DHFR in iPKB_GCF_009874195_1
- dihydrofolate reductase
- dhf_c:-2 + h_c:1 + nadph_c:-4 ⇌ nadp_c:-3 + thf_c:-2
- Bounds: (-1000.0, 1000.0)
- Universal Reaction: DHFR
RHEA:15009
- (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)
- View on RHEA
Properties
- Names: 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase[1,2,3], 7,8-dihydrofolate reductase[1,2,3], Dihydrofolate reductase[1,2,3], NADPH-dihydrofolate reductase[1,2,3], Tetrahydrofolate dehydrogenase[1,2,3], dihydrofolate reductase[1,2,3], dihydrofolate reductase (irreversible)[1,2,3], dihydrofolate reductase:thymidylate synthase[1,2,3], dihydrofolatereductase-irreversible[1,2,3], dihydrofolic acid reductase[1,2,3], dihydrofolic reductase[1,2,3], dihydropholate reductase[1,2,3], folic acid reductase[1,2,3], folic reductase[1,2,3], pteridine reductase:dihydrofolate reductase[1,2,3], tetrahydrofolate dehydrogenase[1,2,3], thymidylate synthetase-dihydrofolate reductase[1,2,3], DIHYDROFOLATEREDUCT-RXN.m[3]
Reaction Participants
| Stoich. | BiGG ID | Name | Reference | x [side] | Compartment | |
|---|---|---|---|---|---|---|
 |
-1 | dhf_c:-2 | dihydrofolate(2-) | CHEBI:57451 | 1 [R] | 0 |
|
-1 | h_c:1 | hydron | CHEBI:15378 | 1 [R] | 0 |
|
-1 | nadph_c:-4 | NADPH(4-) | CHEBI:57783 | 1 [R] | 0 |
 |
1 | nadp_c:-3 | NADP(3-) | CHEBI:58349 | 1 [L] | 0 |
|
1 | thf_c:-2 | (6S)-5,6,7,8-tetrahydrofolate(2-) | CHEBI:57453 | 1 [L] | 0 |
Gene Reaction Rule
CLOINNGCF_009874195_04905 or CLOINNGCF_009874195_09230 or CLOINNGCF_009874195_15115
