Universal:GLYCLm
- R_glycine_cleavage_system__mitochondrial
-
nad_m + gly_m + thf_m ⇌ nh4_m + nadh_m + co2_m + mlthf_m nad_m:-1 + gly_m:0 + thf_m:-2 ⇌ nh4_m:1 + nadh_m:-2 + co2_m:0 + mlthf_m:-2
RHEA:27758
- (6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+) + CO2 + NADH
- View on RHEA
Properties
- Names: glycine synthase[1,2,3,4], Aminomethyltransferase[1,2,3,4], Glycine Cleavage System[1,2,3,4], glycine cleavage system[1,2,3,4], GCVMULTI-RXN.m[2], glycine cleavage system, mitochondrial[4]
Linkouts
- RHEA: 27758 [0], 27759 [0], 27760 [0], 27761 [0]
- EC: 1.4.1.27 [0]
- MetaCyc Reaction: GCVMULTI-RXN [0,1,2,3,4]
- KEGG Reaction: R01221 [0,1,2,3,4]
- seed.reaction: rxn00908 [1], rxn19763 [2], rxn30025 [3], rxn30388 [4]
- MetaNetX Reaction: MNXR139026 [1,2,3,4], MNXR141866 [1,2,3,4]
Reaction Participants
| Stoich. | BiGG ID | Name | Reference | x [side] | Compartment | |
|---|---|---|---|---|---|---|
 |
-1 | nad_m | NAD(1-) | CHEBI:57540 | 1 [L] | 0 |
|
-1 | gly_m | glycine zwitterion | CHEBI:57305, CHEBI:15428 | 1 [L] | 0 |
|
-1 | thf_m | (6S)-5,6,7,8-tetrahydrofolate(2-) | CHEBI:57453 | 1 [L] | 0 |
 |
1 | nh4_m | ammonium | CHEBI:28938 | 1 [R] | 0 |
|
1 | nadh_m | NADH(2-) | CHEBI:57945 | 1 [R] | 0 |
|
1 | co2_m | carbon dioxide | CHEBI:16526 | 1 [R] | 0 |
|
1 | mlthf_m | (6R)-5,10-methylenetetrahydrofolate(2-) | CHEBI:15636 | 1 [R] | 0 |