Universal:DHFRim
- R_dihydrofolate_reductase__mitochondrial
-
dhf_m + h_m + nadph_m ⇌ thf_m + nadp_m dhf_m:-2 + h_m:1 + nadph_m:-4 ⇌ thf_m:-2 + nadp_m:-3
RHEA:15009
- (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)
- View on RHEA
Properties
- Names: 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase[1,2,3], 7,8-dihydrofolate reductase[1,2,3], Dihydrofolate reductase[1,2,3], NADPH-dihydrofolate reductase[1,2,3], Tetrahydrofolate dehydrogenase[1,2,3], dihydrofolate reductase[1,2,3], dihydrofolate reductase (irreversible)[1,2,3], dihydrofolate reductase:thymidylate synthase[1,2,3], dihydrofolatereductase-irreversible[1,2,3], dihydrofolic acid reductase[1,2,3], dihydrofolic reductase[1,2,3], dihydropholate reductase[1,2,3], folic acid reductase[1,2,3], folic reductase[1,2,3], pteridine reductase:dihydrofolate reductase[1,2,3], tetrahydrofolate dehydrogenase[1,2,3], thymidylate synthetase-dihydrofolate reductase[1,2,3], DIHYDROFOLATEREDUCT-RXN.m[3]
Reaction Participants
| Stoich. | BiGG ID | Name | Reference | x [side] | Compartment | |
|---|---|---|---|---|---|---|
 |
1 | thf_m | (6S)-5,6,7,8-tetrahydrofolate(2-) | CHEBI:57453 | 1 [L] | 0 |
|
1 | nadp_m | NADP(3-) | CHEBI:58349 | 1 [L] | 0 |
 |
-1 | dhf_m | dihydrofolate(2-) | CHEBI:57451 | 1 [R] | 0 |
|
-1 | h_m | hydron | CHEBI:15378 | 1 [R] | 0 |
|
-1 | nadph_m | NADPH(4-) | CHEBI:57783 | 1 [R] | 0 |
In BiGGr Models
| Organism | Model |
|---|---|
| Saccharomyces cerevisiae S288C | iMM904 |