Universal:DHFS
- dihydrofolate synthase
-
glu__L_c + dhpt_c + atp_c ⇌ dhf_c + adp_c + h_c + pi_c glu__L_c:-1 + dhpt_c:-1 + atp_c:-4 ⇌ dhf_c:-2 + adp_c:-3 + h_c:1 + pi_c:-2
RHEA:23584
- 7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)
- View on RHEA
Properties
- Names: 7,8-dihydropteroate:L-glutamate ligase (ADP-forming)[1,2], 7,8-dihydrofolate synthetase[1,2], 7,8-dihydropteroate:L-glutamate ligase (ADP)[1,2], FHFS[1,2], FHFS/FPGS[1,2], H2-folate synthetase[1,2], dihydrofolate synthase[1,2], dihydrofolate synthetase[1,2], dihydrofolate synthetase-folylpolyglutamate synthetase[1,2], dihydrofolatesynthase[1,2], dihydropteroate:L-glutamate ligase (ADP-forming)[1,2], folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase[1,2]
Linkouts
- RHEA: 23584 [0], 23585 [0], 23586 [0], 23587 [0]
- GO: 0008841 [0]
- EC: 6.3.2.12 [0]
- MetaCyc Reaction: DIHYDROFOLATESYNTH-RXN [0,1,2]
- KEGG Reaction: R02237 [0,1,2]
- seed.reaction: rxn01603 [1], rxn19488 [2]
- MetaNetX Reaction: MNXR140043 [1,2], MNXR138234 [1,2]
Reaction Participants
| Stoich. | BiGG ID | Name | Reference | x [side] | Compartment | |
|---|---|---|---|---|---|---|
 |
-1 | glu__L_c | L-glutamate(1-) | CHEBI:29985 | 1 [L] | 0 |
|
-1 | dhpt_c | 7,8-dihydropteroate | CHEBI:17839 | 1 [L] | 0 |
|
-1 | atp_c | ATP(4-) | CHEBI:30616 | 1 [L] | 0 |
 |
1 | dhf_c | dihydrofolate(2-) | CHEBI:57451 | 1 [R] | 0 |
|
1 | adp_c | ADP(3-) | CHEBI:456216 | 1 [R] | 0 |
|
1 | h_c | hydron | CHEBI:15378 | 1 [R] | 0 |
|
1 | pi_c | hydrogenphosphate | CHEBI:43474 | 1 [R] | 0 |