLK2",
"name":"L-xylulokinase",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h_c":1.0,
"xu5p__L_c":1.0,
"xylu__L_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00063 or HFPHFOGF_03689",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"XYLK2",
"rhea":"RHEA:18869",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__GLBRAN2:2",
"name":"1,4-alpha-glucan branching enzyme (glycogen -> bglycogen)",
"metabolites":{
"__Ecoli_panGEMs__bglycogen_c":-1.0,
"__Ecoli_panGEMs__glycogen_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03534",
"subsystem":"Glycolysis/Gluconeogenesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__GLBRAN2",
"sbo":"SBO:0000176"
}
},
{
"id":"LALADGLUtex",
"name":"L-alanyl-D-glutamate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"LalaDglu_e":-1.0,
"LalaDglu_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02300 or HFPHFOGF_01462 or HFPHFOGF_00262 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"LALADGLUtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__S2FE2SR",
"name":"SUF [2Fe-2S] regeneration",
"metabolites":{
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"__Ecoli_panGEMs__sufbcd_2fe2s_c":1.0,
"__Ecoli_panGEMs__sufbcd_c":-1.0,
"__Ecoli_panGEMs__sufse_c":1.0,
"__Ecoli_panGEMs__sufsesh_c":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":5.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01737 and HFPHFOGF_01736 and HFPHFOGF_01739 and HFPHFOGF_01738 and HFPHFOGF_01740",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__S2FE2SR",
"sbo":"SBO:0000176"
}
},
{
"id":"CDGUNPD",
"name":"cyclic bis(3->5')diguanylate phosphodiesterase",
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"cdigmp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02582 or HFPHFOGF_01579 or HFPHFOGF_03630 or HFPHFOGF_01399 or HFPHFOGF_00349",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"CDGUNPD",
"rhea":"RHEA:24902",
"sbo":"SBO:0000176"
}
},
{
"id":"ACACT8r",
"name":"acetyl-CoA acyltransferase (hexadecanoyl-CoA), (r)",
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"accoa_c":1.0,
"coa_c":-1.0,
"pmtcoa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02427 or HFPHFOGF_03971",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"ACACT8r",
"rhea":"RHEA:35279",
"sbo":"SBO:0000176"
}
},
{
"id":"LALALGLUtpp",
"name":"L-alanyl-L-glutamate transport in via proton symport (periplasm)",
"metabolites":{
"LalaLglu_c":1.0,
"LalaLglu_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01690 or HFPHFOGF_03598 or HFPHFOGF_04269 or HFPHFOGF_00728",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"LALALGLUtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"CTECOAI7",
"name":"3-cis-2-trans-enoyl-CoA isomerase",
"metabolites":{
"hdcoa_c":-1.0,
"hdd2coa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03972",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
"biggr":"CTECOAI7",
"rhea":"RHEA:28771",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CLIPAabctex",
"name":"Cold lipid A transport via ABC system (periplasm to extracellular)",
"metabolites":{
"__Ecoli_panGEMs__lipa_cold_e":1.0,
"__Ecoli_panGEMs__lipa_cold_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04409 and HFPHFOGF_04408 and HFPHFOGF_03300 and HFPHFOGF_03302 and HFPHFOGF_03301 and HFPHFOGF_00055 and HFPHFOGF_00660",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__CLIPAabctex",
"sbo":"SBO:0000655"
}
},
{
"id":"3AMACHYD",
"name":"3-aminoacrylate hydrolase",
"metabolites":{
"3amac_c":-1.0,
"h2o_c":-1.0,
"h_c":-1.0,
"msa_c":1.0,
"nh4_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01029",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"3AMACHYD",
"rhea":"RHEA:34947",
"sbo":"SBO:0000176"
}
},
{
"id":"K2L4Aabctex",
"name":"KDO(2)-lipid IV A transport via ABC system (periplasm to extracellular)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"kdo2lipid4_e":1.0,
"kdo2lipid4_p":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04409 and HFPHFOGF_04408 and HFPHFOGF_03300 and HFPHFOGF_03302 and HFPHFOGF_03301 and HFPHFOGF_00055 and HFPHFOGF_00660",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"K2L4Aabctex",
"sbo":"SBO:0000655"
}
},
{
"id":"FDH4pp",
"name":"formate dehydrogenase (quinone-8) (periplasm)",
"metabolites":{
"co2_p":1.0,
"for_p":-1.0,
"h_c":-2.0,
"h_p":1.0,
"q8_c":-1.0,
"q8h2_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_04021 and HFPHFOGF_04023 and HFPHFOGF_04020) or (HFPHFOGF_01563 and HFPHFOGF_01566 and HFPHFOGF_01565)",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"FDH4pp",
"sbo":"SBO:0000655"
}
},
{
"id":"FDH5pp",
"name":"Formate Dehydrogenase (menaquinone-8) (periplasm)",
"metabolites":{
"co2_p":1.0,
"for_p":-1.0,
"h_c":-2.0,
"h_p":1.0,
"mql8_c":1.0,
"mqn8_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_01563 and HFPHFOGF_01566 and HFPHFOGF_01565) or (HFPHFOGF_04021 and HFPHFOGF_04023 and HFPHFOGF_04020)",
"subsystem":"Oxidative Phosphorylation",
"annotation":{
"biggr":"FDH5pp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__ACPPAT140",
"name":"Acyl-(acyl carrier protein):phosphate acyltransferase (C14:0)",
"metabolites":{
"__Ecoli_panGEMs__ACP_c":1.0,
"__Ecoli_panGEMs__myrsACP_c":-1.0,
"__Ecoli_panGEMs__ttdcap_c":1.0,
"h_c":-1.0,
"pi_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01112 and HFPHFOGF_01108",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__ACPPAT140",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__APG3PAT140",
"name":"Acyl-phosphate:glycerol-3-phosphate acyltransferase (C14:0)",
"metabolites":{
"__Ecoli_panGEMs__1tdecg3p_c":1.0,
"__Ecoli_panGEMs__ttdcap_c":-1.0,
"glyc3p_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03169",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__APG3PAT140",
"sbo":"SBO:0000176"
}
},
{
"id":"LDGUNPD",
"name":"linear diguanylate phosphodiesterase",
"metabolites":{
"5pg35pg_c":-1.0,
"gmp_c":2.0,
"h2o_c":-1.0,
"h_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01399",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"LDGUNPD",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MPTAT",
"name":"Molybdopterin adenylyltransferase",
"metabolites":{
"__Ecoli_panGEMs__mpt_c":-1.0,
"__Ecoli_panGEMs__mptamp_c":1.0,
"atp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00008",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__MPTAT",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__APG3PAT141",
"name":"Acyl-phosphate:glycerol-3-phosphate acyltransferase (C14:1)",
"metabolites":{
"__Ecoli_panGEMs__1tdec7eg3p_c":1.0,
"__Ecoli_panGEMs__ttdceap_c":-1.0,
"glyc3p_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03169",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__APG3PAT141",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MOADSUx",
"name":"MoaD sulfuration (nadh, assumed)",
"metabolites":{
"__Ecoli_panGEMs__iscs_c":1.0,
"__Ecoli_panGEMs__iscssh_c":-1.0,
"__Ecoli_panGEMs__moadamp_c":-1.0,
"__Ecoli_panGEMs__moadcosh_c":1.0,
"amp_c":1.0,
"nad_c":1.0,
"nadh_c":-1.0
},
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"sbo":"SBO:0000176"
}
},
{
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"name":"3-hydroxypropionate transport via diffusion (extracellular to periplasm)",
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}
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{
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}
},
{
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"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__APG3PAT181",
"name":"Acyl-phosphate:glycerol-3-phosphate acyltransferase (C18:1)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__APH140",
"name":"Acylphosphatase (C14:0)",
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}
},
{
"id":"__Ecoli_panGEMs__APH160",
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"sbo":"SBO:0000176"
}
},
{
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}
},
{
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{
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}
},
{
"id":"__Ecoli_panGEMs__AOXSr2",
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},
{
"id":"MINCYCtpp",
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}
},
{
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}
},
{
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}
},
{
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{
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{
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{
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{
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},
{
"id":"__Ecoli_panGEMs__OGMEACPD",
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{
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{
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},
{
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},
{
"id":"REPHACCOAI",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ACPPAT141",
"name":"Acyl-(acyl carrier protein):phosphate acyltransferase (C14:1)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ACPPAT161",
"name":"Acyl-(acyl carrier protein):phosphate acyltransferase (C16:1)",
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"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ACPPAT180",
"name":"Acyl-(acyl carrier protein):phosphate acyltransferase (C18:0)",
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}
},
{
"id":"__Ecoli_panGEMs__APG3PAT160",
"name":"Acyl-phosphate:glycerol-3-phosphate acyltransferase (C16:0)",
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}
},
{
"id":"__Ecoli_panGEMs__APG3PAT161",
"name":"Acyl-phosphate:glycerol-3-phosphate acyltransferase (C16:1)",
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"sbo":"SBO:0000176"
}
},
{
"id":"MEOHtex",
"name":"Methanol transport via diffusion (extracellular to periplasm)",
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"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"MEOHtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_5mtr_e",
"name":"Exchange of S-methyl-5-thio-D-ribofuranose.",
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"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_5mtr_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__APG3PAT180",
"name":"Acyl-phosphate:glycerol-3-phosphate acyltransferase (C18:0)",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ICYSDS",
"name":"ISC Cysteine desulfuration",
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"annotation":{
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}
},
{
"id":"__Ecoli_panGEMs__MECDPDH5",
"name":"2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydratase",
"metabolites":{
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"h2o_c":1.0,
"h_c":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"(HFPHFOGF_02598 and HFPHFOGF_03028) or (HFPHFOGF_02598 and HFPHFOGF_00699)",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__MECDPDH5",
"sbo":"SBO:0000176"
}
},
{
"id":"CDGR",
"name":"7-cyano-7-deazaguanine reductase",
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"preq0_c":-1.0,
"preq1_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_04307",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
