Universal:MTHFR2
- 5,10-methylenetetrahydrofolate reductase (NADH)
-
nadh_c + h_c + mlthf_c ⇌ 5mthf_c + nad_c nadh_c:-2 + h_c:1 + mlthf_c:-2 ⇌ 5mthf_c:-2 + nad_c:-1 nadh_c:-2 + mlthf_c:-2 + h_c:1 ⇌ 5mthf_c:-1 + nad_c:-1
RHEA:19821
- (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADH + H(+)
- View on RHEA
Properties
- Names: 5-methyltetrahydrofolate:NAD+ oxidoreductase[1,2,3], 5,10-CH2-H4folate reductase[1,2,3], 5,10-methylenetetrahydrofolate reductase[1,2,3], 5,10-methylenetetrahydrofolate reductase (FADH2)[1,2,3], 5,10-methylenetetrahydrofolate reductase (NADH)[1,2,3], 5,10-methylenetetrahydrofolate reductase (NADPH)[1,2,3], 5,10-methylenetetrahydrofolate reductase (fadh)[1,2,3], 5,10-methylenetetrahydrofolic acid reductase[1,2,3], 5,10-methylenetetrahydropteroylglutamate reductase[1,2,3], 5-10-methylenetetrahydrofolatereductase-NADH[1,2,3], 5-methyltetrahydrofolate:(acceptor) oxidoreductase (incorrect)[1,2,3], 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase[1,2,3], 5-methyltetrahydrofolate:NADP+ oxidoreductase[1,2,3], MetF[1,2,3], N5,10-methylenetetrahydrofolate reductase[1,2,3], N5,N10-methylenetetrahydrofolate reductase[1,2,3], methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase[1,2,3], methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase[1,2,3], methylenetetrahydrofolate reductase[1,2,3], methylenetetrahydrofolate reductase (NADPH)[1,2,3], methylenetetrahydrofolate reductase (NADPH2)[1,2,3], methylenetetrahydrofolate reductase [NAD(P)H][1,2,3], methylenetetrahydrofolic acid reductase[1,2,3]
Linkouts
- RHEA: 19821 [0], 19822 [0], 19823 [0], 19824 [0]
- GO: 0106312 [0]
- EC: 1.5.1.20 [0], 1.5.1.54 [0]
- MetaCyc Reaction: RXN-22438 [0], 1.5.1.20-RXN [1,2,3]
- KEGG Reaction: R07168 [0,1,2,3]
- seed.reaction: rxn04954 [1], rxn17243 [2], rxn35346 [3]
- MetaNetX Reaction: MNXR101751 [1,2,3], MNXR142121 [1,2,3]
Reaction Participants
| Stoich. | BiGG ID | Name | Reference | x [side] | Compartment | |
|---|---|---|---|---|---|---|
 |
1 | 5mthf_c | (6S)-5-methyltetrahydrofolate(2-) | CHEBI:18608 | 1 [L] | 0 |
|
1 | nad_c | NAD(1-) | CHEBI:57540 | 1 [L] | 0 |
 |
-1 | nadh_c | NADH(2-) | CHEBI:57945 | 1 [R] | 0 |
|
-1 | h_c | hydron | CHEBI:15378 | 1 [R] | 0 |
|
-1 | mlthf_c | (6R)-5,10-methylenetetrahydrofolate(2-) | CHEBI:15636 | 1 [R] | 0 |