The ratio of the absolute values of the largest coefficient 45.0 and the lowest, non-zero coefficient 1e-05 is: 4.5E+06.

This test will return the absolute largest and smallest, non-zero coefficients of the stoichiometric matrix. A large ratio of these values may point to potential numerical issues when trying to solve different mathematical optimization problems such as flux-balance analysis. To pass this test the ratio should not exceed 10^9. This threshold has been selected based on experience, and is likely to be adapted when more data on solver performance becomes available. Implementation: Compose the stoichiometric matrix, then calculate absolute coefficients and lastly use the maximal value and minimal non-zero value to calculate the ratio.