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"rhea":"RHEA:13409",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__RNTR1c2",
"name":"Ribonucleoside-triphosphate reductase (ATP) (flavodoxin)",
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"datp_c":1.0,
"h2o_c":1.0,
"h_c":-2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_04053 and HFPHFOGF_00699 and HFPHFOGF_04387 and HFPHFOGF_04386) or (HFPHFOGF_04053 and HFPHFOGF_03028 and HFPHFOGF_04387 and HFPHFOGF_04386) or (HFPHFOGF_00699 and HFPHFOGF_04387) or (HFPHFOGF_03028 and HFPHFOGF_04387)",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"__Ecoli_panGEMs__RNTR1c2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__RNTR2c2",
"name":"Ribonucleoside-triphosphate reductase (GTP) (flavodoxin)",
"metabolites":{
"__Ecoli_panGEMs__flxr_c":-2.0,
"__Ecoli_panGEMs__flxso_c":2.0,
"dgtp_c":1.0,
"gtp_c":-1.0,
"h2o_c":1.0,
"h_c":-2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_04053 and HFPHFOGF_03028 and HFPHFOGF_04387 and HFPHFOGF_04386) or (HFPHFOGF_03028 and HFPHFOGF_04387) or (HFPHFOGF_04053 and HFPHFOGF_00699 and HFPHFOGF_04387 and HFPHFOGF_04386) or (HFPHFOGF_00699 and HFPHFOGF_04387)",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"__Ecoli_panGEMs__RNTR2c2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__I4FE4SR",
"name":"ISC [4Fe-4S] Reduction",
"metabolites":{
"__Ecoli_panGEMs__fad_c":1.0,
"__Ecoli_panGEMs__iscu_2fe2s2_c":-1.0,
"__Ecoli_panGEMs__iscu_4fe4s_c":1.0,
"fadh2_c":-1.0,
"h_c":-2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02612",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__I4FE4SR",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__S2FE2ST",
"name":"SUF [2Fe-2S] Transfer",
"metabolites":{
"2fe2s_c":1.0,
"__Ecoli_panGEMs__sufbcd_2fe2s_c":-1.0,
"__Ecoli_panGEMs__sufbcd_c":1.0,
"h_c":-4.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01739 and HFPHFOGF_01738 and HFPHFOGF_01741 and HFPHFOGF_01740",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__S2FE2ST",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__BMOCOS",
"name":"Bis-molybdenum cofactor synthase",
"metabolites":{
"__Ecoli_panGEMs__bmoco_c":1.0,
"__Ecoli_panGEMs__moco_c":-1.0,
"__Ecoli_panGEMs__mptamp_c":-1.0,
"amp_c":1.0,
"cu2_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00847",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__BMOCOS",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__BWCOS",
"name":"Tungsten bispterin cofactor synthase",
"metabolites":{
"__Ecoli_panGEMs__bwco_c":1.0,
"__Ecoli_panGEMs__mptamp_c":-1.0,
"__Ecoli_panGEMs__wco_c":-1.0,
"amp_c":1.0,
"cu2_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00847",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__BWCOS",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__RNTR3c2",
"name":"Ribonucleoside-triphosphate reductase (CTP) (flavodoxin)",
"metabolites":{
"__Ecoli_panGEMs__flxr_c":-2.0,
"__Ecoli_panGEMs__flxso_c":2.0,
"ctp_c":-1.0,
"dctp_c":1.0,
"h2o_c":1.0,
"h_c":-2.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_04053 and HFPHFOGF_00699 and HFPHFOGF_04387 and HFPHFOGF_04386) or (HFPHFOGF_04053 and HFPHFOGF_03028 and HFPHFOGF_04387 and HFPHFOGF_04386) or (HFPHFOGF_03028 and HFPHFOGF_04387) or (HFPHFOGF_00699 and HFPHFOGF_04387)",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"__Ecoli_panGEMs__RNTR3c2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__RNTR4c2",
"name":"Ribonucleoside-triphosphate reductase (UTP) (flavodoxin)",
"metabolites":{
"__Ecoli_panGEMs__flxr_c":-2.0,
"__Ecoli_panGEMs__flxso_c":2.0,
"dutp_c":1.0,
"h2o_c":1.0,
"h_c":-2.0,
"utp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_04053 and HFPHFOGF_00699 and HFPHFOGF_04387 and HFPHFOGF_04386) or (HFPHFOGF_04053 and HFPHFOGF_03028 and HFPHFOGF_04387 and HFPHFOGF_04386) or (HFPHFOGF_00699 and HFPHFOGF_04387) or (HFPHFOGF_03028 and HFPHFOGF_04387)",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"__Ecoli_panGEMs__RNTR4c2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__BWCOGDS1",
"name":"Tungsten bispterin guanine dinucleotide synthase (single GDP)",
"metabolites":{
"__Ecoli_panGEMs__bwco1gdp_c":1.0,
"__Ecoli_panGEMs__bwco_c":-1.0,
"gtp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_03983 and HFPHFOGF_03982) or HFPHFOGF_03983",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__BWCOGDS1",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__BWCOGDS2",
"name":"Tungsten bispterin guanine dinucleotide synthase",
"metabolites":{
"__Ecoli_panGEMs__bwco1gdp_c":-1.0,
"__Ecoli_panGEMs__bwcogdp_c":1.0,
"gtp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_03983 and HFPHFOGF_03982) or HFPHFOGF_03983",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__BWCOGDS2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FLDR2",
"name":"Flavodoxin reductase (NADPH)",
"metabolites":{
"__Ecoli_panGEMs__flxr_c":2.0,
"__Ecoli_panGEMs__flxso_c":-2.0,
"h_c":1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_04053 and HFPHFOGF_03028) or (HFPHFOGF_04053 and HFPHFOGF_00699)",
"subsystem":"Unassigned",
"annotation":{
"biggr":"__Ecoli_panGEMs__FLDR2",
"sbo":"SBO:0000176"
}
},
{
"id":"CDGS",
"name":"7-deaza-7-carboxyguanine synthase",
"metabolites":{
"cdg_c":1.0,
"cph4_c":-1.0,
"h_c":-1.0,
"nh4_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"CDGS",
"rhea":"RHEA:27974",
"sbo":"SBO:0000176"
}
},
{
"id":"5MTRtpp",
"name":"5-Methylthio-D-ribose transport via proton symport (periplasm)",
"metabolites":{
"5mtr_c":-1.0,
"5mtr_p":1.0,
"h_c":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"5MTRtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"TTRCYCtex",
"name":"Tetracycline transport via diffusion (extracellular to periplasm)",
"metabolites":{
"ttrcyc_e":-1.0,
"ttrcyc_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00950 or HFPHFOGF_00262 or HFPHFOGF_01462 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"TTRCYCtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__DHNPTE",
"name":"Dihydroneopterin epimerase",
"metabolites":{
"__Ecoli_panGEMs__dhnpt_c":-1.0,
"dhmpt_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03168",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__DHNPTE",
"sbo":"SBO:0000176"
}
},
{
"id":"DHMPTR",
"name":"Dihydromonapterin reductase",
"metabolites":{
"dhmpt_c":-1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"thmnp_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01660",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"DHMPTR",
"sbo":"SBO:0000176"
}
},
{
"id":"NOVBCNtpp",
"name":"Novobiocin transport via TolC system",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"novbcn_e":1.0,
"novbcn_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00492 and HFPHFOGF_03147 and HFPHFOGF_02547) or (HFPHFOGF_00492 and HFPHFOGF_03147 and HFPHFOGF_00491)",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"NOVBCNtpp:2",
"sbo":"SBO:0000655"
}
},
{
"id":"CMtex",
"name":"Chloramphenicol transport via diffusion (extracellular to periplasm)",
"metabolites":{
"cm_e":-1.0,
"cm_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02300 or HFPHFOGF_00950 or HFPHFOGF_01462 or HFPHFOGF_00262",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"CMtex",
"sbo":"SBO:0000655"
}
},
{
"id":"TTRCYCtpp",
"name":"Tetracycline transport via TolC system",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"ttrcyc_e":1.0,
"ttrcyc_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00492 and HFPHFOGF_03147 and HFPHFOGF_02547) or (HFPHFOGF_00492 and HFPHFOGF_03147 and HFPHFOGF_00491)",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"TTRCYCtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"LALALGLUtex",
"name":"L-alanyl-L-glutamate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"LalaLglu_e":-1.0,
"LalaLglu_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_02300",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"LALALGLUtex",
"sbo":"SBO:0000655"
}
},
{
"id":"LALADGLUtpp",
"name":"L-alanyl-D-glutamate transport in via proton symport (periplasm)",
"metabolites":{
"LalaDglu_c":1.0,
"LalaDglu_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00728 or HFPHFOGF_01690 or HFPHFOGF_03598 or HFPHFOGF_04269",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"LALADGLUtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__I2FE2SS",
"name":"ISC [2Fe-2S] Synthesis",
"metabolites":{
"__Ecoli_panGEMs__fad_c":1.0,
"__Ecoli_panGEMs__iscs_c":2.0,
"__Ecoli_panGEMs__iscssh_c":-2.0,
"__Ecoli_panGEMs__iscu_2fe2s_c":1.0,
"__Ecoli_panGEMs__iscu_c":-1.0,
"fadh2_c":-1.0,
"fe2_c":-2.0,
"h_c":6.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02613 and HFPHFOGF_02612",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__I2FE2SS",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__I2FE2ST",
"name":"ISC [2Fe-2S] Transfer",
"metabolites":{
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"__Ecoli_panGEMs__iscu_2fe2s_c":-1.0,
"__Ecoli_panGEMs__iscu_c":1.0,
"h_c":-4.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02612 and HFPHFOGF_02611",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__I2FE2ST",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FESR",
"name":"Iron-sulfur cluster repair",
"metabolites":{
"4fe4s_c":1.0,
"__Ecoli_panGEMs__3fe4s_c":-1.0,
"fe2_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04360",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__FESR",
"sbo":"SBO:0000176"
}
},
{
"id":"OXCOAHDH",
"name":"oxepin-CoA hydrolase/ 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (NADP+)",
"metabolites":{
"2oxpaccoa_c":-1.0,
"3oxdhscoa_c":1.0,
"h2o_c":-2.0,
"h_c":2.0,
"nadp_c":-1.0,
"nadph_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01473",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"OXCOAHDH",
"rhea":"RHEA:34875",
"sbo":"SBO:0000176"
}
},
{
"id":"DHACOAH",
"name":"2,3-dehydroadipyl-CoA hydratase",
"metabolites":{
"23dhacoa_c":-1.0,
"3hadpcoa_c":1.0,
"h2o_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01479",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"DHACOAH",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__I2FE2SS2",
"name":"ISC [2Fe-2S] Synthesis II",
"metabolites":{
"__Ecoli_panGEMs__fad_c":1.0,
"__Ecoli_panGEMs__iscs_c":2.0,
"__Ecoli_panGEMs__iscssh_c":-2.0,
"__Ecoli_panGEMs__iscu_2fe2s2_c":1.0,
"__Ecoli_panGEMs__iscu_2fe2s_c":-1.0,
"fadh2_c":-1.0,
"fe2_c":-2.0,
"h_c":6.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02613 and HFPHFOGF_02612",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__I2FE2SS2",
"sbo":"SBO:0000176"
}
},
{
"id":"MSAR",
"name":"malonic semialdehyde reductase",
"metabolites":{
"3hpp_c":1.0,
"h_c":-1.0,
"msa_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01028 or HFPHFOGF_01629",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"MSAR",
"rhea":"RHEA:26438",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__I4FE4ST",
"name":"ISC [4Fe-4S] Transfer",
"metabolites":{
"4fe4s_c":1.0,
"__Ecoli_panGEMs__iscu_4fe4s_c":-1.0,
"__Ecoli_panGEMs__iscu_c":1.0,
