Universal:MTHFR3_1
- 5,10-methylenetetrahydrofolatereductase (NADPH)
-
h_c + nadph_c + mlthf_c ⇌ 5mthf_c + nadp_c h_c:1 + nadph_c:-4 + mlthf_c:-2 ⇌ 5mthf_c:-2 + nadp_c:-3 nadph_c:-4 + mlthf_c:-2 + h_c:1 ⇌ 5mthf_c:-1 + nadp_c:-3
RHEA:19817
- (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+)
- View on RHEA
Properties
- Names: 5-methyltetrahydrofolate:NADP+ oxidoreductase[1,2,3], 5,10-methylenetetrahydrofolate reductase (FADH)-(NADP)[1,2,3], 5,10-methylenetetrahydrofolate reductase (NADP)[1,2,3], 5,10-methylenetetrahydrofolatereductase (NADPH)[1,2,3], MTHFR[1,2,3], Methylenetetrahydrofolate reductase (NADPH)[1,2,3], Methylenetetrahydrofolate reductase 1[1,2,3]
Reaction Participants
| Stoich. | BiGG ID | Name | Reference | x [side] | Compartment | |
|---|---|---|---|---|---|---|
 |
1 | 5mthf_c | (6S)-5-methyltetrahydrofolate(2-) | CHEBI:18608 | 1 [L] | 0 |
|
1 | nadp_c | NADP(3-) | CHEBI:58349 | 1 [L] | 0 |
 |
-1 | h_c | hydron | CHEBI:15378 | 1 [R] | 0 |
|
-1 | nadph_c | NADPH(4-) | CHEBI:57783 | 1 [R] | 0 |
|
-1 | mlthf_c | (6R)-5,10-methylenetetrahydrofolate(2-) | CHEBI:15636 | 1 [R] | 0 |