Universal:FTHFDH
- formyltetrahydrofolate dehydrogenase
-
h2o_c + 10fthf_c + nadp_c ⇌ h_c + nadph_c + co2_c + thf_c h2o_c:0 + 10fthf_c:-2 + nadp_c:-3 ⇌ h_c:1 + nadph_c:-4 + co2_c:0 + thf_c:-2
RHEA:10180
- (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)
- View on RHEA
Properties
- Names: 10-formyltetrahydrofolate:NADP+ oxidoreductase[1], 10-formyl tetrahydrofolate:NADP oxidoreductase[1], 10-formyl-H2PtGlu:NADP oxidoreductase[1], 10-formyl-H4folate dehydrogenase[1], 10-formyltetrahydrofolate dehydrogenase[1], N10-formyltetrahydrofolate dehydrogenase[1], formyltetrahydrofolate dehydrogenase[1]
Linkouts
- RHEA: 10180 [0], 10181 [0], 10182 [0], 10183 [0]
- MetaCyc Reaction: FORMYLTETRAHYDROFOLATE-DEHYDROGENASE-RXN [0,1]
- GO: 0016155 [0]
- EC: 1.5.1.6 [0]
- KEGG Reaction: R00941 [0,1]
- seed.reaction: rxn00688 [1]
- MetaNetX Reaction: MNXR139014 [1]
Reaction Participants
| Stoich. | BiGG ID | Name | Reference | x [side] | Compartment | |
|---|---|---|---|---|---|---|
 |
-1 | h2o_c | water | CHEBI:15377 | 1 [L] | 0 |
|
-1 | 10fthf_c | (6R)-10-formyltetrahydrofolate(2-) | CHEBI:195366 | 1 [L] | 0 |
|
-1 | nadp_c | NADP(3-) | CHEBI:58349 | 1 [L] | 0 |
 |
1 | h_c | hydron | CHEBI:15378 | 1 [R] | 0 |
|
1 | nadph_c | NADPH(4-) | CHEBI:57783 | 1 [R] | 0 |
|
1 | co2_c | carbon dioxide | CHEBI:16526 | 1 [R] | 0 |
|
1 | thf_c | (6S)-5,6,7,8-tetrahydrofolate(2-) | CHEBI:57453 | 1 [R] | 0 |
In BiGGr Models
| Organism | Model |
|---|---|
| Homo sapiens | RECON1 |