"h_c":-4.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02612 and HFPHFOGF_02611",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__I4FE4ST",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__S4FE4ST",
"name":"SUF [4Fe-4S] Transfer",
"metabolites":{
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"__Ecoli_panGEMs__sufbcd_4fe4s_c":-1.0,
"__Ecoli_panGEMs__sufbcd_c":1.0,
"h_c":-4.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01739 and HFPHFOGF_01738 and HFPHFOGF_01741 and HFPHFOGF_01740",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__S4FE4ST",
"sbo":"SBO:0000176"
}
},
{
"id":"THFAT",
"name":"Aminomethyltransferase",
"metabolites":{
"5fthf_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"methf_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02634",
"subsystem":"Folate Metabolism",
"annotation":{
"biggr":"THFAT",
"rhea":"RHEA:34767",
"sbo":"SBO:0000176"
}
},
{
"id":"THFAT:2",
"name":"Aminomethyltransferase",
"metabolites":{
"5fthf_c":-1.0,
"h2o_c":1.0,
"h_c":-1.0,
"methf_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03043",
"subsystem":"Folate Metabolism",
"annotation":{
"biggr":"THFAT",
"rhea":"RHEA:34767",
"sbo":"SBO:0000176"
}
},
{
"id":"SLNTtex",
"name":"selenite transport via diffusion (extracellular to periplasm)",
"metabolites":{
"slnt_e":-1.0,
"slnt_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_00950 or HFPHFOGF_02300 or HFPHFOGF_00262",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"SLNTtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__S2FE2SS2",
"name":"SUF [2Fe-2S] Synthesis II",
"metabolites":{
"__Ecoli_panGEMs__fad_c":1.0,
"__Ecoli_panGEMs__sufbcd_2fe2s2_c":1.0,
"__Ecoli_panGEMs__sufbcd_2fe2s_c":-1.0,
"__Ecoli_panGEMs__sufse_c":2.0,
"__Ecoli_panGEMs__sufsesh_c":-2.0,
"adp_c":1.0,
"atp_c":-1.0,
"fadh2_c":-1.0,
"fe2_c":-2.0,
"h2o_c":-1.0,
"h_c":7.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01737 and HFPHFOGF_01740 and HFPHFOGF_01738 and HFPHFOGF_01739 and HFPHFOGF_01736",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__S2FE2SS2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__BTS5",
"name":"Biotin synthase",
"metabolites":{
"2fe2s_c":-1.0,
"__Ecoli_panGEMs__2fe1s_c":1.0,
"amet_c":-1.0,
"btn_c":1.0,
"dad_5_c":1.0,
"dtbt_c":-1.0,
"h_c":1.0,
"met__L_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00795",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__BTS5",
"sbo":"SBO:0000176"
}
},
{
"id":"SELGTHR2",
"name":"selenate glutathione reductase II",
"metabolites":{
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"gslnt_c":1.0,
"gthrd_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"SELGTHR2",
"rhea":"RHEA:34927",
"sbo":"SBO:0000176"
}
},
{
"id":"EX_LalaLglu_e",
"name":"Exchange of L-alanyl-L-glutamate(1-).",
"metabolites":{
"LalaLglu_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_LalaLglu_e",
"sbo":"SBO:0000627"
}
},
{
"id":"GDPTPDP",
"name":"guanosine 3'-diphosphate 5'-triphosphate 3'-diphosphatase",
"metabolites":{
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"gtp_c":1.0,
"h2o_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03764",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"GDPTPDP:2",
"rhea":"RHEA:33055",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LIPOS",
"name":"Lipoate synthase",
"metabolites":{
"2fe2s_c":1.0,
"4fe4s_c":-1.0,
"__Ecoli_panGEMs__lipopb_c":1.0,
"__Ecoli_panGEMs__octapb_c":-1.0,
"amet_c":-2.0,
"dad_5_c":2.0,
"fe2_c":2.0,
"h_c":-1.0,
"met__L_c":2.0,
"nad_c":-1.0,
"nadh_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00647",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__LIPOS",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__COLIPAKpp",
"name":"Lipid A core kinase (periplasm)",
"metabolites":{
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"__Ecoli_panGEMs__colipap_p":1.0,
"udcpdp_p":-1.0,
"udcpp_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02260",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__COLIPAKpp",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ACPPAT120",
"name":"Acyl-(acyl carrier protein):phosphate acyltransferase (C12:0)",
"metabolites":{
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"h_c":-1.0,
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_01112 and HFPHFOGF_01108",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__ACPPAT120",
"sbo":"SBO:0000176"
}
},
{
"id":"3HPPtpp",
"name":"3-hydroxypropionate transport via proton symport (periplasm)",
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"3hpp_c":-1.0,
"3hpp_p":1.0,
"h_c":-1.0,
"h_p":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"3HPPtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__MPTSS",
"name":"Molybdopterin synthase sulfurylase",
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"__Ecoli_panGEMs__moadcoo_c":-1.0,
"atp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00846",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__MPTSS",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CPMPS",
"name":"Cyclic pyranopterin monophosphate synthase",
"metabolites":{
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"gtp_c":-1.0,
"h2o_c":-1.0,
"ppi_c":1.0
},
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"gene_reaction_rule":"HFPHFOGF_00803 and HFPHFOGF_00801",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__CPMPS",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LIPOCT",
"name":"Lipoyl(octanoyl) transferase",
"metabolites":{
"__Ecoli_panGEMs__ACP_c":1.0,
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"__Ecoli_panGEMs__octapb_c":1.0,
"h_c":-1.0
},
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"gene_reaction_rule":"HFPHFOGF_00649",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__LIPOCT",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LIPATPT",
"name":"Lipoate-ATP adenylate transferase",
"metabolites":{
"__Ecoli_panGEMs__lipoamp_c":1.0,
"atp_c":-1.0,
"lipoate_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04525",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__LIPATPT",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__LIPAMPL",
"name":"Lipoyl-adenylate protein ligase",
"metabolites":{
"__Ecoli_panGEMs__lipoamp_c":-1.0,
"__Ecoli_panGEMs__lipopb_c":1.0,
"amp_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_04525",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__LIPAMPL",
"sbo":"SBO:0000176"
}
},
{
"id":"ALDD19xr",
"name":"aldehyde dehydrogenase (phenylacetaldehyde, NAD)",
"metabolites":{
"h2o_c":-1.0,
"h_c":2.0,
"nad_c":-1.0,
"nadh_c":1.0,
"pac_c":1.0,
"pacald_c":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01471",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"ALDD19xr",
"rhea":"RHEA:21392",
"sbo":"SBO:0000176"
}
},
{
"id":"MMM",
"name":"Methylmalonyl-CoA mutase",
"metabolites":{
"mmcoa__S_c":1.0,
"succoa_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03048",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"MMM",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MOGDS",
"name":"Molybdopterin guanine dinucleotide synthase",
"metabolites":{
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"__Ecoli_panGEMs__mocogdp_c":1.0,
"gtp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"(HFPHFOGF_03983 and HFPHFOGF_03982) or HFPHFOGF_03983",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__MOGDS",
"sbo":"SBO:0000176"
}
},
{
"id":"CPH4S",
"name":"6-carboxy-5,6,7,8-tetrahydropterin synthase",
"metabolites":{
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"ahdt_c":-1.0,
"cph4_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02868",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"CPH4S:2",
"rhea":"RHEA:27966",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__WCOS",
"name":"Tungsten pterin cofactor synthase",
"metabolites":{
"__Ecoli_panGEMs__mptamp_c":-1.0,
"__Ecoli_panGEMs__wco_c":1.0,
"amp_c":1.0,
"cu2_c":1.0,
"h2o_c":1.0,
"h_c":-2.0,
"tungs_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00847",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__WCOS",
"sbo":"SBO:0000176"
}
},
{
"id":"RFAMPtpp",
"name":"Rifampin transport via TolC system",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"rfamp_e":1.0,
"rfamp_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_00492 and HFPHFOGF_03147 and HFPHFOGF_00491) or (HFPHFOGF_00492 and HFPHFOGF_03147 and HFPHFOGF_02547)",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"RFAMPtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"SHCHCS3",
"name":"2-succinyl-6-hydroxy-2,4-cyclohexadiene 1-carboxylate synthase",
"metabolites":{
"2sephchc_c":-1.0,
"2shchc_c":1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02351",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"SHCHCS3",
"rhea":"RHEA:25597",
"sbo":"SBO:0000176"
}
},
{
"id":"VPAMTr",
"name":"Valine-pyruvate aminotransferase",
"metabolites":{
"3mob_c":-1.0,
"ala__L_c":-1.0,
"pyr_c":1.0,
"val__L_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03681",
"subsystem":"Valine, Leucine, and Isoleucine Metabolism",
"annotation":{
"biggr":"VPAMTr",
"rhea":"RHEA:22912",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ACOLIPAabctex",
"name":"Arabinose modified core oligosaccharide lipid A transport via ABC system (periplasm to extracellular)",
"metabolites":{
"__Ecoli_panGEMs__acolipa_e":1.0,
"__Ecoli_panGEMs__acolipa_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_04409 and HFPHFOGF_04408 and HFPHFOGF_03300 and HFPHFOGF_03302 and HFPHFOGF_03301 and HFPHFOGF_00055 and HFPHFOGF_00660",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__ACOLIPAabctex",
"sbo":"SBO:0000655"
}
},
{
"id":"PYK4",
"name":"Pyruvate Kinase (Anaerobic, CTP forming)",
"metabolites":{
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"ctp_c":1.0,
"h_c":-1.0,
"pep_c":-1.0,
"pyr_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01915",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"PYK4",
"rhea":"RHEA:56952",
"sbo":"SBO:0000176"
}
},
{
"id":"NADPHXD",
"name":"NADPHX dehydratase",
"metabolites":{
"adp_c":-1.0,
"amp_c":1.0,
"h_c":1.0,
"nadph_c":1.0,
"nadphx__S_c":-1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04308",
"subsystem":"Metabolite Repair",
"annotation":{
"biggr":"NADPHXD",
"rhea":"RHEA:32235",
"sbo":"SBO:0000176"
}
},
{
"id":"NADHHR",
"name":"NADH hydratase",
"metabolites":{
"h2o_c":-1.0,
"nadh_c":-1.0,
"nadhx__R_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01838",
"subsystem":"Metabolite Repair",
"annotation":{
"biggr":"NADHHR",
"rhea":"RHEA:57360",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ECA4COLIPAabctex",
"name":"Enterobacterial common antigen (x4) core oligosaccharide lipid A transport via ABC system (periplasm to extracellular)",
"metabolites":{
"__Ecoli_panGEMs__eca4colipa_e":1.0,
"__Ecoli_panGEMs__eca4colipa_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04409 and HFPHFOGF_04408 and HFPHFOGF_03300 and HFPHFOGF_03302 and HFPHFOGF_03301 and HFPHFOGF_00055 and HFPHFOGF_00660",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__ECA4COLIPAabctex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_ttrcyc_e",
"name":"Exchange of tetracycline zwitterion.",
"metabolites":{
