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DHORDi in iYO844
  • R_dihydoorotic_acid_dehydrogenase__irreversible_
  • dhor__S_c:-1 + o2_c:0 ⇌ h2o2_c:0 + orot_c:-1
  • Bounds: (-999999.0, 999999.0)
  • Universal Reaction: DHORDi
Properties
  • Names: 4,5-L-dihydroorotate:oxygen oxidoreductase[0,1,2,3,4], DHOD (ambiguous)[0,1,2,3,4], DHODase (ambiguous)[0,1,2,3,4], DHOdehase[0,1,2,3,4], DHOdehase (ambiguous)[0,1,2,3,4], Dihydoorotic acid dehydrogenase[0,1,2,3,4], Dihydroorotate dehydrogenase[0,1,2,3,4], Dihydroorotate oxidase[0,1,2,3,4], Fumarate dependent DHORD[0,1,2,3,4], dihydoorotic acid dehydrogenase[0,1,2,3,4], dihydoorotic acid dehydrogenase (ambiguous)[0,1,2,3,4], dihydroorotate dehydrogenase (ambiguous)[0,1,2,3,4], dihydroorotate dehydrogenase (fumarate)[0,1,2,3,4], dihydroorotate dehydrogenase A[0,1,2,3,4], dihydroorotate dehydrogenase B[0,1,2,3,4], dihydroorotate oxidase[0,1,2,3,4], dihydroorotate oxidase, pyr4 (gene name)[0,1,2,3,4], (S)-dihydroorotate:fumarate oxidoreductase[0,1,2,3,4], (DHO) dehydrogenase[0,1,2,3,4], (S)-Dihydroorotate:oxygen oxidoreductase[0,1,2,3,4], (S)-dihydroorotate:oxygen oxidoreductase[0,1,2,3,4], dihydroorotate oxidase, mitochondria[3]
Data Sources: [0] rxn01360 via ModelSEED, [1] rxn27812 via ModelSEED, [2] rxn27813 via ModelSEED, [3] rxn35450 via ModelSEED, [4] rxn38082 via ModelSEED
Linkouts
Data Sources: [0] rxn01360 via ModelSEED, [1] rxn27812 via ModelSEED, [2] rxn27813 via ModelSEED, [3] rxn35450 via ModelSEED, [4] rxn38082 via ModelSEED
Reaction Participants
Stoich. BiGG ID Name Reference x [side] Compartment
-1 dhor__S_c:-1 (S)-dihydroorotate CHEBI:30864 - -
-1 o2_c:0 dioxygen CHEBI:15379 - -
1 h2o2_c:0 hydrogen peroxide CHEBI:16240 - -
1 orot_c:-1 orotate CHEBI:30839 - -
Gene Reaction Rule
BG10717 and BG10718
BiGG ID Name
BG10717 BG10717
BG10718 BG10718
MEMOTE Flags
This reaction was flagged in the following MEMOTE tests:

There are a total of 3 reversible oxygen-containing reactions (9.68% of all oxygen-containing reactions): O2t, SPODM_1, DHORDi

The directionality of oxygen-producing/-consuming reactions affects the model's ability to grow anaerobically i.e. create faux-anaerobic organisms. This test reports how many of these oxygen-containing reactions are reversible. This test does not have any mandatory 'pass' criteria. Implementation: First, find the metabolite representing atmospheric oxygen in the model on the basis of an internal mapping table or by specifically looking for the formula "O2". Then, find all reactions that produce or consume oxygen and report those that are reversible.

Escher Maps
This reaction is present in the following Escher maps:
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