IPPS in 562_7845_json
- 2-isopropylmalate synthase
- 3mob_c:-1 + accoa_c:-4 + h2o_c:0 → 3c3hmp_c:-2 + coa_c:-4 + h_c:1
- Bounds: (0.0, 1000.0)
- Universal Reaction: IPPS
RHEA:21524
- 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)
- View on RHEA
Properties
- Names: acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)[1,2,3], (CoA-acetylating)[1,2,3], 2-isopropylmalate synthase[1,2,3], 3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase[1,2,3], 3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)[1,2,3], 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)[1,2,3], Alpha-IPM synthetase[1,2,3], Alpha-isopropylmalate synthase[1,2,3], alpha-IPM synthase[1,2,3], alpha-isopropylmalate synthase[1,2,3], alpha-isopropylmalate synthetase[1,2,3], alpha-isopropylmalic synthetase[1,2,3], isopropylmalate synthase[1,2,3], isopropylmalate synthetase[1,2,3]
Linkouts
- RHEA: 21524 [0], 21525 [0], 21526 [0], 21527 [0]
- GO: 0003852 [0]
- EC: 2.3.3.13 [0]
- MetaCyc Reaction: 2-ISOPROPYLMALATESYN-RXN [0,1,2,3]
- KEGG Reaction: R01213 [0,1,2,3]
- seed.reaction: rxn00902 [1], rxn27497 [2], rxn30151 [3]
- MetaNetX Reaction: MNXR100879 [1,2,3], MNXR132738 [1,2,3]
Reaction Participants
| Stoich. | BiGG ID | Name | Reference | x [side] | Compartment | |
|---|---|---|---|---|---|---|
 |
-1 | 3mob_c:-1 | 3-methyl-2-oxobutanoate | CHEBI:11851 | 1 [L] | 0 |
|
-1 | accoa_c:-4 | acetyl-CoA(4-) | CHEBI:57288 | 1 [L] | 0 |
|
-1 | h2o_c:0 | water | CHEBI:15377 | 1 [L] | 0 |
 |
1 | 3c3hmp_c:-2 | (2S)-2-isopropylmalate(2-) | CHEBI:1178 | 1 [R] | 0 |
|
1 | coa_c:-4 | coenzyme A(4-) | CHEBI:57287 | 1 [R] | 0 |
|
1 | h_c:1 | hydron | CHEBI:15378 | 1 [R] | 0 |