"ttrcyc_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_ttrcyc_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__COLIPAPabctex",
"name":"Core oligosaccharide lipid A diphosphate transport via ABC system (periplasm to extracellular)",
"metabolites":{
"__Ecoli_panGEMs__colipap_e":1.0,
"__Ecoli_panGEMs__colipap_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04409 and HFPHFOGF_04408 and HFPHFOGF_03300 and HFPHFOGF_03302 and HFPHFOGF_03301 and HFPHFOGF_00055 and HFPHFOGF_00660",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__COLIPAPabctex",
"sbo":"SBO:0000655"
}
},
{
"id":"NADPHXE",
"name":"NADPHX epimerase",
"metabolites":{
"nadphx__R_c":-1.0,
"nadphx__S_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_04308",
"subsystem":"Metabolite Repair",
"annotation":{
"biggr":"NADPHXE",
"rhea":"RHEA:32227",
"sbo":"SBO:0000176"
}
},
{
"id":"ALAtpp",
"name":"L-alanine export via facilited diffusion",
"metabolites":{
"ala__L_c":-1.0,
"ala__L_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02762",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"ALAtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"CH4tex",
"name":"Methane Transport(extracellular via diffusion)",
"metabolites":{
"ch4_e":-1.0,
"ch4_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"CH4tex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_mincyc_e",
"name":"Exchange of minocycline zwitterion.",
"metabolites":{
"mincyc_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_mincyc_e",
"sbo":"SBO:0000627"
}
},
{
"id":"TARTRDtex",
"name":"D-tartrate transport via diffusion (extracellular to periplasm)",
"metabolites":{
"tartr__D_e":-1.0,
"tartr__D_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01462 or HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"TARTRDtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_pcresol_c",
"name":"Exchange of p-cresol.",
"metabolites":{
"pcresol_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Intracellular demand",
"annotation":{
"biggr":"EX_pcresol_c",
"sbo":"SBO:0000627"
}
},
{
"id":"3OXCOAT",
"name":"3-oxoadipyl-CoA thiolase",
"metabolites":{
"accoa_c":1.0,
"coa_c":-1.0,
"oxadpcoa_c":-1.0,
"succoa_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01483",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"3OXCOAT",
"rhea":"RHEA:19481",
"sbo":"SBO:0000176"
}
},
{
"id":"BTNt2ipp",
"name":"Biotin transport via proton symport (periplasm)",
"metabolites":{
"btn_c":1.0,
"btn_p":-1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"BTNt2ipp",
"sbo":"SBO:0000655"
}
},
{
"id":"URACPAH",
"name":"peroxyureidoacrylate hydrolase",
"metabolites":{
"cbm_c":1.0,
"h2o_c":-1.0,
"h_c":1.0,
"poaac_c":1.0,
"uracp_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01031",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"URACPAH",
"sbo":"SBO:0000176"
}
},
{
"id":"BTNtex",
"name":"Biotin transport via diffusion (extracellular to periplasm)",
"metabolites":{
"btn_e":-1.0,
"btn_p":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02300 or HFPHFOGF_01462 or HFPHFOGF_00262 or HFPHFOGF_00950",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"BTNtex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__DHBSZ3FEabcpp",
"name":"23dhbsz3 Fe III transport via ABC system periplasm",
"metabolites":{
"__Ecoli_panGEMs__fe3dhbzs3_c":1.0,
"__Ecoli_panGEMs__fe3dhbzs3_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00606 and HFPHFOGF_00607 and HFPHFOGF_00608 and HFPHFOGF_00610",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__DHBSZ3FEabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__FE3DHBZS3R",
"name":"Fe(III)-(2,3-dihydroxybenzoylserine)3 reductase via NADPH",
"metabolites":{
"__Ecoli_panGEMs__23dhbzs3_c":2.0,
"__Ecoli_panGEMs__fe3dhbzs3_c":-2.0,
"fe2_c":2.0,
"h_c":3.0,
"nadp_c":1.0,
"nadph_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03180",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"__Ecoli_panGEMs__FE3DHBZS3R",
"sbo":"SBO:0000176"
}
},
{
"id":"DXYLONtpp",
"name":"D-xylonate reversible tranposrt (periplasm)",
"metabolites":{
"dxylnt_c":1.0,
"dxylnt_p":-1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"DXYLONtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"2DGLCptspp",
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{
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{
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{
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{
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},
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},
{
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},
{
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},
{
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{
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{
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},
{
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},
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{
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{
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{
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{
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{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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}
},
{
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"name":"Gamma-hydroxybutyrate dehydrogenase (NADH)",
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{
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{
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}
},
{
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"sbo":"SBO:0000176"
}
},
{
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"name":"spermidine transport out via proton antiport (periplasm)",
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}
},
{
"id":"__Ecoli_panGEMs__FMNtex",
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}
},
{
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"sbo":"SBO:0000176"
}
},
{
"id":"EX_dxylnt_e",
"name":"Exchange of D-xylonate.",
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}
},
{
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"sbo":"SBO:0000176"
}
},
{
"id":"PHEtipp",
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}
},
{
"id":"G2PP",
"name":"glycerol-2-phosphate phosphatase",
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"pi_c":1.0
},
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"rhea":"RHEA:13105",
"sbo":"SBO:0000176"
}
},
{
"id":"MALt3pp",
"name":"L-malate transport out via proton antiport (periplasm)",
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"h_p":-1.0,
"mal__L_c":-1.0,
"mal__L_p":1.0
},
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"subsystem":"Transport, Inner Membrane",
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"sbo":"SBO:0000655"
}
},
{
"id":"CITt3pp",
"name":"citrate transport out via proton antiport (periplasm)",
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"sbo":"SBO:0000655"
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},
{
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}
},
{
"id":"__Ecoli_panGEMs__DHNPA2r",
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"sbo":"SBO:0000176"
}
},
{
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},
{
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"subsystem":"Transport, Inner Membrane",
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"sbo":"SBO:0000655"
}
},
{
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"crn__D_p":1.0
},
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}
},
{
"id":"SHGO",
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"sbo":"SBO:0000176"
}
},
{
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},
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}
},
{
"id":"ACOXT",
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"oxa_c":-1.0,
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"sbo":"SBO:0000176"
}
},
{
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"subsystem":"Extracellular exchange",
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},
{
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"name":"2-hydroxyethyldisulfide reductase",
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"mercpeth_c":2.0
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}
},
{
"id":"CHOLID",
"name":"7-?-hydroxysteroid dehydrogenase",
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"dhcholn_c":1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0
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"subsystem":"Alternate Carbon Metabolism",
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"sbo":"SBO:0000176"
}
},
{
"id":"CHOLATEtpp",
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"h_c":1.0,
"h_p":-1.0
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}
},
{
"id":"NADHXD",
"name":"NADHX dehydratase",
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"sbo":"SBO:0000176"
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},
{
"id":"NADPHHR",
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}
},
{
"id":"NADPHHS",
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"sbo":"SBO:0000176"
}
},
{
"id":"4ABZGLUH",
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"sbo":"SBO:0000176"
}
},
{
"id":"4ABZGLUtr",
"name":"p-aminobenzoyl glutamate:H+ symporter",
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"h_c":1.0,
"h_p":-1.0
},
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"subsystem":"Transport, Inner Membrane",
"annotation":{
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"sbo":"SBO:0000655"
}
},
{
"id":"NADHHS",
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},
"lower_bound":0.0,
"upper_bound":1000.0,
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"subsystem":"Metabolite Repair",
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"rhea":"RHEA:57364",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__APH180",
"name":"Acylphosphatase (C18:0)",
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"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"NADHXE",
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},
"lower_bound":-1000.0,
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"sbo":"SBO:0000176"
}
},
{
"id":"SELabcpp",
"name":"selenatenate transport via ABC system (periplasm)",
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"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
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}
},
{
"id":"PHDA",
"name":"phenylhydantoinase",
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"5phua_c":1.0,
"h2o_c":-1.0
},
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"subsystem":"Alternate Carbon Metabolism",
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"rhea":"RHEA:51664",
"sbo":"SBO:0000176"
}
},
{
"id":"TEO2M",
"name":"tellurite methyltransferase",
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},
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"gene_reaction_rule":"HFPHFOGF_01515",
"subsystem":"Unassigned",
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"sbo":"SBO:0000176"
}
},
{
"id":"PACOAT",
"name":"phenylacetyl-CoA thioesterase",
