Universal:MTHFD2i
- R_methylenetetrahydrofolate_dehydrogenase__NAD_
-
nad_c + mlthf_c ⇌ nadh_c + methf_c nad_c:-1 + mlthf_c:-2 ⇌ nadh_c:-2 + methf_c:-1
RHEA:22892
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methenyltetrahydrofolate + NADH
- View on RHEA
Properties
- Names: 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase[1,2], Methylenetetrahydrofolate dehydrogenase (NAD+)[1,2], Methylenetetrahydrofolate dehydrogenase [NAD+][1,2], methylenetetrahydrofolate dehydrogenase (NAD)[1,2], methylenetetrahydrofolate dehydrogenase (NAD+)[1,2]
Linkouts
- RHEA: 22892 [0], 22893 [0], 22894 [0], 22895 [0]
- GO: 0004487 [0]
- EC: 1.5.1.15 [0]
- MetaCyc Reaction: 1.5.1.15-RXN [0,1,2]
- KEGG Reaction: R01218 [0,1,2]
- seed.reaction: rxn00906 [1], rxn31886 [2]
- MetaNetX Reaction: MNXR141864 [1,2], MNXR101750 [1,2]
Reaction Participants
| Stoich. | BiGG ID | Name | Reference | x [side] | Compartment | |
|---|---|---|---|---|---|---|
 |
-1 | nad_c | NAD(1-) | CHEBI:57540 | 1 [L] | 0 |
|
-1 | mlthf_c | (6R)-5,10-methylenetetrahydrofolate(2-) | CHEBI:15636 | 1 [L] | 0 |
 |
1 | nadh_c | NADH(2-) | CHEBI:57945 | 1 [R] | 0 |
|
1 | methf_c | (6R)-5,10-methenyltetrahydrofolate | CHEBI:57455 | 1 [R] | 0 |