Universal:GLYCL
- Glycine Cleavage System
-
nad_c + gly_c + thf_c ⇌ nh4_c + nadh_c + co2_c + mlthf_c nad_c:-1 + gly_c:0 + thf_c:-2 ⇌ nh4_c:1 + nadh_c:-2 + co2_c:0 + mlthf_c:-2
RHEA:27758
- (6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+) + CO2 + NADH
- View on RHEA
Reaction Participants
| Stoich. | BiGG ID | Name | Reference | x [side] | Compartment | |
|---|---|---|---|---|---|---|
 |
-1 | nad_c | NAD(1-) | CHEBI:57540 | 1 [L] | 0 |
|
-1 | gly_c | glycine zwitterion | CHEBI:57305, CHEBI:15428 | 1 [L] | 0 |
|
-1 | thf_c | (6S)-5,6,7,8-tetrahydrofolate(2-) | CHEBI:57453 | 1 [L] | 0 |
 |
1 | nh4_c | ammonium | CHEBI:28938 | 1 [R] | 0 |
|
1 | nadh_c | NADH(2-) | CHEBI:57945 | 1 [R] | 0 |
|
1 | co2_c | carbon dioxide | CHEBI:16526 | 1 [R] | 0 |
|
1 | mlthf_c | (6R)-5,10-methylenetetrahydrofolate(2-) | CHEBI:15636 | 1 [R] | 0 |