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"h_c":1.0,
"pac_c":1.0,
"phaccoa_c":-1.0
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"rhea":"RHEA:70427",
"sbo":"SBO:0000176"
}
},
{
"id":"CYSItpp",
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},
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"subsystem":"Transport, Inner Membrane",
"annotation":{
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"sbo":"SBO:0000655"
}
},
{
"id":"PYK2",
"name":"Pyruvate Kinase (Anaerobic, UTP forming)",
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"pep_c":-1.0,
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"udp_c":-1.0,
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"subsystem":"Nucleotide Salvage Pathway",
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"sbo":"SBO:0000176"
}
},
{
"id":"PYK3",
"name":"Pyruvate Kinase (Anaerobic, GTP forming)",
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"gtp_c":1.0,
"h_c":-1.0,
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"subsystem":"Nucleotide Salvage Pathway",
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"rhea":"RHEA:30295",
"sbo":"SBO:0000176"
}
},
{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__DHPTDNR",
"name":"Dihydropteridine reductase",
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},
"lower_bound":0.0,
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"subsystem":"Alternate Carbon Metabolism",
"annotation":{
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}
},
{
"id":"__Ecoli_panGEMs__DHPTDNRN",
"name":"Dihydropteridine reductase (NADH)",
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"subsystem":"Alternate Carbon Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"GTHPi",
"name":"glutathione peridoxase",
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"h2o2_c":-1.0,
"h2o_c":2.0
},
"lower_bound":0.0,
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"sbo":"SBO:0000176"
}
},
{
"id":"SEPHCHCS",
"name":"2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase",
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}
},
{
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},
{
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"sbo":"SBO:0000176"
}
},
{
"id":"PYK6",
"name":"Pyruvate Kinase (Anaerobic, dTTP forming)",
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"dttp_c":1.0,
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}
},
{
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},
{
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},
{
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}
},
{
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}
},
{
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"sbo":"SBO:0000176"
}
},
{
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}
},
{
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}
},
{
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}
},
{
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},
{
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},
{
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"sbo":"SBO:0000176"
}
},
{
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},
{
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{
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{
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},
{
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},
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{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
"id":"RU5PP",
"name":"Ribulose-5-Phosphate Phosphatase",
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},
{
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},
{
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},
{
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"name":"3-sulfolactaldehyde reductase",
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},
{
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},
{
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"name":"inosine transport out via proton antiport (perisplasm)",
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},
{
"id":"INDOLEt2pp:2",
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},
{
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}
},
{
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},
{
"id":"GLYtpp",
"name":"glycine transport via facillitated diffusion",
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"gly_p":1.0
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"subsystem":"Transport, Inner Membrane",
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},
{
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"name":"2,3-Dihydroxypropane-1-sulfonate exchange",
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"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
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"sbo":"SBO:0000627"
}
},
{
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"mal__L_c":-1.0,
"o2_c":-1.0,
"oaa_c":1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"",
"subsystem":"Citric Acid Cycle",
"annotation":{
"biggr":"MOX",
"sbo":"SBO:0000176"
}
},
{
"id":"URATEtex",
"name":"uric acid transport",
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"urate_p":1.0
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"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02300 or HFPHFOGF_00262 or HFPHFOGF_00950 or HFPHFOGF_01462",
"subsystem":"Transport, Outer Membrane Porin",
"annotation":{
"biggr":"URATEtex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_cs1_e",
"name":"Exchange of caesium(1+).",
"metabolites":{
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"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
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"sbo":"SBO:0000627"
}
},
{
"id":"EX___Ecoli_panGEMs__fusa_e",
"name":"Fusidic acid exchange",
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
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"sbo":"SBO:0000627"
}
},
{
"id":"CBL1tonex",
"name":"Cob(1)alamin transport via ton system (extermal)",
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"cbl1_p":1.0,
"h_c":1.0,
"h_p":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"(HFPHFOGF_01361 and HFPHFOGF_03120 and HFPHFOGF_03121) and HFPHFOGF_04094",
"subsystem":"Transport, Outer Membrane",
"annotation":{
"biggr":"CBL1tonex",
"sbo":"SBO:0000655"
}
},
{
"id":"CBItonex",
"name":"Cobinamide transport via ton system (extermal)",
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},
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"sbo":"SBO:0000655"
}
},
{
"id":"ARHGDx",
"name":"(R)-alpha-hydroxyglutarate dehydrogenase",
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"h_c":1.0,
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},
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"rhea":"RHEA:49612",
"sbo":"SBO:0000176"
}
},
{
"id":"CPL",
"name":"carbon-phosphorous lyase",
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},
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}
},
{
"id":"EX_mepn_e",
"name":"Exchange of methylphosphonate(1-).",
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
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"sbo":"SBO:0000627"
}
},
{
"id":"PSURItpp",
"name":"pseudouridine transport via permease",
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}
},
{
"id":"CYSTA",
"name":"cysteine transaminase irreversible",
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"mercppyr_c":1.0
},
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"rhea":"RHEA:17441",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FE3DCITR5",
"name":"Ferric-dicitrate reductase via nadph",
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}
},
{
"id":"CH4t2pp",
"name":"Methane Transport(periplasm)",
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"subsystem":"Transport, Inner Membrane",
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}
},
{
"id":"EX_cm_e",
"name":"Exchange of chloramphenicol.",
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"subsystem":"Extracellular exchange",
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}
},
{
"id":"4HTHRA",
"name":"4-hydroxy-L-threonine aldolase",
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},
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"sbo":"SBO:0000176"
}
},
{
"id":"EX_novbcn_e",
"name":"novobiocin exchange",
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"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_novbcn_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__I2FE2SR",
"name":"ISC [2Fe-2S] regeneration",
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"sbo":"SBO:0000176"
}
},
{
"id":"GAPP",
"name":"Glyceraldehyde-3-phosphate phosphatase",
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"h2o_c":-1.0,
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},
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"sbo":"SBO:0000176"
}
},
{
"id":"TYRL",
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}
},
{
"id":"__Ecoli_panGEMs__METGLCURt2pp",
"name":"1-O-methyl-Beta-D-glucuronate transport via proton symport (periplasm)",
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}
},
{
"id":"__Ecoli_panGEMs__METGLCURtex",
"name":"1-O-methyl-Beta-D-glucuronate via diffusion (extracellular)",
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}
},
{
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"sbo":"SBO:0000176"
}
},
{
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{
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},
{
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},
{
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},
{
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},
{
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}
},
{
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{
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}
},
{
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"name":"Acyl-phosphate:glycerol-3-phosphate acyltransferase (C12:0)",
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}
},
{
"id":"CYSItex",
"name":"L cystine transport via diffusion extracellular to periplasm",
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},
{
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"name":"L-serine export via facilitated transport",
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},
{
"id":"QUINDHyi",
"name":"Quinate dehydrogenase (NADP)",
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"rhea":"RHEA:18425",
"sbo":"SBO:0000176"
}
},
{
"id":"DHCURR",
"name":"NADPH-dependent dihydrocurcumin reductase",
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"h_c":-1.0,
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"rhea":"RHEA:34811",
"sbo":"SBO:0000176"
}
},
{
"id":"RHMND",
"name":"L-rhamnonate dehydratase",
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},
"lower_bound":-1000.0,
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"rhea":"RHEA:23080",
"sbo":"SBO:0000176"
}
},
{
"id":"3HBZCT",
"name":"3-hydroxybenzoyl-CoA thioesterase",
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"coa_c":1.0,
"h2o_c":-1.0
},
"lower_bound":0.0,
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"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
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}
},
{
"id":"CXSAMS",
"name":"carboxy-S-adenosyl-L-methionine synthase",
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}
},
{
"id":"EX_2dglc_e",
"name":"Exchange of 2-deoxy-D-glucopyranose.",
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"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
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"sbo":"SBO:0000627"
}
},
{
"id":"THRt2rpp",
"name":"L-threonine reversible transport via proton symport (periplasm)",
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"subsystem":"Transport, Inner Membrane",
"annotation":{
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"sbo":"SBO:0000655"
}
},
{
"id":"SERt2rpp",
"name":"L-serine reversible transport via proton symport (periplasm)",
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},
"lower_bound":0.0,
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"subsystem":"Transport, Inner Membrane",
"annotation":{
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"sbo":"SBO:0000655"
}
},
{
"id":"PNSPA",
"name":"Purine Nucleoside Phorphoramidase",
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"nalme_c":1.0
},
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"rhea":"RHEA:33395",
"sbo":"SBO:0000176"
}
},
{
"id":"4HTHRK",
"name":"4-Hydroxy-L-threonine kinase",
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"h_c":1.0,
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"rhea":"RHEA:28787",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__ACOAD1fr:2",
"name":"Acyl-CoA dehydrogenase (butanoyl-CoA)",
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"b2coa_c":1.0,
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00241",
"subsystem":"Membrane Lipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"AMPNTAT",
"name":"aminoalkylphosphonate N-acetyltransferase",
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"ampnt_c":-1.0,
"coa_c":1.0
},
"lower_bound":0.0,
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"sbo":"SBO:0000176"
}
},
{
"id":"EX_sq_e",
"name":"Exchange of 6-sulfo-alpha-D-quinovose(1-).",
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_sq_e",
"sbo":"SBO:0000627"
}
},
{
"id":"__Ecoli_panGEMs__APH120",
"name":"Acylphosphatase (C12:0)",
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00989",
"subsystem":"Glycerophospholipid Metabolism",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"URATEtpp",
"name":"uric acid transporter",
"metabolites":{
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"h_p":-1.0,
"urate_c":1.0,
"urate_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03020",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"URATEtpp",
"sbo":"SBO:0000655"
}
},
{
"id":"CS1tex",
"name":"cesium transport via diffusion",
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"cs1_p":1.0
},
"lower_bound":-1000.0,
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"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX___Ecoli_panGEMs__metglcur_e",
"sbo":"SBO:0000627"
}
},
{
"id":"EX_quin_e",
"name":"Quinate exchange",
"metabolites":{
"quin_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_quin_e",
"sbo":"SBO:0000627"
}
},
{
"id":"MC6PH",
"name":"monoacetylchitobiose-6-phosphate hydrolase",
"metabolites":{
"acgam6p_c":1.0,
"gam_c":1.0,
"h2o_c":-1.0,
"mchtbs6p_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01791",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"MC6PH",
"rhea":"RHEA:35087",
"sbo":"SBO:0000176"
}
},
{
"id":"FORCT",
"name":"Formyl-CoA Transferase",
"metabolites":{
"for_c":1.0,
"forcoa_c":-1.0,
"oxa_c":-1.0,
"oxalcoa_c":1.0
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_02461",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"FORCT",
"rhea":"RHEA:16545",
"sbo":"SBO:0000176"
}
},
{
"id":"SLNTabcpp",
"name":"selenite ABC transporter (periplasm)",
"metabolites":{
"adp_c":1.0,
"atp_c":-1.0,
"h2o_c":-1.0,
"h_c":1.0,
"pi_c":1.0,
"slnt_c":1.0,
"slnt_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_02508 and HFPHFOGF_02507 and HFPHFOGF_02510 and HFPHFOGF_02509) or (HFPHFOGF_02508 and HFPHFOGF_02507 and HFPHFOGF_04046 and HFPHFOGF_02509)",
"subsystem":"Inorganic Ion Transport and Metabolism",
"annotation":{
"biggr":"SLNTabcpp",
"sbo":"SBO:0000655"
}
},
{
"id":"VALt2rpp",
"name":"L-valine reversible transport via proton symport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"val__L_c":1.0,
"val__L_p":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00431",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"VALt2rpp",
"sbo":"SBO:0000655"
}
},
{
"id":"VALt3pp",
"name":"L-valine transport out via proton antiport (periplasm)",
"metabolites":{
"h_c":1.0,
"h_p":-1.0,
"val__L_c":-1.0,
"val__L_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"(HFPHFOGF_02774 and HFPHFOGF_02773) or HFPHFOGF_04280",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"VALt3pp",
"sbo":"SBO:0000655"
}
},
{
"id":"MN2tpp:2",
"name":"manganese transport in via permease (no H+)",
"metabolites":{
"mn2_c":-1.0,
"mn2_p":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01881",
"subsystem":"Transport, Inner Membrane",
"annotation":{
"biggr":"MN2tpp",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_3hpp_e",
"name":"Exchange of 3-hydroxypropionate.",
"metabolites":{
"3hpp_e":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Extracellular exchange",
"annotation":{
"biggr":"EX_3hpp_e",
"sbo":"SBO:0000627"
}
},
{
"id":"PACCOAE",
"name":"ring 1,2-phenylacetyl-CoA epoxidase (NADPH)",
"metabolites":{
"h2o_c":1.0,
"h_c":-1.0,
"nadp_c":1.0,
"nadph_c":-1.0,
"o2_c":-1.0,
"phaccoa_c":-1.0,
"rephaccoa_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01477 and HFPHFOGF_01474 and HFPHFOGF_01478 and HFPHFOGF_01475 and HFPHFOGF_01476",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"PACCOAE",
"rhea":"RHEA:32171",
"sbo":"SBO:0000176"
}
},
{
"id":"OXDHCOAT",
"name":"3-oxo-5,6-dehydrosuberyl-CoA thiolase",
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"3oxdhscoa_c":-1.0,
"accoa_c":1.0,
"coa_c":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_01483 and HFPHFOGF_01480",
"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"OXDHCOAT",
"rhea":"RHEA:34799",
"sbo":"SBO:0000176"
}
},
{
"id":"HADPCOADH3",
"name":"3-hydroxyadipyl-CoA dehydrogenase (NAD+)",
"metabolites":{
"3hadpcoa_c":-1.0,
"h_c":1.0,
"nad_c":-1.0,
"nadh_c":1.0,
"oxadpcoa_c":1.0
},
"lower_bound":-1000.0,
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"subsystem":"Alternate Carbon Metabolism",
"annotation":{
"biggr":"HADPCOADH3",
"rhea":"RHEA:34851",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__O16A4COLIPAabctex",
"name":"O16 antigen (x4) core oligosaccharide lipid A transport via ABC system (periplasm to extracellular)",
"metabolites":{
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"__Ecoli_panGEMs__o16a4colipa_p":-1.0,
"adp_c":1.0,
"atp_c":-1.0,
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"gene_reaction_rule":"HFPHFOGF_04409 and HFPHFOGF_04408 and HFPHFOGF_03300 and HFPHFOGF_03302 and HFPHFOGF_03301 and HFPHFOGF_00055 and HFPHFOGF_00660",
"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__O16A4COLIPAabctex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__COLIPAabctex",
"name":"Core oligosaccharide lipid A transport via ABC system (periplasm to extracellular)",
"metabolites":{
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"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__COLIPAabctex",
"sbo":"SBO:0000655"
}
},
{
"id":"__Ecoli_panGEMs__ENLIPAabctex",
"name":"Phosphoethanolamine lipid A transport via ABC system (periplasm to extracellular)",
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"__Ecoli_panGEMs__enlipa_p":-1.0,
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"subsystem":"Lipopolysaccharide Biosynthesis / Recycling",
"annotation":{
"biggr":"__Ecoli_panGEMs__ENLIPAabctex",
"sbo":"SBO:0000655"
}
},
{
"id":"EX_mththf_c",
"name":"Exchange of (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol.",
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"mththf_c":-1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"",
"subsystem":"Intracellular demand",
"annotation":{
"biggr":"EX_mththf_c",
"sbo":"SBO:0000627"
}
},
{
"id":"PYROX",
"name":"pyrimidine oxygenase",
"metabolites":{
"h_c":-1.0,
"nad_c":1.0,
"nadh_c":-1.0,
"o2_c":-1.0,
"ura_c":-1.0,
"uracp_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01027 and HFPHFOGF_01032",
"subsystem":"Nucleotide Salvage Pathway",
"annotation":{
"biggr":"PYROX",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__BMOGDS1",
"name":"Bis-molybdopterin guanine dinucleotide synthase (single GDP)",
"metabolites":{
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"__Ecoli_panGEMs__bmoco_c":-1.0,
"gtp_c":-1.0,
"h_c":-1.0,
"ppi_c":1.0
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_03983 or (HFPHFOGF_03983 and HFPHFOGF_03982)",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__BMOGDS1",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MPTS",
"name":"Molybdopterin synthase",
"metabolites":{
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"__Ecoli_panGEMs__moadcoo_c":2.0,
"__Ecoli_panGEMs__moadcosh_c":-2.0,
"__Ecoli_panGEMs__mpt_c":1.0,
"cu2_c":-1.0,
"h_c":5.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00805 and HFPHFOGF_00804",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__MPTS",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__MOCOS",
"name":"Molybdenum cofactor synthase",
"metabolites":{
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"h_c":-2.0,
"mobd_c":-1.0
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_00847",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__BMOGDS2",
"name":"Bis-molybdopterin guanine dinucleotide synthase",
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"gene_reaction_rule":"(HFPHFOGF_03983 and HFPHFOGF_03982) or HFPHFOGF_03983",
"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
"annotation":{
"biggr":"__Ecoli_panGEMs__BMOGDS2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__OCTNLL",
"name":"Octanoate non-lipoylated apo domain ligase",
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_04525",
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"annotation":{
"biggr":"__Ecoli_panGEMs__OCTNLL",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__R08991",
"name":"cyclic bis(3'->5')diguanylate 3'-guanylylhydrolase",
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},
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"annotation":{
"biggr":"__Ecoli_panGEMs__R08991",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__R00601",
"name":"S-adenosyl-L-methionine:tRNA 5-(aminomethyl)-2-thiouridylate N-methyltransferase",
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"gene_reaction_rule":"HFPHFOGF_02410",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__R10002",
"name":"6-carboxy-5,6,7,8-tetrahydropterin ammonia-lyase",
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"cdg_c":1
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02881",
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}
},
{
"id":"__Ecoli_panGEMs__R00577",
"name":"acyl-CoA:L-glutamine N-acyltransferase",
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"gln__L_c":-1
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_02961",
"annotation":{
"biggr":"__Ecoli_panGEMs__R00577",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__R12635",
"name":"N4-acetylcytidine amidohydrolase",
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"h2o_c":-1
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03033",
"annotation":{
"biggr":"__Ecoli_panGEMs__R12635",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__R10648",
"name":"L-threonylcarbamoyladenylate:adenine37 in tRNA N6-L-threonylcarbamoyltransferase",
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"gene_reaction_rule":"HFPHFOGF_03174",
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__R10463",
"name":"ATP:L-threonyl,HCO3- adenylyltransferase",
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"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03386",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__R04273",
"name":"peptidylproline cis-trans-isomerase",
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"((((HFPHFOGF_03451 and HFPHFOGF_03468) and HFPHFOGF_03904) and HFPHFOGF_04358) and HFPHFOGF_00028) and HFPHFOGF_00552",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__CCP",
"name":"ferrocytochrome-c:hydrogen-peroxide oxidoreductase",
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"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03621 and HFPHFOGF_03623",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__R00693",
"name":"acetyl-CoA:L-phenylalanine N-acetyltransferase",
"metabolites":{
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"coa_c":1,
"phe__L_c":-1
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03543",
"annotation":{
"biggr":"__Ecoli_panGEMs__R00693",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__R08224",
"name":"selenophosphate:O-phospho-L-seryl-tRNASec selenium transferase",
"metabolites":{
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},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_03701",
"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__R11202",
"name":"[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine acylhydrolase",
"metabolites":{
"__Ecoli_panGEMs__C08362_c":1,
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"h2o_c":-1
},
"lower_bound":0.0,
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"gene_reaction_rule":"HFPHFOGF_04339 and HFPHFOGF_00701",
"annotation":{
"biggr":"__Ecoli_panGEMs__R11202",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__R06264",
"name":"dolichyl beta-D-glucosyl-phosphate:alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol alpha-1,2-glucosyltransferase (configuration-retaining)",
"metabolites":{
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"__Ecoli_panGEMs__G10618_c":-1,
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},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_00393",
"annotation":{
"biggr":"__Ecoli_panGEMs__R06264",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__R02030",
"name":"CDP-diacylglycerol:phosphatidylglycerol diacylglycerolphosphotransferase (CMP-forming)",
"metabolites":{
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"cmp_c":1
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"gene_reaction_rule":"HFPHFOGF_01064",
"annotation":{
"biggr":"__Ecoli_panGEMs__R02030",
"sbo":"SBO:0000176"
}
},
{
"id":"GAPD:2",
"name":"glyceraldehyde-3-phosphate dehydrogenase",
"metabolites":{
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"g3p_c":-1,
"h_c":1,
"nad_c":-1,
"nadh_c":1,
"pi_c":-1
},
"lower_bound":-1000.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01502",
"annotation":{
"biggr":"GAPD",
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}
},
{
"id":"__Ecoli_panGEMs__GGCLUT2",
"name":"glutathione gamma-glutamyl cyclotransferase (5-oxo-L-proline producing)",
"metabolites":{
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"cgly_c":1,
"gthrd_c":-1
},
"lower_bound":0.0,
"upper_bound":1000.0,
"gene_reaction_rule":"HFPHFOGF_01325",
"annotation":{
"biggr":"__Ecoli_panGEMs__GGCLUT2",
"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__R05790",
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},
{
"id":"PYDXOR",
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},
{
"id":"__Ecoli_panGEMs__R02961",
"name":"S-adenosyl-L-methionine:adenine in DNA N6-methyltransferase",
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}
},
{
"id":"__Ecoli_panGEMs__RBK_Dr",
"name":"ATP:D-ribulose 5-phosphotransferase",
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},
{
"id":"AOBUTDs",
"name":"L-2-amino-3-oxobutanoate decarboxylation (spontaneous)",
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"co2_c":1.0,
"h_c":-1.0
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},
{
"id":"G5SADs",
"name":"L-glutamate 5-semialdehyde dehydratase (spontaneous)",
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"h_c":1.0,
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},
{
"id":"O2tpp",
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},
{
"id":"CO2tpp",
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},
{
"id":"ACALDtpp",
"name":"acetaldehyde reversible transport (periplasm)",
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{
"id":"DATPHs",
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"h_c":-1.0,
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{
"id":"NOtpp",
"name":"NO transport (diffusion)",
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"no_c":1.0,
"no_p":-1.0
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"upper_bound":1000.0,
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"subsystem":"Inorganic Ion Transport and Metabolism",
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},
{
"id":"N2Otpp",
"name":"nitrious oxide transport (diffusion)",
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},
{
"id":"FALDtpp",
"name":"formaldehyde transport via diffusion (periplasm)",
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"fald_p":-1.0
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"subsystem":"Transport, Inner Membrane",
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"sbo":"SBO:0000655"
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},
{
"id":"__Ecoli_panGEMs__FECRMexs",
"name":"Ferrichrome Fe(III)-loading reaction (spontaneous)",
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"fe3_e":-1.0
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"annotation":{
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"sbo":"SBO:0000176"
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},
{
"id":"__Ecoli_panGEMs__ARBTNexs",
"name":"Aerobactin Fe-loading reaction (spontaneous)",
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"fe3_e":-1.0
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"sbo":"SBO:0000176"
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},
{
"id":"__Ecoli_panGEMs__FEOXAMexs",
"name":"Ferroxamine Fe3-loading reaction (spontaneous)",
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"__Ecoli_panGEMs__feoxam_un_e":-1.0,
"fe3_e":-1.0
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"sbo":"SBO:0000176"
}
},
{
"id":"__Ecoli_panGEMs__FEENTERexs",
"name":"Enterobactin Fe(III) binding (spontaneous)",
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"enter_e":-1.0,
"fe3_e":-1.0
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"biggr":"__Ecoli_panGEMs__FEENTERexs",
"sbo":"SBO:0000176"
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{
"id":"__Ecoli_panGEMs__FE3HOXexs",
"name":"Fe(III) hydroxamate Fe-loading reaction (spontaneaous)",
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"__Ecoli_panGEMs__fe3hox_un_e":-1.0,
"fe3_e":-1.0
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"annotation":{
"biggr":"__Ecoli_panGEMs__FE3HOXexs",
"sbo":"SBO:0000176"
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},
{
"id":"__Ecoli_panGEMs__CPGNexs",
"name":"Coprogen Fe-loading reaction (spontaneaous)",
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"__Ecoli_panGEMs__cpgn_un_e":-1.0,
"fe3_e":-1.0
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"sbo":"SBO:0000176"
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{
"id":"ATPHs",
"name":"ATP amine hydrolysis (spontaneous)",
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"h2o_c":-1.0,
"h_c":-1.0,
"itp_c":1.0,
"nh4_c":1.0
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"sbo":"SBO:0000176"
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{
"id":"GTPHs",
"name":"GTP amine hydrolysis (spontaneous)",
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"h2o_c":-1.0,
"h_c":-1.0,
"nh4_c":1.0,
"xtp_c":1.0
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{
"id":"METOX1s",
"name":"methionine oxidation (spontaneous)",
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"h2o_c":1.0,
"met__L_c":-1.0,
"metsox_S__L_c":1.0
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"subsystem":"Methionine Metabolism",
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},
{
"id":"METOX2s",
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"h2o_c":1.0,
"met__L_c":-1.0,
"metsox_R__L_c":1.0
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},
{
"id":"FALGTHLs",
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"gthrd_c":-1.0,
"hmgth_c":1.0
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"rhea":"RHEA:22488",
"sbo":"SBO:0000176"
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{
"id":"OMCDC",
"name":"2-Oxo-4-methyl-3-carboxypentanoate decarboxylation",
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"co2_c":1.0,
"h_c":-1.0
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"lower_bound":0.0,
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"subsystem":"Valine, Leucine, and Isoleucine Metabolism",
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"sbo":"SBO:0000176"
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{
"id":"H2St1pp",
"name":"h2s transport (periplasm)",
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{
"id":"SO2tpp",
"name":"SO2 transport via diffusion (periplasm)",
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{
"id":"H2tpp",
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},
{
"id":"ACONIs",
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{
"id":"MTHTHFSs",
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"mdhdhf_c":-1.0,
"mththf_c":1.0
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"lower_bound":0.0,
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"sbo":"SBO:0000176"
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},
{
"id":"RFAMPtex",
"name":"Rifampin transport via diffusion (extracellular to periplasm)",
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"rfamp_p":1.0
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{
"id":"MEOHtrpp",
"name":"Methanol reversible transport via diffusion (periplasm)",
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"meoh_p":-1.0
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"subsystem":"Transport, Inner Membrane",
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},
{
"id":"ETOHtrpp",
"name":"ethanol reversible transport via diffusion (periplasm)",
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"etoh_p":-1.0
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{
"id":"CBMD",
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"co2_c":1.0,
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"sbo":"SBO:0000176"
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},
{
"id":"DMSOtpp",
"name":"Dimethyl sulfoxide transport via diffusion (periplasm)",
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"dmso_p":-1.0
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},
{
"id":"__Ecoli_panGEMs__FE3DCITexs",
"name":"Dicitrate Fe(III) binding (spontaneous)",
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{
"id":"__Ecoli_panGEMs__FESD1s",
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"h_c":-2.0
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{
"id":"DHGLYH",
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"h_c":-1.0,
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},
{
"id":"NOVBCNtex",
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{
"id":"DHPTDCs2",
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"sbo":"SBO:0000176"
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},
{
"id":"__Ecoli_panGEMs__FESD2s",
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{
"id":"GLYCTO2",
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"q8h2_c":1.0
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{
"id":"GLYCTO3",
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"mqn8_c":-1.0
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},
{
"id":"GLYCTO4",
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},
{
"id":"PMANM",
"name":"phosphomannomutase",
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},
{
"id":"GOFUCR",
"name":"GDP-4-oxo-L-fucose reductase",
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"h_c":-1.0,
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"sbo":"SBO:0000176"
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},
{
"id":"UDPGALM",
"name":"UDPgalactopyranose mutase",
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"sbo":"SBO:0000176"
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},
{
"id":"TDPDRE",
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"sbo":"SBO:0000176"
}
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{
"id":"IDOND",
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"id":"__Ecoli_panGEMs__O16A4Lpp",
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"id":"__Ecoli_panGEMs__O16AT",
"name":"Rhamanosyl-N-acetylglucosamyl-undecaprenyl diphosphate O-acetyltransferase (LPS O16 antigen biosynthesis)",
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"id":"__Ecoli_panGEMs__O16GALFT",
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}
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"id":"__Ecoli_panGEMs__O16AUNDtpp",
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"id":"__Ecoli_panGEMs__O16AP1pp",
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{
"id":"GALTptspp",
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}
},
{
"id":"__Ecoli_panGEMs__RHAT1",
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}
},
{
"id":"__Ecoli_panGEMs__GDMANE",
"name":"GDP-4-dehydro-6-deoxy-D-mannose epimerase",
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}
},
{
"id":"5DGLCNt2rpp",
"name":"5-Dehydro-D-gluconate transport via proton symport, reversible (periplasm)",
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}
},
{
"id":"DXYLTD",
"name":"D-xylonate dehydratase",
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"sbo":"SBO:0000176"
}
},
{
"id":"2DDARAA",
"name":"2-dehydro-3-deoxy-D-arabinonate Aldolase",
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},
{
"id":"CHLt3pp",
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}
},
{
"id":"GLYBt3pp",
"name":"Glycine betaine transport via proton antiport (periplasm)",
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"subsystem":"Transport, Inner Membrane",
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}
},
{
"id":"5DGLCNR",
"name":"5-dehydro-D-gluconate reductase",
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"sbo":"SBO:0000176"
}
},
{
"id":"UDPGPT",
"name":"undecaprenyl-phosphate glucose phosphotransferase",
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"ump_c":1.0
},
"lower_bound":-1000.0,
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"annotation":{
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"sbo":"SBO:0000176"
}
},
{
"id":"MEPNabcpp",
"name":"methylpshophonic acid abc transporter",
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"annotation":{
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}
},
{
"id":"THZPSN",
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"atp_c":-1.0,
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"subsystem":"Cofactor and Prosthetic Group Biosynthesis",
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},
"annotation":{
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}
},
{
"id":"__Ecoli_panGEMs__ENLIPIDAt2ex",
"name":"Phosphoethanolamine lipid IVa transport via vector periplasm to extracellular",
"metabolites":{
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},
"lower_bound":0.0,
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},
"annotation":{
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"sbo":"SBO:0000655"
}
}
],
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"id":"HFPHFOGF_02157",
"name":""
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{
"id":"HFPHFOGF_00259",
"name":""
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{
"id":"HFPHFOGF_00122",
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"id":"HFPHFOGF_02601",
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{
"id":"HFPHFOGF_00503",
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{
"id":"HFPHFOGF_01749",
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{
"id":"HFPHFOGF_03385",
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{
"id":"HFPHFOGF_01079",
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"id":"HFPHFOGF_01394",
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{
"id":"HFPHFOGF_03959",
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{
"id":"HFPHFOGF_00264",
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{
"id":"HFPHFOGF_00739",
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{
"id":"HFPHFOGF_00890",
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"id":"HFPHFOGF_02634",
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{
"id":"HFPHFOGF_04523",
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{
"id":"HFPHFOGF_04521",
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{
"id":"HFPHFOGF_00385",
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{
"id":"HFPHFOGF_01347",
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{
"id":"HFPHFOGF_03183",
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{
"id":"HFPHFOGF_04204",
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{
"id":"HFPHFOGF_03835",
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{
"id":"HFPHFOGF_03122",
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{
"id":"HFPHFOGF_01667",
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{
"id":"HFPHFOGF_02581",
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{
"id":"HFPHFOGF_04376",
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{
"id":"HFPHFOGF_02844",
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{
"id":"HFPHFOGF_00444",
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{
"id":"HFPHFOGF_03507",
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{
"id":"HFPHFOGF_01569",
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{
"id":"HFPHFOGF_03153",
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{
"id":"HFPHFOGF_04187",
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{
"id":"HFPHFOGF_01292",
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{
"id":"HFPHFOGF_00025",
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{
"id":"HFPHFOGF_02376",
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{
"id":"HFPHFOGF_02466",
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{
"id":"HFPHFOGF_00063",
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{
"id":"HFPHFOGF_03673",
"name":""
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{
"id":"HFPHFOGF_03883",
"name":""
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{
"id":"HFPHFOGF_04055",
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{
"id":"HFPHFOGF_04522",
"name":""
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{
"id":"HFPHFOGF_04188",
"name":""
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{
"id":"HFPHFOGF_00949",
"name":""
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{
"id":"HFPHFOGF_03941",
"name":""
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{
"id":"HFPHFOGF_00476",
"name":""
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{
"id":"HFPHFOGF_00864",
"name":""
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{
"id":"HFPHFOGF_01719",
"name":""
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{
"id":"HFPHFOGF_03725",
"name":""
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{
"id":"HFPHFOGF_01208",
"name":""
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{
"id":"HFPHFOGF_03061",
"name":""
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{
"id":"HFPHFOGF_04381",
"name":""
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{
"id":"HFPHFOGF_04054",
"name":""
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{
"id":"HFPHFOGF_03825",
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{
"id":"HFPHFOGF_03533",
"name":""
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{
"id":"HFPHFOGF_01733",
"name":""
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{
"id":"HFPHFOGF_01915",
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{
"id":"HFPHFOGF_03473",
"name":""
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{
"id":"HFPHFOGF_02800",
"name":""
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{
"id":"HFPHFOGF_03298",
"name":""
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{
"id":"HFPHFOGF_02522",
"name":""
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{
"id":"HFPHFOGF_03602",
"name":""
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{
"id":"HFPHFOGF_03899",
"name":""
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{
"id":"HFPHFOGF_00966",
"name":""
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{
"id":"HFPHFOGF_00072",
"name":""
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{
"id":"HFPHFOGF_00073",
"name":""
},
{
"id":"HFPHFOGF_03752",
"name":""
},
{
"id":"HFPHFOGF_00445",
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